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Protein

Myelin protein zero-like protein 3

Gene

MPZL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates homophilic cell-cell adhesion.By similarity

Caution

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein zero-like protein 3
Gene namesi
Name:MPZL3
ORF Names:UNQ2966/PRO7425
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000160588.9
HGNCiHGNC:27279 MPZL3
MIMi611707 gene
neXtProtiNX_Q6UWV2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 158ExtracellularSequence analysisAdd BLAST127
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 235CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi196264
OpenTargetsiENSG00000160588
PharmGKBiPA162396160

Polymorphism and mutation databases

BioMutaiMPZL3
DMDMi74758560

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000028028232 – 235Myelin protein zero-like protein 3Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 128PROSITE-ProRule annotation
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UWV2
PeptideAtlasiQ6UWV2
PRIDEiQ6UWV2

PTM databases

iPTMnetiQ6UWV2
PhosphoSitePlusiQ6UWV2

Expressioni

Gene expression databases

BgeeiENSG00000160588
CleanExiHS_MPZL3
ExpressionAtlasiQ6UWV2 baseline and differential
GenevisibleiQ6UWV2 HS

Organism-specific databases

HPAiHPA029116

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MPZL2O604873EBI-4314854,EBI-3906725

Protein-protein interaction databases

BioGridi1281932 interactors.
IntActiQ6UWV2 1 interactor.
STRINGi9606.ENSP00000278949

Structurei

3D structure databases

ProteinModelPortaliQ6UWV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 148Ig-like V-typeAdd BLAST117

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGFH Eukaryota
ENOG4111TUJ LUCA
GeneTreeiENSGT00900000140913
HOGENOMiHOG000012980
HOVERGENiHBG108144
InParanoidiQ6UWV2
OMAiFHYQSFQ
OrthoDBiEOG091G0K34
PhylomeDBiQ6UWV2
TreeFamiTF331728

Family and domain databases

Gene3Di2.60.40.101 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR029862 MPZL3
IPR000920 Myelin_P0-rel
PANTHERiPTHR13869 PTHR13869, 1 hit
PTHR13869:SF20 PTHR13869:SF20, 1 hit
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PRINTSiPR00213 MYELINP0
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQRGAAGSR GCALFPLLGV LFFQGVYIVF SLEIRADAHV RGYVGEKIKL
60 70 80 90 100
KCTFKSTSDV TDKLTIDWTY RPPSSSHTVS IFHYQSFQYP TTAGTFRDRI
110 120 130 140 150
SWVGNVYKGD ASISISNPTI KDNGTFSCAV KNPPDVHHNI PMTELTVTER
160 170 180 190 200
GFGTMLSSVA LLSILVFVPS AVVVALLLVR MGRKAAGLKK RSRSGYKKSS
210 220 230
IEVSDDTDQE EEEACMARLC VRCAECLDSD YEETY
Length:235
Mass (Da):25,989
Last modified:July 5, 2004 - v1
Checksum:i009B7ED8C82C7B4F
GO
Isoform 2 (identifier: Q6UWV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-36: Missing.

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):24,640
Checksum:i5AF5E0CB143CA7EC
GO
Isoform 3 (identifier: Q6UWV2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-108: IFHYQSFQYPTTAGTFRDRISWVGNVYK → VLAPCFPLWPFFPSLSLCPQPWWLLCCW
     109-235: Missing.

Note: No experimental confirmation available.
Show »
Length:108
Mass (Da):12,187
Checksum:iFDB8F7E74B892B70
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031108155M → V. Corresponds to variant dbSNP:rs17121966Ensembl.1
Natural variantiVAR_050455168V → G. Corresponds to variant dbSNP:rs36102742Ensembl.1
Natural variantiVAR_050456172V → M. Corresponds to variant dbSNP:rs34507994Ensembl.1
Natural variantiVAR_031109228D → V. Corresponds to variant dbSNP:rs7105729Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05398825 – 36Missing in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_05532481 – 108IFHYQ…GNVYK → VLAPCFPLWPFFPSLSLCPQ PWWLLCCW in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_055325109 – 235Missing in isoform 3. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358626 mRNA Translation: AAQ88989.1
AK289390 mRNA Translation: BAF82079.1
AK095399 mRNA Translation: BAG53045.1
AK296951 mRNA Translation: BAG59497.1
AK304292 mRNA Translation: BAG65150.1
AP002800 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67357.1
BC113586 mRNA Translation: AAI13587.1
BC143897 mRNA Translation: AAI43898.1
CCDSiCCDS66241.1 [Q6UWV2-2]
CCDS8392.1 [Q6UWV2-1]
RefSeqiNP_001273081.1, NM_001286152.1 [Q6UWV2-2]
NP_938016.1, NM_198275.2 [Q6UWV2-1]
UniGeneiHs.15396

Genome annotation databases

EnsembliENST00000278949; ENSP00000278949; ENSG00000160588 [Q6UWV2-1]
ENST00000446386; ENSP00000393594; ENSG00000160588 [Q6UWV2-3]
ENST00000527472; ENSP00000432106; ENSG00000160588 [Q6UWV2-2]
GeneIDi196264
KEGGihsa:196264
UCSCiuc001psm.5 human [Q6UWV2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMPZL3_HUMAN
AccessioniPrimary (citable) accession number: Q6UWV2
Secondary accession number(s): A8K025, B4DLD5, B4E2I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome