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Protein

Interleukin-27 receptor subunit alpha

Gene

IL27RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.1 Publication

GO - Molecular functioni

  • interleukin-27 receptor activity Source: Ensembl
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-6788467. IL-6-type cytokine receptor ligand interactions.
SignaLinkiQ6UWB1.
SIGNORiQ6UWB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-27 receptor subunit alpha
Short name:
IL-27 receptor subunit alpha
Short name:
IL-27R subunit alpha
Short name:
IL-27R-alpha
Short name:
IL-27RA
Alternative name(s):
Cytokine receptor WSX-1
Cytokine receptor-like 1
Type I T-cell cytokine receptor
Short name:
TCCR
ZcytoR1
Gene namesi
Name:IL27RA
Synonyms:CRL1, TCCR, WSX1
ORF Names:UNQ296/PRO336
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17290. IL27RA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 516ExtracellularSequence analysisAdd BLAST484
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21
Topological domaini538 – 636CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9466.
OpenTargetsiENSG00000104998.
PharmGKBiPA134891276.

Polymorphism and mutation databases

BioMutaiIL27RA.
DMDMi116242518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001087633 – 636Interleukin-27 receptor subunit alphaAdd BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi382N-linked (GlcNAc...)Sequence analysis1
Glycosylationi467N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UWB1.
MaxQBiQ6UWB1.
PaxDbiQ6UWB1.
PeptideAtlasiQ6UWB1.
PRIDEiQ6UWB1.

PTM databases

iPTMnetiQ6UWB1.
PhosphoSitePlusiQ6UWB1.

Expressioni

Tissue specificityi

Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.2 Publications

Gene expression databases

BgeeiENSG00000104998.
CleanExiHS_IL27RA.
GenevisibleiQ6UWB1. HS.

Organism-specific databases

HPAiHPA047188.

Interactioni

Protein-protein interaction databases

BioGridi114852. 31 interactors.
STRINGi9606.ENSP00000263379.

Structurei

3D structure databases

ProteinModelPortaliQ6UWB1.
SMRiQ6UWB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 231Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST101
Domaini322 – 417Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini419 – 511Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi217 – 221WSXWS motif5
Motifi554 – 562Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK7Q. Eukaryota.
ENOG411182T. LUCA.
GeneTreeiENSGT00700000104610.
HOGENOMiHOG000036880.
HOVERGENiHBG052068.
InParanoidiQ6UWB1.
KOiK19598.
OMAiKVLICQF.
OrthoDBiEOG091G0BPO.
PhylomeDBiQ6UWB1.
TreeFamiTF338122.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGGRGAPFW LWPLPKLALL PLLWVLFQRT RPQGSAGPLQ CYGVGPLGDL
60 70 80 90 100
NCSWEPLGDL GAPSELHLQS QKYRSNKTQT VAVAAGRSWV AIPREQLTMS
110 120 130 140 150
DKLLVWGTKA GQPLWPPVFV NLETQMKPNA PRLGPDVDFS EDDPLEATVH
160 170 180 190 200
WAPPTWPSHK VLICQFHYRR CQEAAWTLLE PELKTIPLTP VEIQDLELAT
210 220 230 240 250
GYKVYGRCRM EKEEDLWGEW SPILSFQTPP SAPKDVWVSG NLCGTPGGEE
260 270 280 290 300
PLLLWKAPGP CVQVSYKVWF WVGGRELSPE GITCCCSLIP SGAEWARVSA
310 320 330 340 350
VNATSWEPLT NLSLVCLDSA SAPRSVAVSS IAGSTELLVT WQPGPGEPLE
360 370 380 390 400
HVVDWARDGD PLEKLNWVRL PPGNLSALLP GNFTVGVPYR ITVTAVSASG
410 420 430 440 450
LASASSVWGF REELAPLVGP TLWRLQDAPP GTPAIAWGEV PRHQLRGHLT
460 470 480 490 500
HYTLCAQSGT SPSVCMNVSG NTQSVTLPDL PWGPCELWVT ASTIAGQGPP
510 520 530 540 550
GPILRLHLPD NTLRWKVLPG ILFLWGLFLL GCGLSLATSG RCYHLRHKVL
560 570 580 590 600
PRWVWEKVPD PANSSSGQPH MEQVPEAQPL GDLPILEVEE MEPPPVMESS
610 620 630
QPAQATAPLD SGYEKHFLPT PEELGLLGPP RPQVLA
Length:636
Mass (Da):69,474
Last modified:October 17, 2006 - v2
Checksum:iDC7DAAABA643CE97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → G in AAG27297 (PubMed:11057672).Curated1
Sequence conflicti7A → G in AAQ89235 (PubMed:12975309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053004 mRNA. Translation: AAC39755.1.
AF106912 mRNA. Translation: AAG26090.1.
AF265242 mRNA. Translation: AAG27297.1.
EF064719 Genomic DNA. Translation: ABK41902.1.
AY358876 mRNA. Translation: AAQ89235.1.
BC028003 mRNA. Translation: AAH28003.1.
CCDSiCCDS12303.1.
PIRiJW0047.
RefSeqiNP_004834.1. NM_004843.3.
UniGeneiHs.132781.
Hs.352155.

