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Protein

CD164 sialomucin-like 2 protein

Gene

CD164L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
CD164 sialomucin-like 2 protein
Gene namesi
Name:CD164L2
ORF Names:UNQ6122/PRO20044
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174950.10.
HGNCiHGNC:32043. CD164L2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 141ExtracellularSequence analysisAdd BLAST112
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 174CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672146.

Polymorphism and mutation databases

BioMutaiCD164L2.
DMDMi85700457.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000004577930 – 174CD164 sialomucin-like 2 proteinAdd BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6UWJ8.
PeptideAtlasiQ6UWJ8.
PRIDEiQ6UWJ8.

PTM databases

iPTMnetiQ6UWJ8.
PhosphoSitePlusiQ6UWJ8.

Expressioni

Gene expression databases

BgeeiENSG00000174950.
CleanExiHS_CD164L2.

Organism-specific databases

HPAiHPA062915.

Interactioni

Protein-protein interaction databases

BioGridi132771. 6 interactors.
IntActiQ6UWJ8. 2 interactors.
STRINGi9606.ENSP00000363139.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8SQ. Eukaryota.
ENOG410Z06V. LUCA.
HOGENOMiHOG000060100.
HOVERGENiHBG056403.
InParanoidiQ6UWJ8.
OrthoDBiEOG091G141K.
PhylomeDBiQ6UWJ8.
TreeFamiTF333380.

Family and domain databases

InterProiView protein in InterPro
IPR007947. CD164_MGC24.
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiView protein in Pfam
PF05283. MGC-24. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAPGPRALR TALCGGCCCL LLCAQLAVAG KGARGFGRGA LIRLNIWPAV
60 70 80 90 100
QGACKQLEVC EHCVEGDRAR NLSSCMWEQC RPEEPGHCVA QSEVVKEGCS
110 120 130 140 150
IYNRSEACPA AHHHPTYEPK TVTTGSPPVP EAHSPGFDGA SFIGGVVLVL
160 170
SLQAVAFFVL HFLKAKDSTY QTLI
Note: Gene prediction based on EST data.
Length:174
Mass (Da):18,534
Last modified:January 24, 2006 - v2
Checksum:i486D2D03CD34FCBE
GO
Isoform 2 (identifier: Q6UWJ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: Missing.

Show »
Length:173
Mass (Da):18,421
Checksum:iFD2D03CD34FCBE36
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05750876M → V. Corresponds to variant dbSNP:rs2504779Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017031174Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358761 mRNA. Translation: AAQ89121.1.
AL096774 Genomic DNA. Translation: CAI19568.1.
AL096774 Genomic DNA. Translation: CAI19569.1.
CH471059 Genomic DNA. Translation: EAX07755.1.
BC137466 mRNA. Translation: AAI37467.1.
CCDSiCCDS302.1. [Q6UWJ8-2]
CCDS81287.1. [Q6UWJ8-1]
RefSeqiNP_997280.2. NM_207397.4.
UniGeneiHs.664836.

Genome annotation databases

EnsembliENST00000374027; ENSP00000363139; ENSG00000174950.
ENST00000374030; ENSP00000363142; ENSG00000174950.
GeneIDi388611.
KEGGihsa:388611.
UCSCiuc031tuv.2. human. [Q6UWJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiC16L2_HUMAN
AccessioniPrimary (citable) accession number: Q6UWJ8
Secondary accession number(s): B2RPJ0, Q5JXD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: September 27, 2017
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families