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Protein

Cerebellin-3

Gene

CBLN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in synaptic functions in the CNS.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebellin-3
Gene namesi
Name:CBLN3
ORF Names:UNQ755/PRO1486
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20146. CBLN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Endoplasmic reticulum, Golgi apparatus, Secreted, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885212.

Polymorphism and mutation databases

BioMutaiCBLN3.
DMDMi52782722.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32321 PublicationAdd
BLAST
Chaini33 – 205173Cerebellin-3PRO_0000003554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 – 45InterchainBy similarity
Disulfide bondi49 – 49InterchainBy similarity
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UW01.
PRIDEiQ6UW01.

PTM databases

PhosphoSiteiQ6UW01.

Expressioni

Gene expression databases

BgeeiQ6UW01.
CleanExiHS_CBLN3.
ExpressionAtlasiQ6UW01. baseline and differential.
GenevisibleiQ6UW01. HS.

Organism-specific databases

HPAiHPA041266.

Interactioni

Subunit structurei

Heterohexamer; disulfide-linked heterotrimers. Interacts with CBLN1. May also form oligomers with CBLN2 AND CBLN4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000267406.

Structurei

3D structure databases

ProteinModelPortaliQ6UW01.
SMRiQ6UW01. Positions 71-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 205139C1qPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni72 – 205134Necessary for interaction with CBLN3, and homotrimerizationBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J973. Eukaryota.
ENOG4111BES. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085657.
HOVERGENiHBG108329.
InParanoidiQ6UW01.
OMAiWAQEGTE.
OrthoDBiEOG7MD4R8.
PhylomeDBiQ6UW01.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UW01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAKPHWLP GPLHSPGLPL VLVLLALGAG WAQEGSEPVL LEGECLVVCE
60 70 80 90 100
PGRAAAGGPG GAALGEAPPG RVAFAAVRSH HHEPAGETGN GTSGAIYFDQ
110 120 130 140 150
VLVNEGGGFD RASGSFVAPV RGVYSFRFHV VKVYNRQTVQ VSLMLNTWPV
160 170 180 190 200
ISAFANDPDV TREAATSSVL LPLDPGDRVS LRLRRGNLLG GWKYSSFSGF

LIFPL
Length:205
Mass (Da):21,521
Last modified:July 5, 2004 - v1
Checksum:i500991AFBB834946
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359070 mRNA. Translation: AAQ89429.1.
CCDSiCCDS32057.1.
RefSeqiNP_001034860.1. NM_001039771.2.
UniGeneiHs.207603.

Genome annotation databases

EnsembliENST00000267406; ENSP00000267406; ENSG00000139899.
GeneIDi643866.
KEGGihsa:643866.
UCSCiuc001wpg.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359070 mRNA. Translation: AAQ89429.1.
CCDSiCCDS32057.1.
RefSeqiNP_001034860.1. NM_001039771.2.
UniGeneiHs.207603.

3D structure databases

ProteinModelPortaliQ6UW01.
SMRiQ6UW01. Positions 71-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000267406.

PTM databases

PhosphoSiteiQ6UW01.

Polymorphism and mutation databases

BioMutaiCBLN3.
DMDMi52782722.

Proteomic databases

PaxDbiQ6UW01.
PRIDEiQ6UW01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267406; ENSP00000267406; ENSG00000139899.
GeneIDi643866.
KEGGihsa:643866.
UCSCiuc001wpg.5. human.

Organism-specific databases

CTDi643866.
GeneCardsiCBLN3.
HGNCiHGNC:20146. CBLN3.
HPAiHPA041266.
MIMi612978. gene.
neXtProtiNX_Q6UW01.
PharmGKBiPA134885212.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J973. Eukaryota.
ENOG4111BES. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085657.
HOVERGENiHBG108329.
InParanoidiQ6UW01.
OMAiWAQEGTE.
OrthoDBiEOG7MD4R8.
PhylomeDBiQ6UW01.
TreeFamiTF329591.

Miscellaneous databases

GenomeRNAii643866.
NextBioi115513.
PROiQ6UW01.
SOURCEiSearch...

Gene expression databases

BgeeiQ6UW01.
CleanExiHS_CBLN3.
ExpressionAtlasiQ6UW01. baseline and differential.
GenevisibleiQ6UW01. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-47.

Entry informationi

Entry nameiCBLN3_HUMAN
AccessioniPrimary (citable) accession number: Q6UW01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.