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Protein

Secreted protein C10orf99

Gene

C10orf99

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential cytokine proposed to be a ligand of SUSD2; can induce SUSD2 internalization upon binding. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). Specifically inhibits cell growth of lymphoblastoid Raji cell line (PubMed:25585381).2 Publications
Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381).1 Publication

GO - Biological processi

  • defense response to fungus Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • negative regulation of cell cycle G1/S phase transition Source: UniProtKB
  • negative regulation of cell division Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Cytokine

Enzyme and pathway databases

BioCyciZFISH:G66-31750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted protein C10orf99
Alternative name(s):
Antimicrobial peptide-57
Short name:
AP-57
Colon-derived SUSD2 binding factor
Short name:
CSBF
Gene namesi
ORF Names:UNQ1833/PRO3446
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:31428. C10orf99.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi387695.
OpenTargetsiENSG00000188373.
PharmGKBiPA134990747.

Polymorphism and mutation databases

BioMutaiC10orf99.
DMDMi74749393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000026008425 – 81Secreted protein C10orf99Add BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Contains intermolecular disulfide bonds (PubMed:25585381).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UWK7.
PeptideAtlasiQ6UWK7.
PRIDEiQ6UWK7.

PTM databases

iPTMnetiQ6UWK7.
PhosphoSitePlusiQ6UWK7.

Expressioni

Tissue specificityi

Expressed at high levels in colon and at moderate level in tonsil. Highly reduced expression in primary colon cancer tissues compared with that in adjacent tissues (PubMed:25351403). Highest levels of expression detected in stomach and colon; expressed in epithelium of skin and esophagus, and in some tumor and/or tumor adjacent tissues (TAT), including TAT of esophagus cancer, hepatocellular carcinoma (HCC), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and invasive ductal carcinoma (IDC) tissues (at protein level) (PubMed:25585381).1 Publication

Gene expression databases

BgeeiENSG00000188373.
CleanExiHS_C10orf99.
GenevisibleiQ6UWK7. HS.

Organism-specific databases

HPAiHPA050920.

Interactioni

Subunit structurei

Interacts with SUSD2; the interaction is direct.

Protein-protein interaction databases

STRINGi9606.ENSP00000361199.

Structurei

3D structure databases

ProteinModelPortaliQ6UWK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JJ2R. Eukaryota.
ENOG41115Y9. LUCA.
GeneTreeiENSGT00390000015172.
HOGENOMiHOG000111701.
InParanoidiQ6UWK7.
OMAiCRPCKLK.
OrthoDBiEOG091G1AMP.
PhylomeDBiQ6UWK7.
TreeFamiTF336385.

Family and domain databases

InterProiIPR031713. DUF4725.
[Graphical view]
PfamiPF15854. DUF4725. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLVLSSLL CILLLCFSIF STEGKRRPAK AWSGRRTRLC CHRVPSPNST
60 70 80
NLKGHHVRLC KPCKLEPEPR LWVVPGALPQ V
Length:81
Mass (Da):9,173
Last modified:July 5, 2004 - v1
Checksum:i276E720364160B8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358751 mRNA. Translation: AAQ89111.1.
CCDSiCCDS7371.1.
RefSeqiNP_997256.1. NM_207373.2.
UniGeneiHs.298713.
Hs.499145.

Genome annotation databases

EnsembliENST00000372126; ENSP00000361199; ENSG00000188373.
GeneIDi387695.
KEGGihsa:387695.
UCSCiuc001kcu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358751 mRNA. Translation: AAQ89111.1.
CCDSiCCDS7371.1.
RefSeqiNP_997256.1. NM_207373.2.
UniGeneiHs.298713.
Hs.499145.

3D structure databases

ProteinModelPortaliQ6UWK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361199.

PTM databases

iPTMnetiQ6UWK7.
PhosphoSitePlusiQ6UWK7.

Polymorphism and mutation databases

BioMutaiC10orf99.
DMDMi74749393.

Proteomic databases

PaxDbiQ6UWK7.
PeptideAtlasiQ6UWK7.
PRIDEiQ6UWK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372126; ENSP00000361199; ENSG00000188373.
GeneIDi387695.
KEGGihsa:387695.
UCSCiuc001kcu.4. human.

Organism-specific databases

CTDi387695.
DisGeNETi387695.
GeneCardsiC10orf99.
HGNCiHGNC:31428. C10orf99.
HPAiHPA050920.
neXtProtiNX_Q6UWK7.
OpenTargetsiENSG00000188373.
PharmGKBiPA134990747.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JJ2R. Eukaryota.
ENOG41115Y9. LUCA.
GeneTreeiENSGT00390000015172.
HOGENOMiHOG000111701.
InParanoidiQ6UWK7.
OMAiCRPCKLK.
OrthoDBiEOG091G1AMP.
PhylomeDBiQ6UWK7.
TreeFamiTF336385.

Enzyme and pathway databases

BioCyciZFISH:G66-31750-MONOMER.

Miscellaneous databases

ChiTaRSiC10orf99. human.
GenomeRNAii387695.
PROiQ6UWK7.

Gene expression databases

BgeeiENSG00000188373.
CleanExiHS_C10orf99.
GenevisibleiQ6UWK7. HS.

Family and domain databases

InterProiIPR031713. DUF4725.
[Graphical view]
PfamiPF15854. DUF4725. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCJ099_HUMAN
AccessioniPrimary (citable) accession number: Q6UWK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.