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Q6UWB1

- I27RA_HUMAN

UniProt

Q6UWB1 - I27RA_HUMAN

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Protein

Interleukin-27 receptor subunit alpha

Gene

IL27RA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.1 Publication

GO - Molecular functioni

  1. interleukin-27 receptor activity Source: Ensembl
  2. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. defense response to Gram-positive bacterium Source: Ensembl
  3. immune response Source: ProtInc
  4. negative regulation of type 2 immune response Source: Ensembl
  5. positive regulation of interferon-gamma production Source: Ensembl
  6. positive regulation of T-helper 1 type immune response Source: Ensembl
  7. regulation of isotype switching to IgG isotypes Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiQ6UWB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-27 receptor subunit alpha
Short name:
IL-27 receptor subunit alpha
Short name:
IL-27R subunit alpha
Short name:
IL-27R-alpha
Short name:
IL-27RA
Alternative name(s):
Cytokine receptor WSX-1
Cytokine receptor-like 1
Type I T-cell cytokine receptor
Short name:
TCCR
ZcytoR1
Gene namesi
Name:IL27RA
Synonyms:CRL1, TCCR, WSX1
ORF Names:UNQ296/PRO336
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:17290. IL27RA.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 636604Interleukin-27 receptor subunit alphaPRO_0000010876Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6UWB1.
PaxDbiQ6UWB1.
PRIDEiQ6UWB1.

PTM databases

PhosphoSiteiQ6UWB1.

Expressioni

Tissue specificityi

Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.2 Publications

Gene expression databases

BgeeiQ6UWB1.
CleanExiHS_IL27RA.
GenevestigatoriQ6UWB1.

Interactioni

Protein-protein interaction databases

BioGridi114852. 5 interactions.
STRINGi9606.ENSP00000263379.

Structurei

3D structure databases

ProteinModelPortaliQ6UWB1.
SMRiQ6UWB1. Positions 125-509.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 516484ExtracellularSequence AnalysisAdd
BLAST
Topological domaini538 – 63699CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei517 – 53721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 231101Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini322 – 41796Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini419 – 51193Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi217 – 2215WSXWS motif
Motifi554 – 5629Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44355.
GeneTreeiENSGT00700000104610.
HOGENOMiHOG000036880.
HOVERGENiHBG052068.
InParanoidiQ6UWB1.
OMAiPCELWVT.
OrthoDBiEOG7SBNND.
PhylomeDBiQ6UWB1.
TreeFamiTF338122.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRGGRGAPFW LWPLPKLALL PLLWVLFQRT RPQGSAGPLQ CYGVGPLGDL
60 70 80 90 100
NCSWEPLGDL GAPSELHLQS QKYRSNKTQT VAVAAGRSWV AIPREQLTMS
110 120 130 140 150
DKLLVWGTKA GQPLWPPVFV NLETQMKPNA PRLGPDVDFS EDDPLEATVH
160 170 180 190 200
WAPPTWPSHK VLICQFHYRR CQEAAWTLLE PELKTIPLTP VEIQDLELAT
210 220 230 240 250
GYKVYGRCRM EKEEDLWGEW SPILSFQTPP SAPKDVWVSG NLCGTPGGEE
260 270 280 290 300
PLLLWKAPGP CVQVSYKVWF WVGGRELSPE GITCCCSLIP SGAEWARVSA
310 320 330 340 350
VNATSWEPLT NLSLVCLDSA SAPRSVAVSS IAGSTELLVT WQPGPGEPLE
360 370 380 390 400
HVVDWARDGD PLEKLNWVRL PPGNLSALLP GNFTVGVPYR ITVTAVSASG
410 420 430 440 450
LASASSVWGF REELAPLVGP TLWRLQDAPP GTPAIAWGEV PRHQLRGHLT
460 470 480 490 500
HYTLCAQSGT SPSVCMNVSG NTQSVTLPDL PWGPCELWVT ASTIAGQGPP
510 520 530 540 550
GPILRLHLPD NTLRWKVLPG ILFLWGLFLL GCGLSLATSG RCYHLRHKVL
560 570 580 590 600
PRWVWEKVPD PANSSSGQPH MEQVPEAQPL GDLPILEVEE MEPPPVMESS
610 620 630
QPAQATAPLD SGYEKHFLPT PEELGLLGPP RPQVLA
Length:636
Mass (Da):69,474
Last modified:October 17, 2006 - v2
Checksum:iDC7DAAABA643CE97
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71A → G in AAG27297. (PubMed:11057672)Curated
Sequence conflicti7 – 71A → G in AAQ89235. (PubMed:12975309)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053004 mRNA. Translation: AAC39755.1.
AF106912 mRNA. Translation: AAG26090.1.
AF265242 mRNA. Translation: AAG27297.1.
EF064719 Genomic DNA. Translation: ABK41902.1.
AY358876 mRNA. Translation: AAQ89235.1.
BC028003 mRNA. Translation: AAH28003.1.
CCDSiCCDS12303.1.
PIRiJW0047.
RefSeqiNP_004834.1. NM_004843.3.
UniGeneiHs.132781.
Hs.352155.

