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Q6UW88

- EPGN_HUMAN

UniProt

Q6UW88 - EPGN_HUMAN

Protein

Epigen

Gene

EPGN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.1 Publication

    GO - Molecular functioni

    1. epidermal growth factor receptor binding Source: HGNC
    2. growth factor activity Source: HGNC
    3. MAP kinase kinase activity Source: HGNC

    GO - Biological processi

    1. activation of MAPK activity Source: HGNC
    2. angiogenesis Source: HGNC
    3. positive regulation of cell proliferation Source: HGNC
    4. positive regulation of epidermal growth factor-activated receptor activity Source: HGNC
    5. positive regulation of epithelial cell proliferation Source: HGNC
    6. positive regulation of MAP kinase activity Source: HGNC
    7. positive regulation of mitosis Source: HGNC

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epigen
    Alternative name(s):
    Epithelial mitogen
    Short name:
    EPG
    Gene namesi
    Name:EPGN
    ORF Names:UNQ3072/PRO9904
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:17470. EPGN.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: HGNC

    Keywords - Cellular componenti

    Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162385143.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 154132EpigenPRO_0000045462Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
    Disulfide bondi68 ↔ 84PROSITE-ProRule annotation
    Disulfide bondi86 ↔ 95PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Gene expression databases

    BgeeiQ6UW88.
    CleanExiHS_EPGN.
    GenevestigatoriQ6UW88.

    Organism-specific databases

    HPAiHPA014369.
    HPA014420.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000330375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UW88.
    SMRiQ6UW88. Positions 60-100.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 11088ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 15423CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 9641EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 EGF-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43616.
    HOVERGENiHBG079616.
    InParanoidiQ6UW88.
    OMAiINGLCAF.
    OrthoDBiEOG761BWF.
    PhylomeDBiQ6UW88.
    TreeFamiTF335931.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR015497. EGF_rcpt_ligand.
    [Graphical view]
    PANTHERiPTHR10740. PTHR10740. 1 hit.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6UW88-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALGVPISVY LLFNAMTALT EEAAVTVTPP ITAQQGNWTV NKTEADNIEG    50
    PIALKFSHLC LEDHNSYCIN GACAFHHELE KAICRCFTGY TGERCEHLTL 100
    TSYAVDSYEK YIAIGIGVGL LLSGFLVIFY CYIRKRCLKL KSPYNVCSGE 150
    RRPL 154
    Length:154
    Mass (Da):17,091
    Last modified:March 24, 2009 - v2
    Checksum:iBC78016BE3026474
    GO
    Isoform 2 (identifier: Q6UW88-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-44: Missing.
         137-154: CLKLKSPYNVCSGERRPL → YEKDKI

    Show »
    Length:133
    Mass (Da):14,792
    Checksum:i7A5B3257D0484182
    GO
    Isoform 3 (identifier: Q6UW88-3) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         96-137: Missing.

    Show »
    Length:112
    Mass (Da):12,319
    Checksum:i8D0EE50785FA2891
    GO
    Isoform 4 (identifier: Q6UW88-4) [UniParc]FASTAAdd to Basket

    Also known as: E

    The sequence of this isoform differs from the canonical sequence as follows:
         87-137: Missing.

    Show »
    Length:103
    Mass (Da):11,304
    Checksum:i062973EAC9EA4570
    GO
    Isoform 5 (identifier: Q6UW88-5) [UniParc]FASTAAdd to Basket

    Also known as: F

    The sequence of this isoform differs from the canonical sequence as follows:
         36-44: Missing.
         96-137: Missing.

    Show »
    Length:103
    Mass (Da):11,289
    Checksum:i1C1FB863C2FE3419
    GO
    Isoform 6 (identifier: Q6UW88-6) [UniParc]FASTAAdd to Basket

    Also known as: G

    The sequence of this isoform differs from the canonical sequence as follows:
         36-44: Missing.
         87-137: Missing.

    Show »
    Length:94
    Mass (Da):10,274
    Checksum:i13193DA6BF249099
    GO
    Isoform 7 (identifier: Q6UW88-7) [UniParc]FASTAAdd to Basket

    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         15-44: Missing.
         87-137: Missing.

