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Protein

Adropin

Gene

ENHO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of glucose homeostasis and lipid metabolism.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Adropin
Alternative name(s):
Energy homeostasis-associated protein
Gene namesi
Name:ENHO
Synonyms:C9orf165
ORF Names:UNQ470/PRO830
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:24838. ENHO.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719156.

Polymorphism and mutation databases

BioMutaiENHO.
DMDMi150438882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 7643AdropinPRO_0000292879Add
BLAST

Proteomic databases

PaxDbiQ6UWT2.
PRIDEiQ6UWT2.

PTM databases

iPTMnetiQ6UWT2.
PhosphoSiteiQ6UWT2.

Expressioni

Tissue specificityi

Expressed in liver and brain.1 Publication

Gene expression databases

BgeeiQ6UWT2.
CleanExiHS_ENHO.
GenevisibleiQ6UWT2. HS.

Organism-specific databases

HPAiHPA042575.

Structurei

3D structure databases

ProteinModelPortaliQ6UWT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEN8. Eukaryota.
ENOG4111BUX. LUCA.
GeneTreeiENSGT00390000001413.
HOGENOMiHOG000112373.
InParanoidiQ6UWT2.
OMAiQKSSHEG.
OrthoDBiEOG7NGQG3.
PhylomeDBiQ6UWT2.
TreeFamiTF338522.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAAISQGAL IAIVCNGLVG FLLLLLWVIL CWACHSRSAD VDSLSESSPN
60 70
SSPGPCPEKA PPPQKPSHEG SYLLQP
Length:76
Mass (Da):7,927
Last modified:June 26, 2007 - v2
Checksum:i815301219DFE3921
GO
Isoform 2 (identifier: Q6UWT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-76: SPNSSPGPCPEKAPPPQKPSHEGSYLLQP → RTQESACLELDPAAQSLASLAPIGAQWP

Note: No experimental confirmation available.
Show »
Length:75
Mass (Da):7,824
Checksum:i407AFB1892087C77
GO

Sequence cautioni

The sequence AAQ89021.1 differs from that shown. Reason: Frameshift at position 38. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei48 – 7629SPNSS…YLLQP → RTQESACLELDPAAQSLASL APIGAQWP in isoform 2. 1 PublicationVSP_026454Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358658 mRNA. Translation: AAQ89021.1. Frameshift.
BC022101 mRNA. Translation: AAH22101.1.
CCDSiCCDS43795.1. [Q6UWT2-1]
RefSeqiNP_940975.2. NM_198573.2. [Q6UWT2-1]
UniGeneiHs.522085.

Genome annotation databases

EnsembliENST00000399775; ENSP00000382675; ENSG00000168913. [Q6UWT2-1]
GeneIDi375704.
KEGGihsa:375704.
UCSCiuc003zun.2. human. [Q6UWT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358658 mRNA. Translation: AAQ89021.1. Frameshift.
BC022101 mRNA. Translation: AAH22101.1.
CCDSiCCDS43795.1. [Q6UWT2-1]
RefSeqiNP_940975.2. NM_198573.2. [Q6UWT2-1]
UniGeneiHs.522085.

3D structure databases

ProteinModelPortaliQ6UWT2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6UWT2.
PhosphoSiteiQ6UWT2.

Polymorphism and mutation databases

BioMutaiENHO.
DMDMi150438882.

Proteomic databases

PaxDbiQ6UWT2.
PRIDEiQ6UWT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399775; ENSP00000382675; ENSG00000168913. [Q6UWT2-1]
GeneIDi375704.
KEGGihsa:375704.
UCSCiuc003zun.2. human. [Q6UWT2-1]

Organism-specific databases

CTDi375704.
GeneCardsiENHO.
H-InvDBHIX0201391.
HGNCiHGNC:24838. ENHO.
HPAiHPA042575.
neXtProtiNX_Q6UWT2.
PharmGKBiPA164719156.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEN8. Eukaryota.
ENOG4111BUX. LUCA.
GeneTreeiENSGT00390000001413.
HOGENOMiHOG000112373.
InParanoidiQ6UWT2.
OMAiQKSSHEG.
OrthoDBiEOG7NGQG3.
PhylomeDBiQ6UWT2.
TreeFamiTF338522.

Miscellaneous databases

GenomeRNAii375704.
PROiQ6UWT2.

Gene expression databases

BgeeiQ6UWT2.
CleanExiHS_ENHO.
GenevisibleiQ6UWT2. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  3. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiENHO_HUMAN
AccessioniPrimary (citable) accession number: Q6UWT2
Secondary accession number(s): Q8N666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: June 8, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.