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Protein

Dehydrogenase/reductase SDR family member 11

Gene

DHRS11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei151SubstrateBy similarity1
Active sitei166Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 71NADP3
Nucleotide bindingi166 – 170NADP5
Nucleotide bindingi198 – 208NADPAdd BLAST11

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 11 (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 24C member 11 Publication
Gene namesi
Name:DHRS11
Synonyms:SDR24C11 Publication
ORF Names:UNQ836/PRO1774
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28639. DHRS11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi79154.
OpenTargetsiENSG00000275397.
ENSG00000278535.
PharmGKBiPA164718841.

Polymorphism and mutation databases

BioMutaiDHRS11.
DMDMi74749397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004549031 – 260Dehydrogenase/reductase SDR family member 11Add BLAST230

Proteomic databases

EPDiQ6UWP2.
MaxQBiQ6UWP2.
PaxDbiQ6UWP2.
PeptideAtlasiQ6UWP2.
PRIDEiQ6UWP2.

PTM databases

iPTMnetiQ6UWP2.
PhosphoSitePlusiQ6UWP2.

Expressioni

Gene expression databases

BgeeiENSG00000108272.
ExpressionAtlasiQ6UWP2. baseline and differential.
GenevisibleiQ6UWP2. HS.

Organism-specific databases

HPAiHPA041226.
HPA048236.
HPA053623.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

BioGridi122572. 5 interactors.
IntActiQ6UWP2. 1 interactor.
STRINGi9606.ENSP00000251312.

Structurei

Secondary structure

1260
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Beta strandi13 – 18Combined sources6
Helixi22 – 33Combined sources12
Beta strandi37 – 43Combined sources7
Helixi45 – 57Combined sources13
Beta strandi61 – 68Combined sources8
Helixi74 – 88Combined sources15
Beta strandi92 – 96Combined sources5
Turni106 – 108Combined sources3
Helixi111 – 121Combined sources11
Helixi123 – 138Combined sources16
Beta strandi145 – 149Combined sources5
Helixi152 – 154Combined sources3
Helixi161 – 163Combined sources3
Helixi164 – 186Combined sources23
Beta strandi192 – 199Combined sources8
Helixi205 – 209Combined sources5
Turni210 – 212Combined sources3
Helixi214 – 221Combined sources8
Helixi229 – 241Combined sources13
Beta strandi246 – 255Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XG5X-ray1.53A/B/C/D1-256[»]
ProteinModelPortaliQ6UWP2.
SMRiQ6UWP2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6UWP2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IUBV. Eukaryota.
COG4221. LUCA.
GeneTreeiENSGT00840000129887.
HOVERGENiHBG105262.
InParanoidiQ6UWP2.
OMAiARMIPRG.
OrthoDBiEOG091G0J8P.
PhylomeDBiQ6UWP2.
TreeFamiTF324174.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARPGMERWR DRLALVTGAS GGIGAAVARA LVQQGLKVVG CARTVGNIEE
60 70 80 90 100
LAAECKSAGY PGTLIPYRCD LSNEEDILSM FSAIRSQHSG VDICINNAGL
110 120 130 140 150
ARPDTLLSGS TSGWKDMFNV NVLALSICTR EAYQSMKERN VDDGHIININ
160 170 180 190 200
SMSGHRVLPL SVTHFYSATK YAVTALTEGL RQELREAQTH IRATCISPGV
210 220 230 240 250
VETQFAFKLH DKDPEKAAAT YEQMKCLKPE DVAEAVIYVL STPAHIQIGD
260
IQMRPTEQVT
Length:260
Mass (Da):28,308
Last modified:July 5, 2004 - v1
Checksum:i88DFF656874F19F4
GO
Isoform 2 (identifier: Q6UWP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:181
Mass (Da):20,022
Checksum:i5BFCBE5727835A38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81F → S in BAB15390 (PubMed:14702039).Curated1
Sequence conflicti81F → S in CAG33637 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0169871 – 79Missing in isoform 2. 2 PublicationsAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358712 mRNA. Translation: AAQ89074.1.
AK026196 mRNA. Translation: BAB15390.1.
AK315735 mRNA. Translation: BAG38090.1.
CR457356 mRNA. Translation: CAG33637.1.
BC002731 mRNA. Translation: AAH02731.2.
CCDSiCCDS11315.2. [Q6UWP2-1]
RefSeqiNP_077284.2. NM_024308.3. [Q6UWP2-1]
UniGeneiHs.462859.

