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Q6UWP2

- DHR11_HUMAN

UniProt

Q6UWP2 - DHR11_HUMAN

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Protein

Dehydrogenase/reductase SDR family member 11

Gene

DHRS11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei151 – 1511SubstrateBy similarity
Active sitei166 – 1661Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 713NADP
Nucleotide bindingi166 – 1705NADP
Nucleotide bindingi198 – 20811NADPAdd
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 11 (EC:1.-.-.-)
Gene namesi
Name:DHRS11
ORF Names:UNQ836/PRO1774
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:28639. DHRS11.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 260230Dehydrogenase/reductase SDR family member 11PRO_0000045490Add
BLAST

Proteomic databases

MaxQBiQ6UWP2.
PaxDbiQ6UWP2.
PRIDEiQ6UWP2.

PTM databases

PhosphoSiteiQ6UWP2.

Expressioni

Gene expression databases

BgeeiQ6UWP2.
ExpressionAtlasiQ6UWP2. differential.
GenevestigatoriQ6UWP2.

Organism-specific databases

HPAiHPA041226.
HPA048236.
HPA053623.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000251312.

Structurei

Secondary structure

1
260
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 93
Beta strandi13 – 186
Helixi22 – 3312
Beta strandi37 – 437
Helixi45 – 5713
Beta strandi61 – 688
Helixi74 – 8815
Beta strandi92 – 965
Turni106 – 1083
Helixi111 – 12111
Helixi123 – 13816
Beta strandi145 – 1495
Helixi152 – 1543
Helixi161 – 1633
Helixi164 – 18623
Beta strandi192 – 1998
Helixi205 – 2095
Turni210 – 2123
Helixi214 – 2218
Helixi229 – 24113
Beta strandi246 – 25510

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XG5X-ray1.53A/B/C/D1-256[»]
ProteinModelPortaliQ6UWP2.
SMRiQ6UWP2. Positions 2-256.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6UWP2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4221.
GeneTreeiENSGT00730000110967.
HOVERGENiHBG105262.
InParanoidiQ6UWP2.
OMAiVSICTRE.
PhylomeDBiQ6UWP2.
TreeFamiTF324174.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UWP2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARPGMERWR DRLALVTGAS GGIGAAVARA LVQQGLKVVG CARTVGNIEE
60 70 80 90 100
LAAECKSAGY PGTLIPYRCD LSNEEDILSM FSAIRSQHSG VDICINNAGL
110 120 130 140 150
ARPDTLLSGS TSGWKDMFNV NVLALSICTR EAYQSMKERN VDDGHIININ
160 170 180 190 200
SMSGHRVLPL SVTHFYSATK YAVTALTEGL RQELREAQTH IRATCISPGV
210 220 230 240 250
VETQFAFKLH DKDPEKAAAT YEQMKCLKPE DVAEAVIYVL STPAHIQIGD
260
IQMRPTEQVT
Length:260
Mass (Da):28,308
Last modified:July 5, 2004 - v1
Checksum:i88DFF656874F19F4
GO
Isoform 2 (identifier: Q6UWP2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:181
Mass (Da):20,022
Checksum:i5BFCBE5727835A38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811F → S in BAB15390. (PubMed:14702039)Curated
Sequence conflicti81 – 811F → S in CAG33637. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979Missing in isoform 2. 2 PublicationsVSP_016987Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358712 mRNA. Translation: AAQ89074.1.
AK026196 mRNA. Translation: BAB15390.1.
AK315735 mRNA. Translation: BAG38090.1.
CR457356 mRNA. Translation: CAG33637.1.
BC002731 mRNA. Translation: AAH02731.2.
CCDSiCCDS11315.2. [Q6UWP2-1]
RefSeqiNP_077284.2. NM_024308.3. [Q6UWP2-1]
XP_006722140.1. XM_006722077.1. [Q6UWP2-2]
XP_006725410.1. XM_006725347.1. [Q6UWP2-2]
UniGeneiHs.462859.

Genome annotation databases

EnsembliENST00000611337; ENSP00000477603; ENSG00000278535. [Q6UWP2-2]
ENST00000618403; ENSP00000482704; ENSG00000278535. [Q6UWP2-1]
GeneIDi79154.
KEGGihsa:79154.
UCSCiuc002hnd.3. human. [Q6UWP2-1]

Polymorphism databases

DMDMi74749397.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358712 mRNA. Translation: AAQ89074.1 .
AK026196 mRNA. Translation: BAB15390.1 .
AK315735 mRNA. Translation: BAG38090.1 .
CR457356 mRNA. Translation: CAG33637.1 .
BC002731 mRNA. Translation: AAH02731.2 .
CCDSi CCDS11315.2. [Q6UWP2-1 ]
RefSeqi NP_077284.2. NM_024308.3. [Q6UWP2-1 ]
XP_006722140.1. XM_006722077.1. [Q6UWP2-2 ]
XP_006725410.1. XM_006725347.1. [Q6UWP2-2 ]
UniGenei Hs.462859.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XG5 X-ray 1.53 A/B/C/D 1-256 [» ]
ProteinModelPortali Q6UWP2.
SMRi Q6UWP2. Positions 2-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000251312.

PTM databases

PhosphoSitei Q6UWP2.

Polymorphism databases

DMDMi 74749397.

Proteomic databases

MaxQBi Q6UWP2.
PaxDbi Q6UWP2.
PRIDEi Q6UWP2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000611337 ; ENSP00000477603 ; ENSG00000278535 . [Q6UWP2-2 ]
ENST00000618403 ; ENSP00000482704 ; ENSG00000278535 . [Q6UWP2-1 ]
GeneIDi 79154.
KEGGi hsa:79154.
UCSCi uc002hnd.3. human. [Q6UWP2-1 ]

Organism-specific databases

CTDi 79154.
GeneCardsi GC17P034948.
HGNCi HGNC:28639. DHRS11.
HPAi HPA041226.
HPA048236.
HPA053623.
neXtProti NX_Q6UWP2.
PharmGKBi PA164718841.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4221.
GeneTreei ENSGT00730000110967.
HOVERGENi HBG105262.
InParanoidi Q6UWP2.
OMAi VSICTRE.
PhylomeDBi Q6UWP2.
TreeFami TF324174.

Miscellaneous databases

ChiTaRSi DHRS11. human.
EvolutionaryTracei Q6UWP2.
GenomeRNAii 79154.
NextBioi 68076.
PROi Q6UWP2.

Gene expression databases

Bgeei Q6UWP2.
ExpressionAtlasi Q6UWP2. differential.
Genevestigatori Q6UWP2.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain cortex and Small intestine.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Structure of the putative human dehydrogenase MGC4172."
    Structural genomics consortium (SGC)
    Submitted (OCT-2004) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.53 ANGSTROMS) OF 1-256 (ISOFORM 1) IN COMPLEX WITH NADP AND ACETATE, SUBUNIT.

Entry informationi

Entry nameiDHR11_HUMAN
AccessioniPrimary (citable) accession number: Q6UWP2
Secondary accession number(s): B2RDZ3, Q9BUC7, Q9H674
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3