Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Suprabasin

Gene

SBSN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31072-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Suprabasin
Gene namesi
Name:SBSN
ORF Names:UNQ698/PRO1343
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24950. SBSN.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi374897.
OpenTargetsiENSG00000189001.
PharmGKBiPA144596385.

Polymorphism and mutation databases

BioMutaiSBSN.
DMDMi449081282.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000031712026 – 590SuprabasinAdd BLAST565

Proteomic databases

EPDiQ6UWP8.
PaxDbiQ6UWP8.
PeptideAtlasiQ6UWP8.
PRIDEiQ6UWP8.

PTM databases

iPTMnetiQ6UWP8.
PhosphoSitePlusiQ6UWP8.

Expressioni

Tissue specificityi

Detected in thymus, uterus and esophagus.1 Publication

Inductioni

Up-regulated in differentiating keratinocytes.1 Publication

Gene expression databases

BgeeiENSG00000189001.
CleanExiHS_SBSN.
ExpressionAtlasiQ6UWP8. baseline and differential.
GenevisibleiQ6UWP8. HS.

Organism-specific databases

HPAiHPA062568.
HPA067734.

Interactioni

Protein-protein interaction databases

BioGridi131933. 18 interactors.
IntActiQ6UWP8. 5 interactors.
STRINGi9606.ENSP00000430242.

Structurei

3D structure databases

ProteinModelPortaliQ6UWP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi48 – 524Ala/Gly/His-richAdd BLAST477

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1KS. Eukaryota.
ENOG410ZRW8. LUCA.
GeneTreeiENSGT00440000039148.
HOGENOMiHOG000130803.
InParanoidiQ6UWP8.
OMAiGQGVHHG.
OrthoDBiEOG091G0NA2.
PhylomeDBiQ6UWP8.
TreeFamiTF351767.

Family and domain databases

InterProiIPR024153. Suprabasin.
[Graphical view]
PANTHERiPTHR23243. PTHR23243. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWP8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLARLVGSC SLLLLLGALS GWAASDDPIE KVIEGINRGL SNAEREVGKA
60 70 80 90 100
LDGINSGITH AGREVEKVFN GLSNMGSHTG KELDKGVQGL NHGMDKVAHE
110 120 130 140 150
INHGIGQAGK EAEKLGHGVN NAAGQVGKEA DKLIHHGVHH GANQAGSEAG
160 170 180 190 200
KFGQGVDNAA GQAGNEAGRF GQGVHHAAGQ AGNEAGRFGQ GVHHAAGQAG
210 220 230 240 250
NEAGRFGQGA HHGLSEGWKE TEKFGQGIHH AAGQVGKEAE KFGQGAHHAA
260 270 280 290 300
GQAGNEAGRF GQGVHHGLSE GWKETEKFGQ GVHHTAGQVG KEAEKFGQGA
310 320 330 340 350
HHAAGQAGNE AGRFGQGAHH AAGQAGNEAG RFGQGVHHGL SEGWKETEKF
360 370 380 390 400
GQGVHHAASQ FGKETEKLGH GVHHGVNEAW KEAEKFGQGV HHAASQVGKE
410 420 430 440 450
EDRVVQGLHH GVSQAGREAG QFGHDIHHTA GQAGKEGDIA VHGVQPGVHE
460 470 480 490 500
AGKEAGQFGQ GVHHTLEQAG KEADKAVQGF HTGVHQAGKE AEKLGQGVNH
510 520 530 540 550
AADQAGKEVE KLGQGAHHAA GQAGKELQNA HNGVNQASKE ANQLLNGNHQ
560 570 580 590
SGSSSHQGGA TTTPLASGAS VNTPFINLPA LWRSVANIMP
Length:590
Mass (Da):60,541
Last modified:February 6, 2013 - v2
Checksum:iCC3391C48A409DEA
GO
Isoform 2 (identifier: Q6UWP8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-467: Missing.

