Q6UW32 (IGFL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Insulin growth factor-like family member 1

Gene names

Name:	IGFL1
ORF Names:	UNQ644/PRO1274

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable ligand of the IGFLR1 cell membrane receptor. Ref.5
Subunit structure	Homodimer; disulfide-linked. Ref.5
Subcellular location	Secreted Ref.1 Ref.5.
Tissue specificity	Detected in ovary and spinal cord. Ref.1
Sequence similarities	Belongs to the IGFL family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	extracellular space Inferred from direct assay Ref.5. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.5. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IGFLR1	Q9H665	5	EBI-3870426,EBI-3870439

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Ref.4
	Chain	25 – 110	86	Insulin growth factor-like family member 1		PRO_0000044633
Amino acid modifications
	Glycosylation	71	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6UW32 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 51087608C0D5949E	FASTA	110	12,363
	10 20 30 40 50 60 MAPRGCIVAV FAIFCISRLL CSHGAPVAPM TPYLMLCQPH KRCGDKFYDP LQHCCYDDAV 70 80 90 100 110 VPLARTQTCG NCTFRVCFEQ CCPWTFMVKL INQNCDSART SDDRLCRSVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily." Emtage P., Vatta P., Arterburn M., Muller M.W., Park E., Boyle B., Hazell S., Polizotto R., Funk W.D., Tang Y.T. Genomics 88:513-520(2006) [PubMed: 16890402] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-39.
[5]	"Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1." Lobito A.A., Ramani S.R., Tom I., Bazan J.F., Luis E., Fairbrother W.J., Ouyang W., Gonzalez L.C. J. Biol. Chem. 286:18969-18981(2011) [PubMed: 21454693] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, HOMODIMERIZATION, DISULFIDE BONDS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY672111 mRNA. Translation: AAT77785.1. AY359013 mRNA. Translation: AAQ89372.1. AC006262 Genomic DNA. No translation available.
IPI	IPI00374666.
RefSeq	NP_940943.1. NM_198541.1.
UniGene	Hs.546554.
3D structure databases
ProteinModelPortal	Q6UW32.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6UW32. 3 interactions.
STRING	Q6UW32.
Polymorphism databases
DMDM	74738058.
Proteomic databases
PRIDE	Q6UW32.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341204; ENSP00000344327; ENSG00000188293. ENST00000437936; ENSP00000415823; ENSG00000188293.
GeneID	374918.
KEGG	hsa:374918.
NMPDR	fig|9606.3.peg.16727.
UCSC	uc002pee.1. human.
Organism-specific databases
CTD	374918.
GeneCards	GC19P046733.
H-InvDB	HIX0040067.
HGNC	HGNC:24093. IGFL1.
HPA	HPA014270.
MIM	610544. gene.
neXtProt	NX_Q6UW32.
PharmGKB	PA147357921.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20007.
GeneTree	ENSGT00390000009557.
HOGENOM	HBG506017.
InParanoid	Q6UW32.
OMA	EQCCPWT.
OrthoDB	EOG4DZ1WX.
PhylomeDB	Q6UW32.
Gene expression databases
ArrayExpress	Q6UW32.
Bgee	Q6UW32.
CleanEx	HS_IGFL1.
Genevestigator	Q6UW32.
GermOnline	ENSG00000188293. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	100333.
SOURCE	Search...

Entry information

Entry name

IGFL1_HUMAN

Accession

Primary (citable) accession number: Q6UW32

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.