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Q6UW63 (KDEL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
KDEL motif-containing protein 1
Alternative name(s):
Endoplasmic reticulum resident protein 58
Short name=ER protein 58
Short name=ERp58
Gene names
Name:KDELC1
Synonyms:EP58
ORF Names:UNQ1910/PRO4357
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum lumen By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the KDELC family.

Contains 1 filamin repeat.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMGlycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 502483KDEL motif-containing protein 1
PRO_0000247163

Regions

Repeat24 – 130107Filamin
Motif499 – 5024Prevents secretion from ER Potential

Amino acid modifications

Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation4141N-linked (GlcNAc...) Potential

Natural variations

Natural variant1141I → V. Ref.4
Corresponds to variant rs1047740 [ dbSNP | Ensembl ].
VAR_027080

Experimental info

Sequence conflict1091N → S in BAD96287. Ref.2
Sequence conflict1631D → G in BAD96287. Ref.2

Secondary structure

................. 502
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q6UW63 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 82633729E373E116

FASTA50258,043
        10         20         30         40         50         60 
MFGTLLLYCF FLATVPALAE TGGERQLSPE KSEIWGPGLK ADVVLPARYF YIQAVDTSGN 

        70         80         90        100        110        120 
KFTSSPGEKV FQVKVSAPEE QFTRVGVQVL DRKDGSFIVR YRMYASYKNL KVEIKFQGQH 

       130        140        150        160        170        180 
VAKSPYILKG PVYHENCDCP LQDSAAWLRE MNCPETIAQI QRDLAHFPAV DPEKIAVEIP 

       190        200        210        220        230        240 
KRFGQRQSLC HYTLKDNKVY IKTHGEHVGF RIFMDAILLS LTRKVKMPDV ELFVNLGDWP 

       250        260        270        280        290        300 
LEKKKSNSNI HPIFSWCGST DSKDIVMPTY DLTDSVLETM GRVSLDMMSV QANTGPPWES 

       310        320        330        340        350        360 
KNSTAVWRGR DSRKERLELV KLSRKHPELI DAAFTNFFFF KHDENLYGPI VKHISFFDFF 

       370        380        390        400        410        420 
KHKYQINIDG TVAAYRLPYL LVGDSVVLKQ DSIYYEHFYN ELQPWKHYIP VKSNLSDLLE 

       430        440        450        460        470        480 
KLKWAKDHDE EAKKIAKAGQ EFARNNLMGD DIFCYYFKLF QEYANLQVSE PQIREGMKRV 

       490        500 
EPQTEDDLFP CTCHRKKTKD EL 

« Hide

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Coronary arterial endothelium.
[3]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-114.
Tissue: Cervix carcinoma.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Solution structure of the filamin domain from human BK158_1 protein."
RIKEN structural genomics initiative (RSGI)
Submitted (SEP-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 20-130.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358959 mRNA. Translation: AAQ89318.1.
AK222567 mRNA. Translation: BAD96287.1.
AL157769 Genomic DNA. Translation: CAI14525.1.
BC001297 mRNA. Translation: AAH01297.1.
CCDSCCDS9504.1.
RefSeqNP_076994.2. NM_024089.2.
UniGeneHs.408629.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DI7NMR-A20-130[»]
ProteinModelPortalQ6UW63.
SMRQ6UW63. Positions 25-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122521. 3 interactions.
STRING9606.ENSP00000365172.

Protein family/group databases

CAZyGT90. Glycosyltransferase Family 90.

PTM databases

PhosphoSiteQ6UW63.

Polymorphism databases

DMDM74749382.

Proteomic databases

MaxQBQ6UW63.
PaxDbQ6UW63.
PeptideAtlasQ6UW63.
PRIDEQ6UW63.

Protocols and materials databases

DNASU79070.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376004; ENSP00000365172; ENSG00000134901.
GeneID79070.
KEGGhsa:79070.
UCSCuc001vpq.4. human.

Organism-specific databases

CTD79070.
GeneCardsGC13M103436.
HGNCHGNC:19350. KDELC1.
HPACAB020780.
MIM611613. gene.
neXtProtNX_Q6UW63.
PharmGKBPA134974174.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG248922.
HOGENOMHOG000286007.
HOVERGENHBG081852.
InParanoidQ6UW63.
OMALLLYCFF.
OrthoDBEOG7XDBG0.
PhylomeDBQ6UW63.
TreeFamTF323280.

Gene expression databases

BgeeQ6UW63.
CleanExHS_KDELC1.
GenevestigatorQ6UW63.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMSSF81296. SSF81296. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ6UW63.
GenomeRNAi79070.
NextBio67853.
PROQ6UW63.
SOURCESearch...

Entry information

Entry nameKDEL1_HUMAN
AccessionPrimary (citable) accession number: Q6UW63
Secondary accession number(s): Q53HL3, Q9BVD2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM