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Protein

Serine protease 55

Gene

PRSS55

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable serine protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Charge relay systemBy similarity1
Active sitei156Charge relay systemBy similarity1
Active sitei250Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.299.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 55 (EC:3.4.21.-)
Alternative name(s):
Testis serine protease 1
Short name:
T-SP1
Gene namesi
Name:PRSS55
Synonyms:TSP1
ORF Names:UNQ9391/PRO34284
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:30824. PRSS55.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini68 – 326ExtracellularSequence analysisAdd BLAST259
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 352CytoplasmicSequence analysis5

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi203074.
OpenTargetsiENSG00000184647.
PharmGKBiPA165585933.

Polymorphism and mutation databases

BioMutaiPRSS55.
DMDMi296453030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000042364319 – 67Activation propeptideBy similarityAdd BLAST49
ChainiPRO_000032881568 – 352Serine protease 55Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi93 ↔ 109PROSITE-ProRule annotation
Disulfide bondi189 ↔ 256PROSITE-ProRule annotation
Disulfide bondi222 ↔ 235PROSITE-ProRule annotation
Glycosylationi240N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi246 ↔ 276PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UWB4.
PeptideAtlasiQ6UWB4.
PRIDEiQ6UWB4.

Expressioni

Tissue specificityi

Only detected in testis. Expressed in spermatogonia, spermatocytes, spermatids, Leydig and Sertoli cells. Expressed in prostate cancer and ovarian cancer (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000184647.
ExpressionAtlasiQ6UWB4. baseline and differential.
GenevisibleiQ6UWB4. HS.

Organism-specific databases

HPAiHPA027977.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333003.

Structurei

3D structure databases

ProteinModelPortaliQ6UWB4.
SMRiQ6UWB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 300Peptidase S1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00770000120569.
HOGENOMiHOG000251820.
HOVERGENiHBG078102.
InParanoidiQ6UWB4.
OMAiPEPGEKW.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ6UWB4.
TreeFamiTF338267.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q6UWB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLFSVLLLL SLVTGTQLGP RTPLPEAGVA ILGRARGAHR PQPPHPPSPV
60 70 80 90 100
SECGDRSIFE GRTRYSRITG GMEAEVGEFP WQVSIQARSE PFCGGSILNK
110 120 130 140 150
WWILTAAHCL YSEELFPEEL SVVLGTNDLT SPSMEIKEVA SIILHKDFKR
160 170 180 190 200
ANMDNDIALL LLASPIKLDD LKVPICLPTQ PGPATWRECW VAGWGQTNAA
210 220 230 240 250
DKNSVKTDLM KAPMVIMDWE ECSKMFPKLT KNMLCAGYKN ESYDACKGDS
260 270 280 290 300
GGPLVCTPEP GEKWYQVGII SWGKSCGEKN TPGIYTSLVN YNLWIEKVTQ
310 320 330 340 350
LEGRPFNAEK RRTSVKQKPM GSPVSGVPEP GSPRSWLLLC PLSHVLFRAI

LY
Length:352
Mass (Da):38,856
Last modified:May 18, 2010 - v2
Checksum:i0DBDFC385D5413A4
GO
Isoform 2 (identifier: Q6UWB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-352: GDSGGPLVCT...SHVLFRAILY → QSYFPTLQRMNTGSSQTKPPGSHTFHLQN

Show »
Length:276
Mass (Da):30,559
Checksum:i67146392FCFD41CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15G → R in BC033497 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04252544P → R.1 PublicationCorresponds to variant rs4521726dbSNPEnsembl.1
Natural variantiVAR_042526212A → V.1 PublicationCorresponds to variant rs4406360dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044557248 – 352GDSGG…RAILY → QSYFPTLQRMNTGSSQTKPP GSHTFHLQN in isoform 2. 2 PublicationsAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358867 mRNA. Translation: AAQ89226.1.
AC104964 Genomic DNA. No translation available.
BC033497 mRNA. No translation available.
CCDSiCCDS56523.1. [Q6UWB4-2]
CCDS5976.1. [Q6UWB4-1]
RefSeqiNP_001183949.1. NM_001197020.1. [Q6UWB4-2]
NP_940866.2. NM_198464.3. [Q6UWB4-1]
UniGeneiHs.591394.

Genome annotation databases

EnsembliENST00000328655; ENSP00000333003; ENSG00000184647. [Q6UWB4-1]
ENST00000522210; ENSP00000430459; ENSG00000184647. [Q6UWB4-2]
GeneIDi203074.
KEGGihsa:203074.
UCSCiuc003wta.4. human. [Q6UWB4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358867 mRNA. Translation: AAQ89226.1.
AC104964 Genomic DNA. No translation available.
BC033497 mRNA. No translation available.
CCDSiCCDS56523.1. [Q6UWB4-2]
CCDS5976.1. [Q6UWB4-1]
RefSeqiNP_001183949.1. NM_001197020.1. [Q6UWB4-2]
NP_940866.2. NM_198464.3. [Q6UWB4-1]
UniGeneiHs.591394.

3D structure databases

ProteinModelPortaliQ6UWB4.
SMRiQ6UWB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333003.

Protein family/group databases

MEROPSiS01.299.

Polymorphism and mutation databases

BioMutaiPRSS55.
DMDMi296453030.

Proteomic databases

PaxDbiQ6UWB4.
PeptideAtlasiQ6UWB4.
PRIDEiQ6UWB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328655; ENSP00000333003; ENSG00000184647. [Q6UWB4-1]
ENST00000522210; ENSP00000430459; ENSG00000184647. [Q6UWB4-2]
GeneIDi203074.
KEGGihsa:203074.
UCSCiuc003wta.4. human. [Q6UWB4-1]

Organism-specific databases

CTDi203074.
DisGeNETi203074.
GeneCardsiPRSS55.
H-InvDBHIX0034319.
HGNCiHGNC:30824. PRSS55.
HPAiHPA027977.
MIMi615144. gene.
neXtProtiNX_Q6UWB4.
OpenTargetsiENSG00000184647.
PharmGKBiPA165585933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00770000120569.
HOGENOMiHOG000251820.
HOVERGENiHBG078102.
InParanoidiQ6UWB4.
OMAiPEPGEKW.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ6UWB4.
TreeFamiTF338267.

Miscellaneous databases

GenomeRNAii203074.
PROiQ6UWB4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184647.
ExpressionAtlasiQ6UWB4. baseline and differential.
GenevisibleiQ6UWB4. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRS55_HUMAN
AccessioniPrimary (citable) accession number: Q6UWB4
Secondary accession number(s): E5RJX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.