Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Insulin growth factor-like family member 2

Gene

IGFL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential ligand of the IGFLR1 cell membrane receptor.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin growth factor-like family member 2
Gene namesi
Name:IGFL2
ORF Names:UNQ645/PRO1275
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32929. IGFL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147357935.

Polymorphism and mutation databases

BioMutaiIGFL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 11994Insulin growth factor-like family member 2PRO_0000045061Add
BLAST

Proteomic databases

PaxDbiQ6UWQ7.
PRIDEiQ6UWQ7.
TopDownProteomicsiQ6UWQ7-1. [Q6UWQ7-1]

Expressioni

Tissue specificityi

Detected in cerebellum, heart, placenta, spleen, stomach, testis and thymus.1 Publication

Gene expression databases

BgeeiENSG00000204866.
CleanExiHS_IGFL2.
ExpressionAtlasiQ6UWQ7. baseline and differential.
GenevisibleiQ6UWQ7. HS.

Organism-specific databases

HPAiHPA059137.

Interactioni

Protein-protein interaction databases

IntActiQ6UWQ7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6UWQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IGFL family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JECN. Eukaryota.
ENOG41116KJ. LUCA.
GeneTreeiENSGT00390000009557.
HOGENOMiHOG000113010.
HOVERGENiHBG081785.
InParanoidiQ6UWQ7.
OMAiLCPREVI.
OrthoDBiEOG091G0X76.
PhylomeDBiQ6UWQ7.
TreeFamiTF343427.

Family and domain databases

InterProiIPR032744. IGFL.
[Graphical view]
PANTHERiPTHR34827. PTHR34827. 1 hit.
PfamiPF14653. IGFL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPRIFAPAY VSVCLLLLCP REVIAPAGSE PWLCQPAPRC GDKIYNPLEQ
60 70 80 90 100
CCYNDAIVSL SETRQCGPPC TFWPCFELCC LDSFGLTNDF VVKLKVQGVN
110
SQCHSSPISS KCESRRRFP
Note: No experimental confirmation available.
Length:119
Mass (Da):13,248
Last modified:July 5, 2004 - v1
Checksum:i6CF304D7104A67C7
GO
Isoform 2 (identifier: Q6UWQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MVPRIF → MRFSVSGMRTDYPRSVL

Show »
Length:130
Mass (Da):14,489
Checksum:i15B5DF322123F9FE
GO

Sequence cautioni

The sequence AAT77786 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66MVPRIF → MRFSVSGMRTDYPRSVL in isoform 2. 1 PublicationVSP_016606

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY672112 mRNA. Translation: AAT77786.1. Different initiation.
AY358692 mRNA. Translation: AAQ89055.1.
AC007785 Genomic DNA. No translation available.
CCDSiCCDS46121.1. [Q6UWQ7-1]
CCDS46122.1. [Q6UWQ7-2]
RefSeqiNP_001002915.2. NM_001002915.2. [Q6UWQ7-2]
NP_001128585.1. NM_001135113.1. [Q6UWQ7-1]
XP_011524803.1. XM_011526501.1. [Q6UWQ7-2]
UniGeneiHs.99376.

Genome annotation databases

EnsembliENST00000377693; ENSP00000366922; ENSG00000204866. [Q6UWQ7-1]
ENST00000434646; ENSP00000395219; ENSG00000204866. [Q6UWQ7-2]
GeneIDi147920.
KEGGihsa:147920.
UCSCiuc002peb.4. human. [Q6UWQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY672112 mRNA. Translation: AAT77786.1. Different initiation.
AY358692 mRNA. Translation: AAQ89055.1.
AC007785 Genomic DNA. No translation available.
CCDSiCCDS46121.1. [Q6UWQ7-1]
CCDS46122.1. [Q6UWQ7-2]
RefSeqiNP_001002915.2. NM_001002915.2. [Q6UWQ7-2]
NP_001128585.1. NM_001135113.1. [Q6UWQ7-1]
XP_011524803.1. XM_011526501.1. [Q6UWQ7-2]
UniGeneiHs.99376.

3D structure databases

ProteinModelPortaliQ6UWQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6UWQ7. 1 interaction.

Polymorphism and mutation databases

BioMutaiIGFL2.

Proteomic databases

PaxDbiQ6UWQ7.
PRIDEiQ6UWQ7.
TopDownProteomicsiQ6UWQ7-1. [Q6UWQ7-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377693; ENSP00000366922; ENSG00000204866. [Q6UWQ7-1]
ENST00000434646; ENSP00000395219; ENSG00000204866. [Q6UWQ7-2]
GeneIDi147920.
KEGGihsa:147920.
UCSCiuc002peb.4. human. [Q6UWQ7-1]

Organism-specific databases

CTDi147920.
GeneCardsiIGFL2.
HGNCiHGNC:32929. IGFL2.
HPAiHPA059137.
MIMi610545. gene.
neXtProtiNX_Q6UWQ7.
PharmGKBiPA147357935.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JECN. Eukaryota.
ENOG41116KJ. LUCA.
GeneTreeiENSGT00390000009557.
HOGENOMiHOG000113010.
HOVERGENiHBG081785.
InParanoidiQ6UWQ7.
OMAiLCPREVI.
OrthoDBiEOG091G0X76.
PhylomeDBiQ6UWQ7.
TreeFamiTF343427.

Miscellaneous databases

GenomeRNAii147920.
PROiQ6UWQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204866.
CleanExiHS_IGFL2.
ExpressionAtlasiQ6UWQ7. baseline and differential.
GenevisibleiQ6UWQ7. HS.

Family and domain databases

InterProiIPR032744. IGFL.
[Graphical view]
PANTHERiPTHR34827. PTHR34827. 1 hit.
PfamiPF14653. IGFL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGFL2_HUMAN
AccessioniPrimary (citable) accession number: Q6UWQ7
Secondary accession number(s): E9PAV1, Q6B9Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.