Q6UWP2 (DHR11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dehydrogenase/reductase SDR family member 11
EC=1.-.-.-

Gene names

Name:	DHRS11
ORF Names:	UNQ836/PRO1774

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homotetramer. Ref.6
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UWP2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UWP2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

30

Potential

Chain

31 – 260

230

Dehydrogenase/reductase SDR family member 11

PRO_0000045490

Regions

Nucleotide binding

69 – 71

3

NADP

Nucleotide binding

166 – 170

5

NADP

Nucleotide binding

198 – 208

11

NADP

Sites

Active site

166

1

Proton acceptor By similarity

Binding site

151

1

Substrate By similarity

Natural variations

Alternative sequence

1 – 79

79

Missing in isoform 2.

VSP_016987

Experimental info

Sequence conflict

81

1

F → S in BAB15390. Ref.2

Sequence conflict

81

1

F → S in CAG33637. Ref.3

Secondary structure

1

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260

Helix Strand Turn

Details...

Helix

7 – 9

3

Beta strand

13 – 18

6

Helix

22 – 33

12

Beta strand

37 – 43

7

Helix

45 – 57

13

Beta strand

61 – 68

8

Helix

74 – 88

15

Beta strand

92 – 96

5

Turn

106 – 108

3

Helix

111 – 121

11

Helix

123 – 138

16

Beta strand

145 – 149

5

Helix

152 – 154

3

Helix

161 – 163

3

Helix

164 – 186

23

Beta strand

192 – 199

8

Helix

205 – 209

5

Turn

210 – 212

3

Helix

214 – 221

8

Helix

229 – 241

13

Beta strand

246 – 255

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 88DFF656874F19F4	FASTA	260	28,308
	10 20 30 40 50 60 MARPGMERWR DRLALVTGAS GGIGAAVARA LVQQGLKVVG CARTVGNIEE LAAECKSAGY 70 80 90 100 110 120 PGTLIPYRCD LSNEEDILSM FSAIRSQHSG VDICINNAGL ARPDTLLSGS TSGWKDMFNV 130 140 150 160 170 180 NVLALSICTR EAYQSMKERN VDDGHIININ SMSGHRVLPL SVTHFYSATK YAVTALTEGL 190 200 210 220 230 240 RQELREAQTH IRATCISPGV VETQFAFKLH DKDPEKAAAT YEQMKCLKPE DVAEAVIYVL 250 260 STPAHIQIGD IQMRPTEQVT
	Isoform 2 [UniParc]. Checksum: 5BFCBE5727835A38	FASTA	181	20,022
	10 20 30 40 50 60 MFSAIRSQHS GVDICINNAG LARPDTLLSG STSGWKDMFN VNVLALSICT REAYQSMKER 70 80 90 100 110 120 NVDDGHIINI NSMSGHRVLP LSVTHFYSAT KYAVTALTEG LRQELREAQT HIRATCISPG 130 140 150 160 170 180 VVETQFAFKL HDKDPEKAAA TYEQMKCLKP EDVAEAVIYV LSTPAHIQIG DIQMRPTEQV T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain cortex and Small intestine.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterus.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]	"Structure of the putative human dehydrogenase MGC4172." Structural genomics consortium (SGC) Submitted (OCT-2004) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.53 ANGSTROMS) OF 1-256 (ISOFORM 1) IN COMPLEX WITH NADP AND ACETATE, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY358712 mRNA. Translation: AAQ89074.1.
AK026196 mRNA. Translation: BAB15390.1.
AK315735 mRNA. Translation: BAG38090.1.
CR457356 mRNA. Translation: CAG33637.1.
BC002731 mRNA. Translation: AAH02731.2.

IPI

IPI00034280.
IPI00658011.

RefSeq

NP_077284.2. NM_024308.3.

UniGene

Hs.462859.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XG5	X-ray	1.53	A/B/C/D	1-256	[»]

ProteinModelPortal

Q6UWP2.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000251312.

PTM databases

PhosphoSite

Q6UWP2.

Polymorphism databases

DMDM

74749397.

Proteomic databases

PaxDb

Q6UWP2.

PRIDE

Q6UWP2.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000251312; ENSP00000251312; ENSG00000108272.
ENST00000568873; ENSP00000456222; ENSG00000261508.
ENST00000590554; ENSP00000467412; ENSG00000108272.

GeneID

79154.

KEGG

hsa:79154.

UCSC

uc002hnd.3. human.

Organism-specific databases

CTD

79154.

GeneCards

GC17P034948.

HGNC

HGNC:28639. DHRS11.

HPA

HPA041226.
HPA048236.
HPA053623.

neXtProt

NX_Q6UWP2.

PharmGKB

PA164718841.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG4221.

HOVERGEN

HBG105262.

InParanoid

Q6UWP2.

OMA

QRANIDI.

OrthoDB

EOG4GHZPT.

Gene expression databases

ArrayExpress

Q6UWP2.

Bgee

Q6UWP2.

Genevestigator

Q6UWP2.

GermOnline

ENSG00000108272. Homo sapiens.

Family and domain databases

Gene3D

3.40.50.720. 1 hit.

InterPro

IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]

Pfam

PF00106. adh_short. 1 hit.
[Graphical view]

PRINTS

PR00081. GDHRDH.
PR00080. SDRFAMILY.

PROSITE

PS00061. ADH_SHORT. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

DHRS11. human.

EvolutionaryTrace

Q6UWP2.

GenomeRNAi

79154.

NextBio

68076.

Entry information

Entry name

DHR11_HUMAN

Accession

Primary (citable) accession number: Q6UWP2
Secondary accession number(s): B2RDZ3, Q9BUC7, Q9H674

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.