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Q6UWB4

- PRS55_HUMAN

UniProt

Q6UWB4 - PRS55_HUMAN

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Protein

Serine protease 55

Gene
PRSS55, TSP1, UNQ9391/PRO34284
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable serine protease By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Charge relay system By similarity
Active sitei156 – 1561Charge relay system By similarity
Active sitei250 – 2501Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.415.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 55 (EC:3.4.21.-)
Alternative name(s):
Testis serine protease 1
Short name:
T-SP1
Gene namesi
Name:PRSS55
Synonyms:TSP1
ORF Names:UNQ9391/PRO34284
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:30824. PRSS55.

Subcellular locationi

Isoform 1 : Membrane; Single-pass type I membrane protein Reviewed prediction 1 Publication
Isoform 2 : Cytoplasmcytosol 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini68 – 326259Extracellular Reviewed predictionAdd
BLAST
Transmembranei327 – 34721Helical; Reviewed predictionAdd
BLAST
Topological domaini348 – 3525Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Propeptidei19 – 6749Activation propeptide By similarityPRO_0000423643Add
BLAST
Chaini68 – 352285Serine protease 55PRO_0000328815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi93 ↔ 109 By similarity
Disulfide bondi189 ↔ 256 By similarity
Disulfide bondi222 ↔ 235 By similarity
Glycosylationi240 – 2401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi246 ↔ 276 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UWB4.
PRIDEiQ6UWB4.

Expressioni

Tissue specificityi

Only detected in testis. Expressed in spermatogonia, spermatocytes, spermatids, Leydig and Sertoli cells. Expressed in prostate cancer and ovarian cancer (at protein level).2 Publications

Gene expression databases

ArrayExpressiQ6UWB4.
BgeeiQ6UWB4.
GenevestigatoriQ6UWB4.

Organism-specific databases

HPAiHPA027977.

Structurei

3D structure databases

ProteinModelPortaliQ6UWB4.
SMRiQ6UWB4. Positions 68-300.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 300233Peptidase S1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG078102.
InParanoidiQ6UWB4.
OMAiPEPGEKW.
OrthoDBiEOG7MKW6Q.
PhylomeDBiQ6UWB4.
TreeFamiTF338267.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q6UWB4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLFSVLLLL SLVTGTQLGP RTPLPEAGVA ILGRARGAHR PQPPHPPSPV    50
SECGDRSIFE GRTRYSRITG GMEAEVGEFP WQVSIQARSE PFCGGSILNK 100
WWILTAAHCL YSEELFPEEL SVVLGTNDLT SPSMEIKEVA SIILHKDFKR 150
ANMDNDIALL LLASPIKLDD LKVPICLPTQ PGPATWRECW VAGWGQTNAA 200
DKNSVKTDLM KAPMVIMDWE ECSKMFPKLT KNMLCAGYKN ESYDACKGDS 250
GGPLVCTPEP GEKWYQVGII SWGKSCGEKN TPGIYTSLVN YNLWIEKVTQ 300
LEGRPFNAEK RRTSVKQKPM GSPVSGVPEP GSPRSWLLLC PLSHVLFRAI 350
LY 352
Length:352
Mass (Da):38,856
Last modified:May 18, 2010 - v2
Checksum:i0DBDFC385D5413A4
GO
Isoform 2 (identifier: Q6UWB4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-352: GDSGGPLVCT...SHVLFRAILY → QSYFPTLQRMNTGSSQTKPPGSHTFHLQN

Show »
Length:276
Mass (Da):30,559
Checksum:i67146392FCFD41CA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441P → R.1 Publication
Corresponds to variant rs4521726 [ dbSNP | Ensembl ].
VAR_042525
Natural varianti212 – 2121A → V.1 Publication
Corresponds to variant rs4406360 [ dbSNP | Ensembl ].
VAR_042526

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei248 – 352105GDSGG…RAILY → QSYFPTLQRMNTGSSQTKPP GSHTFHLQN in isoform 2. VSP_044557Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151G → R in BC033497. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358867 mRNA. Translation: AAQ89226.1.
AC104964 Genomic DNA. No translation available.
BC033497 mRNA. No translation available.
CCDSiCCDS56523.1. [Q6UWB4-2]
CCDS5976.1. [Q6UWB4-1]
RefSeqiNP_001183949.1. NM_001197020.1. [Q6UWB4-2]
NP_940866.2. NM_198464.3. [Q6UWB4-1]
UniGeneiHs.591394.

Genome annotation databases

EnsembliENST00000328655; ENSP00000333003; ENSG00000184647. [Q6UWB4-1]
ENST00000522210; ENSP00000430459; ENSG00000184647. [Q6UWB4-2]
GeneIDi203074.
KEGGihsa:203074.
UCSCiuc003wta.3. human. [Q6UWB4-1]

Polymorphism databases

DMDMi296453030.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358867 mRNA. Translation: AAQ89226.1 .
AC104964 Genomic DNA. No translation available.
BC033497 mRNA. No translation available.
CCDSi CCDS56523.1. [Q6UWB4-2 ]
CCDS5976.1. [Q6UWB4-1 ]
RefSeqi NP_001183949.1. NM_001197020.1. [Q6UWB4-2 ]
NP_940866.2. NM_198464.3. [Q6UWB4-1 ]
UniGenei Hs.591394.

3D structure databases

ProteinModelPortali Q6UWB4.
SMRi Q6UWB4. Positions 68-300.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.415.

Polymorphism databases

DMDMi 296453030.

Proteomic databases

PaxDbi Q6UWB4.
PRIDEi Q6UWB4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328655 ; ENSP00000333003 ; ENSG00000184647 . [Q6UWB4-1 ]
ENST00000522210 ; ENSP00000430459 ; ENSG00000184647 . [Q6UWB4-2 ]
GeneIDi 203074.
KEGGi hsa:203074.
UCSCi uc003wta.3. human. [Q6UWB4-1 ]

Organism-specific databases

CTDi 203074.
GeneCardsi GC08P010383.
H-InvDB HIX0034319.
HGNCi HGNC:30824. PRSS55.
HPAi HPA027977.
MIMi 615144. gene.
neXtProti NX_Q6UWB4.
PharmGKBi PA165585933.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG078102.
InParanoidi Q6UWB4.
OMAi PEPGEKW.
OrthoDBi EOG7MKW6Q.
PhylomeDBi Q6UWB4.
TreeFami TF338267.

Miscellaneous databases

GenomeRNAii 203074.
NextBioi 90334.
PROi Q6UWB4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6UWB4.
Bgeei Q6UWB4.
Genevestigatori Q6UWB4.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-44 AND VAL-212.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "T-SP1: a novel serine protease-like protein predominantly expressed in testis."
    Neth P., Profanter B., Geissler C., Naegler D.K., Nerlich A., Sommerhoff C.P., Jochum M.
    Biol. Chem. 389:1495-1504(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  5. "Scanning of novel cancer/testis proteins by human testis proteomic analysis."
    Liu M., Hu Z., Qi L., Wang J., Zhou T., Guo Y., Zeng Y., Zheng B., Wu Y., Zhang P., Chen X., Tu W., Zhang T., Zhou Q., Jiang M., Guo X., Zhou Z., Sha J.
    Proteomics 13:1200-1210(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPRS55_HUMAN
AccessioniPrimary (citable) accession number: Q6UWB4
Secondary accession number(s): E5RJX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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