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Protein

DBH-like monooxygenase protein 1

Gene

MOXD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei203Sequence analysis1
Metal bindingi235Copper ABy similarity1
Metal bindingi236Copper ABy similarity1
Metal bindingi307Copper ABy similarity1
Active sitei389Sequence analysis1
Metal bindingi389Copper BBy similarity1
Metal bindingi391Copper BBy similarity1
Metal bindingi464Copper BBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

SignaLinkiQ6UVY6.

Names & Taxonomyi

Protein namesi
Recommended name:
DBH-like monooxygenase protein 1 (EC:1.14.17.-)
Alternative name(s):
Monooxygenase X
Gene namesi
Name:MOXD1
Synonyms:MOX
ORF Names:UNQ2493/PRO5780
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21063. MOXD1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 592LumenalSequence analysisAdd BLAST573
Transmembranei593 – 613HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: CACAO
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26002.
OpenTargetsiENSG00000079931.
PharmGKBiPA134979178.

Polymorphism and mutation databases

BioMutaiMOXD1.
DMDMi74749373.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000030521720 – 613DBH-like monooxygenase protein 1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi205 ↔ 257By similarity
Disulfide bondi242 ↔ 269By similarity
Glycosylationi247N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi364 ↔ 480By similarity
Disulfide bondi368 ↔ 550By similarity
Disulfide bondi443 ↔ 465By similarity
Glycosylationi476N-linked (GlcNAc...)Sequence analysis1
Glycosylationi517N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6UVY6.
MaxQBiQ6UVY6.
PaxDbiQ6UVY6.
PeptideAtlasiQ6UVY6.
PRIDEiQ6UVY6.

PTM databases

iPTMnetiQ6UVY6.
PhosphoSitePlusiQ6UVY6.

Expressioni

Tissue specificityi

Highly expressed in lung, kidney, brain and spinal cord.2 Publications

Developmental stagei

Expressed in fetal liver and fetal brain.1 Publication

Inductioni

By replicative senescence.1 Publication

Gene expression databases

BgeeiENSG00000079931.
CleanExiHS_MOXD1.
ExpressionAtlasiQ6UVY6. baseline and differential.
GenevisibleiQ6UVY6. HS.

Organism-specific databases

HPAiHPA035740.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GLRX3O760035EBI-7134667,EBI-374781

Protein-protein interaction databases

BioGridi117478. 24 interactors.
IntActiQ6UVY6. 2 interactors.
MINTiMINT-6776984.
STRINGi9606.ENSP00000356940.

Structurei

3D structure databases

ProteinModelPortaliQ6UVY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 148DOMONPROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Contains 1 DOMON domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3568. Eukaryota.
ENOG410XR89. LUCA.
GeneTreeiENSGT00530000063085.
HOGENOMiHOG000037925.
HOVERGENiHBG100597.
InParanoidiQ6UVY6.
OMAiQDYFTNA.
OrthoDBiEOG091G06B3.
PhylomeDBiQ6UVY6.
TreeFamiTF320698.

