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Q6UW88

- EPGN_HUMAN

UniProt

Q6UW88 - EPGN_HUMAN

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Protein

Epigen

Gene

EPGN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.1 Publication

GO - Molecular functioni

  1. epidermal growth factor receptor binding Source: HGNC
  2. growth factor activity Source: HGNC
  3. MAP kinase kinase activity Source: HGNC

GO - Biological processi

  1. activation of MAPK activity Source: HGNC
  2. angiogenesis Source: HGNC
  3. positive regulation of cell proliferation Source: HGNC
  4. positive regulation of epidermal growth factor-activated receptor activity Source: HGNC
  5. positive regulation of epithelial cell proliferation Source: HGNC
  6. positive regulation of MAP kinase activity Source: HGNC
  7. positive regulation of mitosis Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Epigen
Alternative name(s):
Epithelial mitogen
Short name:
EPG
Gene namesi
Name:EPGN
ORF Names:UNQ3072/PRO9904
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:17470. EPGN.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. integral component of plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385143.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 154132EpigenPRO_0000045462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
Disulfide bondi68 ↔ 84PROSITE-ProRule annotation
Disulfide bondi86 ↔ 95PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiQ6UW88.
CleanExiHS_EPGN.
ExpressionAtlasiQ6UW88. baseline.
GenevestigatoriQ6UW88.

Organism-specific databases

HPAiHPA014369.
HPA014420.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330375.

Structurei

3D structure databases

ProteinModelPortaliQ6UW88.
SMRiQ6UW88. Positions 60-100.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 11088ExtracellularSequence AnalysisAdd
BLAST
Topological domaini132 – 15423CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 9641EGF-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43616.
GeneTreeiENSGT00510000048556.
HOVERGENiHBG079616.
InParanoidiQ6UW88.
OMAiINGLCAF.
OrthoDBiEOG761BWF.
PhylomeDBiQ6UW88.
TreeFamiTF335931.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UW88-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALGVPISVY LLFNAMTALT EEAAVTVTPP ITAQQGNWTV NKTEADNIEG
60 70 80 90 100
PIALKFSHLC LEDHNSYCIN GACAFHHELE KAICRCFTGY TGERCEHLTL
110 120 130 140 150
TSYAVDSYEK YIAIGIGVGL LLSGFLVIFY CYIRKRCLKL KSPYNVCSGE

RRPL
Length:154
Mass (Da):17,091
Last modified:March 24, 2009 - v2
Checksum:iBC78016BE3026474
GO
Isoform 2 (identifier: Q6UW88-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     137-154: CLKLKSPYNVCSGERRPL → YEKDKI

Show »
Length:133
Mass (Da):14,792
Checksum:i7A5B3257D0484182
GO
Isoform 3 (identifier: Q6UW88-3) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     96-137: Missing.

Show »
Length:112
Mass (Da):12,319
Checksum:i8D0EE50785FA2891
GO
Isoform 4 (identifier: Q6UW88-4) [UniParc]FASTAAdd to Basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     87-137: Missing.

Show »
Length:103
Mass (Da):11,304
Checksum:i062973EAC9EA4570
GO
Isoform 5 (identifier: Q6UW88-5) [UniParc]FASTAAdd to Basket

Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     96-137: Missing.

Show »
Length:103
Mass (Da):11,289
Checksum:i1C1FB863C2FE3419
GO
Isoform 6 (identifier: Q6UW88-6) [UniParc]FASTAAdd to Basket

Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     87-137: Missing.

Show »
Length:94
Mass (Da):10,274
Checksum:i13193DA6BF249099
GO
Isoform 7 (identifier: Q6UW88-7) [UniParc]FASTAAdd to Basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     15-44: Missing.
     87-137: Missing.

Show »
Length:73
Mass (Da):8,149
Checksum:i860BFE12C853D368
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → A in ABB60048. 1 PublicationCurated
Sequence conflicti62 – 621E → G in ABB60047. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei15 – 4430Missing in isoform 7. 1 PublicationVSP_036654Add
BLAST
Alternative sequencei36 – 449Missing in isoform 2, isoform 5 and isoform 6. 2 PublicationsVSP_036655
Alternative sequencei87 – 13751Missing in isoform 4, isoform 6 and isoform 7. 1 PublicationVSP_036656Add
BLAST
Alternative sequencei96 – 13742Missing in isoform 3 and isoform 5. 1 PublicationVSP_036657Add
BLAST
Alternative sequencei137 – 15418CLKLK…ERRPL → YEKDKI in isoform 2. 1 PublicationVSP_036658Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ235264 mRNA. Translation: ABB60043.1.
DQ235265 mRNA. Translation: ABB60044.1.
DQ235266 mRNA. Translation: ABB60045.1.
DQ235267 mRNA. Translation: ABB60046.1.
DQ235268 mRNA. Translation: ABB60047.1.
DQ235269 mRNA. Translation: ABB60048.1.
AY358920 mRNA. Translation: AAQ89279.1.
AK289455 mRNA. Translation: BAF82144.1.
CCDSiCCDS59475.1. [Q6UW88-5]
CCDS59476.1. [Q6UW88-6]
CCDS59477.1. [Q6UW88-3]
CCDS59478.1. [Q6UW88-1]
CCDS59479.1. [Q6UW88-4]
RefSeqiNP_001257918.1. NM_001270989.1. [Q6UW88-1]
NP_001257919.1. NM_001270990.1. [Q6UW88-3]
NP_001257920.1. NM_001270991.1. [Q6UW88-5]
NP_001257921.1. NM_001270992.1. [Q6UW88-4]
NP_001257922.1. NM_001270993.1. [Q6UW88-6]
XP_005265723.1. XM_005265666.2. [Q6UW88-2]
UniGeneiHs.401237.

