Q6UWI2 (PARM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prostate androgen-regulated mucin-like protein 1
Short name=PARM-1

Gene names

Name:	PARM1
ORF Names:	UNQ1879/PRO4322

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein Ref.6.
Tissue specificity	Widely expressed with highest levels in heart, kidney and placenta. Ref.6
Induction	By androgens. Ref.6
Post-translational modification	Highly N-glycosylated and O-glycosylated. Ref.6
Sequence similarities	Belongs to the PARM family.
Sequence caution	The sequence CAB45720.1 differs from that shown. Reason: Frameshift at position 239.

Ontologies

Keywords
Cellular component	Cell membrane Endosome Golgi apparatus Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of telomerase activity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay Ref.6. Source: UniProtKB Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell early endosome Inferred from direct assay Ref.6. Source: UniProtKB endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW late endosome Inferred from direct assay Ref.6. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.5
	Chain	21 – 310	290	Prostate androgen-regulated mucin-like protein 1		PRO_0000045498
Regions
	Topological domain	21 – 258	238	Extracellular Potential
	Transmembrane	259 – 279	21	Helical; Potential
	Topological domain	280 – 310	31	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	58	1	N-linked (GlcNAc...) Potential
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Glycosylation	176	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	127	1	S → L. Ref.2 Corresponds to variant rs3822109 [ dbSNP | Ensembl ].		VAR_062257
Experimental info
	Sequence conflict	82	1	S → P in BAG51071. Ref.3
	Sequence conflict	123	1	E → K in AAH13294. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q6UWI2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0DFD58B134FAF9BD	FASTA	310	32,289
	10 20 30 40 50 60 MVYKTLFALC ILTAGWRVQS LPTSAPLSVS LPTNIVPPTT IWTSSPQNTD ADTASPSNGT 70 80 90 100 110 120 HNNSVLPVTA SAPTSLLPKN ISIESREEEI TSPGSNWEGT NTDPSPSGFS STSGGVHLTT 130 140 150 160 170 180 TLEEHSSGTP EAGVAATLSQ SAAEPPTLIS PQAPASSPSS LSTSPPEVFS ASVTTNHSST 190 200 210 220 230 240 VTSTQPTGAP TAPESPTEES SSDHTPTSHA TAEPVPQEKT PPTTVSGKVM CELIDMETTT 250 260 270 280 290 300 TFPRVIMQEV EHALSSGSIA AITVTVIAVV LLVFGVAAYL KIRHSSYGRL LDDHDYGSWG 310 NYNNPLYDDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-127. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-35.
[6]	"Human PARM-1 is a novel mucin-like, androgen-regulated gene exhibiting proliferative effects in prostate cancer cells." Fladeby C., Gupta S.N., Barois N., Lorenzo P.I., Simpson J.C., Saatcioglu F., Bakke O. Int. J. Cancer 122:1229-1235(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, GLYCOSYLATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358777 mRNA. Translation: AAQ89137.1. AL080121 mRNA. Translation: CAB45720.1. Frameshift. AK022311 mRNA. Translation: BAG51071.1. BC013294 mRNA. Translation: AAH13294.1.
IPI	IPI00294910.
PIR	T12458.
RefSeq	NP_056208.2. NM_015393.3.
UniGene	Hs.105460. Hs.623905.
3D structure databases
ProteinModelPortal	Q6UWI2.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4726424.
STRING	9606.ENSP00000370224.
PTM databases
PhosphoSite	Q6UWI2.
Polymorphism databases
DMDM	74738099.
Proteomic databases
PRIDE	Q6UWI2.
Protocols and materials databases
DNASU	25849.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307428; ENSP00000370224; ENSG00000169116.
GeneID	25849.
KEGG	hsa:25849.
UCSC	uc003hih.2. human.
Organism-specific databases
CTD	25849.
GeneCards	GC04P075858.
HGNC	HGNC:24536. PARM1.
HPA	HPA038236.
neXtProt	NX_Q6UWI2.
PharmGKB	PA165664393.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84663.
HOGENOM	HOG000280689.
HOVERGEN	HBG082108.
InParanoid	Q6UWI2.
OMA	MQEVEHA.
Gene expression databases
ArrayExpress	Q6UWI2.
Bgee	Q6UWI2.
Genevestigator	Q6UWI2.
GermOnline	ENSG00000169116. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	PARM1. human.
GenomeRNAi	25849.
NextBio	47186.

Entry information

Entry name

PARM1_HUMAN

Accession

Primary (citable) accession number: Q6UWI2
Secondary accession number(s): B3KMQ9, Q96DV8, Q9Y4S1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.