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Protein

DBH-like monooxygenase protein 1

Gene

MOXD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei203 – 2031Sequence analysis
Metal bindingi235 – 2351Copper ABy similarity
Metal bindingi236 – 2361Copper ABy similarity
Metal bindingi307 – 3071Copper ABy similarity
Active sitei389 – 3891Sequence analysis
Metal bindingi389 – 3891Copper BBy similarity
Metal bindingi391 – 3911Copper BBy similarity
Metal bindingi464 – 4641Copper BBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

SignaLinkiQ6UVY6.

Names & Taxonomyi

Protein namesi
Recommended name:
DBH-like monooxygenase protein 1 (EC:1.14.17.-)
Alternative name(s):
Monooxygenase X
Gene namesi
Name:MOXD1
Synonyms:MOX
ORF Names:UNQ2493/PRO5780
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21063. MOXD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 592573LumenalSequence analysisAdd
BLAST
Transmembranei593 – 61321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: CACAO
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979178.

Polymorphism and mutation databases

BioMutaiMOXD1.
DMDMi74749373.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 613594DBH-like monooxygenase protein 1PRO_0000305217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi205 ↔ 257By similarity
Disulfide bondi242 ↔ 269By similarity
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence analysis
Disulfide bondi364 ↔ 480By similarity
Disulfide bondi368 ↔ 550By similarity
Disulfide bondi443 ↔ 465By similarity
Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence analysis
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6UVY6.
MaxQBiQ6UVY6.
PaxDbiQ6UVY6.
PRIDEiQ6UVY6.

PTM databases

iPTMnetiQ6UVY6.
PhosphoSiteiQ6UVY6.

Expressioni

Tissue specificityi

Highly expressed in lung, kidney, brain and spinal cord.2 Publications

Developmental stagei

Expressed in fetal liver and fetal brain.1 Publication

Inductioni

By replicative senescence.1 Publication

Gene expression databases

BgeeiQ6UVY6.
CleanExiHS_MOXD1.
ExpressionAtlasiQ6UVY6. baseline and differential.
GenevisibleiQ6UVY6. HS.

Organism-specific databases

HPAiHPA035740.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GLRX3O760033EBI-7134667,EBI-374781

Protein-protein interaction databases

BioGridi117478. 24 interactions.
IntActiQ6UVY6. 2 interactions.
MINTiMINT-6776984.
STRINGi9606.ENSP00000356940.

Structurei

3D structure databases

ProteinModelPortaliQ6UVY6.
SMRiQ6UVY6. Positions 197-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 148114DOMONPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DOMON domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3568. Eukaryota.
ENOG410XR89. LUCA.
GeneTreeiENSGT00530000063085.
HOGENOMiHOG000037925.
HOVERGENiHBG100597.
InParanoidiQ6UVY6.
OMAiQDYFTNA.
OrthoDBiEOG7XDBFB.
PhylomeDBiQ6UVY6.
TreeFamiTF320698.

Family and domain databases

Gene3Di2.60.120.230. 1 hit.
2.60.120.310. 1 hit.
InterProiIPR014784. Cu2_ascorb_mOase-like_C.
IPR000323. Cu2_ascorb_mOase_N.
IPR024548. Cu2_monoox_C.
IPR000945. DBH-rel.
IPR005018. DOMON_domain.
IPR028463. MOXD1.
IPR008977. PHM/PNGase_F_dom.
[Graphical view]
PANTHERiPTHR10157. PTHR10157. 1 hit.
PTHR10157:SF28. PTHR10157:SF28. 1 hit.
PfamiPF03712. Cu2_monoox_C. 1 hit.
PF01082. Cu2_monooxygen. 1 hit.
PF03351. DOMON. 1 hit.
[Graphical view]
PRINTSiPR00767. DBMONOXGNASE.
SMARTiSM00664. DoH. 1 hit.
[Graphical view]
SUPFAMiSSF49742. SSF49742. 2 hits.
PROSITEiPS50836. DOMON. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UVY6-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCCWPLLLLW GLLPGTAAGG SGRTYPHRTL LDSEGKYWLG WSQRGSQIAF
60 70 80 90 100
RLQVRTAGYV GFGFSPTGAM ASADIVVGGV AHGRPYLQDY FTNANRELKK
110 120 130 140 150
DAQQDYHLEY AMENSTHTII EFTRELHTCD INDKSITDST VRVIWAYHHE
160 170 180 190 200
DAGEAGPKYH DSNRGTKSLR LLNPEKTSVL STALPYFDLV NQDVPIPNKD
210 220 230 240 250
TTYWCQMFKI PVFQEKHHVI KVEPVIQRGH ESLVHHILLY QCSNNFNDSV
260 270 280 290 300
LESGHECYHP NMPDAFLTCE TVIFAWAIGG EGFSYPPHVG LSLGTPLDPH
310 320 330 340 350
YVLLEVHYDN PTYEEGLIDN SGLRLFYTMD IRKYDAGVIE AGLWVSLFHT
360 370 380 390 400
IPPGMPEFQS EGHCTLECLE EALEAEKPSG IHVFAVLLHA HLAGRGIRLR
410 420 430 440 450
HFRKGKEMKL LAYDDDFDFN FQEFQYLKEE QTILPGDNLI TECRYNTKDR
460 470 480 490 500
AEMTWGGLST RSEMCLSYLL YYPRINLTRC ASIPDIMEQL QFIGVKEIYR
510 520 530 540 550
PVTTWPFIIK SPKQYKNLSF MDAMNKFKWT KKEGLSFNKL VLSLPVNVRC
560 570 580 590 600
SKTDNAEWSI QGMTALPPDI ERPYKAEPLV CGTSSSSSLH RDFSINLLVC
610
LLLLSCTLST KSL
Note: Major.
Length:613
Mass (Da):69,652
Last modified:July 5, 2004 - v1
Checksum:i57B407655A8294BB
GO
Isoform 2 (identifier: Q6UVY6-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     27-87: HRTLLDSEGK...GGVAHGRPYL → MNSFLSVFRYPDFSFPYFP