Genome annotation databases

EnsembliENST00000611337; ENSP00000477603; ENSG00000278535. [Q6UWP2-2]
ENST00000618403; ENSP00000482704; ENSG00000278535. [Q6UWP2-1]
ENST00000621143; ENSP00000483747; ENSG00000275397. [Q6UWP2-1]
ENST00000631686; ENSP00000488610; ENSG00000275397. [Q6UWP2-2]
GeneIDi79154.
KEGGihsa:79154.
UCSCiuc002hnd.4. human. [Q6UWP2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358712 mRNA. Translation: AAQ89074.1.
AK026196 mRNA. Translation: BAB15390.1.
AK315735 mRNA. Translation: BAG38090.1.
CR457356 mRNA. Translation: CAG33637.1.
BC002731 mRNA. Translation: AAH02731.2.
CCDSiCCDS11315.2. [Q6UWP2-1]
RefSeqiNP_077284.2. NM_024308.3. [Q6UWP2-1]
UniGeneiHs.462859.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XG5X-ray1.53A/B/C/D1-256[»]
ProteinModelPortaliQ6UWP2.
SMRiQ6UWP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122572. 5 interactors.
IntActiQ6UWP2. 1 interactor.
STRINGi9606.ENSP00000251312.

PTM databases

iPTMnetiQ6UWP2.
PhosphoSitePlusiQ6UWP2.

Polymorphism and mutation databases

BioMutaiDHRS11.
DMDMi74749397.

Proteomic databases

EPDiQ6UWP2.
MaxQBiQ6UWP2.
PaxDbiQ6UWP2.
PeptideAtlasiQ6UWP2.
PRIDEiQ6UWP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611337; ENSP00000477603; ENSG00000278535. [Q6UWP2-2]
ENST00000618403; ENSP00000482704; ENSG00000278535. [Q6UWP2-1]
ENST00000621143; ENSP00000483747; ENSG00000275397. [Q6UWP2-1]
ENST00000631686; ENSP00000488610; ENSG00000275397. [Q6UWP2-2]
GeneIDi79154.
KEGGihsa:79154.
UCSCiuc002hnd.4. human. [Q6UWP2-1]

Organism-specific databases

CTDi79154.
DisGeNETi79154.
GeneCardsiDHRS11.
HGNCiHGNC:28639. DHRS11.
HPAiHPA041226.
HPA048236.
HPA053623.
MIMi616159. gene.
neXtProtiNX_Q6UWP2.
OpenTargetsiENSG00000275397.
ENSG00000278535.
PharmGKBiPA164718841.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUBV. Eukaryota.
COG4221. LUCA.
GeneTreeiENSGT00840000129887.
HOVERGENiHBG105262.
InParanoidiQ6UWP2.
OMAiARMIPRG.
OrthoDBiEOG091G0J8P.
PhylomeDBiQ6UWP2.
TreeFamiTF324174.

Miscellaneous databases

ChiTaRSiDHRS11. human.
EvolutionaryTraceiQ6UWP2.
GenomeRNAii79154.
PROiQ6UWP2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108272.
ExpressionAtlasiQ6UWP2. baseline and differential.
GenevisibleiQ6UWP2. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHR11_HUMAN
AccessioniPrimary (citable) accession number: Q6UWP2
Secondary accession number(s): B2RDZ3, Q9BUC7, Q9H674
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.