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Protein

Lactase-like protein

Gene

LCTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32683-MONOMER.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactase-like protein
Alternative name(s):
Klotho/lactase-phlorizin hydrolase-related protein
Gene namesi
Name:LCTL
Synonyms:KLPH
ORF Names:UNQ3022/PRO9820
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:15583. LCTL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 541ExtracellularSequence analysisAdd BLAST519
Transmembranei542 – 562HelicalSequence analysisAdd BLAST21
Topological domaini563 – 567CytoplasmicSequence analysis5

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188501.
PharmGKBiPA142671560.

Polymorphism and mutation databases

DMDMi77416521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000004225122 – 567Lactase-like proteinAdd BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Glycosylationi245N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6UWM7.
PRIDEiQ6UWM7.

PTM databases

iPTMnetiQ6UWM7.
PhosphoSitePlusiQ6UWM7.

Expressioni

Gene expression databases

BgeeiENSG00000188501.
CleanExiHS_LCTL.
ExpressionAtlasiQ6UWM7. baseline and differential.
GenevisibleiQ6UWM7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000343490.

Structurei

3D structure databases

ProteinModelPortaliQ6UWM7.
SMRiQ6UWM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0626. Eukaryota.
COG2723. LUCA.
GeneTreeiENSGT00550000074452.
HOGENOMiHOG000088630.
HOVERGENiHBG053101.
InParanoidiQ6UWM7.
OMAiVKRFATF.
OrthoDBiEOG091G0035.
PhylomeDBiQ6UWM7.
TreeFamiTF314803.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR033132. Glyco_hydro_1_N_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPVWVATLL WMLLLVPRLG AARKGSPEEA SFYYGTFPLG FSWGVGSSAY
60 70 80 90 100
QTEGAWDQDG KGPSIWDVFT HSGKGKVLGN ETADVACDGY YKVQEDIILL
110 120 130 140 150
RELHVNHYRF SLSWPRLLPT GIRAEQVNKK GIEFYSDLID ALLSSNITPI
160 170 180 190 200
VTLHHWDLPQ LLQVKYGGWQ NVSMANYFRD YANLCFEAFG DRVKHWITFS
210 220 230 240 250
DPRAMAEKGY ETGHHAPGLK LRGTGLYKAA HHIIKAHAKA WHSYNTTWRS
260 270 280 290 300
KQQGLVGISL NCDWGEPVDI SNPKDLEAAE RYLQFCLGWF ANPIYAGDYP
310 320 330 340 350
QVMKDYIGRK SAEQGLEMSR LPVFSLQEKS YIKGTSDFLG LGHFTTRYIT
360 370 380 390 400
ERNYPSRQGP SYQNDRDLIE LVDPNWPDLG SKWLYSVPWG FRRLLNFAQT
410 420 430 440 450
QYGDPPIYVM ENGASQKFHC TQLCDEWRIQ YLKGYINEML KAIKDGANIK
460 470 480 490 500
GYTSWSLLDK FEWEKGYSDR YGFYYVEFND RNKPRYPKAS VQYYKKIIIA
510 520 530 540 550
NGFPNPREVE SWYLKALETC SINNQMLAAE PLLSHMQMVT EIVVPTVCSL
560
CVLITAVLLM LLLRRQS
Length:567
Mass (Da):65,088
Last modified:October 11, 2005 - v2
Checksum:iDA840A92E933C0AE
GO
Isoform 2 (identifier: Q6UWM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.

Note: No experimental confirmation available.
Show »
Length:394
Mass (Da):45,666
Checksum:i057BD43AA044FF4A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049297212T → M.Corresponds to variant rs7179073dbSNPEnsembl.1
Natural variantiVAR_023586240A → T.Corresponds to variant rs1030986dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545961 – 173Missing in isoform 2. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358729 mRNA. Translation: AAQ89091.1.
AK090598 mRNA. Translation: BAG52192.1.
AC116913 Genomic DNA. No translation available.
CCDSiCCDS10220.1. [Q6UWM7-1]
CCDS61678.1. [Q6UWM7-2]
RefSeqiNP_001265491.1. NM_001278562.1. [Q6UWM7-2]
NP_997221.2. NM_207338.3. [Q6UWM7-1]
UniGeneiHs.680983.

Genome annotation databases

EnsembliENST00000341509; ENSP00000343490; ENSG00000188501. [Q6UWM7-1]
ENST00000537670; ENSP00000445419; ENSG00000188501. [Q6UWM7-2]
GeneIDi197021.
KEGGihsa:197021.
UCSCiuc002aqc.5. human. [Q6UWM7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358729 mRNA. Translation: AAQ89091.1.
AK090598 mRNA. Translation: BAG52192.1.
AC116913 Genomic DNA. No translation available.
CCDSiCCDS10220.1. [Q6UWM7-1]
CCDS61678.1. [Q6UWM7-2]
RefSeqiNP_001265491.1. NM_001278562.1. [Q6UWM7-2]
NP_997221.2. NM_207338.3. [Q6UWM7-1]
UniGeneiHs.680983.

3D structure databases

ProteinModelPortaliQ6UWM7.
SMRiQ6UWM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000343490.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

PTM databases

iPTMnetiQ6UWM7.
PhosphoSitePlusiQ6UWM7.

Polymorphism and mutation databases

DMDMi77416521.

Proteomic databases

PaxDbiQ6UWM7.
PRIDEiQ6UWM7.

Protocols and materials databases

DNASUi197021.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341509; ENSP00000343490; ENSG00000188501. [Q6UWM7-1]
ENST00000537670; ENSP00000445419; ENSG00000188501. [Q6UWM7-2]
GeneIDi197021.
KEGGihsa:197021.
UCSCiuc002aqc.5. human. [Q6UWM7-1]

Organism-specific databases

CTDi197021.
GeneCardsiLCTL.
H-InvDBHIX0012367.
HGNCiHGNC:15583. LCTL.
neXtProtiNX_Q6UWM7.
OpenTargetsiENSG00000188501.
PharmGKBiPA142671560.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0626. Eukaryota.
COG2723. LUCA.
GeneTreeiENSGT00550000074452.
HOGENOMiHOG000088630.
HOVERGENiHBG053101.
InParanoidiQ6UWM7.
OMAiVKRFATF.
OrthoDBiEOG091G0035.
PhylomeDBiQ6UWM7.
TreeFamiTF314803.

Enzyme and pathway databases

BioCyciZFISH:G66-32683-MONOMER.

Miscellaneous databases

GenomeRNAii197021.
PROiQ6UWM7.

Gene expression databases

BgeeiENSG00000188501.
CleanExiHS_LCTL.
ExpressionAtlasiQ6UWM7. baseline and differential.
GenevisibleiQ6UWM7. HS.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR033132. Glyco_hydro_1_N_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCTL_HUMAN
AccessioniPrimary (citable) accession number: Q6UWM7
Secondary accession number(s): B3KQY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although it belongs to the glycosyl hydrolase 1 family, Asp-201 is present instead of the conserved Glu which is an active site residue. It is therefore expected that this protein lacks glycosidase activity.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.