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Q6UWB1

- I27RA_HUMAN

UniProt

Q6UWB1 - I27RA_HUMAN

Protein

Interleukin-27 receptor subunit alpha

Gene

IL27RA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.1 Publication

    GO - Molecular functioni

    1. interleukin-27 receptor activity Source: Ensembl
    2. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. defense response to Gram-positive bacterium Source: Ensembl
    3. immune response Source: ProtInc
    4. negative regulation of type 2 immune response Source: Ensembl
    5. positive regulation of interferon-gamma production Source: Ensembl
    6. positive regulation of T-helper 1 type immune response Source: Ensembl
    7. regulation of isotype switching to IgG isotypes Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiQ6UWB1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-27 receptor subunit alpha
    Short name:
    IL-27 receptor subunit alpha
    Short name:
    IL-27R subunit alpha
    Short name:
    IL-27R-alpha
    Short name:
    IL-27RA
    Alternative name(s):
    Cytokine receptor WSX-1
    Cytokine receptor-like 1
    Type I T-cell cytokine receptor
    Short name:
    TCCR
    ZcytoR1
    Gene namesi
    Name:IL27RA
    Synonyms:CRL1, TCCR, WSX1
    ORF Names:UNQ296/PRO336
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:17290. IL27RA.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891276.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 636604Interleukin-27 receptor subunit alphaPRO_0000010876Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ6UWB1.
    PaxDbiQ6UWB1.
    PRIDEiQ6UWB1.

    PTM databases

    PhosphoSiteiQ6UWB1.

    Expressioni

    Tissue specificityi

    Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.2 Publications

    Gene expression databases

    BgeeiQ6UWB1.
    CleanExiHS_IL27RA.
    GenevestigatoriQ6UWB1.

    Interactioni

    Protein-protein interaction databases

    BioGridi114852. 5 interactions.
    STRINGi9606.ENSP00000263379.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UWB1.
    SMRiQ6UWB1. Positions 125-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 516484ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini538 – 63699CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei517 – 53721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 231101Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini322 – 41796Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini419 – 51193Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi217 – 2215WSXWS motif
    Motifi554 – 5629Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44355.
    HOGENOMiHOG000036880.
    HOVERGENiHBG052068.
    InParanoidiQ6UWB1.
    OMAiPCELWVT.
    OrthoDBiEOG7SBNND.
    PhylomeDBiQ6UWB1.
    TreeFamiTF338122.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 3 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6UWB1-1 [UniParc]FASTAAdd to Basket

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    MRGGRGAPFW LWPLPKLALL PLLWVLFQRT RPQGSAGPLQ CYGVGPLGDL    50
    NCSWEPLGDL GAPSELHLQS QKYRSNKTQT VAVAAGRSWV AIPREQLTMS 100
    DKLLVWGTKA GQPLWPPVFV NLETQMKPNA PRLGPDVDFS EDDPLEATVH 150
    WAPPTWPSHK VLICQFHYRR CQEAAWTLLE PELKTIPLTP VEIQDLELAT 200
    GYKVYGRCRM EKEEDLWGEW SPILSFQTPP SAPKDVWVSG NLCGTPGGEE 250
    PLLLWKAPGP CVQVSYKVWF WVGGRELSPE GITCCCSLIP SGAEWARVSA 300
    VNATSWEPLT NLSLVCLDSA SAPRSVAVSS IAGSTELLVT WQPGPGEPLE 350
    HVVDWARDGD PLEKLNWVRL PPGNLSALLP GNFTVGVPYR ITVTAVSASG 400
    LASASSVWGF REELAPLVGP TLWRLQDAPP GTPAIAWGEV PRHQLRGHLT 450
    HYTLCAQSGT SPSVCMNVSG NTQSVTLPDL PWGPCELWVT ASTIAGQGPP 500
    GPILRLHLPD NTLRWKVLPG ILFLWGLFLL GCGLSLATSG RCYHLRHKVL 550
    PRWVWEKVPD PANSSSGQPH MEQVPEAQPL GDLPILEVEE MEPPPVMESS 600
    QPAQATAPLD SGYEKHFLPT PEELGLLGPP RPQVLA 636
    Length:636
    Mass (Da):69,474
    Last modified:October 17, 2006 - v2
    Checksum:iDC7DAAABA643CE97
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71A → G in AAG27297. (PubMed:11057672)Curated
    Sequence conflicti7 – 71A → G in AAQ89235. (PubMed:12975309)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053004 mRNA. Translation: AAC39755.1.
    AF106912 mRNA. Translation: AAG26090.1.
    AF265242 mRNA. Translation: AAG27297.1.
    EF064719 Genomic DNA. Translation: ABK41902.1.
    AY358876 mRNA. Translation: AAQ89235.1.
    BC028003 mRNA. Translation: AAH28003.1.
    CCDSiCCDS12303.1.
    PIRiJW0047.
    RefSeqiNP_004834.1. NM_004843.3.
    UniGeneiHs.132781.
    Hs.352155.

