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Protein

Myelin protein zero-like protein 3

Gene

MPZL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates homophilic cell-cell adhesion.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein zero-like protein 3
Gene namesi
Name:MPZL3
ORF Names:UNQ2966/PRO7425
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:27279. MPZL3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 158ExtracellularSequence analysisAdd BLAST127
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 235CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi196264.
OpenTargetsiENSG00000160588.
PharmGKBiPA162396160.

Polymorphism and mutation databases

BioMutaiMPZL3.
DMDMi74758560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000028028232 – 235Myelin protein zero-like protein 3Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 128PROSITE-ProRule annotation
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UWV2.
PeptideAtlasiQ6UWV2.
PRIDEiQ6UWV2.

PTM databases

iPTMnetiQ6UWV2.
PhosphoSitePlusiQ6UWV2.

Expressioni

Gene expression databases

BgeeiENSG00000160588.
CleanExiHS_MPZL3.
ExpressionAtlasiQ6UWV2. baseline and differential.
GenevisibleiQ6UWV2. HS.

Organism-specific databases

HPAiHPA029116.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MPZL2O604873EBI-4314854,EBI-3906725

Protein-protein interaction databases

BioGridi128193. 2 interactors.
IntActiQ6UWV2. 1 interactor.
STRINGi9606.ENSP00000278949.

Structurei

3D structure databases

ProteinModelPortaliQ6UWV2.
SMRiQ6UWV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 148Ig-like V-typeAdd BLAST117

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGFH. Eukaryota.
ENOG4111TUJ. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000012980.
HOVERGENiHBG108144.
InParanoidiQ6UWV2.
OMAiFHYQSFQ.
OrthoDBiEOG091G0K34.
PhylomeDBiQ6UWV2.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR029862. MPZL3.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF20. PTHR13869:SF20. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQRGAAGSR GCALFPLLGV LFFQGVYIVF SLEIRADAHV RGYVGEKIKL
60 70 80 90 100
KCTFKSTSDV TDKLTIDWTY RPPSSSHTVS IFHYQSFQYP TTAGTFRDRI
110 120 130 140 150
SWVGNVYKGD ASISISNPTI KDNGTFSCAV KNPPDVHHNI PMTELTVTER
160 170 180 190 200
GFGTMLSSVA LLSILVFVPS AVVVALLLVR MGRKAAGLKK RSRSGYKKSS
210 220 230
IEVSDDTDQE EEEACMARLC VRCAECLDSD YEETY
Length:235
Mass (Da):25,989
Last modified:July 5, 2004 - v1
Checksum:i009B7ED8C82C7B4F
GO
Isoform 2 (identifier: Q6UWV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-36: Missing.

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):24,640
Checksum:i5AF5E0CB143CA7EC
GO
Isoform 3 (identifier: Q6UWV2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-108: IFHYQSFQYPTTAGTFRDRISWVGNVYK → VLAPCFPLWPFFPSLSLCPQPWWLLCCW
     109-235: Missing.

Note: No experimental confirmation available.
Show »
Length:108
Mass (Da):12,187
Checksum:iFDB8F7E74B892B70
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031108155M → V.Corresponds to variant rs17121966dbSNPEnsembl.1
Natural variantiVAR_050455168V → G.Corresponds to variant rs36102742dbSNPEnsembl.1
Natural variantiVAR_050456172V → M.Corresponds to variant rs34507994dbSNPEnsembl.1
Natural variantiVAR_031109228D → V.Corresponds to variant rs7105729dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05398825 – 36Missing in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_05532481 – 108IFHYQ…GNVYK → VLAPCFPLWPFFPSLSLCPQ PWWLLCCW in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_055325109 – 235Missing in isoform 3. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358626 mRNA. Translation: AAQ88989.1.
AK289390 mRNA. Translation: BAF82079.1.
AK095399 mRNA. Translation: BAG53045.1.
AK296951 mRNA. Translation: BAG59497.1.
AK304292 mRNA. Translation: BAG65150.1.
AP002800 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67357.1.
BC113586 mRNA. Translation: AAI13587.1.
BC143897 mRNA. Translation: AAI43898.1.
CCDSiCCDS66241.1. [Q6UWV2-2]
CCDS8392.1. [Q6UWV2-1]
RefSeqiNP_001273081.1. NM_001286152.1. [Q6UWV2-2]
NP_938016.1. NM_198275.2. [Q6UWV2-1]
UniGeneiHs.15396.

Genome annotation databases

EnsembliENST00000278949; ENSP00000278949; ENSG00000160588. [Q6UWV2-1]
ENST00000446386; ENSP00000393594; ENSG00000160588. [Q6UWV2-3]
ENST00000527472; ENSP00000432106; ENSG00000160588. [Q6UWV2-2]
GeneIDi196264.
KEGGihsa:196264.
UCSCiuc001psm.5. human. [Q6UWV2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358626 mRNA. Translation: AAQ88989.1.
AK289390 mRNA. Translation: BAF82079.1.
AK095399 mRNA. Translation: BAG53045.1.
AK296951 mRNA. Translation: BAG59497.1.
AK304292 mRNA. Translation: BAG65150.1.
AP002800 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67357.1.
BC113586 mRNA. Translation: AAI13587.1.
BC143897 mRNA. Translation: AAI43898.1.
CCDSiCCDS66241.1. [Q6UWV2-2]
CCDS8392.1. [Q6UWV2-1]
RefSeqiNP_001273081.1. NM_001286152.1. [Q6UWV2-2]
NP_938016.1. NM_198275.2. [Q6UWV2-1]
UniGeneiHs.15396.

3D structure databases

ProteinModelPortaliQ6UWV2.
SMRiQ6UWV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128193. 2 interactors.
IntActiQ6UWV2. 1 interactor.
STRINGi9606.ENSP00000278949.

PTM databases

iPTMnetiQ6UWV2.
PhosphoSitePlusiQ6UWV2.

Polymorphism and mutation databases

BioMutaiMPZL3.
DMDMi74758560.

Proteomic databases

PaxDbiQ6UWV2.
PeptideAtlasiQ6UWV2.
PRIDEiQ6UWV2.

Protocols and materials databases

DNASUi196264.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278949; ENSP00000278949; ENSG00000160588. [Q6UWV2-1]
ENST00000446386; ENSP00000393594; ENSG00000160588. [Q6UWV2-3]
ENST00000527472; ENSP00000432106; ENSG00000160588. [Q6UWV2-2]
GeneIDi196264.
KEGGihsa:196264.
UCSCiuc001psm.5. human. [Q6UWV2-1]

Organism-specific databases

CTDi196264.
DisGeNETi196264.
GeneCardsiMPZL3.
HGNCiHGNC:27279. MPZL3.
HPAiHPA029116.
MIMi611707. gene.
neXtProtiNX_Q6UWV2.
OpenTargetsiENSG00000160588.
PharmGKBiPA162396160.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGFH. Eukaryota.
ENOG4111TUJ. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000012980.
HOVERGENiHBG108144.
InParanoidiQ6UWV2.
OMAiFHYQSFQ.
OrthoDBiEOG091G0K34.
PhylomeDBiQ6UWV2.
TreeFamiTF331728.

Miscellaneous databases

GenomeRNAii196264.
PROiQ6UWV2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160588.
CleanExiHS_MPZL3.
ExpressionAtlasiQ6UWV2. baseline and differential.
GenevisibleiQ6UWV2. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR029862. MPZL3.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF20. PTHR13869:SF20. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPZL3_HUMAN
AccessioniPrimary (citable) accession number: Q6UWV2
Secondary accession number(s): A8K025, B4DLD5, B4E2I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.