Family and domain databases

Gene3Di2.60.120.230. 1 hit.
2.60.120.310. 1 hit.
InterProiIPR014784. Cu2_ascorb_mOase-like_C.
IPR000323. Cu2_ascorb_mOase_N.
IPR024548. Cu2_monoox_C.
IPR000945. DBH-rel.
IPR005018. DOMON_domain.
IPR028463. MOXD1.
IPR008977. PHM/PNGase_F_dom.
[Graphical view]
PANTHERiPTHR10157. PTHR10157. 1 hit.
PTHR10157:SF28. PTHR10157:SF28. 1 hit.
PfamiPF03712. Cu2_monoox_C. 1 hit.
PF01082. Cu2_monooxygen. 1 hit.
PF03351. DOMON. 1 hit.
[Graphical view]
PRINTSiPR00767. DBMONOXGNASE.
SMARTiSM00664. DoH. 1 hit.
[Graphical view]
SUPFAMiSSF49742. SSF49742. 2 hits.
PROSITEiPS50836. DOMON. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UVY6-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCCWPLLLLW GLLPGTAAGG SGRTYPHRTL LDSEGKYWLG WSQRGSQIAF
60 70 80 90 100
RLQVRTAGYV GFGFSPTGAM ASADIVVGGV AHGRPYLQDY FTNANRELKK
110 120 130 140 150
DAQQDYHLEY AMENSTHTII EFTRELHTCD INDKSITDST VRVIWAYHHE
160 170 180 190 200
DAGEAGPKYH DSNRGTKSLR LLNPEKTSVL STALPYFDLV NQDVPIPNKD
210 220 230 240 250
TTYWCQMFKI PVFQEKHHVI KVEPVIQRGH ESLVHHILLY QCSNNFNDSV
260 270 280 290 300
LESGHECYHP NMPDAFLTCE TVIFAWAIGG EGFSYPPHVG LSLGTPLDPH
310 320 330 340 350
YVLLEVHYDN PTYEEGLIDN SGLRLFYTMD IRKYDAGVIE AGLWVSLFHT
360 370 380 390 400
IPPGMPEFQS EGHCTLECLE EALEAEKPSG IHVFAVLLHA HLAGRGIRLR
410 420 430 440 450
HFRKGKEMKL LAYDDDFDFN FQEFQYLKEE QTILPGDNLI TECRYNTKDR
460 470 480 490 500
AEMTWGGLST RSEMCLSYLL YYPRINLTRC ASIPDIMEQL QFIGVKEIYR
510 520 530 540 550
PVTTWPFIIK SPKQYKNLSF MDAMNKFKWT KKEGLSFNKL VLSLPVNVRC
560 570 580 590 600
SKTDNAEWSI QGMTALPPDI ERPYKAEPLV CGTSSSSSLH RDFSINLLVC
610
LLLLSCTLST KSL
Note: Major.
Length:613
Mass (Da):69,652
Last modified:July 5, 2004 - v1
Checksum:i57B407655A8294BB
GO
Isoform 2 (identifier: Q6UVY6-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     27-87: HRTLLDSEGK...GGVAHGRPYL → MNSFLSVFRYPDFSFPYFP

Show »
Length:545
Mass (Da):62,700
Checksum:iB0E23E7DE2B03CD7
GO

Sequence cautioni

The sequence BAC11263 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148H → Y in BAC11263 (PubMed:14702039).Curated1
Sequence conflicti438N → Y in CAB45692 (PubMed:17974005).Curated1
Sequence conflicti512P → L in AAG09636 (PubMed:9751809).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035185488E → Q.Corresponds to variant rs36075540dbSNPEnsembl.1
Natural variantiVAR_035186539K → E.1 PublicationCorresponds to variant rs17851680dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0282881 – 26Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_02828927 – 87HRTLL…GRPYL → MNSFLSVFRYPDFSFPYFP in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007239 mRNA. Translation: AAG09636.1.
AY359094 mRNA. Translation: AAQ89452.1.
AL357034, AL023578 Genomic DNA. Translation: CAI15715.1.
AL357034, AL023578 Genomic DNA. Translation: CAI15718.1.
AL023578, AL357034 Genomic DNA. Translation: CAI19937.1.
AL023578, AL357034 Genomic DNA. Translation: CAI19938.1.
CH471051 Genomic DNA. Translation: EAW48033.1.
CH471051 Genomic DNA. Translation: EAW48034.1.
BC018756 mRNA. Translation: AAH18756.1.
AK074879 mRNA. Translation: BAC11263.1. Different initiation.
AL080058 mRNA. Translation: CAB45692.1.
CCDSiCCDS5152.2. [Q6UVY6-1]
PIRiT12460.
RefSeqiNP_056344.2. NM_015529.3. [Q6UVY6-1]
UniGeneiHs.6909.

