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Q6UWB1 (I27RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-27 receptor subunit alpha

Short name=IL-27 receptor subunit alpha
Short name=IL-27R subunit alpha
Short name=IL-27R-alpha
Short name=IL-27RA
Alternative name(s):
Cytokine receptor WSX-1
Cytokine receptor-like 1
Type I T-cell cytokine receptor
Short name=TCCR
ZcytoR1
Gene names
Name:IL27RA
Synonyms:CRL1, TCCR, WSX1
ORF Names:UNQ296/PRO336
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length636 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. Ref.7

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes. Ref.1 Ref.3

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 2 subfamily.

Contains 3 fibronectin type-III domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 636604Interleukin-27 receptor subunit alpha
PRO_0000010876

Regions

Topological domain33 – 516484Extracellular Potential
Transmembrane517 – 53721Helical; Potential
Topological domain538 – 63699Cytoplasmic Potential
Domain131 – 231101Fibronectin type-III 1
Domain322 – 41796Fibronectin type-III 2
Domain419 – 51193Fibronectin type-III 3
Motif217 – 2215WSXWS motif
Motif554 – 5629Box 1 motif

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation761N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential
Glycosylation3741N-linked (GlcNAc...) Potential
Glycosylation3821N-linked (GlcNAc...) Potential
Glycosylation4671N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict71A → G in AAG27297. Ref.3
Sequence conflict71A → G in AAQ89235. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q6UWB1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: DC7DAAABA643CE97

FASTA63669,474
        10         20         30         40         50         60 
MRGGRGAPFW LWPLPKLALL PLLWVLFQRT RPQGSAGPLQ CYGVGPLGDL NCSWEPLGDL 

        70         80         90        100        110        120 
GAPSELHLQS QKYRSNKTQT VAVAAGRSWV AIPREQLTMS DKLLVWGTKA GQPLWPPVFV 

       130        140        150        160        170        180 
NLETQMKPNA PRLGPDVDFS EDDPLEATVH WAPPTWPSHK VLICQFHYRR CQEAAWTLLE 

       190        200        210        220        230        240 
PELKTIPLTP VEIQDLELAT GYKVYGRCRM EKEEDLWGEW SPILSFQTPP SAPKDVWVSG 

       250        260        270        280        290        300 
NLCGTPGGEE PLLLWKAPGP CVQVSYKVWF WVGGRELSPE GITCCCSLIP SGAEWARVSA 

       310        320        330        340        350        360 
VNATSWEPLT NLSLVCLDSA SAPRSVAVSS IAGSTELLVT WQPGPGEPLE HVVDWARDGD 

       370        380        390        400        410        420 
PLEKLNWVRL PPGNLSALLP GNFTVGVPYR ITVTAVSASG LASASSVWGF REELAPLVGP 

       430        440        450        460        470        480 
TLWRLQDAPP GTPAIAWGEV PRHQLRGHLT HYTLCAQSGT SPSVCMNVSG NTQSVTLPDL 

       490        500        510        520        530        540 
PWGPCELWVT ASTIAGQGPP GPILRLHLPD NTLRWKVLPG ILFLWGLFLL GCGLSLATSG 

       550        560        570        580        590        600 
RCYHLRHKVL PRWVWEKVPD PANSSSGQPH MEQVPEAQPL GDLPILEVEE MEPPPVMESS 

       610        620        630 
QPAQATAPLD SGYEKHFLPT PEELGLLGPP RPQVLA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel class I cytokine receptor."
Sprecher C.A., Grant F.J., Baumgartner J.W., Presnell S.R., Schrader S.K., Yamagiwa T., Whitmore T.E., O'Hara P.J., Foster D.F.
Biochem. Biophys. Res. Commun. 246:82-90(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Erythroleukemia.
[2]"A novel gp130-like cytokine receptor."
Zhang W., Wan T., He L., Yuan Z., Cao X.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Development of Th1-type immune responses requires the type I cytokine receptor TCCR."
Chen Q., Ghilardi N., Wang H., Baker T., Xie M.-H., Gurney A., Grewal I.S., de Sauvage F.J.
Nature 407:916-920(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Peripheral blood leukocyte.
[4]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
[7]"WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27."
Pflanz S., Hibbert L., Mattson J., Rosales R., Vaisberg E., Bazan J.F., Phillips J.H., McClanahan T.K., de Waal Malefyt R., Kastelein R.A.
J. Immunol. 172:2225-2231(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTIONAL COMPLEX WITH GP130.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF053004 mRNA. Translation: AAC39755.1.
AF106912 mRNA. Translation: AAG26090.1.
AF265242 mRNA. Translation: AAG27297.1.
EF064719 Genomic DNA. Translation: ABK41902.1.
AY358876 mRNA. Translation: AAQ89235.1.
BC028003 mRNA. Translation: AAH28003.1.
PIRJW0047.
RefSeqNP_004834.1. NM_004843.3.
UniGeneHs.132781.
Hs.352155.

3D structure databases

ProteinModelPortalQ6UWB1.
SMRQ6UWB1. Positions 30-512.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114852. 5 interactions.
STRING9606.ENSP00000263379.

PTM databases

PhosphoSiteQ6UWB1.

Polymorphism databases

DMDM116242518.

Proteomic databases

PaxDbQ6UWB1.
PRIDEQ6UWB1.

Protocols and materials databases

DNASU9466.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263379; ENSP00000263379; ENSG00000104998.
GeneID9466.
KEGGhsa:9466.
UCSCuc002mxx.4. human.

Organism-specific databases

CTD9466.
GeneCardsGC19P014142.
HGNCHGNC:17290. IL27RA.
MIM605350. gene.
neXtProtNX_Q6UWB1.
PharmGKBPA134891276.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44355.
HOGENOMHOG000036880.
HOVERGENHBG052068.
InParanoidQ6UWB1.
OMAPCELWVT.
OrthoDBEOG7SBNND.
PhylomeDBQ6UWB1.
TreeFamTF338122.

Enzyme and pathway databases

SignaLinkQ6UWB1.

Gene expression databases

BgeeQ6UWB1.
CleanExHS_IL27RA.
GenevestigatorQ6UWB1.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF00041. fn3. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 3 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiInterleukin_27_receptor,_alpha_subunit.
GenomeRNAi9466.
NextBio35472.
PROQ6UWB1.
SOURCESearch...

Entry information

Entry nameI27RA_HUMAN
AccessionPrimary (citable) accession number: Q6UWB1
Secondary accession number(s): A0N0L1, O60624
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 17, 2006
Last modified: March 19, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM