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Q6UWB4

- PRS55_HUMAN

UniProt

Q6UWB4 - PRS55_HUMAN

Protein

Serine protease 55

Gene

PRSS55

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Probable serine protease.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081Charge relay systemBy similarity
    Active sitei156 – 1561Charge relay systemBy similarity
    Active sitei250 – 2501Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.415.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine protease 55 (EC:3.4.21.-)
    Alternative name(s):
    Testis serine protease 1
    Short name:
    T-SP1
    Gene namesi
    Name:PRSS55
    Synonyms:TSP1
    ORF Names:UNQ9391/PRO34284
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:30824. PRSS55.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165585933.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 6749Activation propeptideBy similarityPRO_0000423643Add
    BLAST
    Chaini68 – 352285Serine protease 55PRO_0000328815Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi93 ↔ 109PROSITE-ProRule annotation
    Disulfide bondi189 ↔ 256PROSITE-ProRule annotation
    Disulfide bondi222 ↔ 235PROSITE-ProRule annotation
    Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi246 ↔ 276PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6UWB4.
    PRIDEiQ6UWB4.

    Expressioni

    Tissue specificityi

    Only detected in testis. Expressed in spermatogonia, spermatocytes, spermatids, Leydig and Sertoli cells. Expressed in prostate cancer and ovarian cancer (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ6UWB4.
    BgeeiQ6UWB4.
    GenevestigatoriQ6UWB4.

    Organism-specific databases

    HPAiHPA027977.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UWB4.
    SMRiQ6UWB4. Positions 68-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini68 – 326259ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini348 – 3525CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini68 – 300233Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG078102.
    InParanoidiQ6UWB4.
    OMAiPEPGEKW.
    OrthoDBiEOG7MKW6Q.
    PhylomeDBiQ6UWB4.
    TreeFamiTF338267.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q6UWB4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLFSVLLLL SLVTGTQLGP RTPLPEAGVA ILGRARGAHR PQPPHPPSPV    50
    SECGDRSIFE GRTRYSRITG GMEAEVGEFP WQVSIQARSE PFCGGSILNK 100
    WWILTAAHCL YSEELFPEEL SVVLGTNDLT SPSMEIKEVA SIILHKDFKR 150
    ANMDNDIALL LLASPIKLDD LKVPICLPTQ PGPATWRECW VAGWGQTNAA 200
    DKNSVKTDLM KAPMVIMDWE ECSKMFPKLT KNMLCAGYKN ESYDACKGDS 250
    GGPLVCTPEP GEKWYQVGII SWGKSCGEKN TPGIYTSLVN YNLWIEKVTQ 300
    LEGRPFNAEK RRTSVKQKPM GSPVSGVPEP GSPRSWLLLC PLSHVLFRAI 350
    LY 352
    Length:352
    Mass (Da):38,856
    Last modified:May 18, 2010 - v2
    Checksum:i0DBDFC385D5413A4
    GO
    Isoform 2 (identifier: Q6UWB4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         248-352: GDSGGPLVCT...SHVLFRAILY → QSYFPTLQRMNTGSSQTKPPGSHTFHLQN

    Show »
    Length:276
    Mass (Da):30,559
    Checksum:i67146392FCFD41CA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151G → R in BC033497. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441P → R.1 Publication
    Corresponds to variant rs4521726 [ dbSNP | Ensembl ].
    VAR_042525
    Natural varianti212 – 2121A → V.1 Publication
    Corresponds to variant rs4406360 [ dbSNP | Ensembl ].
    VAR_042526

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei248 – 352105GDSGG…RAILY → QSYFPTLQRMNTGSSQTKPP GSHTFHLQN in isoform 2. 2 PublicationsVSP_044557Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358867 mRNA. Translation: AAQ89226.1.
    AC104964 Genomic DNA. No translation available.
    BC033497 mRNA. No translation available.
    CCDSiCCDS56523.1. [Q6UWB4-2]
    CCDS5976.1. [Q6UWB4-1]
    RefSeqiNP_001183949.1. NM_001197020.1. [Q6UWB4-2]
    NP_940866.2. NM_198464.3. [Q6UWB4-1]
    UniGeneiHs.591394.

    Genome annotation databases

    EnsembliENST00000328655; ENSP00000333003; ENSG00000184647. [Q6UWB4-1]
    ENST00000522210; ENSP00000430459; ENSG00000184647. [Q6UWB4-2]
    GeneIDi203074.
    KEGGihsa:203074.
    UCSCiuc003wta.3. human. [Q6UWB4-1]

    Polymorphism databases

    DMDMi296453030.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358867 mRNA. Translation: AAQ89226.1 .
    AC104964 Genomic DNA. No translation available.
    BC033497 mRNA. No translation available.
    CCDSi CCDS56523.1. [Q6UWB4-2 ]
    CCDS5976.1. [Q6UWB4-1 ]
    RefSeqi NP_001183949.1. NM_001197020.1. [Q6UWB4-2 ]
    NP_940866.2. NM_198464.3. [Q6UWB4-1 ]
    UniGenei Hs.591394.

    3D structure databases

    ProteinModelPortali Q6UWB4.
    SMRi Q6UWB4. Positions 68-300.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.415.

    Polymorphism databases

    DMDMi 296453030.

    Proteomic databases

    PaxDbi Q6UWB4.
    PRIDEi Q6UWB4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328655 ; ENSP00000333003 ; ENSG00000184647 . [Q6UWB4-1 ]
    ENST00000522210 ; ENSP00000430459 ; ENSG00000184647 . [Q6UWB4-2 ]
    GeneIDi 203074.
    KEGGi hsa:203074.
    UCSCi uc003wta.3. human. [Q6UWB4-1 ]

    Organism-specific databases

    CTDi 203074.
    GeneCardsi GC08P010383.
    H-InvDB HIX0034319.
    HGNCi HGNC:30824. PRSS55.
    HPAi HPA027977.
    MIMi 615144. gene.
    neXtProti NX_Q6UWB4.
    PharmGKBi PA165585933.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG078102.
    InParanoidi Q6UWB4.
    OMAi PEPGEKW.
    OrthoDBi EOG7MKW6Q.
    PhylomeDBi Q6UWB4.
    TreeFami TF338267.

    Miscellaneous databases

    GenomeRNAii 203074.
    NextBioi 90334.
    PROi Q6UWB4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6UWB4.
    Bgeei Q6UWB4.
    Genevestigatori Q6UWB4.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-44 AND VAL-212.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "T-SP1: a novel serine protease-like protein predominantly expressed in testis."
      Neth P., Profanter B., Geissler C., Naegler D.K., Nerlich A., Sommerhoff C.P., Jochum M.
      Biol. Chem. 389:1495-1504(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    5. "Scanning of novel cancer/testis proteins by human testis proteomic analysis."
      Liu M., Hu Z., Qi L., Wang J., Zhou T., Guo Y., Zeng Y., Zheng B., Wu Y., Zhang P., Chen X., Tu W., Zhang T., Zhou Q., Jiang M., Guo X., Zhou Z., Sha J.
      Proteomics 13:1200-1210(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPRS55_HUMAN
    AccessioniPrimary (citable) accession number: Q6UWB4
    Secondary accession number(s): E5RJX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3