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Protein

Beta-galactosidase-1-like protein

Gene

GLB1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable glycosyl hydrolase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei186Proton donorSequence analysis1
Active sitei264NucleophileSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-2022857 Keratan sulfate degradation
R-HSA-2024096 HS-GAG degradation

Protein family/group databases

CAZyiGH35 Glycoside Hydrolase Family 35

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase-1-like protein (EC:3.2.1.-)
Gene namesi
Name:GLB1L
ORF Names:UNQ229/PRO262
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163521.15
HGNCiHGNC:28129 GLB1L
neXtProtiNX_Q6UWU2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163521
PharmGKBiPA134885559

Polymorphism and mutation databases

DMDMi74749401

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000031360428 – 654Beta-galactosidase-1-like proteinAdd BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UWU2
MaxQBiQ6UWU2
PaxDbiQ6UWU2
PeptideAtlasiQ6UWU2
PRIDEiQ6UWU2
ProteomicsDBi67523
67524 [Q6UWU2-2]

PTM databases

iPTMnetiQ6UWU2
PhosphoSitePlusiQ6UWU2

Expressioni

Gene expression databases

BgeeiENSG00000163521
CleanExiHS_GLB1L
ExpressionAtlasiQ6UWU2 baseline and differential
GenevisibleiQ6UWU2 HS

Organism-specific databases

HPAiHPA043058

Interactioni

Protein-protein interaction databases

BioGridi122661, 13 interactors
IntActiQ6UWU2, 1 interactor
STRINGi9606.ENSP00000295759

Structurei

3D structure databases

ProteinModelPortaliQ6UWU2
SMRiQ6UWU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0496 Eukaryota
COG1874 LUCA
GeneTreeiENSGT00390000006586
HOGENOMiHOG000221607
HOVERGENiHBG004841
InParanoidiQ6UWU2
OMAiDFLCPQG
OrthoDBiEOG091G006X
PhylomeDBiQ6UWU2
TreeFamiTF314816

Family and domain databases

Gene3Di2.60.120.260, 3 hits
InterProiView protein in InterPro
IPR026283 B-gal_1-like
IPR008979 Galactose-bd-like_sf
IPR031330 Gly_Hdrlase_35_cat
IPR001944 Glycoside_Hdrlase_35
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR23421 PTHR23421, 1 hit
PfamiView protein in Pfam
PF01301 Glyco_hydro_35, 1 hit
PIRSFiPIRSF006336 B-gal, 1 hit
PRINTSiPR00742 GLHYDRLASE35
SUPFAMiSSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKKLSCLR SLLLPLSLTL LLPQADTRSF VVDRGHDRFL LDGAPFRYVS
60 70 80 90 100
GSLHYFRVPR VLWADRLLKM RWSGLNAIQF YVPWNYHEPQ PGVYNFNGSR
110 120 130 140 150
DLIAFLNEAA LANLLVILRP GPYICAEWEM GGLPSWLLRK PEIHLRTSDP
160 170 180 190 200
DFLAAVDSWF KVLLPKIYPW LYHNGGNIIS IQVENEYGSY RACDFSYMRH
210 220 230 240 250
LAGLFRALLG EKILLFTTDG PEGLKCGSLR GLYTTVDFGP ADNMTKIFTL
260 270 280 290 300
LRKYEPHGPL VNSEYYTGWL DYWGQNHSTR SVSAVTKGLE NMLKLGASVN
310 320 330 340 350
MYMFHGGTNF GYWNGADKKG RFLPITTSYD YDAPISEAGD PTPKLFALRD
360 370 380 390 400
VISKFQEVPL GPLPPPSPKM MLGPVTLHLV GHLLAFLDLL CPRGPIHSIL
410 420 430 440 450
PMTFEAVKQD HGFMLYRTYM THTIFEPTPF WVPNNGVHDR AYVMVDGVFQ
460 470 480 490 500
GVVERNMRDK LFLTGKLGSK LDILVENMGR LSFGSNSSDF KGLLKPPILG
510 520 530 540 550
QTILTQWMMF PLKIDNLVKW WFPLQLPKWP YPQAPSGPTF YSKTFPILGS
560 570 580 590 600
VGDTFLYLPG WTKGQVWING FNLGRYWTKQ GPQQTLYVPR FLLFPRGALN
610 620 630 640 650
KITLLELEDV PLQPQVQFLD KPILNSTSTL HRTHINSLSA DTLSASEPME

LSGH
Length:654
Mass (Da):74,158
Last modified:July 5, 2004 - v1
Checksum:i73BFEEDC768B5A07
GO
Isoform 2 (identifier: Q6UWU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-239: Missing.

Show »
Length:564
Mass (Da):64,024
Checksum:iFCA4D69D2C8A93E1
GO

Sequence cautioni

The sequence BAB70855 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030059150 – 239Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358639 mRNA Translation: AAQ89002.1
AK055098 mRNA Translation: BAB70855.1 Different initiation.
CCDSiCCDS2437.1 [Q6UWU2-1]
CCDS74657.1 [Q6UWU2-2]
RefSeqiNP_001273352.1, NM_001286423.1 [Q6UWU2-1]
NP_078782.3, NM_024506.4 [Q6UWU2-1]
XP_016860384.1, XM_017004895.1 [Q6UWU2-2]
UniGeneiHs.181173

Genome annotation databases

EnsembliENST00000295759; ENSP00000295759; ENSG00000163521 [Q6UWU2-1]
ENST00000392089; ENSP00000375939; ENSG00000163521 [Q6UWU2-1]
ENST00000409640; ENSP00000386354; ENSG00000163521 [Q6UWU2-2]
GeneIDi79411
KEGGihsa:79411
UCSCiuc002vkm.5 human [Q6UWU2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGLB1L_HUMAN
AccessioniPrimary (citable) accession number: Q6UWU2
Secondary accession number(s): Q96DR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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