Genome annotation databases

EnsembliENST00000336749; ENSP00000336998; ENSG00000079931. [Q6UVY6-2]
ENST00000367963; ENSP00000356940; ENSG00000079931. [Q6UVY6-1]
GeneIDi26002.
KEGGihsa:26002.
UCSCiuc003qde.4. human. [Q6UVY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007239 mRNA. Translation: AAG09636.1.
AY359094 mRNA. Translation: AAQ89452.1.
AL357034, AL023578 Genomic DNA. Translation: CAI15715.1.
AL357034, AL023578 Genomic DNA. Translation: CAI15718.1.
AL023578, AL357034 Genomic DNA. Translation: CAI19937.1.
AL023578, AL357034 Genomic DNA. Translation: CAI19938.1.
CH471051 Genomic DNA. Translation: EAW48033.1.
CH471051 Genomic DNA. Translation: EAW48034.1.
BC018756 mRNA. Translation: AAH18756.1.
AK074879 mRNA. Translation: BAC11263.1. Different initiation.
AL080058 mRNA. Translation: CAB45692.1.
CCDSiCCDS5152.2. [Q6UVY6-1]
PIRiT12460.
RefSeqiNP_056344.2. NM_015529.3. [Q6UVY6-1]
UniGeneiHs.6909.

3D structure databases

ProteinModelPortaliQ6UVY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117478. 24 interactors.
IntActiQ6UVY6. 2 interactors.
MINTiMINT-6776984.
STRINGi9606.ENSP00000356940.

PTM databases

iPTMnetiQ6UVY6.
PhosphoSitePlusiQ6UVY6.

Polymorphism and mutation databases

BioMutaiMOXD1.
DMDMi74749373.

Proteomic databases

EPDiQ6UVY6.
MaxQBiQ6UVY6.
PaxDbiQ6UVY6.
PeptideAtlasiQ6UVY6.
PRIDEiQ6UVY6.

Protocols and materials databases

DNASUi26002.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336749; ENSP00000336998; ENSG00000079931. [Q6UVY6-2]
ENST00000367963; ENSP00000356940; ENSG00000079931. [Q6UVY6-1]
GeneIDi26002.
KEGGihsa:26002.
UCSCiuc003qde.4. human. [Q6UVY6-1]

Organism-specific databases

CTDi26002.
DisGeNETi26002.
GeneCardsiMOXD1.
HGNCiHGNC:21063. MOXD1.
HPAiHPA035740.
MIMi609000. gene.
neXtProtiNX_Q6UVY6.
OpenTargetsiENSG00000079931.
PharmGKBiPA134979178.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3568. Eukaryota.
ENOG410XR89. LUCA.
GeneTreeiENSGT00530000063085.
HOGENOMiHOG000037925.
HOVERGENiHBG100597.
InParanoidiQ6UVY6.
OMAiQDYFTNA.
OrthoDBiEOG091G06B3.
PhylomeDBiQ6UVY6.
TreeFamiTF320698.

Enzyme and pathway databases

SignaLinkiQ6UVY6.

Miscellaneous databases

ChiTaRSiMOXD1. human.
GeneWikiiMonooxygenase_DBH-like_1.
GenomeRNAii26002.
PROiQ6UVY6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079931.
CleanExiHS_MOXD1.
ExpressionAtlasiQ6UVY6. baseline and differential.
GenevisibleiQ6UVY6. HS.

Family and domain databases

Gene3Di2.60.120.230. 1 hit.
2.60.120.310. 1 hit.
InterProiIPR014784. Cu2_ascorb_mOase-like_C.
IPR000323. Cu2_ascorb_mOase_N.
IPR024548. Cu2_monoox_C.
IPR000945. DBH-rel.
IPR005018. DOMON_domain.
IPR028463. MOXD1.
IPR008977. PHM/PNGase_F_dom.
[Graphical view]
PANTHERiPTHR10157. PTHR10157. 1 hit.
PTHR10157:SF28. PTHR10157:SF28. 1 hit.
PfamiPF03712. Cu2_monoox_C. 1 hit.
PF01082. Cu2_monooxygen. 1 hit.
PF03351. DOMON. 1 hit.
[Graphical view]
PRINTSiPR00767. DBMONOXGNASE.
SMARTiSM00664. DoH. 1 hit.
[Graphical view]
SUPFAMiSSF49742. SSF49742. 2 hits.
PROSITEiPS50836. DOMON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOXD1_HUMAN
AccessioniPrimary (citable) accession number: Q6UVY6
Secondary accession number(s): Q5THU6
, Q8NC97, Q8WV49, Q9H4M6, Q9Y4U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.