Q6UWN8 (ISK6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine protease inhibitor Kazal-type 6

Gene names

Name:	SPINK6
ORF Names:	UNQ844/PRO1782

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	80 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable serine protease inhibitor.
Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 Kazal-like domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Disulfide bond Pyrrolidone carboxylic acid
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Ref.3
	Chain	24 – 80	57	Serine protease inhibitor Kazal-type 6		PRO_0000016575
Regions
	Domain	24 – 80	57	Kazal-like
Sites
	Site	42 – 43	2	Reactive bond By similarity
Amino acid modifications
	Modified residue	24	1	Pyrrolidone carboxylic acid By similarity
	Disulfide bond	30 ↔ 62		By similarity
	Disulfide bond	40 ↔ 59		By similarity
	Disulfide bond	48 ↔ 80		By similarity
Natural variations
	Natural variant	36	1	P → T. Ref.2 Corresponds to variant rs12186491 [ dbSNP | Ensembl ].		VAR_034020

Sequences

	Sequence		Length	Mass (Da)
	Q6UWN8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: C83CCA45AE69A900	FASTA	80	8,585
	10 20 30 40 50 60 MKLSGMFLLL SLALFCFLTG VFSQGGQVDC GEFQDPKVYC TRESNPHCGS DGQTYGNKCA 70 80 FCKAIVKSGG KISLKHPGKC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-36. Tissue: Skin.
[3]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358716 mRNA. Translation: AAQ89078.1. BC032003 mRNA. Translation: AAH32003.1.
IPI	IPI00297040.
RefSeq	NP_001182219.1. NM_001195290.1. NP_995313.2. NM_205841.3.
UniGene	Hs.334274.
3D structure databases
ProteinModelPortal	Q6UWN8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6UWN8.
Protein family/group databases
MEROPS	I01.015.
Polymorphism databases
DMDM	59799771.
Proteomic databases
PRIDE	Q6UWN8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325630; ENSP00000324870; ENSG00000178172.
GeneID	404203.
KEGG	hsa:404203.
UCSC	uc003lpa.1. human.
Organism-specific databases
CTD	404203.
GeneCards	GC05P147564.
H-InvDB	HIX0005289.
HGNC	HGNC:29486. SPINK6.
neXtProt	NX_Q6UWN8.
PharmGKB	PA134915474.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20995.
GeneTree	ENSGT00530000064225.
HOGENOM	HBG278047.
HOVERGEN	HBG006182.
InParanoid	Q6UWN8.
OMA	CKAMVKS.
PhylomeDB	Q6UWN8.
Gene expression databases
ArrayExpress	Q6UWN8.
Bgee	Q6UWN8.
CleanEx	HS_SPINK6.
Genevestigator	Q6UWN8.
GermOnline	ENSG00000178172. Homo sapiens.
Family and domain databases
InterPro	IPR002350. Prot_inh_Kazal. [Graphical view]
Pfam	PF00050. Kazal_1. 1 hit. [Graphical view]
SMART	SM00280. KAZAL. 1 hit. [Graphical view]
PROSITE	PS00282. KAZAL_1. 1 hit. PS51465. KAZAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	107819.

Entry information

Entry name

ISK6_HUMAN

Accession

Primary (citable) accession number: Q6UWN8
Secondary accession number(s): Q8N5P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.