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Q6UW63

- KDEL1_HUMAN

UniProt

Q6UW63 - KDEL1_HUMAN

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Protein

KDEL motif-containing protein 1

Gene

KDELC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL motif-containing protein 1
Alternative name(s):
Endoplasmic reticulum resident protein 58
Short name:
ER protein 58
Short name:
ERp58
Gene namesi
Name:KDELC1
Synonyms:EP58
ORF Names:UNQ1910/PRO4357
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:19350. KDELC1.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134974174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 502483KDEL motif-containing protein 1PRO_0000247163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6UW63.
PaxDbiQ6UW63.
PeptideAtlasiQ6UW63.
PRIDEiQ6UW63.

PTM databases

PhosphoSiteiQ6UW63.

Expressioni

Gene expression databases

BgeeiQ6UW63.
CleanExiHS_KDELC1.
GenevestigatoriQ6UW63.

Organism-specific databases

HPAiCAB020780.

Interactioni

Protein-protein interaction databases

BioGridi122521. 5 interactions.
STRINGi9606.ENSP00000365172.

Structurei

Secondary structure

1
502
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni29 – 313Combined sources
Beta strandi39 – 424Combined sources
Beta strandi72 – 765Combined sources
Beta strandi88 – 903Combined sources
Beta strandi93 – 953Combined sources
Beta strandi98 – 1003Combined sources
Beta strandi111 – 1188Combined sources
Beta strandi125 – 1273Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DI7NMR-A20-130[»]
ProteinModelPortaliQ6UW63.
SMRiQ6UW63. Positions 25-130.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6UW63.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 130107FilaminAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi499 – 5024Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the KDELC family.Curated
Contains 1 filamin repeat.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248922.
GeneTreeiENSGT00530000063132.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ6UW63.
OMAiLLLYCFF.
OrthoDBiEOG7XDBG0.
PhylomeDBiQ6UW63.
TreeFamiTF323280.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UW63-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFGTLLLYCF FLATVPALAE TGGERQLSPE KSEIWGPGLK ADVVLPARYF
60 70 80 90 100
YIQAVDTSGN KFTSSPGEKV FQVKVSAPEE QFTRVGVQVL DRKDGSFIVR
110 120 130 140 150
YRMYASYKNL KVEIKFQGQH VAKSPYILKG PVYHENCDCP LQDSAAWLRE
160 170 180 190 200
MNCPETIAQI QRDLAHFPAV DPEKIAVEIP KRFGQRQSLC HYTLKDNKVY
210 220 230 240 250
IKTHGEHVGF RIFMDAILLS LTRKVKMPDV ELFVNLGDWP LEKKKSNSNI
260 270 280 290 300
HPIFSWCGST DSKDIVMPTY DLTDSVLETM GRVSLDMMSV QANTGPPWES
310 320 330 340 350
KNSTAVWRGR DSRKERLELV KLSRKHPELI DAAFTNFFFF KHDENLYGPI
360 370 380 390 400
VKHISFFDFF KHKYQINIDG TVAAYRLPYL LVGDSVVLKQ DSIYYEHFYN
410 420 430 440 450
ELQPWKHYIP VKSNLSDLLE KLKWAKDHDE EAKKIAKAGQ EFARNNLMGD
460 470 480 490 500
DIFCYYFKLF QEYANLQVSE PQIREGMKRV EPQTEDDLFP CTCHRKKTKD

EL
Length:502
Mass (Da):58,043
Last modified:July 5, 2004 - v1
Checksum:i82633729E373E116
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091N → S in BAD96287. 1 PublicationCurated
Sequence conflicti163 – 1631D → G in BAD96287. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti114 – 1141I → V.1 Publication
Corresponds to variant rs1047740 [ dbSNP | Ensembl ].
VAR_027080

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358959 mRNA. Translation: AAQ89318.1.
AK222567 mRNA. Translation: BAD96287.1.
AL157769 Genomic DNA. Translation: CAI14525.1.
BC001297 mRNA. Translation: AAH01297.1.
CCDSiCCDS9504.1.
RefSeqiNP_076994.2. NM_024089.2.
UniGeneiHs.408629.

Genome annotation databases

EnsembliENST00000376004; ENSP00000365172; ENSG00000134901.
GeneIDi79070.
KEGGihsa:79070.
UCSCiuc001vpq.4. human.

Polymorphism databases

DMDMi74749382.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358959 mRNA. Translation: AAQ89318.1 .
AK222567 mRNA. Translation: BAD96287.1 .
AL157769 Genomic DNA. Translation: CAI14525.1 .
BC001297 mRNA. Translation: AAH01297.1 .
CCDSi CCDS9504.1.
RefSeqi NP_076994.2. NM_024089.2.
UniGenei Hs.408629.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DI7 NMR - A 20-130 [» ]
ProteinModelPortali Q6UW63.
SMRi Q6UW63. Positions 25-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122521. 5 interactions.
STRINGi 9606.ENSP00000365172.

Protein family/group databases

CAZyi GT90. Glycosyltransferase Family 90.

PTM databases

PhosphoSitei Q6UW63.

Polymorphism databases

DMDMi 74749382.

Proteomic databases

MaxQBi Q6UW63.
PaxDbi Q6UW63.
PeptideAtlasi Q6UW63.
PRIDEi Q6UW63.

Protocols and materials databases

DNASUi 79070.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376004 ; ENSP00000365172 ; ENSG00000134901 .
GeneIDi 79070.
KEGGi hsa:79070.
UCSCi uc001vpq.4. human.

Organism-specific databases

CTDi 79070.
GeneCardsi GC13M103436.
HGNCi HGNC:19350. KDELC1.
HPAi CAB020780.
MIMi 611613. gene.
neXtProti NX_Q6UW63.
PharmGKBi PA134974174.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248922.
GeneTreei ENSGT00530000063132.
HOGENOMi HOG000286007.
HOVERGENi HBG081852.
InParanoidi Q6UW63.
OMAi LLLYCFF.
OrthoDBi EOG7XDBG0.
PhylomeDBi Q6UW63.
TreeFami TF323280.

Miscellaneous databases

EvolutionaryTracei Q6UW63.
GenomeRNAii 79070.
NextBioi 67853.
PROi Q6UW63.
SOURCEi Search...

Gene expression databases

Bgeei Q6UW63.
CleanExi HS_KDELC1.
Genevestigatori Q6UW63.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view ]
Pfami PF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view ]
SMARTi SM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view ]
SUPFAMi SSF81296. SSF81296. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Coronary arterial endothelium.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-114.
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Solution structure of the filamin domain from human BK158_1 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (SEP-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 20-130.

Entry informationi

Entry nameiKDEL1_HUMAN
AccessioniPrimary (citable) accession number: Q6UW63
Secondary accession number(s): Q53HL3, Q9BVD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3