Reviewed,
UniProtKB/Swiss-Prot Q6UW01 (CBLN3_HUMAN)
Last modified
January 19, 2010.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Cerebellin-3 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 205 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be involved in synaptic functions in the CNS. |
| Subunit structure | Heterohexamer; disulfide-linked heterotrimers. Does not homooligomerize, but probably forms a complex with at least CBLN1. May interact with CBLN2 and CBLN4 By similarity. |
| Subcellular location | Secreted. Cell junction › synapse By similarity. Note: Secretion depends probably on a association with CBLN1 or perhaps CBLN4 but not on CBLN2 By similarity. |
| Sequence similarities | Contains 1 C1q domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell junction Secreted Synapse |
| Domain | Signal |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | cell junction Inferred from electronic annotation. Source: UniProtKB-KW extracellular regionInferred from electronic annotation. Source: UniProtKB-SubCell synapseInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 32 | 32 | Ref.2 | ||||||
| Chain | 33 – 205 | 173 | Cerebellin-3 | PRO_0000003554 | |||||
Regions | |||||||||
| Domain | 67 – 205 | 139 | C1q | ||||||
| Region | 72 – 205 | 134 | Necessary for interaction with CBLN3, and homotrimerization By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 90 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Disulfide bond | 45 | Interchain By similarity | |||||||
| Disulfide bond | 49 | Interchain By similarity | |||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E.  Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 33-47. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY359070 mRNA. Translation: AAQ89429.1. |
| IPI | IPI00402157. |
| RefSeq | NP_001034860.1. |
| UniGene | Hs.207603 |
3D structure databases | |
| SMR | Q6UW01. Positions 71-205. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6UW01. |
Proteomic databases | |
| PRIDE | Q6UW01. |
Genome annotation databases | |
| Ensembl | ENST00000267406; ENSP00000267406; ENSG00000139899; Homo sapiens. [Genome view] |
| GeneID | 643866. |
| KEGG | hsa:643866. |
| UCSC | uc001wpg.2. human. |
Organism-specific databases | |
| CTD | 643866. |
| GeneCards | GC14M023967. |
| H-InvDB | HIX0037707. |
| HGNC | HGNC:20146. CBLN3. |
| PharmGKB | PA134885212. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG12520. |
| HOGENOM | HBG444750. |
| HOVERGEN | Q6UW01. |
| InParanoid | Q6UW01. |
| OMA | QEGTEPV. |
| OrthoDB | EOG9MGVSJ. |
| PhylomeDB | Q6UW01. |
Gene expression databases | |
| ArrayExpress | Q6UW01. |
| Bgee | Q6UW01. |
| CleanEx | HS_CBLN3. |
| Genevestigator | Q6UW01. |
| GermOnline | ENSG00000139899. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001073. C1q. IPR008983. Tumour_necrosis_fac-like. [Graphical view] |
| Gene3D | G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit. |
| Pfam | PF00386. C1q. 1 hit. [Graphical view] |
| PRINTS | PR00007. COMPLEMNTC1Q. |
| SMART | SM00110. C1Q. 1 hit. [Graphical view] |
| PROSITE | PS50871. C1Q. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 115513. |
Entry information
| Entry name | CBLN3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6UW01 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |
