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Q6UW63

- KDEL1_HUMAN

UniProt

Q6UW63 - KDEL1_HUMAN

Protein

KDEL motif-containing protein 1

Gene

KDELC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    CAZyiGT90. Glycosyltransferase Family 90.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KDEL motif-containing protein 1
    Alternative name(s):
    Endoplasmic reticulum resident protein 58
    Short name:
    ER protein 58
    Short name:
    ERp58
    Gene namesi
    Name:KDELC1
    Synonyms:EP58
    ORF Names:UNQ1910/PRO4357
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:19350. KDELC1.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134974174.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 502483KDEL motif-containing protein 1PRO_0000247163Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ6UW63.
    PaxDbiQ6UW63.
    PeptideAtlasiQ6UW63.
    PRIDEiQ6UW63.

    PTM databases

    PhosphoSiteiQ6UW63.

    Expressioni

    Gene expression databases

    BgeeiQ6UW63.
    CleanExiHS_KDELC1.
    GenevestigatoriQ6UW63.

    Organism-specific databases

    HPAiCAB020780.

    Interactioni

    Protein-protein interaction databases

    BioGridi122521. 3 interactions.
    STRINGi9606.ENSP00000365172.

    Structurei

    Secondary structure

    1
    502
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni29 – 313
    Beta strandi39 – 424
    Beta strandi72 – 765
    Beta strandi88 – 903
    Beta strandi93 – 953
    Beta strandi98 – 1003
    Beta strandi111 – 1188
    Beta strandi125 – 1273

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DI7NMR-A20-130[»]
    ProteinModelPortaliQ6UW63.
    SMRiQ6UW63. Positions 25-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6UW63.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati24 – 130107FilaminAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi499 – 5024Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the KDELC family.Curated
    Contains 1 filamin repeat.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG248922.
    HOGENOMiHOG000286007.
    HOVERGENiHBG081852.
    InParanoidiQ6UW63.
    OMAiLLLYCFF.
    OrthoDBiEOG7XDBG0.
    PhylomeDBiQ6UW63.
    TreeFamiTF323280.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR006598. LipoPS_modifying.
    [Graphical view]
    PfamiPF00630. Filamin. 1 hit.
    PF05686. Glyco_transf_90. 1 hit.
    [Graphical view]
    SMARTiSM00672. CAP10. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6UW63-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFGTLLLYCF FLATVPALAE TGGERQLSPE KSEIWGPGLK ADVVLPARYF    50
    YIQAVDTSGN KFTSSPGEKV FQVKVSAPEE QFTRVGVQVL DRKDGSFIVR 100
    YRMYASYKNL KVEIKFQGQH VAKSPYILKG PVYHENCDCP LQDSAAWLRE 150
    MNCPETIAQI QRDLAHFPAV DPEKIAVEIP KRFGQRQSLC HYTLKDNKVY 200
    IKTHGEHVGF RIFMDAILLS LTRKVKMPDV ELFVNLGDWP LEKKKSNSNI 250
    HPIFSWCGST DSKDIVMPTY DLTDSVLETM GRVSLDMMSV QANTGPPWES 300
    KNSTAVWRGR DSRKERLELV KLSRKHPELI DAAFTNFFFF KHDENLYGPI 350
    VKHISFFDFF KHKYQINIDG TVAAYRLPYL LVGDSVVLKQ DSIYYEHFYN 400
    ELQPWKHYIP VKSNLSDLLE KLKWAKDHDE EAKKIAKAGQ EFARNNLMGD 450
    DIFCYYFKLF QEYANLQVSE PQIREGMKRV EPQTEDDLFP CTCHRKKTKD 500
    EL 502
    Length:502
    Mass (Da):58,043
    Last modified:July 5, 2004 - v1
    Checksum:i82633729E373E116
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091N → S in BAD96287. 1 PublicationCurated
    Sequence conflicti163 – 1631D → G in BAD96287. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti114 – 1141I → V.1 Publication
    Corresponds to variant rs1047740 [ dbSNP | Ensembl ].
    VAR_027080

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358959 mRNA. Translation: AAQ89318.1.
    AK222567 mRNA. Translation: BAD96287.1.
    AL157769 Genomic DNA. Translation: CAI14525.1.
    BC001297 mRNA. Translation: AAH01297.1.
    CCDSiCCDS9504.1.
    RefSeqiNP_076994.2. NM_024089.2.
    UniGeneiHs.408629.

    Genome annotation databases

    EnsembliENST00000376004; ENSP00000365172; ENSG00000134901.
    GeneIDi79070.
    KEGGihsa:79070.
    UCSCiuc001vpq.4. human.

    Polymorphism databases

    DMDMi74749382.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358959 mRNA. Translation: AAQ89318.1 .
    AK222567 mRNA. Translation: BAD96287.1 .
    AL157769 Genomic DNA. Translation: CAI14525.1 .
    BC001297 mRNA. Translation: AAH01297.1 .
    CCDSi CCDS9504.1.
    RefSeqi NP_076994.2. NM_024089.2.
    UniGenei Hs.408629.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DI7 NMR - A 20-130 [» ]
    ProteinModelPortali Q6UW63.
    SMRi Q6UW63. Positions 25-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122521. 3 interactions.
    STRINGi 9606.ENSP00000365172.

    Protein family/group databases

    CAZyi GT90. Glycosyltransferase Family 90.

    PTM databases

    PhosphoSitei Q6UW63.

    Polymorphism databases

    DMDMi 74749382.

    Proteomic databases

    MaxQBi Q6UW63.
    PaxDbi Q6UW63.
    PeptideAtlasi Q6UW63.
    PRIDEi Q6UW63.

    Protocols and materials databases

    DNASUi 79070.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376004 ; ENSP00000365172 ; ENSG00000134901 .
    GeneIDi 79070.
    KEGGi hsa:79070.
    UCSCi uc001vpq.4. human.

    Organism-specific databases

    CTDi 79070.
    GeneCardsi GC13M103436.
    HGNCi HGNC:19350. KDELC1.
    HPAi CAB020780.
    MIMi 611613. gene.
    neXtProti NX_Q6UW63.
    PharmGKBi PA134974174.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG248922.
    HOGENOMi HOG000286007.
    HOVERGENi HBG081852.
    InParanoidi Q6UW63.
    OMAi LLLYCFF.
    OrthoDBi EOG7XDBG0.
    PhylomeDBi Q6UW63.
    TreeFami TF323280.

    Miscellaneous databases

    EvolutionaryTracei Q6UW63.
    GenomeRNAii 79070.
    NextBioi 67853.
    PROi Q6UW63.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6UW63.
    CleanExi HS_KDELC1.
    Genevestigatori Q6UW63.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR006598. LipoPS_modifying.
    [Graphical view ]
    Pfami PF00630. Filamin. 1 hit.
    PF05686. Glyco_transf_90. 1 hit.
    [Graphical view ]
    SMARTi SM00672. CAP10. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Coronary arterial endothelium.
    3. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-114.
      Tissue: Cervix carcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Solution structure of the filamin domain from human BK158_1 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (SEP-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 20-130.

    Entry informationi

    Entry nameiKDEL1_HUMAN
    AccessioniPrimary (citable) accession number: Q6UW63
    Secondary accession number(s): Q53HL3, Q9BVD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3