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Protein

Colipase-like protein 2

Gene

CLPSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase-like protein 2
Gene namesi
Name:CLPSL2
Synonyms:C6orf126
ORF Names:UNQ3045/PRO9861
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000196748.9.
HGNCiHGNC:21250. CLPSL2.
neXtProtiNX_Q6UWE3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196748.
PharmGKBiPA134977993.

Polymorphism and mutation databases

DMDMi212276514.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000002260822 – 100Colipase-like protein 2Add BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 45PROSITE-ProRule annotation
Disulfide bondi40 ↔ 56PROSITE-ProRule annotation
Disulfide bondi44 ↔ 78PROSITE-ProRule annotation
Disulfide bondi66 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 97PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6UWE3.
PeptideAtlasiQ6UWE3.
PRIDEiQ6UWE3.
TopDownProteomicsiQ6UWE3-2. [Q6UWE3-2]

PTM databases

iPTMnetiQ6UWE3.
PhosphoSitePlusiQ6UWE3.

Expressioni

Gene expression databases

BgeeiENSG00000196748.
CleanExiHS_C6orf126.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN2Q9UHD94EBI-12183429,EBI-947187

Protein-protein interaction databases

IntActiQ6UWE3. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6UWE3.
SMRiQ6UWE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFYG. Eukaryota.
ENOG411160Z. LUCA.
GeneTreeiENSGT00390000011494.
HOGENOMiHOG000111565.
InParanoidiQ6UWE3.
OMAiMICLPQW.
OrthoDBiEOG091G0Z2E.
PhylomeDBiQ6UWE3.
TreeFamiTF343049.

Family and domain databases

InterProiView protein in InterPro
IPR001981. Colipase.
PANTHERiPTHR10041. PTHR10041. 1 hit.
PROSITEiView protein in PROSITE
PS51342. COLIPASE_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAALALVAG VLSGAVLPLW SALPQYKKKI TDRCFHHSEC YSGCCLMDLD
60 70 80 90 100
SGGAFCAPRA RITMICLPQT KGATNIICPC RMGLTCISKD LMCSRRCHMI
Length:100
Mass (Da):10,812
Last modified:November 4, 2008 - v3
Checksum:i2458FFEA1F48C563
GO
Isoform 2 (identifier: Q6UWE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-100: TKGATNIICPCRMGLTCISKDLMCSRRCHMI → WLELFKGRDR...LPPTCSKSSS

Show »
Length:153
Mass (Da):16,885
Checksum:i0DCCCAE292DA2852
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q6UWE3-2)
Sequence conflicti79R → C in AAQ89182 (PubMed:12975309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03562170 – 100TKGAT…RCHMI → WLELFKGRDRIIFIYEAPTP SLVSAHNQGSYQHHLPLPDG LDVHIQGLDVFPPVPYDLEE DAGWSLLPWGHRPWLPPTCS KSSS in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358823 mRNA. Translation: AAQ89182.1.
AL157823 Genomic DNA. No translation available.
CCDSiCCDS4810.2. [Q6UWE3-1]
CCDS69095.1. [Q6UWE3-2]
RefSeqiNP_001273479.1. NM_001286550.1. [Q6UWE3-2]
NP_997292.2. NM_207409.3. [Q6UWE3-1]
UniGeneiHs.259563.

Genome annotation databases

EnsembliENST00000360454; ENSP00000353639; ENSG00000196748. [Q6UWE3-2]
ENST00000403376; ENSP00000385898; ENSG00000196748. [Q6UWE3-1]
GeneIDi389383.
KEGGihsa:389383.
UCSCiuc003olc.3. human. [Q6UWE3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCOLL2_HUMAN
AccessioniPrimary (citable) accession number: Q6UWE3
Secondary accession number(s): B0QZ45, Q5T9G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 4, 2008
Last modified: November 22, 2017
This is version 95 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families