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Protein

Transmembrane protein 205

Gene

TMEM205

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.1 Publication

Protein family/group databases

TCDBi9.A.55.1.1. the tmem205 (tmem205) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 205
Gene namesi
Name:TMEM205
ORF Names:UNQ501/PRO1018
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29631. TMEM205.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406385.

Polymorphism and mutation databases

BioMutaiTMEM205.
DMDMi74749383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Transmembrane protein 205PRO_0000317501Add
BLAST

Proteomic databases

EPDiQ6UW68.
MaxQBiQ6UW68.
PaxDbiQ6UW68.
PeptideAtlasiQ6UW68.
PRIDEiQ6UW68.
TopDownProteomicsiQ6UW68.

PTM databases

iPTMnetiQ6UW68.
PhosphoSiteiQ6UW68.
SwissPalmiQ6UW68.

Expressioni

Tissue specificityi

Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).1 Publication

Gene expression databases

BgeeiQ6UW68.
CleanExiHS_TMEM205.
ExpressionAtlasiQ6UW68. baseline and differential.
GenevisibleiQ6UW68. HS.

Organism-specific databases

HPAiHPA041504.

Interactioni

Protein-protein interaction databases

BioGridi131930. 12 interactions.
IntActiQ6UW68. 1 interaction.
STRINGi9606.ENSP00000346954.

Structurei

3D structure databases

ProteinModelPortaliQ6UW68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM205 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2886. Eukaryota.
ENOG4111HFX. LUCA.
GeneTreeiENSGT00390000016298.
HOGENOMiHOG000160735.
HOVERGENiHBG107300.
InParanoidiQ6UW68.
OMAiTINARWL.
PhylomeDBiQ6UW68.
TreeFamiTF323838.

Family and domain databases

InterProiIPR025423. DUF4149.
[Graphical view]
PfamiPF13664. DUF4149. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UW68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGGNLGGL IKMVHLLVLS GAWGMQMWVT FVSGFLLFRS LPRHTFGLVQ
60 70 80 90 100
SKLFPFYFHI SMGCAFINLC ILASQHAWAQ LTFWEASQLY LLFLSLTLAT
110 120 130 140 150
VNARWLEPRT TAAMWALQTV EKERGLGGEV PGSHQGPDPY RQLREKDPKY
160 170 180
SALRQNFFRY HGLSSLCNLG CVLSNGLCLA GLALEIRSL
Length:189
Mass (Da):21,198
Last modified:July 5, 2004 - v1
Checksum:iFCC1C48C5B1601B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358949 mRNA. Translation: AAQ89308.1.
AK291979 mRNA. Translation: BAF84668.1.
CH471106 Genomic DNA. Translation: EAW84191.1.
BC064948 mRNA. Translation: AAH64948.1.
BC091472 mRNA. Translation: AAH91472.1.
CCDSiCCDS32909.1.
RefSeqiNP_001138888.1. NM_001145416.1.
NP_212133.1. NM_033408.3.
NP_940938.1. NM_198536.2.
XP_005259956.1. XM_005259899.2.
XP_005259958.1. XM_005259901.3.
UniGeneiHs.737060.
Hs.8036.

Genome annotation databases

EnsembliENST00000354882; ENSP00000346954; ENSG00000105518.
ENST00000447337; ENSP00000398258; ENSG00000105518.
ENST00000586590; ENSP00000466986; ENSG00000105518.
ENST00000586956; ENSP00000465483; ENSG00000105518.
ENST00000587948; ENSP00000465149; ENSG00000105518.
ENST00000588560; ENSP00000466495; ENSG00000105518.
ENST00000589555; ENSP00000465553; ENSG00000105518.
ENST00000593256; ENSP00000468733; ENSG00000105518.
GeneIDi374882.
KEGGihsa:374882.
UCSCiuc002mqz.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358949 mRNA. Translation: AAQ89308.1.
AK291979 mRNA. Translation: BAF84668.1.
CH471106 Genomic DNA. Translation: EAW84191.1.
BC064948 mRNA. Translation: AAH64948.1.
BC091472 mRNA. Translation: AAH91472.1.
CCDSiCCDS32909.1.
RefSeqiNP_001138888.1. NM_001145416.1.
NP_212133.1. NM_033408.3.
NP_940938.1. NM_198536.2.
XP_005259956.1. XM_005259899.2.
XP_005259958.1. XM_005259901.3.
UniGeneiHs.737060.
Hs.8036.

3D structure databases

ProteinModelPortaliQ6UW68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131930. 12 interactions.
IntActiQ6UW68. 1 interaction.
STRINGi9606.ENSP00000346954.

Protein family/group databases

TCDBi9.A.55.1.1. the tmem205 (tmem205) family.

PTM databases

iPTMnetiQ6UW68.
PhosphoSiteiQ6UW68.
SwissPalmiQ6UW68.

Polymorphism and mutation databases

BioMutaiTMEM205.
DMDMi74749383.

Proteomic databases

EPDiQ6UW68.
MaxQBiQ6UW68.
PaxDbiQ6UW68.
PeptideAtlasiQ6UW68.
PRIDEiQ6UW68.
TopDownProteomicsiQ6UW68.

Protocols and materials databases

DNASUi374882.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354882; ENSP00000346954; ENSG00000105518.
ENST00000447337; ENSP00000398258; ENSG00000105518.
ENST00000586590; ENSP00000466986; ENSG00000105518.
ENST00000586956; ENSP00000465483; ENSG00000105518.
ENST00000587948; ENSP00000465149; ENSG00000105518.
ENST00000588560; ENSP00000466495; ENSG00000105518.
ENST00000589555; ENSP00000465553; ENSG00000105518.
ENST00000593256; ENSP00000468733; ENSG00000105518.
GeneIDi374882.
KEGGihsa:374882.
UCSCiuc002mqz.3. human.

Organism-specific databases

CTDi374882.
GeneCardsiTMEM205.
HGNCiHGNC:29631. TMEM205.
HPAiHPA041504.
MIMi613771. gene.
neXtProtiNX_Q6UW68.
PharmGKBiPA162406385.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2886. Eukaryota.
ENOG4111HFX. LUCA.
GeneTreeiENSGT00390000016298.
HOGENOMiHOG000160735.
HOVERGENiHBG107300.
InParanoidiQ6UW68.
OMAiTINARWL.
PhylomeDBiQ6UW68.
TreeFamiTF323838.

Miscellaneous databases

ChiTaRSiTMEM205. human.
GenomeRNAii374882.
PROiQ6UW68.
SOURCEiSearch...

Gene expression databases

BgeeiQ6UW68.
CleanExiHS_TMEM205.
ExpressionAtlasiQ6UW68. baseline and differential.
GenevisibleiQ6UW68. HS.

Family and domain databases

InterProiIPR025423. DUF4149.
[Graphical view]
PfamiPF13664. DUF4149. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Placenta.
  5. "Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance."
    Shen D.W., Ma J., Okabe M., Zhang G., Xia D., Gottesman M.M.
    J. Cell. Physiol. 225:822-828(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM205_HUMAN
AccessioniPrimary (citable) accession number: Q6UW68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.