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Protein

Prostate androgen-regulated mucin-like protein 1

Gene

PARM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate androgen-regulated mucin-like protein 1
Short name:
PARM-1
Gene namesi
Name:PARM1
ORF Names:UNQ1879/PRO4322
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24536. PARM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 258238ExtracellularSequence analysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence analysisAdd
BLAST
Topological domaini280 – 31031CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: HPA
  • early endosome Source: UniProtKB
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: HPA
  • late endosome Source: UniProtKB
  • nucleus Source: HPA
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664393.

Polymorphism and mutation databases

BioMutaiPARM1.
DMDMi74738099.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 310290Prostate androgen-regulated mucin-like protein 1PRO_0000045498Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Glycosylationi80 – 801N-linked (GlcNAc...) (complex)1 Publication
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Modified residuei298 – 2981PhosphoserineBy similarity

Post-translational modificationi

Highly N-glycosylated and O-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6UWI2.
PaxDbiQ6UWI2.
PeptideAtlasiQ6UWI2.
PRIDEiQ6UWI2.

PTM databases

iPTMnetiQ6UWI2.
PhosphoSiteiQ6UWI2.

Expressioni

Tissue specificityi

Widely expressed with highest levels in heart, kidney and placenta.1 Publication

Inductioni

By androgens.1 Publication

Gene expression databases

BgeeiENSG00000169116.
ExpressionAtlasiQ6UWI2. baseline and differential.
GenevisibleiQ6UWI2. HS.

Organism-specific databases

HPAiHPA038236.

Interactioni

Protein-protein interaction databases

MINTiMINT-4726424.
STRINGi9606.ENSP00000370224.

Structurei

3D structure databases

ProteinModelPortaliQ6UWI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PARM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVTQ. Eukaryota.
ENOG410XTVA. LUCA.
GeneTreeiENSGT00390000014545.
HOGENOMiHOG000280689.
HOVERGENiHBG082108.
InParanoidiQ6UWI2.
OMAiMQEVEHA.
OrthoDBiEOG091G0Z5B.
PhylomeDBiQ6UWI2.
TreeFamiTF335903.

Family and domain databases

InterProiIPR031431. PARM1.
[Graphical view]
PANTHERiPTHR35453. PTHR35453. 1 hit.
PfamiPF17061. PARM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYKTLFALC ILTAGWRVQS LPTSAPLSVS LPTNIVPPTT IWTSSPQNTD
60 70 80 90 100
ADTASPSNGT HNNSVLPVTA SAPTSLLPKN ISIESREEEI TSPGSNWEGT
110 120 130 140 150
NTDPSPSGFS STSGGVHLTT TLEEHSSGTP EAGVAATLSQ SAAEPPTLIS
160 170 180 190 200
PQAPASSPSS LSTSPPEVFS ASVTTNHSST VTSTQPTGAP TAPESPTEES
210 220 230 240 250
SSDHTPTSHA TAEPVPQEKT PPTTVSGKVM CELIDMETTT TFPRVIMQEV
260 270 280 290 300
EHALSSGSIA AITVTVIAVV LLVFGVAAYL KIRHSSYGRL LDDHDYGSWG
310
NYNNPLYDDS
Length:310
Mass (Da):32,289
Last modified:July 5, 2004 - v1
Checksum:i0DFD58B134FAF9BD
GO

Sequence cautioni

The sequence CAB45720 differs from that shown. Reason: Frameshift at position 239. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821S → P in BAG51071 (PubMed:14702039).Curated
Sequence conflicti123 – 1231E → K in AAH13294 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti127 – 1271S → L.1 Publication
Corresponds to variant rs3822109 [ dbSNP | Ensembl ].
VAR_062257

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358777 mRNA. Translation: AAQ89137.1.
AL080121 mRNA. Translation: CAB45720.1. Frameshift.
AK022311 mRNA. Translation: BAG51071.1.
BC013294 mRNA. Translation: AAH13294.1.
CCDSiCCDS47077.1.
PIRiT12458.
RefSeqiNP_056208.2. NM_015393.3.
UniGeneiHs.105460.
Hs.623905.

Genome annotation databases

EnsembliENST00000307428; ENSP00000370224; ENSG00000169116.
GeneIDi25849.
KEGGihsa:25849.
UCSCiuc003hih.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358777 mRNA. Translation: AAQ89137.1.
AL080121 mRNA. Translation: CAB45720.1. Frameshift.
AK022311 mRNA. Translation: BAG51071.1.
BC013294 mRNA. Translation: AAH13294.1.
CCDSiCCDS47077.1.
PIRiT12458.
RefSeqiNP_056208.2. NM_015393.3.
UniGeneiHs.105460.
Hs.623905.

3D structure databases

ProteinModelPortaliQ6UWI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4726424.
STRINGi9606.ENSP00000370224.

PTM databases

iPTMnetiQ6UWI2.
PhosphoSiteiQ6UWI2.

Polymorphism and mutation databases

BioMutaiPARM1.
DMDMi74738099.

Proteomic databases

MaxQBiQ6UWI2.
PaxDbiQ6UWI2.
PeptideAtlasiQ6UWI2.
PRIDEiQ6UWI2.

Protocols and materials databases

DNASUi25849.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307428; ENSP00000370224; ENSG00000169116.
GeneIDi25849.
KEGGihsa:25849.
UCSCiuc003hih.3. human.

Organism-specific databases

CTDi25849.
GeneCardsiPARM1.
HGNCiHGNC:24536. PARM1.
HPAiHPA038236.
neXtProtiNX_Q6UWI2.
PharmGKBiPA165664393.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVTQ. Eukaryota.
ENOG410XTVA. LUCA.
GeneTreeiENSGT00390000014545.
HOGENOMiHOG000280689.
HOVERGENiHBG082108.
InParanoidiQ6UWI2.
OMAiMQEVEHA.
OrthoDBiEOG091G0Z5B.
PhylomeDBiQ6UWI2.
TreeFamiTF335903.

Miscellaneous databases

ChiTaRSiPARM1. human.
GeneWikiiDKFZP564O0823.
GenomeRNAii25849.
PROiQ6UWI2.

Gene expression databases

BgeeiENSG00000169116.
ExpressionAtlasiQ6UWI2. baseline and differential.
GenevisibleiQ6UWI2. HS.

Family and domain databases

InterProiIPR031431. PARM1.
[Graphical view]
PANTHERiPTHR35453. PTHR35453. 1 hit.
PfamiPF17061. PARM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPARM1_HUMAN
AccessioniPrimary (citable) accession number: Q6UWI2
Secondary accession number(s): B3KMQ9, Q96DV8, Q9Y4S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.