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Protein

KDEL motif-containing protein 1

Gene

KDELC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL motif-containing protein 1
Alternative name(s):
Endoplasmic reticulum resident protein 58
Short name:
ER protein 58
Short name:
ERp58
Gene namesi
Name:KDELC1
Synonyms:EP58
ORF Names:UNQ1910/PRO4357
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:19350. KDELC1.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134901.
PharmGKBiPA134974174.

Polymorphism and mutation databases

BioMutaiKDELC1.
DMDMi74749382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024716320 – 502KDEL motif-containing protein 1Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi414N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UW63.
MaxQBiQ6UW63.
PaxDbiQ6UW63.
PeptideAtlasiQ6UW63.
PRIDEiQ6UW63.

PTM databases

iPTMnetiQ6UW63.
PhosphoSitePlusiQ6UW63.

Expressioni

Gene expression databases

BgeeiENSG00000134901.
CleanExiHS_KDELC1.
GenevisibleiQ6UW63. HS.

Organism-specific databases

HPAiCAB020780.

Interactioni

Protein-protein interaction databases

BioGridi122521. 8 interactors.
IntActiQ6UW63. 1 interactor.
STRINGi9606.ENSP00000365172.

Structurei

Secondary structure

1502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni29 – 31Combined sources3
Beta strandi39 – 42Combined sources4
Beta strandi72 – 76Combined sources5
Beta strandi88 – 90Combined sources3
Beta strandi93 – 95Combined sources3
Beta strandi98 – 100Combined sources3
Beta strandi111 – 118Combined sources8
Beta strandi125 – 127Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DI7NMR-A20-130[»]
ProteinModelPortaliQ6UW63.
SMRiQ6UW63.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6UW63.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 130FilaminAdd BLAST107

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi499 – 502Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the KDELC family.Curated
Contains 1 filamin repeat.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2458. Eukaryota.
ENOG410XT5U. LUCA.
GeneTreeiENSGT00530000063132.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ6UW63.
OMAiCPLQDSA.
OrthoDBiEOG091G04SJ.
PhylomeDBiQ6UW63.
TreeFamiTF323280.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UW63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGTLLLYCF FLATVPALAE TGGERQLSPE KSEIWGPGLK ADVVLPARYF
60 70 80 90 100
YIQAVDTSGN KFTSSPGEKV FQVKVSAPEE QFTRVGVQVL DRKDGSFIVR
110 120 130 140 150
YRMYASYKNL KVEIKFQGQH VAKSPYILKG PVYHENCDCP LQDSAAWLRE
160 170 180 190 200
MNCPETIAQI QRDLAHFPAV DPEKIAVEIP KRFGQRQSLC HYTLKDNKVY
210 220 230 240 250
IKTHGEHVGF RIFMDAILLS LTRKVKMPDV ELFVNLGDWP LEKKKSNSNI
260 270 280 290 300
HPIFSWCGST DSKDIVMPTY DLTDSVLETM GRVSLDMMSV QANTGPPWES
310 320 330 340 350
KNSTAVWRGR DSRKERLELV KLSRKHPELI DAAFTNFFFF KHDENLYGPI
360 370 380 390 400
VKHISFFDFF KHKYQINIDG TVAAYRLPYL LVGDSVVLKQ DSIYYEHFYN
410 420 430 440 450
ELQPWKHYIP VKSNLSDLLE KLKWAKDHDE EAKKIAKAGQ EFARNNLMGD
460 470 480 490 500
DIFCYYFKLF QEYANLQVSE PQIREGMKRV EPQTEDDLFP CTCHRKKTKD

EL
Length:502
Mass (Da):58,043
Last modified:July 5, 2004 - v1
Checksum:i82633729E373E116
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109N → S in BAD96287 (Ref. 2) Curated1
Sequence conflicti163D → G in BAD96287 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027080114I → V.1 PublicationCorresponds to variant rs1047740dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358959 mRNA. Translation: AAQ89318.1.
AK222567 mRNA. Translation: BAD96287.1.
AL157769 Genomic DNA. Translation: CAI14525.1.
BC001297 mRNA. Translation: AAH01297.1.
CCDSiCCDS9504.1.
RefSeqiNP_001305661.1. NM_001318732.1.
NP_076994.2. NM_024089.2.
UniGeneiHs.408629.

Genome annotation databases

EnsembliENST00000376004; ENSP00000365172; ENSG00000134901.
GeneIDi79070.
KEGGihsa:79070.
UCSCiuc001vpq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358959 mRNA. Translation: AAQ89318.1.
AK222567 mRNA. Translation: BAD96287.1.
AL157769 Genomic DNA. Translation: CAI14525.1.
BC001297 mRNA. Translation: AAH01297.1.
CCDSiCCDS9504.1.
RefSeqiNP_001305661.1. NM_001318732.1.
NP_076994.2. NM_024089.2.
UniGeneiHs.408629.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DI7NMR-A20-130[»]
ProteinModelPortaliQ6UW63.
SMRiQ6UW63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122521. 8 interactors.
IntActiQ6UW63. 1 interactor.
STRINGi9606.ENSP00000365172.

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

PTM databases

iPTMnetiQ6UW63.
PhosphoSitePlusiQ6UW63.

Polymorphism and mutation databases

BioMutaiKDELC1.
DMDMi74749382.

Proteomic databases

EPDiQ6UW63.
MaxQBiQ6UW63.
PaxDbiQ6UW63.
PeptideAtlasiQ6UW63.
PRIDEiQ6UW63.

Protocols and materials databases

DNASUi79070.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376004; ENSP00000365172; ENSG00000134901.
GeneIDi79070.
KEGGihsa:79070.
UCSCiuc001vpq.5. human.

Organism-specific databases

CTDi79070.
GeneCardsiKDELC1.
HGNCiHGNC:19350. KDELC1.
HPAiCAB020780.
MIMi611613. gene.
neXtProtiNX_Q6UW63.
OpenTargetsiENSG00000134901.
PharmGKBiPA134974174.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2458. Eukaryota.
ENOG410XT5U. LUCA.
GeneTreeiENSGT00530000063132.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ6UW63.
OMAiCPLQDSA.
OrthoDBiEOG091G04SJ.
PhylomeDBiQ6UW63.
TreeFamiTF323280.

Miscellaneous databases

EvolutionaryTraceiQ6UW63.
GenomeRNAii79070.
PROiQ6UW63.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134901.
CleanExiHS_KDELC1.
GenevisibleiQ6UW63. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDEL1_HUMAN
AccessioniPrimary (citable) accession number: Q6UW63
Secondary accession number(s): Q53HL3, Q9BVD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.