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Reviewed, UniProtKB/Swiss-Prot Q6UWI4 (SHSA2_HUMAN)

Last modified January 19, 2010. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein shisa-2 homolog
Alternative name(s):
    Transmembrane protein 46
Gene names
Name: SHISA2
Synonyms: C13orf13, TMEM46
ORF Names: UNQ9166/PRO28631
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the shisa protein family.

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Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
   DomainSignal
Transmembrane
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-KW

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Ref.5
Chain34 – 295262Protein shisa-2 homolog
PRO_0000022615

Regions

Topological domain34 – 11077Extracellular Potential
Transmembrane111 – 13121 Potential
Topological domain132 – 295164Cytoplasmic Potential

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Sequences

Sequence LengthMass (Da)Tools
Q6UWI4-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 180416B9D6490803

FASTA29531,375
        10         20         30         40         50         60 
MWGARRSSVS SSWNAASLLQ LLLAALLAAG ARASGEYCHG WLDAQGVWRI GFQCPERFDG 

        70         80         90        100        110        120 
GDATICCGSC ALRYCCSSAE ARLDQGGCDN DRQQGAGEPG RADKDGPDGS AVPIYVPFLI 

       130        140        150        160        170        180 
VGSVFVAFII LGSLVAACCC RCLRPKQDPQ QSRAPGGNRL METIPMIPSA STSRGSSSRQ 

       190        200        210        220        230        240 
SSTAASSSSS ANSGARAPPT RSQTNCCLPE GTMNNVYVNM PTNFSVLNCQ QATQIVPHQG 

       250        260        270        280        290 
QYLHPPYVGY TVQHDSVPMT AVPPFMDGLQ PGYRQIQSPF PHTNSEQKMY PAVTV

« Hide

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References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed: 15057823] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Testis.
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 34-47.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY358775 mRNA. Translation: AAQ89135.1.
AL139004 Genomic DNA. Translation: CAH73406.1.
CH471075 Genomic DNA. Translation: EAX08378.1.
BC132898 mRNA. Translation: AAI32899.1.
BC137092 mRNA. Translation: AAI37093.1.
IPIIPI00244512.
RefSeqNP_001007539.1.
UniGeneHs.433791

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ6UWI4.

Proteomic databases

PRIDEQ6UWI4.

Genome annotation databases

EnsemblENST00000319420; ENSP00000313079; ENSG00000180730; Homo sapiens. [Genome view]
GeneID387914.
KEGGhsa:387914.
NMPDRfig|9606.3.peg.8653.
UCSCuc001uqm.1. human.

Organism-specific databases

CTD387914.
GeneCardsGC13M025516.
H-InvDBHIX0031427.
HIX0037322.
HGNCHGNC:20366. SHISA2.
PharmGKBPA134865838.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18008.
HOGENOMHBG717400.
HOVERGENQ6UWI4.
InParanoidQ6UWI4.
OMASRAPGGN.
OrthoDBEOG9VMJ0T.
PhylomeDBQ6UWI4.

Gene expression databases

ArrayExpressQ6UWI4.
BgeeQ6UWI4.
CleanExHS_SHISA2.
GenevestigatorQ6UWI4.
GermOnlineENSG00000180730. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio101724.

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Entry information

Entry nameSHSA2_HUMAN
AccessionPrimary (citable) accession number: Q6UWI4
Secondary accession number(s): B9EH70, Q5W0G8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: July 5, 2004
Last modified: January 19, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents