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Q6UWM5

- GPRL1_HUMAN

UniProt

Q6UWM5 - GPRL1_HUMAN

Protein

GLIPR1-like protein 1

Gene

GLIPR1L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. binding of sperm to zona pellucida Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GLIPR1-like protein 1
    Gene namesi
    ORF Names:UNQ2972/PRO7434
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:28392. GLIPR1L1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. sperm connecting piece Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145008265.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 242220GLIPR1-like protein 1PRO_0000272653Add
    BLAST

    Proteomic databases

    PaxDbiQ6UWM5.
    PRIDEiQ6UWM5.

    PTM databases

    PhosphoSiteiQ6UWM5.

    Expressioni

    Tissue specificityi

    Highly expressed in testis.1 Publication

    Gene expression databases

    BgeeiQ6UWM5.
    CleanExiHS_GLIPR1L1.
    GenevestigatoriQ6UWM5.

    Organism-specific databases

    HPAiHPA042095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UWM5.
    SMRiQ6UWM5. Positions 25-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 171133SCPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRISP family.Curated
    Contains 1 SCP domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2340.
    HOGENOMiHOG000036879.
    HOVERGENiHBG072125.
    InParanoidiQ6UWM5.
    OMAiTDPHFID.
    OrthoDBiEOG7F7WB4.
    PhylomeDBiQ6UWM5.
    TreeFamiTF316148.

    Family and domain databases

    Gene3Di3.40.33.10. 1 hit.
    InterProiIPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR002413. V5_allergen.
    [Graphical view]
    PANTHERiPTHR10334. PTHR10334. 1 hit.
    PfamiPF00188. CAP. 1 hit.
    [Graphical view]
    PRINTSiPR00838. V5ALLERGEN.
    PR00837. V5TPXLIKE.
    SMARTiSM00198. SCP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55797. SSF55797. 1 hit.
    PROSITEiPS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6UWM5-1) [UniParc]FASTAAdd to Basket

    Also known as: GLIPR1L1beta

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALKNKFSCL WILGLCLVAT TSSKIPSITD PHFIDNCIEA HNEWRGKVNP    50
    PAADMKYMIW DKGLAKMAKA WANQCKFEHN DCLDKSYKCY AAFEYVGENI 100
    WLGGIKSFTP RHAITAWYNE TQFYDFDSLS CSRVCGHYTQ LVWANSFYVG 150
    CAVAMCPNLG GASTAIFVCN YGPAGNFANM PPYVRGESCS LCSKEEKCVK 200
    NLCRTPQLII PNQNPFLKPT GRAPQQTAFN PFSLGFLLLR IF 242
    Length:242
    Mass (Da):27,151
    Last modified:January 23, 2007 - v2
    Checksum:i22843450EC652C76
    GO
    Isoform 2 (identifier: Q6UWM5-2) [UniParc]FASTAAdd to Basket

    Also known as: GLIPR1L1alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         204-213: RTPQLIIPNQ → K

    Show »
    Length:233
    Mass (Da):26,118
    Checksum:iC6BDD4B8DB5B91D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti184 – 1841V → A in AAQ89093. (PubMed:12975309)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei204 – 21310RTPQLIIPNQ → K in isoform 2. 2 PublicationsVSP_022456

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358731 mRNA. Translation: AAQ89093.1.
    BC014603 mRNA. Translation: AAH14603.1.
    CCDSiCCDS9009.1. [Q6UWM5-2]
    RefSeqiNP_689992.1. NM_152779.2. [Q6UWM5-2]
    UniGeneiHs.567788.

    Genome annotation databases

    EnsembliENST00000312442; ENSP00000310770; ENSG00000173401. [Q6UWM5-2]
    ENST00000378695; ENSP00000367967; ENSG00000173401. [Q6UWM5-1]
    GeneIDi256710.
    KEGGihsa:256710.
    UCSCiuc001sxn.3. human. [Q6UWM5-2]
    uc001sxo.3. human. [Q6UWM5-1]

    Polymorphism databases

    DMDMi124007190.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358731 mRNA. Translation: AAQ89093.1 .
    BC014603 mRNA. Translation: AAH14603.1 .
    CCDSi CCDS9009.1. [Q6UWM5-2 ]
    RefSeqi NP_689992.1. NM_152779.2. [Q6UWM5-2 ]
    UniGenei Hs.567788.

    3D structure databases

    ProteinModelPortali Q6UWM5.
    SMRi Q6UWM5. Positions 25-207.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6UWM5.

    Polymorphism databases

    DMDMi 124007190.

    Proteomic databases

    PaxDbi Q6UWM5.
    PRIDEi Q6UWM5.

    Protocols and materials databases

    DNASUi 256710.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312442 ; ENSP00000310770 ; ENSG00000173401 . [Q6UWM5-2 ]
    ENST00000378695 ; ENSP00000367967 ; ENSG00000173401 . [Q6UWM5-1 ]
    GeneIDi 256710.
    KEGGi hsa:256710.
    UCSCi uc001sxn.3. human. [Q6UWM5-2 ]
    uc001sxo.3. human. [Q6UWM5-1 ]

    Organism-specific databases

    CTDi 256710.
    GeneCardsi GC12P075728.
    HGNCi HGNC:28392. GLIPR1L1.
    HPAi HPA042095.
    MIMi 610395. gene.
    neXtProti NX_Q6UWM5.
    PharmGKBi PA145008265.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2340.
    HOGENOMi HOG000036879.
    HOVERGENi HBG072125.
    InParanoidi Q6UWM5.
    OMAi TDPHFID.
    OrthoDBi EOG7F7WB4.
    PhylomeDBi Q6UWM5.
    TreeFami TF316148.

    Miscellaneous databases

    GenomeRNAii 256710.
    NextBioi 92852.
    PROi Q6UWM5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6UWM5.
    CleanExi HS_GLIPR1L1.
    Genevestigatori Q6UWM5.

    Family and domain databases

    Gene3Di 3.40.33.10. 1 hit.
    InterProi IPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR002413. V5_allergen.
    [Graphical view ]
    PANTHERi PTHR10334. PTHR10334. 1 hit.
    Pfami PF00188. CAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00838. V5ALLERGEN.
    PR00837. V5TPXLIKE.
    SMARTi SM00198. SCP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55797. SSF55797. 1 hit.
    PROSITEi PS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster."
      Ren C., Ren C.-H., Li L., Goltsov A.A., Thompson T.C.
      Genomics 88:163-172(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-37.

    Entry informationi

    Entry nameiGPRL1_HUMAN
    AccessioniPrimary (citable) accession number: Q6UWM5
    Secondary accession number(s): Q96L06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3