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Protein

Bombesin receptor-activated protein C6orf89

Gene

C6orf89

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits histone deacetylase (HDAC) enhancer properties (PubMed:23460338). May play a role in cell cycle progression and wound repair of bronchial epithelial cells (PubMed:21857995).2 Publications

GO - Biological processi

  • epithelial cell proliferation Source: UniProtKB
  • positive regulation of cell cycle Source: UniProtKB
  • positive regulation of histone deacetylase activity Source: UniProtKB
  • wound healing Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Bombesin receptor-activated protein C6orf89
Alternative name(s):
Amfion1 Publication
Gene namesi
Name:C6orf89
Synonyms:BRAP
ORF Names:UNQ177/PRO203
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21114. C6orf89.

Subcellular locationi

Isoform 1 :
Isoform 2 :
Isoform 3 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5858Cytoplasmic1 PublicationAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Topological domaini80 – 347268Extracellular1 PublicationAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • Golgi membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • midbody Source: UniProtKB
  • nucleolus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134986915.

Polymorphism and mutation databases

BioMutaiC6orf89.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Bombesin receptor-activated protein C6orf89PRO_0000237621Add
BLAST

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UWU4.
MaxQBiQ6UWU4.
PaxDbiQ6UWU4.
PeptideAtlasiQ6UWU4.
PRIDEiQ6UWU4.

PTM databases

iPTMnetiQ6UWU4.
PhosphoSiteiQ6UWU4.

Expressioni

Gene expression databases

BgeeiQ6UWU4.
CleanExiHS_C6orf89.
ExpressionAtlasiQ6UWU4. baseline and differential.
GenevisibleiQ6UWU4. HS.

Organism-specific databases

HPAiCAB011512.
HPA012548.

Interactioni

Subunit structurei

Homodimer (PubMed:23460338). Interacts with BRS3 (PubMed:21857995). Interacts (via N-terminus) with SIN3B (PubMed:23460338).2 Publications

Protein-protein interaction databases

BioGridi128732. 3 interactions.
STRINGi9606.ENSP00000347322.

Structurei

3D structure databases

ProteinModelPortaliQ6UWU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE6D. Eukaryota.
ENOG410YJCN. LUCA.
GeneTreeiENSGT00390000014270.
HOGENOMiHOG000070100.
HOVERGENiHBG055530.
InParanoidiQ6UWU4.
OMAiDRPFPDF.
OrthoDBiEOG7RRF74.
PhylomeDBiQ6UWU4.
TreeFamiTF335525.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWU4-1) [UniParc]FASTAAdd to basket

Also known as: 42/116mp

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLAANEISI YDKLSETVDL VRQTGHQCGM SEKAIEKFIR QLLEKNEPQR
60 70 80 90 100
PPPQYPLLIV VYKVLATLGL ILLTAYFVIQ PFSPLAPEPV LSGAHTWRSL
110 120 130 140 150
IHHIRLMSLP IAKKYMSENK GVPLHGGDED RPFPDFDPWW TNDCEQNESE
160 170 180 190 200
PIPANCTGCA QKHLKVMLLE DAPRKFERLH PLVIKTGKPL LEEEIQHFLC
210 220 230 240 250
QYPEATEGFS EGFFAKWWRC FPERWFPFPY PWRRPLNRSQ MLRELFPVFT
260 270 280 290 300
HLPFPKDASL NKCSFLHPEP VVGSKMHKMP DLFIIGSGEA MLQLIPPFQC
310 320 330 340
RRHCQSVAMP IEPGDIGYVD TTHWKVYVIA RGVQPLVICD GTAFSEL
Length:347
Mass (Da):39,870
Last modified:December 21, 2004 - v1
Checksum:iEFE39F1A9A514595
GO
Isoform 2 (identifier: Q6UWU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDFILEDM

Show »
Length:354
Mass (Da):40,734
Checksum:i737E3B396D0BE209
GO
Isoform 3 (identifier: Q6UWU4-3) [UniParc]FASTAAdd to basket

Also known as: 34/64sp

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:241
Mass (Da):27,857
Checksum:i9B477916B1427416
GO