Genome annotation databases

EnsembliENST00000263379; ENSP00000263379; ENSG00000104998.
GeneIDi9466.
KEGGihsa:9466.
UCSCiuc002mxx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053004 mRNA. Translation: AAC39755.1.
AF106912 mRNA. Translation: AAG26090.1.
AF265242 mRNA. Translation: AAG27297.1.
EF064719 Genomic DNA. Translation: ABK41902.1.
AY358876 mRNA. Translation: AAQ89235.1.
BC028003 mRNA. Translation: AAH28003.1.
CCDSiCCDS12303.1.
PIRiJW0047.
RefSeqiNP_004834.1. NM_004843.3.
UniGeneiHs.132781.
Hs.352155.

3D structure databases

ProteinModelPortaliQ6UWB1.
SMRiQ6UWB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114852. 31 interactors.
STRINGi9606.ENSP00000263379.

PTM databases

iPTMnetiQ6UWB1.
PhosphoSitePlusiQ6UWB1.

Polymorphism and mutation databases

BioMutaiIL27RA.
DMDMi116242518.

Proteomic databases

EPDiQ6UWB1.
MaxQBiQ6UWB1.
PaxDbiQ6UWB1.
PeptideAtlasiQ6UWB1.
PRIDEiQ6UWB1.

Protocols and materials databases

DNASUi9466.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263379; ENSP00000263379; ENSG00000104998.
GeneIDi9466.
KEGGihsa:9466.
UCSCiuc002mxx.5. human.

Organism-specific databases

CTDi9466.
DisGeNETi9466.
GeneCardsiIL27RA.
HGNCiHGNC:17290. IL27RA.
HPAiHPA047188.
MIMi605350. gene.
neXtProtiNX_Q6UWB1.
OpenTargetsiENSG00000104998.
PharmGKBiPA134891276.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK7Q. Eukaryota.
ENOG411182T. LUCA.
GeneTreeiENSGT00700000104610.
HOGENOMiHOG000036880.
HOVERGENiHBG052068.
InParanoidiQ6UWB1.
KOiK19598.
OMAiKVLICQF.
OrthoDBiEOG091G0BPO.
PhylomeDBiQ6UWB1.
TreeFamiTF338122.

Enzyme and pathway databases

ReactomeiR-HSA-6788467. IL-6-type cytokine receptor ligand interactions.
SignaLinkiQ6UWB1.
SIGNORiQ6UWB1.

Miscellaneous databases

GeneWikiiInterleukin_27_receptor,_alpha_subunit.
GenomeRNAii9466.
PROiQ6UWB1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104998.
CleanExiHS_IL27RA.
GenevisibleiQ6UWB1. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI27RA_HUMAN
AccessioniPrimary (citable) accession number: Q6UWB1
Secondary accession number(s): A0N0L1, O60624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.