Genome annotation databases

GeneIDi255324.
KEGGihsa:255324.
UCSCiuc003hhw.4. human. [Q6UW88-2]
uc003hhy.2. human. [Q6UW88-6]
uc003hhz.2. human. [Q6UW88-4]
uc003hia.2. human. [Q6UW88-5]
uc003hib.2. human. [Q6UW88-3]
uc003hic.2. human. [Q6UW88-1]
uc010iin.2. human. [Q6UW88-7]

Polymorphism databases

DMDMi229464464.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ235264 mRNA. Translation: ABB60043.1 .
DQ235265 mRNA. Translation: ABB60044.1 .
DQ235266 mRNA. Translation: ABB60045.1 .
DQ235267 mRNA. Translation: ABB60046.1 .
DQ235268 mRNA. Translation: ABB60047.1 .
DQ235269 mRNA. Translation: ABB60048.1 .
AY358920 mRNA. Translation: AAQ89279.1 .
AK289455 mRNA. Translation: BAF82144.1 .
CCDSi CCDS59475.1. [Q6UW88-5 ]
CCDS59476.1. [Q6UW88-6 ]
CCDS59477.1. [Q6UW88-3 ]
CCDS59478.1. [Q6UW88-1 ]
CCDS59479.1. [Q6UW88-4 ]
RefSeqi NP_001257918.1. NM_001270989.1. [Q6UW88-1 ]
NP_001257919.1. NM_001270990.1. [Q6UW88-3 ]
NP_001257920.1. NM_001270991.1. [Q6UW88-5 ]
NP_001257921.1. NM_001270992.1. [Q6UW88-4 ]
NP_001257922.1. NM_001270993.1. [Q6UW88-6 ]
XP_005265723.1. XM_005265666.2. [Q6UW88-2 ]
UniGenei Hs.401237.

3D structure databases

ProteinModelPortali Q6UW88.
SMRi Q6UW88. Positions 60-100.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000330375.

Polymorphism databases

DMDMi 229464464.

Protocols and materials databases

DNASUi 255324.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 255324.
KEGGi hsa:255324.
UCSCi uc003hhw.4. human. [Q6UW88-2 ]
uc003hhy.2. human. [Q6UW88-6 ]
uc003hhz.2. human. [Q6UW88-4 ]
uc003hia.2. human. [Q6UW88-5 ]
uc003hib.2. human. [Q6UW88-3 ]
uc003hic.2. human. [Q6UW88-1 ]
uc010iin.2. human. [Q6UW88-7 ]

Organism-specific databases

CTDi 255324.
GeneCardsi GC04P075174.
HGNCi HGNC:17470. EPGN.
HPAi HPA014369.
HPA014420.
neXtProti NX_Q6UW88.
PharmGKBi PA162385143.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43616.
GeneTreei ENSGT00510000048556.
HOVERGENi HBG079616.
InParanoidi Q6UW88.
OMAi INGLCAF.
OrthoDBi EOG761BWF.
PhylomeDBi Q6UW88.
TreeFami TF335931.

Miscellaneous databases

GenomeRNAii 255324.
NextBioi 92547.
PROi Q6UW88.

Gene expression databases

Bgeei Q6UW88.
CleanExi HS_EPGN.
ExpressionAtlasi Q6UW88. baseline.
Genevestigatori Q6UW88.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR015497. EGF_rcpt_ligand.
[Graphical view ]
PANTHERi PTHR10740. PTHR10740. 1 hit.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human keratinocytes express several alternatively spliced forms of EPIGEN, encoding directly secreted and intracellular proteins."
    Johnstone L.S., Abumaree M., Martin J., Webster G., Murison G.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6 AND 7).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-37.
  5. Cited for: FUNCTION.

Entry informationi

Entry nameiEPGN_HUMAN
AccessioniPrimary (citable) accession number: Q6UW88
Secondary accession number(s): A1BMM3
, A1BMM4, A1BMM5, A1BMM6, A1BMM7, A1BMM8, A8K090
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3