Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein shisa-2 homolog

Gene

SHISA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shisa-2 homolog
Alternative name(s):
Transmembrane protein 46
Gene namesi
Name:SHISA2
Synonyms:C13orf13, TMEM46
ORF Names:UNQ9166/PRO28631
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20366. SHISA2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 11077ExtracellularSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Topological domaini132 – 295164CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403292.

Polymorphism and mutation databases

BioMutaiSHISA2.
DMDMi55583902.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 33331 PublicationAdd
BLAST
Chaini34 – 295262Protein shisa-2 homologPRO_0000022615Add
BLAST

Proteomic databases

PaxDbiQ6UWI4.
PRIDEiQ6UWI4.

PTM databases

PhosphoSiteiQ6UWI4.
SwissPalmiQ6UWI4.

Expressioni

Gene expression databases

BgeeiQ6UWI4.
CleanExiHS_SHISA2.
GenevisibleiQ6UWI4. HS.

Organism-specific databases

HPAiHPA049752.
HPA050172.

Interactioni

Protein-protein interaction databases

BioGridi132503. 4 interactions.
IntActiQ6UWI4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6UWI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shisa family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE4F. Eukaryota.
ENOG410ZKJD. LUCA.
GeneTreeiENSGT00390000016402.
HOGENOMiHOG000234350.
HOVERGENiHBG059385.
InParanoidiQ6UWI4.
OMAiGKCELRY.
OrthoDBiEOG77M8PB.
PhylomeDBiQ6UWI4.
TreeFamiTF330800.

Family and domain databases

InterProiIPR026910. Shisa.
[Graphical view]
PfamiPF13908. Shisa. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGARRSSVS SSWNAASLLQ LLLAALLAAG ARASGEYCHG WLDAQGVWRI
60 70 80 90 100
GFQCPERFDG GDATICCGSC ALRYCCSSAE ARLDQGGCDN DRQQGAGEPG
110 120 130 140 150
RADKDGPDGS AVPIYVPFLI VGSVFVAFII LGSLVAACCC RCLRPKQDPQ
160 170 180 190 200
QSRAPGGNRL METIPMIPSA STSRGSSSRQ SSTAASSSSS ANSGARAPPT
210 220 230 240 250
RSQTNCCLPE GTMNNVYVNM PTNFSVLNCQ QATQIVPHQG QYLHPPYVGY
260 270 280 290
TVQHDSVPMT AVPPFMDGLQ PGYRQIQSPF PHTNSEQKMY PAVTV
Length:295
Mass (Da):31,375
Last modified:July 5, 2004 - v1
Checksum:i180416B9D6490803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358775 mRNA. Translation: AAQ89135.1.
AL139004 Genomic DNA. Translation: CAH73406.1.
CH471075 Genomic DNA. Translation: EAX08378.1.
BC132898 mRNA. Translation: AAI32899.1.
BC137092 mRNA. Translation: AAI37093.1.
CCDSiCCDS31951.1.
RefSeqiNP_001007539.1. NM_001007538.1.
UniGeneiHs.433791.

Genome annotation databases

EnsembliENST00000319420; ENSP00000313079; ENSG00000180730.
GeneIDi387914.
KEGGihsa:387914.
UCSCiuc001uqm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358775 mRNA. Translation: AAQ89135.1.
AL139004 Genomic DNA. Translation: CAH73406.1.
CH471075 Genomic DNA. Translation: EAX08378.1.
BC132898 mRNA. Translation: AAI32899.1.
BC137092 mRNA. Translation: AAI37093.1.
CCDSiCCDS31951.1.
RefSeqiNP_001007539.1. NM_001007538.1.
UniGeneiHs.433791.

3D structure databases

ProteinModelPortaliQ6UWI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132503. 4 interactions.
IntActiQ6UWI4. 1 interaction.

PTM databases

PhosphoSiteiQ6UWI4.
SwissPalmiQ6UWI4.

Polymorphism and mutation databases

BioMutaiSHISA2.
DMDMi55583902.

Proteomic databases

PaxDbiQ6UWI4.
PRIDEiQ6UWI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319420; ENSP00000313079; ENSG00000180730.
GeneIDi387914.
KEGGihsa:387914.
UCSCiuc001uqm.2. human.

Organism-specific databases

CTDi387914.
GeneCardsiSHISA2.
HGNCiHGNC:20366. SHISA2.
HPAiHPA049752.
HPA050172.
neXtProtiNX_Q6UWI4.
PharmGKBiPA162403292.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE4F. Eukaryota.
ENOG410ZKJD. LUCA.
GeneTreeiENSGT00390000016402.
HOGENOMiHOG000234350.
HOVERGENiHBG059385.
InParanoidiQ6UWI4.
OMAiGKCELRY.
OrthoDBiEOG77M8PB.
PhylomeDBiQ6UWI4.
TreeFamiTF330800.

Miscellaneous databases

GenomeRNAii387914.
NextBioi101724.
PROiQ6UWI4.

Gene expression databases

BgeeiQ6UWI4.
CleanExiHS_SHISA2.
GenevisibleiQ6UWI4. HS.

Family and domain databases

InterProiIPR026910. Shisa.
[Graphical view]
PfamiPF13908. Shisa. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Testis.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 34-47.

Entry informationi

Entry nameiSHSA2_HUMAN
AccessioniPrimary (citable) accession number: Q6UWI4
Secondary accession number(s): B9EH70, Q5W0G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.