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Protein

Sperm equatorial segment protein 1

Gene

SPESP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm equatorial segment protein 1
Short name:
ESP
Short name:
Equatorial segment protein
Short name:
SP-ESP
Alternative name(s):
Glycosylated 38 kDa sperm protein C-7/8
Gene namesi
Name:SPESP1
ORF Names:UNQ732/PRO1418
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:15570. SPESP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi246777.
OpenTargetsiENSG00000258484.
PharmGKBiPA37980.

Polymorphism and mutation databases

BioMutaiSPESP1.
DMDMi317373280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000004270720 – 350Sperm equatorial segment protein 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6UW49.
PeptideAtlasiQ6UW49.
PRIDEiQ6UW49.

PTM databases

iPTMnetiQ6UW49.
PhosphoSitePlusiQ6UW49.

Expressioni

Tissue specificityi

Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages of spermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed in placenta and fetal lung.1 Publication

Gene expression databases

BgeeiENSG00000258484.
GenevisibleiQ6UW49. HS.

Organism-specific databases

HPAiHPA045936.
HPA051040.

Interactioni

Protein-protein interaction databases

BioGridi128923. 2 interactors.
STRINGi9606.ENSP00000312284.

Structurei

3D structure databases

ProteinModelPortaliQ6UW49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi266 – 271Poly-Ala6

Sequence similaritiesi

Belongs to the SPESP1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J31A. Eukaryota.
ENOG41114JR. LUCA.
GeneTreeiENSGT00390000005362.
HOGENOMiHOG000154382.
HOVERGENiHBG093982.
InParanoidiQ6UW49.
KOiK19923.
OMAiEEQNLNH.
OrthoDBiEOG091G0OPE.
PhylomeDBiQ6UW49.
TreeFamiTF337441.

Family and domain databases

InterProiIPR026743. Equatorial_segment.
[Graphical view]
PANTHERiPTHR31667. PTHR31667. 1 hit.
PfamiPF15754. SPESP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UW49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPLVLLVAL LLWPSSVPAY PSITVTPDEE QNLNHYIQVL ENLVRSVPSG
60 70 80 90 100
EPGREKKSNS PKHVYSIASK GSKFKELVTH GDASTENDVL TNPISEETTT
110 120 130 140 150
FPTGGFTPEI GKKKHTESTP FWSIKPNNVS IVLHAEEPYI ENEEPEPEPE
160 170 180 190 200
PAAKQTEAPR MLPVVTESST SPYVTSYKSP VTTLDKSTGI GISTESEDVP
210 220 230 240 250
QLSGETAIEK PEEFGKHPES WNNDDILKKI LDINSQVQQA LLSDTSNPAY
260 270 280 290 300
REDIEASKDH LKRSLALAAA AEHKLKTMYK SQLLPVGRTS NKIDDIETVI
310 320 330 340 350
NMLCNSRSKL YEYLDIKCVP PEMREKAATV FNTLKNMCRS RRVTALLKVY
Length:350
Mass (Da):38,931
Last modified:January 11, 2011 - v2
Checksum:i5AD0072D0BF79C4E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193S → Y in AAM69364 (PubMed:12773409).Curated1
Sequence conflicti263R → P in AAM69364 (PubMed:12773409).Curated1
Sequence conflicti297E → V in AAM69364 (PubMed:12773409).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031430133L → F.Corresponds to variant rs3743091dbSNPEnsembl.1
Natural variantiVAR_056994134H → Q.Corresponds to variant rs16952684dbSNPEnsembl.1
Natural variantiVAR_023738191G → E.2 PublicationsCorresponds to variant rs3743093dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275321 mRNA. Translation: AAM69364.1.
AY358983 mRNA. Translation: AAQ89342.1.
AC087639 Genomic DNA. No translation available.
BC017998 mRNA. Translation: AAH17998.1.
CCDSiCCDS10230.1.
RefSeqiNP_663633.1. NM_145658.3.
UniGeneiHs.657932.

Genome annotation databases

EnsembliENST00000310673; ENSP00000312284; ENSG00000258484.
GeneIDi246777.
KEGGihsa:246777.
UCSCiuc002arn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275321 mRNA. Translation: AAM69364.1.
AY358983 mRNA. Translation: AAQ89342.1.
AC087639 Genomic DNA. No translation available.
BC017998 mRNA. Translation: AAH17998.1.
CCDSiCCDS10230.1.
RefSeqiNP_663633.1. NM_145658.3.
UniGeneiHs.657932.

3D structure databases

ProteinModelPortaliQ6UW49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128923. 2 interactors.
STRINGi9606.ENSP00000312284.

PTM databases

iPTMnetiQ6UW49.
PhosphoSitePlusiQ6UW49.

Polymorphism and mutation databases

BioMutaiSPESP1.
DMDMi317373280.

Proteomic databases

PaxDbiQ6UW49.
PeptideAtlasiQ6UW49.
PRIDEiQ6UW49.

Protocols and materials databases

DNASUi246777.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310673; ENSP00000312284; ENSG00000258484.
GeneIDi246777.
KEGGihsa:246777.
UCSCiuc002arn.2. human.

Organism-specific databases

CTDi246777.
DisGeNETi246777.
GeneCardsiSPESP1.
HGNCiHGNC:15570. SPESP1.
HPAiHPA045936.
HPA051040.
MIMi609399. gene.
neXtProtiNX_Q6UW49.
OpenTargetsiENSG00000258484.
PharmGKBiPA37980.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J31A. Eukaryota.
ENOG41114JR. LUCA.
GeneTreeiENSGT00390000005362.
HOGENOMiHOG000154382.
HOVERGENiHBG093982.
InParanoidiQ6UW49.
KOiK19923.
OMAiEEQNLNH.
OrthoDBiEOG091G0OPE.
PhylomeDBiQ6UW49.
TreeFamiTF337441.

Miscellaneous databases

GenomeRNAii246777.
PROiQ6UW49.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000258484.
GenevisibleiQ6UW49. HS.

Family and domain databases

InterProiIPR026743. Equatorial_segment.
[Graphical view]
PANTHERiPTHR31667. PTHR31667. 1 hit.
PfamiPF15754. SPESP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPESP_HUMAN
AccessioniPrimary (citable) accession number: Q6UW49
Secondary accession number(s): Q8NG22, Q8WVH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.