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Q6UW02 (CP20A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 20A1

EC=1.14.-.-
Gene names
Name:CYP20A1
ORF Names:UNQ667/PRO1301
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Cytochrome P450 20A1
PRO_0000318095

Regions

Transmembrane4 – 2421Helical; Potential

Sites

Metal binding4091Iron (heme axial ligand) By similarity

Natural variations

Natural variant971S → L. Ref.3
Corresponds to variant rs2043449 [ dbSNP | Ensembl ].
VAR_059153
Natural variant3461L → F. Ref.3
Corresponds to variant rs1048013 [ dbSNP | Ensembl ].
VAR_059154

Experimental info

Sequence conflict1241K → E in AAH20616. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q6UW02 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4C0FEFFA0B9B055A

FASTA46252,432
        10         20         30         40         50         60 
MLDFAIFAVT FLLALVGAVL YLYPASRQAA GIPGITPTEE KDGNLPDIVN SGSLHEFLVN 

        70         80         90        100        110        120 
LHERYGPVVS FWFGRRLVVS LGTVDVLKQH INPNKTSDPF ETMLKSLLRY QSGGGSVSEN 

       130        140        150        160        170        180 
HMRKKLYENG VTDSLKSNFA LLLKLSEELL DKWLSYPETQ HVPLSQHMLG FAMKSVTQMV 

       190        200        210        220        230        240 
MGSTFEDDQE VIRFQKNHGT VWSEIGKGFL DGSLDKNMTR KKQYEDALMQ LESVLRNIIK 

       250        260        270        280        290        300 
ERKGRNFSQH IFIDSLVQGN LNDQQILEDS MIFSLASCII TAKLCTWAIC FLTTSEEVQK 

       310        320        330        340        350        360 
KLYEEINQVF GNGPVTPEKI EQLRYCQHVL CETVRTAKLT PVSAQLQDIE GKIDRFIIPR 

       370        380        390        400        410        420 
ETLVLYALGV VLQDPNTWPS PHKFDPDRFD DELVMKTFSS LGFSGTQECP ELRFAYMVTT 

       430        440        450        460 
VLLSVLVKRL HLLSVEGQVI ETKYELVTSS REEAWITVSK RY 

« Hide

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-97 AND PHE-346.
Tissue: Blood and Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY359068 mRNA. Translation: AAQ89427.1.
AC011737 Genomic DNA. Translation: AAX88915.1.
BC020616 mRNA. Translation: AAH20616.1.
BC033752 mRNA. Translation: AAH33752.1.
RefSeqNP_803882.1. NM_177538.2.
UniGeneHs.446065.
Hs.707756.

3D structure databases

ProteinModelPortalQ6UW02.
SMRQ6UW02. Positions 31-436.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121506. 1 interaction.
STRING9606.ENSP00000348380.

PTM databases

PhosphoSiteQ6UW02.

Polymorphism databases

DMDM74749375.

Proteomic databases

PaxDbQ6UW02.
PRIDEQ6UW02.

Protocols and materials databases

DNASU57404.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356079; ENSP00000348380; ENSG00000119004.
GeneID57404.
KEGGhsa:57404.
UCSCuc002uzv.4. human.

Organism-specific databases

CTD57404.
GeneCardsGC02P204103.
HGNCHGNC:20576. CYP20A1.
HPAHPA055872.
HPA058461.
neXtProtNX_Q6UW02.
PharmGKBPA134911420.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000111913.
HOVERGENHBG076231.
InParanoidQ6UW02.
KOK07435.
OrthoDBEOG7QC7VZ.
PhylomeDBQ6UW02.
TreeFamTF105089.

Gene expression databases

ArrayExpressQ6UW02.
BgeeQ6UW02.
CleanExHS_CYP20A1.
GenevestigatorQ6UW02.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
SUPFAMSSF48264. SSF48264. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCYP20A1. human.
GeneWikiCYP20A1.
GenomeRNAi57404.
NextBio63512.
PROQ6UW02.

Entry information

Entry nameCP20A_HUMAN
AccessionPrimary (citable) accession number: Q6UW02
Secondary accession number(s): Q4ZG61, Q8N4Q8, Q8WWA9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM