Q6UW78 (CK083_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0723 protein C11orf83

Gene names

Name:	C11orf83
ORF Names:	UNQ655/PRO1286

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	93 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the UPF0723 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Ref.4
	Chain	24 – 93	70	UPF0723 protein C11orf83		PRO_0000022611
Experimental info
	Sequence conflict	89	1	G → S in AAQ89294. Ref.1
	Sequence conflict	89	1	G → S in AAH90057. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q6UW78 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 7E65D81280196F93	FASTA	93	10,081
	10 20 30 40 50 60 MDSLRKMLIS VAMLGAGAGV GYALLVIVTP GERRKQEMLK EMPLQDPRSR EEAARTQQLL 70 80 90 LATLQEAATT QENVAWRKNW MVGGEGGAGG RSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-37.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358935 mRNA. Translation: AAQ89294.1. AP001458 Genomic DNA. No translation available. BC090057 mRNA. Translation: AAH90057.1.
IPI	IPI00978059.
RefSeq	NP_001078841.1. NM_001085372.2.
UniGene	Hs.569009.
3D structure databases
ProteinModelPortal	Q6UW78.
ModBase	Search...
Polymorphism databases
DMDM	296434449.
Proteomic databases
PRIDE	Q6UW78.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377953; ENSP00000367189; ENSG00000204922.
GeneID	790955.
KEGG	hsa:790955.
UCSC	uc001nui.2. human.
Organism-specific databases
CTD	790955.
GeneCards	GC11P062439.
H-InvDB	HIX0035944.
HGNC	HGNC:34399. C11orf83.
neXtProt	NX_Q6UW78.
PharmGKB	PA162377760.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21658.
GeneTree	ENSGT00390000001930.
InParanoid	Q6UW78.
OMA	QAMLKEM.
OrthoDB	EOG4C87V4.
Gene expression databases
ArrayExpress	Q6UW78.
Bgee	Q6UW78.
CleanEx	HS_C11orf83.
Genevestigator	Q6UW78.
GermOnline	ENSG00000204922. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	135718.

Entry information

Entry name

CK083_HUMAN

Accession

Primary (citable) accession number: Q6UW78
Secondary accession number(s): Q5FVD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.