Sequence cautioni

The sequence AAH23605.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD98021.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51A → V in CAD98021 (PubMed:17974005).Curated
Sequence conflicti171 – 1711D → H in CCA30148 (PubMed:23460338).Curated
Sequence conflicti171 – 1711D → H in CCA30149 (PubMed:23460338).Curated
Sequence conflicti189 – 1891P → A in BAH14355 (PubMed:14702039).Curated
Sequence conflicti327 – 3271Y → C in CAD98021 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 106106Missing in isoform 3. VSP_058111Add
BLAST
Alternative sequencei1 – 11M → MDFILEDM in isoform 2. 4 PublicationsVSP_018598

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR832871 mRNA. Translation: CCA30148.1.
FR832872 mRNA. Translation: CCA30149.1.
AY358637 mRNA. Translation: AAQ89000.1.
AK172780 mRNA. Translation: BAD18761.1.
AK300351 mRNA. Translation: BAG62093.1.
AK315984 mRNA. Translation: BAH14355.1.
BX538108 mRNA. Translation: CAD98021.1. Different initiation.
AL122034 Genomic DNA. Translation: CAI23297.1.
AL122034 Genomic DNA. Translation: CAI23299.1.
CH471081 Genomic DNA. Translation: EAX03920.1.
CH471081 Genomic DNA. Translation: EAX03919.1.
BC023605 mRNA. Translation: AAH23605.2. Different initiation.
BC095423 mRNA. Translation: AAH95423.1.
BC105947 mRNA. Translation: AAI05948.1.
BC107489 mRNA. Translation: AAI07490.1.
BC105946 mRNA. Translation: AAI05947.1.
CCDSiCCDS4827.1. [Q6UWU4-2]
CCDS69100.1. [Q6UWU4-1]
CCDS75444.1. [Q6UWU4-3]
RefSeqiNP_001273564.1. NM_001286635.1. [Q6UWU4-1]
NP_001273565.1. NM_001286636.1. [Q6UWU4-3]
NP_001273566.1. NM_001286637.1. [Q6UWU4-3]
NP_689947.2. NM_152734.3. [Q6UWU4-2]
XP_011512678.1. XM_011514376.1. [Q6UWU4-1]
XP_011512679.1. XM_011514377.1. [Q6UWU4-1]
XP_011512680.1. XM_011514378.1. [Q6UWU4-1]
XP_011512681.1. XM_011514379.1. [Q6UWU4-1]
XP_011512682.1. XM_011514380.1. [Q6UWU4-1]
UniGeneiHs.433381.

Genome annotation databases

EnsembliENST00000355190; ENSP00000347322; ENSG00000198663. [Q6UWU4-2]
ENST00000359359; ENSP00000352316; ENSG00000198663. [Q6UWU4-3]
ENST00000373685; ENSP00000362789; ENSG00000198663. [Q6UWU4-1]
ENST00000480824; ENSP00000475947; ENSG00000198663. [Q6UWU4-1]
GeneIDi221477.
KEGGihsa:221477.
UCSCiuc003omw.4. human. [Q6UWU4-1]
uc063oez.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR832871 mRNA. Translation: CCA30148.1.
FR832872 mRNA. Translation: CCA30149.1.
AY358637 mRNA. Translation: AAQ89000.1.
AK172780 mRNA. Translation: BAD18761.1.
AK300351 mRNA. Translation: BAG62093.1.
AK315984 mRNA. Translation: BAH14355.1.
BX538108 mRNA. Translation: CAD98021.1. Different initiation.
AL122034 Genomic DNA. Translation: CAI23297.1.
AL122034 Genomic DNA. Translation: CAI23299.1.
CH471081 Genomic DNA. Translation: EAX03920.1.
CH471081 Genomic DNA. Translation: EAX03919.1.
BC023605 mRNA. Translation: AAH23605.2. Different initiation.
BC095423 mRNA. Translation: AAH95423.1.
BC105947 mRNA. Translation: AAI05948.1.
BC107489 mRNA. Translation: AAI07490.1.
BC105946 mRNA. Translation: AAI05947.1.
CCDSiCCDS4827.1. [Q6UWU4-2]
CCDS69100.1. [Q6UWU4-1]
CCDS75444.1. [Q6UWU4-3]
RefSeqiNP_001273564.1. NM_001286635.1. [Q6UWU4-1]
NP_001273565.1. NM_001286636.1. [Q6UWU4-3]
NP_001273566.1. NM_001286637.1. [Q6UWU4-3]
NP_689947.2. NM_152734.3. [Q6UWU4-2]
XP_011512678.1. XM_011514376.1. [Q6UWU4-1]
XP_011512679.1. XM_011514377.1. [Q6UWU4-1]
XP_011512680.1. XM_011514378.1. [Q6UWU4-1]
XP_011512681.1. XM_011514379.1. [Q6UWU4-1]
XP_011512682.1. XM_011514380.1. [Q6UWU4-1]
UniGeneiHs.433381.

