ID   ISK6_HUMAN              Reviewed;          80 AA.
AC   Q6UWN8; Q8N5P0;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   07-JUL-2009, entry version 49.
DE   RecName: Full=Serine protease inhibitor Kazal-type 6;
DE   Flags: Precursor;
GN   Name=SPINK6; ORFNames=UNQ844/PRO1782;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-36.
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 24-38.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Probable serine protease inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- SIMILARITY: Contains 1 Kazal-like domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AY358716; AAQ89078.1; -; mRNA.
DR   EMBL; BC032003; AAH32003.1; -; mRNA.
DR   IPI; IPI00297040; -.
DR   RefSeq; NP_995313.2; -.
DR   UniGene; Hs.334274; -.
DR   MEROPS; I01.015; -.
DR   Ensembl; ENSG00000178172; Homo sapiens.
DR   GeneID; 404203; -.
DR   KEGG; hsa:404203; -.
DR   UCSC; uc003lpa.1; human.
DR   GeneCards; GC05P147564; -.
DR   H-InvDB; HIX0005289; -.
DR   HGNC; HGNC:29486; SPINK6.
DR   PharmGKB; PA134915474; -.
DR   HOGENOM; Q6UWN8; -.
DR   HOVERGEN; Q6UWN8; -.
DR   OMA; Q6UWN8; CKAMVKS.
DR   NextBio; 107819; -.
DR   ArrayExpress; Q6UWN8; -.
DR   Bgee; Q6UWN8; -.
DR   CleanEx; HS_SPINK6; -.
DR   GermOnline; ENSG00000178172; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Prot_inh_Kazal.
DR   Pfam; PF00050; Kazal_1; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   PROSITE; PS00282; KAZAL; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Disulfide bond;
KW   Polymorphism; Protease inhibitor; Pyrrolidone carboxylic acid;
KW   Secreted; Serine protease inhibitor; Signal.
FT   SIGNAL        1     23
FT   CHAIN        24     80       Serine protease inhibitor Kazal-type 6.
FT                                /FTId=PRO_0000016575.
FT   DOMAIN       28     80       Kazal-like.
FT   SITE         42     43       Reactive bond (By similarity).
FT   MOD_RES      24     24       Pyrrolidone carboxylic acid (By
FT                                similarity).
FT   DISULFID     30     62       By similarity.
FT   DISULFID     40     59       By similarity.
FT   DISULFID     48     80       By similarity.
FT   VARIANT      36     36       P -> T (in dbSNP:rs12186491).
FT                                /FTId=VAR_034020.
SQ   SEQUENCE   80 AA;  8585 MW;  C83CCA45AE69A900 CRC64;
     MKLSGMFLLL SLALFCFLTG VFSQGGQVDC GEFQDPKVYC TRESNPHCGS DGQTYGNKCA
     FCKAIVKSGG KISLKHPGKC
//