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Protein

Bombesin receptor-activated protein C6orf89

Gene

C6orf89

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits histone deacetylase (HDAC) enhancer properties (PubMed:23460338). May play a role in cell cycle progression and wound repair of bronchial epithelial cells (PubMed:21857995).2 Publications

GO - Biological processi

  • epithelial cell proliferation Source: UniProtKB
  • positive regulation of cell cycle Source: UniProtKB
  • positive regulation of histone deacetylase activity Source: UniProtKB
  • wound healing Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33080-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bombesin receptor-activated protein C6orf89
Alternative name(s):
Amfion1 Publication
Gene namesi
Name:C6orf89
Synonyms:BRAP
ORF Names:UNQ177/PRO203
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21114. C6orf89.

Subcellular locationi

Isoform 1 :
Isoform 2 :
Isoform 3 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 58Cytoplasmic1 PublicationAdd BLAST58
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 347Extracellular1 PublicationAdd BLAST268

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • Golgi membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • midbody Source: UniProtKB
  • nucleolus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi221477.
OpenTargetsiENSG00000198663.
PharmGKBiPA134986915.

Polymorphism and mutation databases

BioMutaiC6orf89.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002376211 – 347Bombesin receptor-activated protein C6orf89Add BLAST347

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UWU4.
MaxQBiQ6UWU4.
PaxDbiQ6UWU4.
PeptideAtlasiQ6UWU4.
PRIDEiQ6UWU4.

PTM databases

iPTMnetiQ6UWU4.
PhosphoSitePlusiQ6UWU4.

Expressioni

Gene expression databases

BgeeiENSG00000198663.
CleanExiHS_C6orf89.
ExpressionAtlasiQ6UWU4. baseline and differential.
GenevisibleiQ6UWU4. HS.

Organism-specific databases

HPAiCAB011512.
HPA012548.

Interactioni

Subunit structurei

Homodimer (PubMed:23460338). Interacts with BRS3 (PubMed:21857995). Interacts (via N-terminus) with SIN3B (PubMed:23460338).2 Publications

Protein-protein interaction databases

BioGridi128732. 3 interactors.
STRINGi9606.ENSP00000347322.

Structurei

3D structure databases

ProteinModelPortaliQ6UWU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE6D. Eukaryota.
ENOG410YJCN. LUCA.
GeneTreeiENSGT00390000014270.
HOGENOMiHOG000070100.
HOVERGENiHBG055530.
InParanoidiQ6UWU4.
OMAiDRPFPDF.
OrthoDBiEOG091G097D.
PhylomeDBiQ6UWU4.
TreeFamiTF335525.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWU4-1) [UniParc]FASTAAdd to basket
Also known as: 42/116mp

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLAANEISI YDKLSETVDL VRQTGHQCGM SEKAIEKFIR QLLEKNEPQR
60 70 80 90 100
PPPQYPLLIV VYKVLATLGL ILLTAYFVIQ PFSPLAPEPV LSGAHTWRSL
110 120 130 140 150
IHHIRLMSLP IAKKYMSENK GVPLHGGDED RPFPDFDPWW TNDCEQNESE
160 170 180 190 200
PIPANCTGCA QKHLKVMLLE DAPRKFERLH PLVIKTGKPL LEEEIQHFLC
210 220 230 240 250
QYPEATEGFS EGFFAKWWRC FPERWFPFPY PWRRPLNRSQ MLRELFPVFT
260 270 280 290 300
HLPFPKDASL NKCSFLHPEP VVGSKMHKMP DLFIIGSGEA MLQLIPPFQC
310 320 330 340
RRHCQSVAMP IEPGDIGYVD TTHWKVYVIA RGVQPLVICD GTAFSEL
Length:347
Mass (Da):39,870
Last modified:December 21, 2004 - v1
Checksum:iEFE39F1A9A514595
GO
Isoform 2 (identifier: Q6UWU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDFILEDM

Show »
Length:354
Mass (Da):40,734
Checksum:i737E3B396D0BE209
GO
Isoform 3 (identifier: Q6UWU4-3) [UniParc]FASTAAdd to basket
Also known as: 34/64sp

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:241
Mass (Da):27,857
Checksum:i9B477916B1427416
GO

Sequence cautioni

The sequence AAH23605 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD98021 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → V in CAD98021 (PubMed:17974005).Curated1
Sequence conflicti171D → H in CCA30148 (PubMed:23460338).Curated1
Sequence conflicti171D → H in CCA30149 (PubMed:23460338).Curated1
Sequence conflicti189P → A in BAH14355 (PubMed:14702039).Curated1
Sequence conflicti327Y → C in CAD98021 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0581111 – 106Missing in isoform 3. Add BLAST106
Alternative sequenceiVSP_0185981M → MDFILEDM in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR832871 mRNA. Translation: CCA30148.1.
FR832872 mRNA. Translation: CCA30149.1.
AY358637 mRNA. Translation: AAQ89000.1.
AK172780 mRNA. Translation: BAD18761.1.
AK300351 mRNA. Translation: BAG62093.1.
AK315984 mRNA. Translation: BAH14355.1.
BX538108 mRNA. Translation: CAD98021.1. Different initiation.
AL122034 Genomic DNA. Translation: CAI23297.1.
AL122034 Genomic DNA. Translation: CAI23299.1.
CH471081 Genomic DNA. Translation: EAX03920.1.
CH471081 Genomic DNA. Translation: EAX03919.1.
BC023605 mRNA. Translation: AAH23605.2. Different initiation.
BC095423 mRNA. Translation: AAH95423.1.
BC105947 mRNA. Translation: AAI05948.1.
BC107489 mRNA. Translation: AAI07490.1.
BC105946 mRNA. Translation: AAI05947.1.
CCDSiCCDS4827.1. [Q6UWU4-2]
CCDS69100.1. [Q6UWU4-1]
CCDS75444.1. [Q6UWU4-3]
RefSeqiNP_001273564.1. NM_001286635.1. [Q6UWU4-1]
NP_001273565.1. NM_001286636.1. [Q6UWU4-3]
NP_001273566.1. NM_001286637.1. [Q6UWU4-3]
NP_689947.2. NM_152734.3. [Q6UWU4-2]
XP_011512679.1. XM_011514377.2. [Q6UWU4-1]
XP_016865921.1. XM_017010432.1. [Q6UWU4-1]
XP_016865922.1. XM_017010433.1. [Q6UWU4-1]
XP_016865923.1. XM_017010434.1. [Q6UWU4-1]
UniGeneiHs.433381.