3D structure databases

ProteinModelPortaliQ6UWU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128732. 3 interactions.
STRINGi9606.ENSP00000347322.

PTM databases

iPTMnetiQ6UWU4.
PhosphoSiteiQ6UWU4.

Polymorphism and mutation databases

BioMutaiC6orf89.

Proteomic databases

EPDiQ6UWU4.
MaxQBiQ6UWU4.
PaxDbiQ6UWU4.
PeptideAtlasiQ6UWU4.
PRIDEiQ6UWU4.

Protocols and materials databases

DNASUi221477.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355190; ENSP00000347322; ENSG00000198663. [Q6UWU4-2]
ENST00000359359; ENSP00000352316; ENSG00000198663. [Q6UWU4-3]
ENST00000373685; ENSP00000362789; ENSG00000198663. [Q6UWU4-1]
ENST00000480824; ENSP00000475947; ENSG00000198663. [Q6UWU4-1]
GeneIDi221477.
KEGGihsa:221477.
UCSCiuc003omw.4. human. [Q6UWU4-1]
uc063oez.1. human.

Organism-specific databases

CTDi221477.
GeneCardsiC6orf89.
HGNCiHGNC:21114. C6orf89.
HPAiCAB011512.
HPA012548.
MIMi616642. gene.
neXtProtiNX_Q6UWU4.
PharmGKBiPA134986915.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE6D. Eukaryota.
ENOG410YJCN. LUCA.
GeneTreeiENSGT00390000014270.
HOGENOMiHOG000070100.
HOVERGENiHBG055530.
InParanoidiQ6UWU4.
OMAiDRPFPDF.
OrthoDBiEOG7RRF74.
PhylomeDBiQ6UWU4.
TreeFamiTF335525.

Miscellaneous databases

ChiTaRSiC6orf89. human.
GeneWikiiC6orf89.
GenomeRNAii221477.
PROiQ6UWU4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6UWU4.
CleanExiHS_C6orf89.
ExpressionAtlasiQ6UWU4. baseline and differential.
GenevisibleiQ6UWU4. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "C6orf89 encodes three distinct HDAC enhancers that function in the nucleolus, the Golgi and the midbody."
    Lalioti V.S., Vergarajauregui S., Villasante A., Pulido D., Sandoval I.V.
    J. Cell. Physiol. 228:1907-1921(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION (ISOFORMS 1; 2 AND 3), INTERACTION WITH SIN3B, TOPOLOGY, GLYCOSYLATION, SUBUNIT.
    Tissue: Adipocyte.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon endothelium.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Muscle and Placenta.
  8. "Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells."
    Liu H.J., Tan Y.R., Li M.L., Liu C., Xiang Y., Qin X.Q.
    PLoS ONE 6:E23072-E23072(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BRS3, SUBCELLULAR LOCATION (ISOFORM 2).

Entry informationi

Entry nameiCF089_HUMAN
AccessioniPrimary (citable) accession number: Q6UWU4
Secondary accession number(s): B4DTT1
, B7Z9L9, F4NAR0, F4NAR1, Q5TDC5, Q6ZMG5, Q7Z356, Q8IZ35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Named amfion, after 'the 4 Amfion heroes in Greek mythology and their deeds in different locations within the mother land.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.