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Protein

Beta-galactosidase-1-like protein

Gene

GLB1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable glycosyl hydrolase.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei186 – 1861Proton donorSequence analysis
Active sitei264 – 2641NucleophileSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-2022857. Keratan sulfate degradation.
R-HSA-2024096. HS-GAG degradation.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase-1-like protein (EC:3.2.1.-)
Gene namesi
Name:GLB1L
ORF Names:UNQ229/PRO262
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28129. GLB1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885559.

Polymorphism and mutation databases

DMDMi74749401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 654627Beta-galactosidase-1-like proteinPRO_0000313604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6UWU2.
PaxDbiQ6UWU2.
PeptideAtlasiQ6UWU2.
PRIDEiQ6UWU2.

PTM databases

iPTMnetiQ6UWU2.
PhosphoSiteiQ6UWU2.

Expressioni

Gene expression databases

BgeeiENSG00000163521.
CleanExiHS_GLB1L.
ExpressionAtlasiQ6UWU2. baseline and differential.
GenevisibleiQ6UWU2. HS.

Organism-specific databases

HPAiHPA043058.

Interactioni

Protein-protein interaction databases

BioGridi122661. 5 interactions.
IntActiQ6UWU2. 1 interaction.
STRINGi9606.ENSP00000295759.

Structurei

3D structure databases

ProteinModelPortaliQ6UWU2.
SMRiQ6UWU2. Positions 37-624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
GeneTreeiENSGT00390000006586.
HOGENOMiHOG000221607.
HOVERGENiHBG004841.
InParanoidiQ6UWU2.
OMAiAAVDSWF.
OrthoDBiEOG091G006X.
PhylomeDBiQ6UWU2.
TreeFamiTF314816.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKKLSCLR SLLLPLSLTL LLPQADTRSF VVDRGHDRFL LDGAPFRYVS
60 70 80 90 100
GSLHYFRVPR VLWADRLLKM RWSGLNAIQF YVPWNYHEPQ PGVYNFNGSR
110 120 130 140 150
DLIAFLNEAA LANLLVILRP GPYICAEWEM GGLPSWLLRK PEIHLRTSDP
160 170 180 190 200
DFLAAVDSWF KVLLPKIYPW LYHNGGNIIS IQVENEYGSY RACDFSYMRH
210 220 230 240 250
LAGLFRALLG EKILLFTTDG PEGLKCGSLR GLYTTVDFGP ADNMTKIFTL
260 270 280 290 300
LRKYEPHGPL VNSEYYTGWL DYWGQNHSTR SVSAVTKGLE NMLKLGASVN
310 320 330 340 350
MYMFHGGTNF GYWNGADKKG RFLPITTSYD YDAPISEAGD PTPKLFALRD
360 370 380 390 400
VISKFQEVPL GPLPPPSPKM MLGPVTLHLV GHLLAFLDLL CPRGPIHSIL
410 420 430 440 450
PMTFEAVKQD HGFMLYRTYM THTIFEPTPF WVPNNGVHDR AYVMVDGVFQ
460 470 480 490 500
GVVERNMRDK LFLTGKLGSK LDILVENMGR LSFGSNSSDF KGLLKPPILG
510 520 530 540 550
QTILTQWMMF PLKIDNLVKW WFPLQLPKWP YPQAPSGPTF YSKTFPILGS
560 570 580 590 600
VGDTFLYLPG WTKGQVWING FNLGRYWTKQ GPQQTLYVPR FLLFPRGALN
610 620 630 640 650
KITLLELEDV PLQPQVQFLD KPILNSTSTL HRTHINSLSA DTLSASEPME

LSGH
Length:654
Mass (Da):74,158
Last modified:July 5, 2004 - v1
Checksum:i73BFEEDC768B5A07
GO
Isoform 2 (identifier: Q6UWU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-239: Missing.

Show »
Length:564
Mass (Da):64,024
Checksum:iFCA4D69D2C8A93E1
GO

Sequence cautioni

The sequence BAB70855 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei150 – 23990Missing in isoform 2. 1 PublicationVSP_030059Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358639 mRNA. Translation: AAQ89002.1.
AK055098 mRNA. Translation: BAB70855.1. Different initiation.
CCDSiCCDS2437.1. [Q6UWU2-1]
CCDS74657.1. [Q6UWU2-2]
RefSeqiNP_001273352.1. NM_001286423.1. [Q6UWU2-1]
NP_078782.3. NM_024506.4. [Q6UWU2-1]
UniGeneiHs.181173.

Genome annotation databases

EnsembliENST00000295759; ENSP00000295759; ENSG00000163521. [Q6UWU2-1]
ENST00000392089; ENSP00000375939; ENSG00000163521. [Q6UWU2-1]
ENST00000409640; ENSP00000386354; ENSG00000163521. [Q6UWU2-2]
GeneIDi79411.
KEGGihsa:79411.
UCSCiuc002vkm.5. human. [Q6UWU2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358639 mRNA. Translation: AAQ89002.1.
AK055098 mRNA. Translation: BAB70855.1. Different initiation.
CCDSiCCDS2437.1. [Q6UWU2-1]
CCDS74657.1. [Q6UWU2-2]
RefSeqiNP_001273352.1. NM_001286423.1. [Q6UWU2-1]
NP_078782.3. NM_024506.4. [Q6UWU2-1]
UniGeneiHs.181173.

3D structure databases

ProteinModelPortaliQ6UWU2.
SMRiQ6UWU2. Positions 37-624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122661. 5 interactions.
IntActiQ6UWU2. 1 interaction.
STRINGi9606.ENSP00000295759.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

PTM databases

iPTMnetiQ6UWU2.
PhosphoSiteiQ6UWU2.

Polymorphism and mutation databases

DMDMi74749401.

Proteomic databases

MaxQBiQ6UWU2.
PaxDbiQ6UWU2.
PeptideAtlasiQ6UWU2.
PRIDEiQ6UWU2.

Protocols and materials databases

DNASUi79411.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295759; ENSP00000295759; ENSG00000163521. [Q6UWU2-1]
ENST00000392089; ENSP00000375939; ENSG00000163521. [Q6UWU2-1]
ENST00000409640; ENSP00000386354; ENSG00000163521. [Q6UWU2-2]
GeneIDi79411.
KEGGihsa:79411.
UCSCiuc002vkm.5. human. [Q6UWU2-1]

Organism-specific databases

CTDi79411.
GeneCardsiGLB1L.
H-InvDBHIX0002855.
HGNCiHGNC:28129. GLB1L.
HPAiHPA043058.
neXtProtiNX_Q6UWU2.
PharmGKBiPA134885559.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
GeneTreeiENSGT00390000006586.
HOGENOMiHOG000221607.
HOVERGENiHBG004841.
InParanoidiQ6UWU2.
OMAiAAVDSWF.
OrthoDBiEOG091G006X.
PhylomeDBiQ6UWU2.
TreeFamiTF314816.

Enzyme and pathway databases

ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-2022857. Keratan sulfate degradation.
R-HSA-2024096. HS-GAG degradation.

Miscellaneous databases

GenomeRNAii79411.
PROiQ6UWU2.

Gene expression databases

BgeeiENSG00000163521.
CleanExiHS_GLB1L.
ExpressionAtlasiQ6UWU2. baseline and differential.
GenevisibleiQ6UWU2. HS.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLB1L_HUMAN
AccessioniPrimary (citable) accession number: Q6UWU2
Secondary accession number(s): Q96DR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.