Reviewed, UniProtKB/Swiss-Prot Q6UW32 (IGFL1_HUMAN)

Names and origin

Protein names

Recommended name:
    Insulin growth factor-like family member 1

Gene names

Name:	IGFL1
ORF Names:	UNQ644/PRO1274

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the IGFL family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Ref.3
	Chain	25 – 110	86	Insulin growth factor-like family member 1		PRO_0000044633
Amino acid modifications
	Glycosylation	71	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6UW32-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 51087608C0D5949E	FASTA	110	12,363
	10 20 30 40 50 60 MAPRGCIVAV FAIFCISRLL CSHGAPVAPM TPYLMLCQPH KRCGDKFYDP LQHCCYDDAV 70 80 90 100 110 VPLARTQTCG NCTFRVCFEQ CCPWTFMVKL INQNCDSART SDDRLCRSVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"IGFL: a secreted family with conserved cysteine residues and sequence similarity to the IGF superfamily." Tang Y.T., Emtage P., Arterburn M., Park E., Boyle B., Hazell S., Polizotto R., Hu T., Funk W. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-39.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY672111 mRNA. Translation: AAT77785.1. AY359013 mRNA. Translation: AAQ89372.1.
IPI	IPI00374666.
RefSeq	NP_940943.1.
UniGene	Hs.546554
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q6UW32.
Genome annotation databases
Ensembl	ENSG00000188293. Homo sapiens. [Contig view]
GeneID	374918.
KEGG	hsa:374918.
NMPDR	fig|9606.3.peg.16727.
Organism-specific databases
GeneCards	GC19P051425.
H-InvDB	HIX0040067.
HGNC	HGNC:24093. IGFL1.
MIM	610544. gene.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q6UW32.
HOVERGEN	Q6UW32.
Gene expression databases
ArrayExpress	Q6UW32.
CleanEx	HS_IGFL1.
GermOnline	ENSG00000188293. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	100333.
SOURCE	Search...

Entry information

Entry name

IGFL1_HUMAN

Accession

Primary (citable) accession number: Q6UW32

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)