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Protein

UDP-glucuronosyltransferase 2A3

Gene

UGT2A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: UniProtKB

GO - Biological processi

  • cellular glucuronidation Source: BHF-UCL

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiR-HSA-156588. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A3 (EC:2.4.1.17)
Short name:
UDPGT 2A3
Gene namesi
Name:UGT2A3
ORF Names:UNQ2559/PRO6239
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000135220.10.
HGNCiHGNC:28528. UGT2A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 491ExtracellularSequence analysisAdd BLAST468
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Topological domaini513 – 527CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79799.
OpenTargetsiENSG00000135220.
PharmGKBiPA142670641.

Polymorphism and mutation databases

BioMutaiUGT2A3.
DMDMi296452855.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000029914624 – 527UDP-glucuronosyltransferase 2A3Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UWM9.
MaxQBiQ6UWM9.
PaxDbiQ6UWM9.
PeptideAtlasiQ6UWM9.
PRIDEiQ6UWM9.

PTM databases

iPTMnetiQ6UWM9.
PhosphoSitePlusiQ6UWM9.

Expressioni

Gene expression databases

BgeeiENSG00000135220.
CleanExiHS_UGT2A3.
ExpressionAtlasiQ6UWM9. baseline and differential.
GenevisibleiQ6UWM9. HS.

Organism-specific databases

HPAiHPA045108.

Interactioni

Protein-protein interaction databases

BioGridi122896. 3 interactors.
STRINGi9606.ENSP00000251566.

Structurei

3D structure databases

ProteinModelPortaliQ6UWM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ6UWM9.
KOiK00699.
OMAiMMCESFI.
OrthoDBiEOG091G06JC.
PhylomeDBiQ6UWM9.
TreeFamiTF315472.

Family and domain databases

InterProiView protein in InterPro
IPR002213. UDP_glucos_trans.
IPR035595. UDP_glycos_trans_CS.
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiView protein in Pfam
PF00201. UDPGT. 1 hit.
PROSITEiView protein in PROSITE
PS00375. UDPGT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSDKSALVF LLLQLFCVGC GFCGKVLVWP CDMSHWLNVK VILEELIVRG
60 70 80 90 100
HEVTVLTHSK PSLIDYRKPS ALKFEVVHMP QDRTEENEIF VDLALNVLPG
110 120 130 140 150
LSTWQSVIKL NDFFVEIRGT LKMMCESFIY NQTLMKKLQE TNYDVMLIDP
160 170 180 190 200
VIPCGDLMAE LLAVPFVLTL RISVGGNMER SCGKLPAPLS YVPVPMTGLT
210 220 230 240 250
DRMTFLERVK NSMLSVLFHF WIQDYDYHFW EEFYSKALGR PTTLCETVGK
260 270 280 290 300
AEIWLIRTYW DFEFPQPYQP NFEFVGGLHC KPAKALPKEM ENFVQSSGED
310 320 330 340 350
GIVVFSLGSL FQNVTEEKAN IIASALAQIP QKVLWRYKGK KPSTLGANTR
360 370 380 390 400
LYDWIPQNDL LGHPKTKAFI THGGMNGIYE AIYHGVPMVG VPIFGDQLDN
410 420 430 440 450
IAHMKAKGAA VEINFKTMTS EDLLRALRTV ITDSSYKENA MRLSRIHHDQ
460 470 480 490 500
PVKPLDRAVF WIEFVMRHKG AKHLRSAAHD LTWFQHYSID VIGFLLACVA
510 520
TAIFLFTKCF LFSCQKFNKT RKIEKRE
Length:527
Mass (Da):60,254
Last modified:May 18, 2010 - v2
Checksum:i801C8F886B4DF80F
GO

Sequence cautioni

Q6UWM9: The sequence BAB15179 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti497A → T in AAS48425 (Ref. 1) Curated1
Sequence conflicti497A → T in AAQ89089 (PubMed:12975309).Curated1
Sequence conflicti497A → T in AAI30534 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542891 mRNA. Translation: AAS48425.1.
AY358727 mRNA. Translation: AAQ89089.1.
AC021146 Genomic DNA. No translation available.
BC130533 mRNA. Translation: AAI30534.1.
AK025587 mRNA. Translation: BAB15179.1. Different initiation.
CCDSiCCDS3525.1.
RefSeqiNP_079019.3. NM_024743.3.
UniGeneiHs.122583.

Genome annotation databases

EnsembliENST00000251566; ENSP00000251566; ENSG00000135220.
ENST00000611042; ENSP00000479283; ENSG00000278216.
GeneIDi79799.
KEGGihsa:79799.
UCSCiuc003hef.3. human.

Similar proteinsi

Entry informationi

Entry nameiUD2A3_HUMAN
AccessioniPrimary (citable) accession number: Q6UWM9
Secondary accession number(s): Q9H6S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families