    Show »
    Length:73
    Mass (Da):8,149
    Checksum:i860BFE12C853D368
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91V → A in ABB60048. 1 PublicationCurated
    Sequence conflicti62 – 621E → G in ABB60047. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei15 – 4430Missing in isoform 7. 1 PublicationVSP_036654Add
    BLAST
    Alternative sequencei36 – 449Missing in isoform 2, isoform 5 and isoform 6. 2 PublicationsVSP_036655
    Alternative sequencei87 – 13751Missing in isoform 4, isoform 6 and isoform 7. 1 PublicationVSP_036656Add
    BLAST
    Alternative sequencei96 – 13742Missing in isoform 3 and isoform 5. 1 PublicationVSP_036657Add
    BLAST
    Alternative sequencei137 – 15418CLKLK…ERRPL → YEKDKI in isoform 2. 1 PublicationVSP_036658Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ235264 mRNA. Translation: ABB60043.1.
    DQ235265 mRNA. Translation: ABB60044.1.
    DQ235266 mRNA. Translation: ABB60045.1.
    DQ235267 mRNA. Translation: ABB60046.1.
    DQ235268 mRNA. Translation: ABB60047.1.
    DQ235269 mRNA. Translation: ABB60048.1.
    AY358920 mRNA. Translation: AAQ89279.1.
    AK289455 mRNA. Translation: BAF82144.1.
    CCDSiCCDS59475.1. [Q6UW88-5]
    CCDS59476.1. [Q6UW88-6]
    CCDS59477.1. [Q6UW88-3]
    CCDS59478.1. [Q6UW88-1]
    CCDS59479.1. [Q6UW88-4]
    RefSeqiNP_001257918.1. NM_001270989.1. [Q6UW88-1]
    NP_001257919.1. NM_001270990.1. [Q6UW88-3]
    NP_001257920.1. NM_001270991.1. [Q6UW88-5]
    NP_001257921.1. NM_001270992.1. [Q6UW88-4]
    NP_001257922.1. NM_001270993.1. [Q6UW88-6]
    XP_005265723.1. XM_005265666.2. [Q6UW88-2]
    UniGeneiHs.401237.

    Genome annotation databases

    GeneIDi255324.
    KEGGihsa:255324.
    UCSCiuc003hhw.4. human. [Q6UW88-2]
    uc003hhy.2. human. [Q6UW88-6]
    uc003hhz.2. human. [Q6UW88-4]
    uc003hia.2. human. [Q6UW88-5]
    uc003hib.2. human. [Q6UW88-3]
    uc003hic.2. human. [Q6UW88-1]
    uc010iin.2. human. [Q6UW88-7]

    Polymorphism databases

    DMDMi229464464.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ235264 mRNA. Translation: ABB60043.1 .
    DQ235265 mRNA. Translation: ABB60044.1 .
    DQ235266 mRNA. Translation: ABB60045.1 .
    DQ235267 mRNA. Translation: ABB60046.1 .
    DQ235268 mRNA. Translation: ABB60047.1 .
    DQ235269 mRNA. Translation: ABB60048.1 .
    AY358920 mRNA. Translation: AAQ89279.1 .
    AK289455 mRNA. Translation: BAF82144.1 .
    CCDSi CCDS59475.1. [Q6UW88-5 ]
    CCDS59476.1. [Q6UW88-6 ]
    CCDS59477.1. [Q6UW88-3 ]
    CCDS59478.1. [Q6UW88-1 ]
    CCDS59479.1. [Q6UW88-4 ]
    RefSeqi NP_001257918.1. NM_001270989.1. [Q6UW88-1 ]
    NP_001257919.1. NM_001270990.1. [Q6UW88-3 ]
    NP_001257920.1. NM_001270991.1. [Q6UW88-5 ]
    NP_001257921.1. NM_001270992.1. [Q6UW88-4 ]
    NP_001257922.1. NM_001270993.1. [Q6UW88-6 ]
    XP_005265723.1. XM_005265666.2. [Q6UW88-2 ]
    UniGenei Hs.401237.

    3D structure databases

    ProteinModelPortali Q6UW88.
    SMRi Q6UW88. Positions 60-100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000330375.

    Polymorphism databases

    DMDMi 229464464.

    Protocols and materials databases

    DNASUi 255324.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 255324.
    KEGGi hsa:255324.
    UCSCi uc003hhw.4. human. [Q6UW88-2 ]
    uc003hhy.2. human. [Q6UW88-6 ]
    uc003hhz.2. human. [Q6UW88-4 ]
    uc003hia.2. human. [Q6UW88-5 ]
    uc003hib.2. human. [Q6UW88-3 ]
    uc003hic.2. human. [Q6UW88-1 ]
    uc010iin.2. human. [Q6UW88-7 ]

    Organism-specific databases

    CTDi 255324.
    GeneCardsi GC04P075174.
    HGNCi HGNC:17470. EPGN.
    HPAi HPA014369.
    HPA014420.
    neXtProti NX_Q6UW88.
    PharmGKBi PA162385143.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43616.
    HOVERGENi HBG079616.
    InParanoidi Q6UW88.
    OMAi INGLCAF.
    OrthoDBi EOG761BWF.
    PhylomeDBi Q6UW88.
    TreeFami TF335931.

    Miscellaneous databases

    GenomeRNAii 255324.
    NextBioi 92547.
    PROi Q6UW88.

    Gene expression databases

    Bgeei Q6UW88.
    CleanExi HS_EPGN.
    Genevestigatori Q6UW88.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR015497. EGF_rcpt_ligand.
    [Graphical view ]
    PANTHERi PTHR10740. PTHR10740. 1 hit.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human keratinocytes express several alternatively spliced forms of EPIGEN, encoding directly secreted and intracellular proteins."
      Johnstone L.S., Abumaree M., Martin J., Webster G., Murison G.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6 AND 7).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-37.
    5. Cited for: FUNCTION.

    Entry informationi

    Entry nameiEPGN_HUMAN
    AccessioniPrimary (citable) accession number: Q6UW88
    Secondary accession number(s): A1BMM3
    , A1BMM4, A1BMM5, A1BMM6, A1BMM7, A1BMM8, A8K090
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3