Genome annotation databases

EnsembliENST00000263379; ENSP00000263379; ENSG00000104998.
GeneIDi9466.
KEGGihsa:9466.
UCSCiuc002mxx.4. human.

Polymorphism databases

DMDMi116242518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053004 mRNA. Translation: AAC39755.1 .
AF106912 mRNA. Translation: AAG26090.1 .
AF265242 mRNA. Translation: AAG27297.1 .
EF064719 Genomic DNA. Translation: ABK41902.1 .
AY358876 mRNA. Translation: AAQ89235.1 .
BC028003 mRNA. Translation: AAH28003.1 .
CCDSi CCDS12303.1.
PIRi JW0047.
RefSeqi NP_004834.1. NM_004843.3.
UniGenei Hs.132781.
Hs.352155.

3D structure databases

ProteinModelPortali Q6UWB1.
SMRi Q6UWB1. Positions 125-509.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114852. 5 interactions.
STRINGi 9606.ENSP00000263379.

PTM databases

PhosphoSitei Q6UWB1.

Polymorphism databases

DMDMi 116242518.

Proteomic databases

MaxQBi Q6UWB1.
PaxDbi Q6UWB1.
PRIDEi Q6UWB1.

Protocols and materials databases

DNASUi 9466.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263379 ; ENSP00000263379 ; ENSG00000104998 .
GeneIDi 9466.
KEGGi hsa:9466.
UCSCi uc002mxx.4. human.

Organism-specific databases

CTDi 9466.
GeneCardsi GC19P014142.
HGNCi HGNC:17290. IL27RA.
MIMi 605350. gene.
neXtProti NX_Q6UWB1.
PharmGKBi PA134891276.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44355.
GeneTreei ENSGT00700000104610.
HOGENOMi HOG000036880.
HOVERGENi HBG052068.
InParanoidi Q6UWB1.
OMAi PCELWVT.
OrthoDBi EOG7SBNND.
PhylomeDBi Q6UWB1.
TreeFami TF338122.

Enzyme and pathway databases

SignaLinki Q6UWB1.

Miscellaneous databases

GeneWikii Interleukin_27_receptor,_alpha_subunit.
GenomeRNAii 9466.
NextBioi 35472.
PROi Q6UWB1.
SOURCEi Search...

Gene expression databases

Bgeei Q6UWB1.
CleanExi HS_IL27RA.
Genevestigatori Q6UWB1.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Erythroleukemia.
  2. "A novel gp130-like cytokine receptor."
    Zhang W., Wan T., He L., Yuan Z., Cao X.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Development of Th1-type immune responses requires the type I cytokine receptor TCCR."
    Chen Q., Ghilardi N., Wang H., Baker T., Xie M.-H., Gurney A., Grewal I.S., de Sauvage F.J.
    Nature 407:916-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Peripheral blood leukocyte.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  7. Cited for: FUNCTIONAL COMPLEX WITH GP130.

Entry informationi

Entry nameiI27RA_HUMAN
AccessioniPrimary (citable) accession number: Q6UWB1
Secondary accession number(s): A0N0L1, O60624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3