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Protein

GLIPR1-like protein 1

Gene

GLIPR1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region.By similarity

GO - Biological processi

Keywordsi

Biological processFertilization

Names & Taxonomyi

Protein namesi
Recommended name:
GLIPR1-like protein 1
Gene namesi
ORF Names:UNQ2972/PRO7434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000173401.9.
HGNCiHGNC:28392. GLIPR1L1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi256710.
OpenTargetsiENSG00000173401.
PharmGKBiPA145008265.

Polymorphism and mutation databases

BioMutaiGLIPR1L1.
DMDMi124007190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000027265323 – 221GLIPR1-like protein 1Add BLAST199
PropeptideiPRO_0000441107222 – 242Removed in mature formCuratedAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Lipidationi221GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

N-glycosylated. N-glycosylation decreases during the transit in the caput.By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ6UWM5.
PeptideAtlasiQ6UWM5.
PRIDEiQ6UWM5.

PTM databases

iPTMnetiQ6UWM5.
PhosphoSitePlusiQ6UWM5.

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000173401.
CleanExiHS_GLIPR1L1.
ExpressionAtlasiQ6UWM5. baseline and differential.
GenevisibleiQ6UWM5. HS.

Organism-specific databases

HPAiHPA042095.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310770.

Structurei

3D structure databases

ProteinModelPortaliQ6UWM5.
SMRiQ6UWM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 171SCPSequence analysisAdd BLAST133

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000036879.
HOVERGENiHBG072125.
InParanoidiQ6UWM5.
OMAiMAKAWAN.
OrthoDBiEOG091G048D.
PhylomeDBiQ6UWM5.
TreeFamiTF316148.

Family and domain databases

CDDicd05385. SCP_GLIPR-1_like. 1 hit.
Gene3Di3.40.33.10. 1 hit.
InterProiView protein in InterPro
IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR035940. CAP_sf.
IPR034121. SCP_GLIPR-1-like.
IPR002413. V5_allergen.
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiView protein in Pfam
PF00188. CAP. 1 hit.
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiView protein in SMART
SM00198. SCP. 1 hit.
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiView protein in PROSITE
PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWM5-1) [UniParc]FASTAAdd to basket
Also known as: GLIPR1L1beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALKNKFSCL WILGLCLVAT TSSKIPSITD PHFIDNCIEA HNEWRGKVNP
60 70 80 90 100
PAADMKYMIW DKGLAKMAKA WANQCKFEHN DCLDKSYKCY AAFEYVGENI
110 120 130 140 150
WLGGIKSFTP RHAITAWYNE TQFYDFDSLS CSRVCGHYTQ LVWANSFYVG
160 170 180 190 200
CAVAMCPNLG GASTAIFVCN YGPAGNFANM PPYVRGESCS LCSKEEKCVK
210 220 230 240
NLCRTPQLII PNQNPFLKPT GRAPQQTAFN PFSLGFLLLR IF
Length:242
Mass (Da):27,151
Last modified:January 23, 2007 - v2
Checksum:i22843450EC652C76
GO
Isoform 2 (identifier: Q6UWM5-2) [UniParc]FASTAAdd to basket
Also known as: GLIPR1L1alpha

The sequence of this isoform differs from the canonical sequence as follows:
     204-213: RTPQLIIPNQ → K

Show »
Length:233
Mass (Da):26,118
Checksum:iC6BDD4B8DB5B91D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184V → A in AAQ89093 (PubMed:12975309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022456204 – 213RTPQLIIPNQ → K in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358731 mRNA. Translation: AAQ89093.1.
BC014603 mRNA. Translation: AAH14603.1.
CCDSiCCDS76578.1. [Q6UWM5-1]
CCDS9009.1. [Q6UWM5-2]
RefSeqiNP_001291893.1. NM_001304964.1. [Q6UWM5-1]
NP_689992.1. NM_152779.3. [Q6UWM5-2]
UniGeneiHs.567788.

Genome annotation databases

EnsembliENST00000312442; ENSP00000310770; ENSG00000173401. [Q6UWM5-2]
ENST00000378695; ENSP00000367967; ENSG00000173401. [Q6UWM5-1]
GeneIDi256710.
KEGGihsa:256710.
UCSCiuc001sxn.4. human. [Q6UWM5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGPRL1_HUMAN
AccessioniPrimary (citable) accession number: Q6UWM5
Secondary accession number(s): Q96L06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families