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Protein

Transmembrane protein 205

Gene

TMEM205

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.1 Publication

Protein family/group databases

TCDBi9.A.55.1.1 the tmem205 (tmem205) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 205
Gene namesi
Name:TMEM205
ORF Names:UNQ501/PRO1018
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105518.13
HGNCiHGNC:29631 TMEM205
MIMi613771 gene
neXtProtiNX_Q6UW68

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi374882
OpenTargetsiENSG00000105518
PharmGKBiPA162406385

Polymorphism and mutation databases

BioMutaiTMEM205
DMDMi74749383

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175011 – 189Transmembrane protein 205Add BLAST189

Proteomic databases

EPDiQ6UW68
MaxQBiQ6UW68
PaxDbiQ6UW68
PeptideAtlasiQ6UW68
PRIDEiQ6UW68
TopDownProteomicsiQ6UW68

PTM databases

iPTMnetiQ6UW68
PhosphoSitePlusiQ6UW68
SwissPalmiQ6UW68

Expressioni

Tissue specificityi

Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000105518
CleanExiHS_TMEM205
ExpressionAtlasiQ6UW68 baseline and differential
GenevisibleiQ6UW68 HS

Organism-specific databases

HPAiHPA041504

Interactioni

Protein-protein interaction databases

BioGridi131930, 18 interactors
IntActiQ6UW68, 2 interactors
MINTiQ6UW68
STRINGi9606.ENSP00000346954

Structurei

3D structure databases

ProteinModelPortaliQ6UW68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM205 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2886 Eukaryota
ENOG4111HFX LUCA
GeneTreeiENSGT00390000016298
HOGENOMiHOG000160735
HOVERGENiHBG107300
InParanoidiQ6UW68
OMAiATINARW
OrthoDBiEOG091G10EB
PhylomeDBiQ6UW68
TreeFamiTF323838

Family and domain databases

InterProiView protein in InterPro
IPR025423 DUF4149
PfamiView protein in Pfam
PF13664 DUF4149, 1 hit

Sequencei

Sequence statusi: Complete.

Q6UW68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGGNLGGL IKMVHLLVLS GAWGMQMWVT FVSGFLLFRS LPRHTFGLVQ
60 70 80 90 100
SKLFPFYFHI SMGCAFINLC ILASQHAWAQ LTFWEASQLY LLFLSLTLAT
110 120 130 140 150
VNARWLEPRT TAAMWALQTV EKERGLGGEV PGSHQGPDPY RQLREKDPKY
160 170 180
SALRQNFFRY HGLSSLCNLG CVLSNGLCLA GLALEIRSL
Length:189
Mass (Da):21,198
Last modified:July 5, 2004 - v1
Checksum:iFCC1C48C5B1601B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358949 mRNA Translation: AAQ89308.1
AK291979 mRNA Translation: BAF84668.1
CH471106 Genomic DNA Translation: EAW84191.1
BC064948 mRNA Translation: AAH64948.1
BC091472 mRNA Translation: AAH91472.1
CCDSiCCDS32909.1
RefSeqiNP_001138888.1, NM_001145416.1
NP_001308041.1, NM_001321112.1
NP_001308042.1, NM_001321113.1
NP_001308043.1, NM_001321114.1
NP_212133.1, NM_033408.3
NP_940938.1, NM_198536.2
XP_005259956.1, XM_005259899.2
UniGeneiHs.737060
Hs.8036

Genome annotation databases

EnsembliENST00000354882; ENSP00000346954; ENSG00000105518
ENST00000447337; ENSP00000398258; ENSG00000105518
ENST00000586590; ENSP00000466986; ENSG00000105518
ENST00000586956; ENSP00000465483; ENSG00000105518
ENST00000587948; ENSP00000465149; ENSG00000105518
ENST00000588560; ENSP00000466495; ENSG00000105518
ENST00000589555; ENSP00000465553; ENSG00000105518
ENST00000593256; ENSP00000468733; ENSG00000105518
GeneIDi374882
KEGGihsa:374882
UCSCiuc002mqz.3 human

Similar proteinsi

Entry informationi

Entry nameiTM205_HUMAN
AccessioniPrimary (citable) accession number: Q6UW68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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