Show »
Length:247
Mass (Da):25,335
Checksum:iD4118B9456755FFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298Q → L in BX648076 (PubMed:17974005).Curated1
Sequence conflicti372V → A in BX648076 (PubMed:17974005).Curated1
Sequence conflicti406Q → R in BX648076 (PubMed:17974005).Curated1
Sequence conflicti533G → W in BAF83994 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069027419A → G.1 PublicationCorresponds to variant rs10775583dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044973125 – 467Missing in isoform 2. 2 PublicationsAdd BLAST343

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358701 mRNA. Translation: AAQ89064.1.
AK291305 mRNA. Translation: BAF83994.1.
BX648076 mRNA. No translation available.
AC002389 Genomic DNA. No translation available.
BC063640 mRNA. Translation: AAH63640.1.
CCDSiCCDS12464.1. [Q6UWP8-2]
CCDS54253.1. [Q6UWP8-1]
RefSeqiNP_001159506.1. NM_001166034.1. [Q6UWP8-1]
NP_001159507.1. NM_001166035.1.
NP_940940.1. NM_198538.3. [Q6UWP8-2]
UniGeneiHs.433484.

Genome annotation databases

EnsembliENST00000452271; ENSP00000430242; ENSG00000189001. [Q6UWP8-1]
ENST00000518157; ENSP00000428771; ENSG00000189001. [Q6UWP8-2]
GeneIDi374897.
KEGGihsa:374897.
UCSCiuc002oad.3. human. [Q6UWP8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358701 mRNA. Translation: AAQ89064.1.
AK291305 mRNA. Translation: BAF83994.1.
BX648076 mRNA. No translation available.
AC002389 Genomic DNA. No translation available.
BC063640 mRNA. Translation: AAH63640.1.
CCDSiCCDS12464.1. [Q6UWP8-2]
CCDS54253.1. [Q6UWP8-1]
RefSeqiNP_001159506.1. NM_001166034.1. [Q6UWP8-1]
NP_001159507.1. NM_001166035.1.
NP_940940.1. NM_198538.3. [Q6UWP8-2]
UniGeneiHs.433484.

3D structure databases

ProteinModelPortaliQ6UWP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131933. 18 interactors.
IntActiQ6UWP8. 5 interactors.
STRINGi9606.ENSP00000430242.

PTM databases

iPTMnetiQ6UWP8.
PhosphoSitePlusiQ6UWP8.

Polymorphism and mutation databases

BioMutaiSBSN.
DMDMi449081282.

Proteomic databases

EPDiQ6UWP8.
PaxDbiQ6UWP8.
PeptideAtlasiQ6UWP8.
PRIDEiQ6UWP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452271; ENSP00000430242; ENSG00000189001. [Q6UWP8-1]
ENST00000518157; ENSP00000428771; ENSG00000189001. [Q6UWP8-2]
GeneIDi374897.
KEGGihsa:374897.
UCSCiuc002oad.3. human. [Q6UWP8-1]

Organism-specific databases

CTDi374897.
DisGeNETi374897.
GeneCardsiSBSN.
HGNCiHGNC:24950. SBSN.
HPAiHPA062568.
HPA067734.
MIMi609969. gene.
neXtProtiNX_Q6UWP8.
OpenTargetsiENSG00000189001.
PharmGKBiPA144596385.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1KS. Eukaryota.
ENOG410ZRW8. LUCA.
GeneTreeiENSGT00440000039148.
HOGENOMiHOG000130803.
InParanoidiQ6UWP8.
OMAiGQGVHHG.
OrthoDBiEOG091G0NA2.
PhylomeDBiQ6UWP8.
TreeFamiTF351767.

Enzyme and pathway databases

BioCyciZFISH:G66-31072-MONOMER.

Miscellaneous databases

ChiTaRSiSBSN. human.
GenomeRNAii374897.
PROiQ6UWP8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189001.
CleanExiHS_SBSN.
ExpressionAtlasiQ6UWP8. baseline and differential.
GenevisibleiQ6UWP8. HS.

Family and domain databases

InterProiIPR024153. Suprabasin.
[Graphical view]
PANTHERiPTHR23243. PTHR23243. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSBSN_HUMAN
AccessioniPrimary (citable) accession number: Q6UWP8
Secondary accession number(s): A8K5J0, E9PBV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2013
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.