Reviewed,
UniProtKB/Swiss-Prot Q6UWN8 (ISK6_HUMAN)
Last modified
January 19, 2010.
Version 56.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Serine protease inhibitor Kazal-type 6 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 80 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probable serine protease inhibitor. |
| Subcellular location | Secreted Potential. |
| Sequence similarities | Contains 1 Kazal-like domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Molecular function | Protease inhibitor Serine protease inhibitor |
| PTM | Disulfide bond Pyrrolidone carboxylic acid |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Ref.3 | ||||||||
| Chain | 24 – 80 | 57 | Serine protease inhibitor Kazal-type 6 | PRO_0000016575 | |||||||
Regions | |||||||||||
| Domain | 24 – 80 | 57 | Kazal-like | ||||||||
Sites | |||||||||||
| Site | 42 – 43 | 2 | Reactive bond By similarity | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 24 | 1 | Pyrrolidone carboxylic acid By similarity | ||||||||
| Disulfide bond | 30 ↔ 62 | By similarity | |||||||||
| Disulfide bond | 40 ↔ 59 | By similarity | |||||||||
| Disulfide bond | 48 ↔ 80 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 36 | 1 | P → T: dbSNP rs12186491. Ref.2 | VAR_034020 | |||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-36. Tissue: Skin. |
| [3] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY358716 mRNA. Translation: AAQ89078.1. BC032003 mRNA. Translation: AAH32003.1. |
| IPI | IPI00297040. |
| RefSeq | NP_995313.2. |
| UniGene | Hs.334274 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | I01.015. |
Genome annotation databases | |
| Ensembl | ENST00000325630; ENSP00000324870; ENSG00000178172; Homo sapiens. [Genome view] |
| GeneID | 404203. |
| KEGG | hsa:404203. |
| UCSC | uc003lpa.1. human. |
Organism-specific databases | |
| CTD | 404203. |
| GeneCards | GC05P147564. |
| H-InvDB | HIX0005289. |
| HGNC | HGNC:29486. SPINK6. |
| PharmGKB | PA134915474. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG20995. |
| HOGENOM | HBG278047. |
| HOVERGEN | Q6UWN8. |
| InParanoid | Q6UWN8. |
| OMA | AFCKAVM. |
| OrthoDB | EOG9C8BBK. |
| PhylomeDB | Q6UWN8. |
Gene expression databases | |
| ArrayExpress | Q6UWN8. |
| Bgee | Q6UWN8. |
| CleanEx | HS_SPINK6. |
| Genevestigator | Q6UWN8. |
| GermOnline | ENSG00000178172. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002350. Prot_inh_Kazal. [Graphical view] |
| Pfam | PF00050. Kazal_1. 1 hit. [Graphical view] |
| SMART | SM00280. KAZAL. 1 hit. [Graphical view] |
| PROSITE | PS00282. KAZAL_1. 1 hit. PS51465. KAZAL_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 107819. |
Entry information
| Entry name | ISK6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6UWN8 Secondary accession number(s): Q8N5P0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

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