    Genome annotation databases

    EnsembliENST00000263379; ENSP00000263379; ENSG00000104998.
    GeneIDi9466.
    KEGGihsa:9466.
    UCSCiuc002mxx.4. human.

    Polymorphism databases

    DMDMi116242518.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053004 mRNA. Translation: AAC39755.1 .
    AF106912 mRNA. Translation: AAG26090.1 .
    AF265242 mRNA. Translation: AAG27297.1 .
    EF064719 Genomic DNA. Translation: ABK41902.1 .
    AY358876 mRNA. Translation: AAQ89235.1 .
    BC028003 mRNA. Translation: AAH28003.1 .
    CCDSi CCDS12303.1.
    PIRi JW0047.
    RefSeqi NP_004834.1. NM_004843.3.
    UniGenei Hs.132781.
    Hs.352155.

    3D structure databases

    ProteinModelPortali Q6UWB1.
    SMRi Q6UWB1. Positions 125-509.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114852. 5 interactions.
    STRINGi 9606.ENSP00000263379.

    PTM databases

    PhosphoSitei Q6UWB1.

    Polymorphism databases

    DMDMi 116242518.

    Proteomic databases

    MaxQBi Q6UWB1.
    PaxDbi Q6UWB1.
    PRIDEi Q6UWB1.

    Protocols and materials databases

    DNASUi 9466.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263379 ; ENSP00000263379 ; ENSG00000104998 .
    GeneIDi 9466.
    KEGGi hsa:9466.
    UCSCi uc002mxx.4. human.

    Organism-specific databases

    CTDi 9466.
    GeneCardsi GC19P014142.
    HGNCi HGNC:17290. IL27RA.
    MIMi 605350. gene.
    neXtProti NX_Q6UWB1.
    PharmGKBi PA134891276.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44355.
    HOGENOMi HOG000036880.
    HOVERGENi HBG052068.
    InParanoidi Q6UWB1.
    OMAi PCELWVT.
    OrthoDBi EOG7SBNND.
    PhylomeDBi Q6UWB1.
    TreeFami TF338122.

    Enzyme and pathway databases

    SignaLinki Q6UWB1.

    Miscellaneous databases

    GeneWikii Interleukin_27_receptor,_alpha_subunit.
    GenomeRNAii 9466.
    NextBioi 35472.
    PROi Q6UWB1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6UWB1.
    CleanExi HS_IL27RA.
    Genevestigatori Q6UWB1.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Erythroleukemia.
    2. "A novel gp130-like cytokine receptor."
      Zhang W., Wan T., He L., Yuan Z., Cao X.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Development of Th1-type immune responses requires the type I cytokine receptor TCCR."
      Chen Q., Ghilardi N., Wang H., Baker T., Xie M.-H., Gurney A., Grewal I.S., de Sauvage F.J.
      Nature 407:916-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Peripheral blood leukocyte.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    7. Cited for: FUNCTIONAL COMPLEX WITH GP130.

    Entry informationi

    Entry nameiI27RA_HUMAN
    AccessioniPrimary (citable) accession number: Q6UWB1
    Secondary accession number(s): A0N0L1, O60624
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3