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Q6UWM5 (GPRL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GLIPR1-like protein 1
Gene names
Name:GLIPR1L1
ORF Names:UNQ2972/PRO7434
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Potential.

Tissue specificity

Highly expressed in testis. Ref.1

Sequence similarities

Belongs to the CRISP family.

Contains 1 SCP domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processbinding of sperm to zona pellucida

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentacrosomal vesicle

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

sperm connecting piece

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6UWM5-1)

Also known as: GLIPR1L1beta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6UWM5-2)

Also known as: GLIPR1L1alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     204-213: RTPQLIIPNQ → K

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.4
Chain23 – 242220GLIPR1-like protein 1
PRO_0000272653

Regions

Domain39 – 171133SCP

Natural variations

Alternative sequence204 – 21310RTPQLIIPNQ → K in isoform 2.
VSP_022456

Experimental info

Sequence conflict1841V → A in AAQ89093. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (GLIPR1L1beta) [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 22843450EC652C76

FASTA24227,151
        10         20         30         40         50         60 
MALKNKFSCL WILGLCLVAT TSSKIPSITD PHFIDNCIEA HNEWRGKVNP PAADMKYMIW 

        70         80         90        100        110        120 
DKGLAKMAKA WANQCKFEHN DCLDKSYKCY AAFEYVGENI WLGGIKSFTP RHAITAWYNE 

       130        140        150        160        170        180 
TQFYDFDSLS CSRVCGHYTQ LVWANSFYVG CAVAMCPNLG GASTAIFVCN YGPAGNFANM 

       190        200        210        220        230        240 
PPYVRGESCS LCSKEEKCVK NLCRTPQLII PNQNPFLKPT GRAPQQTAFN PFSLGFLLLR 


IF 

« Hide

Isoform 2 (GLIPR1L1alpha) [UniParc].

Checksum: C6BDD4B8DB5B91D2
Show »

FASTA23326,118

References

« Hide 'large scale' references
[1]"Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster."
Ren C., Ren C.-H., Li L., Goltsov A.A., Thompson T.C.
Genomics 88:163-172(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
Tissue: Testis.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[4]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-37.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358731 mRNA. Translation: AAQ89093.1.
BC014603 mRNA. Translation: AAH14603.1.
CCDSCCDS9009.1. [Q6UWM5-2]
RefSeqNP_689992.1. NM_152779.2. [Q6UWM5-2]
UniGeneHs.567788.

3D structure databases

ProteinModelPortalQ6UWM5.
SMRQ6UWM5. Positions 25-207.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6UWM5.

Polymorphism databases

DMDM124007190.

Proteomic databases

PaxDbQ6UWM5.
PRIDEQ6UWM5.

Protocols and materials databases

DNASU256710.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312442; ENSP00000310770; ENSG00000173401. [Q6UWM5-2]
ENST00000378695; ENSP00000367967; ENSG00000173401. [Q6UWM5-1]
GeneID256710.
KEGGhsa:256710.
UCSCuc001sxn.3. human. [Q6UWM5-2]
uc001sxo.3. human. [Q6UWM5-1]

Organism-specific databases

CTD256710.
GeneCardsGC12P075728.
HGNCHGNC:28392. GLIPR1L1.
HPAHPA042095.
MIM610395. gene.
neXtProtNX_Q6UWM5.
PharmGKBPA145008265.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2340.
HOGENOMHOG000036879.
HOVERGENHBG072125.
InParanoidQ6UWM5.
OMATDPHFID.
OrthoDBEOG7F7WB4.
PhylomeDBQ6UWM5.
TreeFamTF316148.

Gene expression databases

BgeeQ6UWM5.
CleanExHS_GLIPR1L1.
GenevestigatorQ6UWM5.

Family and domain databases

Gene3D3.40.33.10. 1 hit.
InterProIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERPTHR10334. PTHR10334. 1 hit.
PfamPF00188. CAP. 1 hit.
[Graphical view]
PRINTSPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMSSF55797. SSF55797. 1 hit.
PROSITEPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi256710.
NextBio92852.
PROQ6UWM5.
SOURCESearch...

Entry information

Entry nameGPRL1_HUMAN
AccessionPrimary (citable) accession number: Q6UWM5
Secondary accession number(s): Q96L06
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM