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Q6UWM5

- GPRL1_HUMAN

UniProt

Q6UWM5 - GPRL1_HUMAN

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Protein

GLIPR1-like protein 1

Gene
GLIPR1L1, UNQ2972/PRO7434
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. binding of sperm to zona pellucida Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
GLIPR1-like protein 1
Gene namesi
ORF Names:UNQ2972/PRO7434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:28392. GLIPR1L1.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
  3. sperm connecting piece Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 242220GLIPR1-like protein 1PRO_0000272653Add
BLAST

Proteomic databases

PaxDbiQ6UWM5.
PRIDEiQ6UWM5.

PTM databases

PhosphoSiteiQ6UWM5.

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Gene expression databases

BgeeiQ6UWM5.
CleanExiHS_GLIPR1L1.
GenevestigatoriQ6UWM5.

Organism-specific databases

HPAiHPA042095.

Structurei

3D structure databases

ProteinModelPortaliQ6UWM5.
SMRiQ6UWM5. Positions 25-207.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 171133SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.
Contains 1 SCP domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2340.
HOGENOMiHOG000036879.
HOVERGENiHBG072125.
InParanoidiQ6UWM5.
OMAiTDPHFID.
OrthoDBiEOG7F7WB4.
PhylomeDBiQ6UWM5.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UWM5-1) [UniParc]FASTAAdd to Basket

Also known as: GLIPR1L1beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALKNKFSCL WILGLCLVAT TSSKIPSITD PHFIDNCIEA HNEWRGKVNP    50
PAADMKYMIW DKGLAKMAKA WANQCKFEHN DCLDKSYKCY AAFEYVGENI 100
WLGGIKSFTP RHAITAWYNE TQFYDFDSLS CSRVCGHYTQ LVWANSFYVG 150
CAVAMCPNLG GASTAIFVCN YGPAGNFANM PPYVRGESCS LCSKEEKCVK 200
NLCRTPQLII PNQNPFLKPT GRAPQQTAFN PFSLGFLLLR IF 242
Length:242
Mass (Da):27,151
Last modified:January 23, 2007 - v2
Checksum:i22843450EC652C76
GO
Isoform 2 (identifier: Q6UWM5-2) [UniParc]FASTAAdd to Basket

Also known as: GLIPR1L1alpha

The sequence of this isoform differs from the canonical sequence as follows:
     204-213: RTPQLIIPNQ → K

Show »
Length:233
Mass (Da):26,118
Checksum:iC6BDD4B8DB5B91D2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei204 – 21310RTPQLIIPNQ → K in isoform 2. VSP_022456

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841V → A in AAQ89093. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358731 mRNA. Translation: AAQ89093.1.
BC014603 mRNA. Translation: AAH14603.1.
CCDSiCCDS9009.1. [Q6UWM5-2]
RefSeqiNP_689992.1. NM_152779.2. [Q6UWM5-2]
UniGeneiHs.567788.

Genome annotation databases

EnsembliENST00000312442; ENSP00000310770; ENSG00000173401. [Q6UWM5-2]
ENST00000378695; ENSP00000367967; ENSG00000173401. [Q6UWM5-1]
GeneIDi256710.
KEGGihsa:256710.
UCSCiuc001sxn.3. human. [Q6UWM5-2]
uc001sxo.3. human. [Q6UWM5-1]

Polymorphism databases

DMDMi124007190.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358731 mRNA. Translation: AAQ89093.1 .
BC014603 mRNA. Translation: AAH14603.1 .
CCDSi CCDS9009.1. [Q6UWM5-2 ]
RefSeqi NP_689992.1. NM_152779.2. [Q6UWM5-2 ]
UniGenei Hs.567788.

3D structure databases

ProteinModelPortali Q6UWM5.
SMRi Q6UWM5. Positions 25-207.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6UWM5.

Polymorphism databases

DMDMi 124007190.

Proteomic databases

PaxDbi Q6UWM5.
PRIDEi Q6UWM5.

Protocols and materials databases

DNASUi 256710.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312442 ; ENSP00000310770 ; ENSG00000173401 . [Q6UWM5-2 ]
ENST00000378695 ; ENSP00000367967 ; ENSG00000173401 . [Q6UWM5-1 ]
GeneIDi 256710.
KEGGi hsa:256710.
UCSCi uc001sxn.3. human. [Q6UWM5-2 ]
uc001sxo.3. human. [Q6UWM5-1 ]

Organism-specific databases

CTDi 256710.
GeneCardsi GC12P075728.
HGNCi HGNC:28392. GLIPR1L1.
HPAi HPA042095.
MIMi 610395. gene.
neXtProti NX_Q6UWM5.
PharmGKBi PA145008265.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2340.
HOGENOMi HOG000036879.
HOVERGENi HBG072125.
InParanoidi Q6UWM5.
OMAi TDPHFID.
OrthoDBi EOG7F7WB4.
PhylomeDBi Q6UWM5.
TreeFami TF316148.

Miscellaneous databases

GenomeRNAii 256710.
NextBioi 92852.
PROi Q6UWM5.
SOURCEi Search...

Gene expression databases

Bgeei Q6UWM5.
CleanExi HS_GLIPR1L1.
Genevestigatori Q6UWM5.

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
[Graphical view ]
PRINTSi PR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster."
    Ren C., Ren C.-H., Li L., Goltsov A.A., Thompson T.C.
    Genomics 88:163-172(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-37.

Entry informationi

Entry nameiGPRL1_HUMAN
AccessioniPrimary (citable) accession number: Q6UWM5
Secondary accession number(s): Q96L06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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