Genome annotation databases

EnsembliENST00000355190; ENSP00000347322; ENSG00000198663. [Q6UWU4-2]
ENST00000359359; ENSP00000352316; ENSG00000198663. [Q6UWU4-3]
ENST00000373685; ENSP00000362789; ENSG00000198663. [Q6UWU4-1]
ENST00000480824; ENSP00000475947; ENSG00000198663. [Q6UWU4-1]
GeneIDi221477.
KEGGihsa:221477.
UCSCiuc003omw.4. human. [Q6UWU4-1]
uc063oez.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR832871 mRNA. Translation: CCA30148.1.
FR832872 mRNA. Translation: CCA30149.1.
AY358637 mRNA. Translation: AAQ89000.1.
AK172780 mRNA. Translation: BAD18761.1.
AK300351 mRNA. Translation: BAG62093.1.
AK315984 mRNA. Translation: BAH14355.1.
BX538108 mRNA. Translation: CAD98021.1. Different initiation.
AL122034 Genomic DNA. Translation: CAI23297.1.
AL122034 Genomic DNA. Translation: CAI23299.1.
CH471081 Genomic DNA. Translation: EAX03920.1.
CH471081 Genomic DNA. Translation: EAX03919.1.
BC023605 mRNA. Translation: AAH23605.2. Different initiation.
BC095423 mRNA. Translation: AAH95423.1.
BC105947 mRNA. Translation: AAI05948.1.
BC107489 mRNA. Translation: AAI07490.1.
BC105946 mRNA. Translation: AAI05947.1.
CCDSiCCDS4827.1. [Q6UWU4-2]
CCDS69100.1. [Q6UWU4-1]
CCDS75444.1. [Q6UWU4-3]
RefSeqiNP_001273564.1. NM_001286635.1. [Q6UWU4-1]
NP_001273565.1. NM_001286636.1. [Q6UWU4-3]
NP_001273566.1. NM_001286637.1. [Q6UWU4-3]
NP_689947.2. NM_152734.3. [Q6UWU4-2]
XP_011512679.1. XM_011514377.2. [Q6UWU4-1]
XP_016865921.1. XM_017010432.1. [Q6UWU4-1]
XP_016865922.1. XM_017010433.1. [Q6UWU4-1]
XP_016865923.1. XM_017010434.1. [Q6UWU4-1]
UniGeneiHs.433381.

3D structure databases

ProteinModelPortaliQ6UWU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128732. 3 interactors.
STRINGi9606.ENSP00000347322.

PTM databases

iPTMnetiQ6UWU4.
PhosphoSitePlusiQ6UWU4.

Polymorphism and mutation databases

BioMutaiC6orf89.

Proteomic databases

EPDiQ6UWU4.
MaxQBiQ6UWU4.
PaxDbiQ6UWU4.
PeptideAtlasiQ6UWU4.
PRIDEiQ6UWU4.

Protocols and materials databases

DNASUi221477.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355190; ENSP00000347322; ENSG00000198663. [Q6UWU4-2]
ENST00000359359; ENSP00000352316; ENSG00000198663. [Q6UWU4-3]
ENST00000373685; ENSP00000362789; ENSG00000198663. [Q6UWU4-1]
ENST00000480824; ENSP00000475947; ENSG00000198663. [Q6UWU4-1]
GeneIDi221477.
KEGGihsa:221477.
UCSCiuc003omw.4. human. [Q6UWU4-1]
uc063oez.1. human.

Organism-specific databases

CTDi221477.
DisGeNETi221477.
GeneCardsiC6orf89.
HGNCiHGNC:21114. C6orf89.
HPAiCAB011512.
HPA012548.
MIMi616642. gene.
neXtProtiNX_Q6UWU4.
OpenTargetsiENSG00000198663.
PharmGKBiPA134986915.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE6D. Eukaryota.
ENOG410YJCN. LUCA.
GeneTreeiENSGT00390000014270.
HOGENOMiHOG000070100.
HOVERGENiHBG055530.
InParanoidiQ6UWU4.
OMAiDRPFPDF.
OrthoDBiEOG091G097D.
PhylomeDBiQ6UWU4.
TreeFamiTF335525.

Enzyme and pathway databases

BioCyciZFISH:G66-33080-MONOMER.

Miscellaneous databases

ChiTaRSiC6orf89. human.
GeneWikiiC6orf89.
GenomeRNAii221477.
PROiQ6UWU4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198663.
CleanExiHS_C6orf89.
ExpressionAtlasiQ6UWU4. baseline and differential.
GenevisibleiQ6UWU4. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCF089_HUMAN
AccessioniPrimary (citable) accession number: Q6UWU4
Secondary accession number(s): B4DTT1
, B7Z9L9, F4NAR0, F4NAR1, Q5TDC5, Q6ZMG5, Q7Z356, Q8IZ35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Named amfion, after 'the 4 Amfion heroes in Greek mythology and their deeds in different locations within the mother land.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.