Q6UWM5 (GPRL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GLIPR1-like protein 1

Gene names

Name:	GLIPR1L1
ORF Names:	UNQ2972/PRO7434

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Highly expressed in testis. Ref.1
Sequence similarities	Belongs to the CRISP family. Contains 1 SCP domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UWM5-1)

Also known as: GLIPR1L1beta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UWM5-2)

Also known as: GLIPR1L1alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     204-213: RTPQLIIPNQ → K

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.4
	Chain	23 – 242	220	GLIPR1-like protein 1		PRO_0000272653
Regions
	Domain	39 – 171	133	SCP
Natural variations
	Alternative sequence	204 – 213	10	RTPQLIIPNQ → K in isoform 2.		VSP_022456
Experimental info
	Sequence conflict	184	1	V → A in AAQ89093. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (GLIPR1L1beta) [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 22843450EC652C76	FASTA	242	27,151
	10 20 30 40 50 60 MALKNKFSCL WILGLCLVAT TSSKIPSITD PHFIDNCIEA HNEWRGKVNP PAADMKYMIW 70 80 90 100 110 120 DKGLAKMAKA WANQCKFEHN DCLDKSYKCY AAFEYVGENI WLGGIKSFTP RHAITAWYNE 130 140 150 160 170 180 TQFYDFDSLS CSRVCGHYTQ LVWANSFYVG CAVAMCPNLG GASTAIFVCN YGPAGNFANM 190 200 210 220 230 240 PPYVRGESCS LCSKEEKCVK NLCRTPQLII PNQNPFLKPT GRAPQQTAFN PFSLGFLLLR IF
	Isoform 2 (GLIPR1L1alpha) [UniParc]. Checksum: C6BDD4B8DB5B91D2	FASTA	233	26,118
	10 20 30 40 50 60 MALKNKFSCL WILGLCLVAT TSSKIPSITD PHFIDNCIEA HNEWRGKVNP PAADMKYMIW 70 80 90 100 110 120 DKGLAKMAKA WANQCKFEHN DCLDKSYKCY AAFEYVGENI WLGGIKSFTP RHAITAWYNE 130 140 150 160 170 180 TQFYDFDSLS CSRVCGHYTQ LVWANSFYVG CAVAMCPNLG GASTAIFVCN YGPAGNFANM 190 200 210 220 230 PPYVRGESCS LCSKEEKCVK NLCKNPFLKP TGRAPQQTAF NPFSLGFLLL RIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster." Ren C., Ren C.-H., Li L., Goltsov A.A., Thompson T.C. Genomics 88:163-172(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358731 mRNA. Translation: AAQ89093.1. BC014603 mRNA. Translation: AAH14603.1.
IPI	IPI00064712. IPI00746106.
RefSeq	NP_689992.1. NM_152779.2.
UniGene	Hs.567788.
3D structure databases
HSSP	HSSP built from PDB template 1QNX based on UniProtKB Q05110.
ProteinModelPortal	Q6UWM5.
ModBase	Search...
PTM databases
PhosphoSite	Q6UWM5.
Polymorphism databases
DMDM	124007190.
Proteomic databases
PaxDb	Q6UWM5.
PRIDE	Q6UWM5.
Protocols and materials databases
DNASU	256710.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312442; ENSP00000310770; ENSG00000173401. ENST00000378695; ENSP00000367967; ENSG00000173401.
GeneID	256710.
KEGG	hsa:256710.
UCSC	uc001sxn.3. human. uc001sxo.3. human.
Organism-specific databases
CTD	256710.
GeneCards	GC12P075728.
HGNC	HGNC:28392. GLIPR1L1.
HPA	HPA042095.
MIM	610395. gene.
neXtProt	NX_Q6UWM5.
PharmGKB	PA145008265.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2340.
HOGENOM	HOG000036879.
HOVERGEN	HBG072125.
InParanoid	Q6UWM5.
OMA	PSITDPH.
Gene expression databases
Bgee	Q6UWM5.
CleanEx	HS_GLIPR1L1.
Genevestigator	Q6UWM5.
Family and domain databases
Gene3D	3.40.33.10. 1 hit.
InterPro	IPR001283. Allrgn_V5/Tpx1. IPR018244. Allrgn_V5/Tpx1_CS. IPR014044. CAP_domain. IPR002413. V5_allergen. [Graphical view]
PANTHER	PTHR10334. PTHR10334. 1 hit.
Pfam	PF00188. CAP. 1 hit. [Graphical view]
PRINTS	PR00838. V5ALLERGEN. PR00837. V5TPXLIKE.
SMART	SM00198. SCP. 1 hit. [Graphical view]
SUPFAM	SSF55797. SCP-like_extracellular. 1 hit.
PROSITE	PS01009. CRISP_1. 1 hit. PS01010. CRISP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	256710.
NextBio	92852.
SOURCE	Search...

Entry information

Entry name

GPRL1_HUMAN

Accession

Primary (citable) accession number: Q6UWM5
Secondary accession number(s): Q96L06

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.