Show »
Length:545
Mass (Da):62,700
Checksum:iB0E23E7DE2B03CD7
GO

Sequence cautioni

The sequence BAC11263.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481H → Y in BAC11263 (PubMed:14702039).Curated
Sequence conflicti438 – 4381N → Y in CAB45692 (PubMed:17974005).Curated
Sequence conflicti512 – 5121P → L in AAG09636 (PubMed:9751809).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti488 – 4881E → Q.
Corresponds to variant rs36075540 [ dbSNP | Ensembl ].
VAR_035185
Natural varianti539 – 5391K → E.1 Publication
Corresponds to variant rs17851680 [ dbSNP | Ensembl ].
VAR_035186

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2626Missing in isoform 2. 1 PublicationVSP_028288Add
BLAST
Alternative sequencei27 – 8761HRTLL…GRPYL → MNSFLSVFRYPDFSFPYFP in isoform 2. 1 PublicationVSP_028289Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007239 mRNA. Translation: AAG09636.1.
AY359094 mRNA. Translation: AAQ89452.1.
AL357034, AL023578 Genomic DNA. Translation: CAI15715.1.
AL357034, AL023578 Genomic DNA. Translation: CAI15718.1.
AL023578, AL357034 Genomic DNA. Translation: CAI19937.1.
AL023578, AL357034 Genomic DNA. Translation: CAI19938.1.
CH471051 Genomic DNA. Translation: EAW48033.1.
CH471051 Genomic DNA. Translation: EAW48034.1.
BC018756 mRNA. Translation: AAH18756.1.
AK074879 mRNA. Translation: BAC11263.1. Different initiation.
AL080058 mRNA. Translation: CAB45692.1.
CCDSiCCDS5152.2. [Q6UVY6-1]
PIRiT12460.
RefSeqiNP_056344.2. NM_015529.3. [Q6UVY6-1]
UniGeneiHs.6909.

Genome annotation databases

EnsembliENST00000336749; ENSP00000336998; ENSG00000079931. [Q6UVY6-2]
ENST00000367963; ENSP00000356940; ENSG00000079931. [Q6UVY6-1]
GeneIDi26002.
KEGGihsa:26002.
UCSCiuc003qde.4. human. [Q6UVY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007239 mRNA. Translation: AAG09636.1.
AY359094 mRNA. Translation: AAQ89452.1.
AL357034, AL023578 Genomic DNA. Translation: CAI15715.1.
AL357034, AL023578 Genomic DNA. Translation: CAI15718.1.
AL023578, AL357034 Genomic DNA. Translation: CAI19937.1.
AL023578, AL357034 Genomic DNA. Translation: CAI19938.1.
CH471051 Genomic DNA. Translation: EAW48033.1.
CH471051 Genomic DNA. Translation: EAW48034.1.
BC018756 mRNA. Translation: AAH18756.1.
AK074879 mRNA. Translation: BAC11263.1. Different initiation.
AL080058 mRNA. Translation: CAB45692.1.
CCDSiCCDS5152.2. [Q6UVY6-1]
PIRiT12460.
RefSeqiNP_056344.2. NM_015529.3. [Q6UVY6-1]
UniGeneiHs.6909.

3D structure databases

ProteinModelPortaliQ6UVY6.
SMRiQ6UVY6. Positions 197-472.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117478. 24 interactions.
IntActiQ6UVY6. 2 interactions.
MINTiMINT-6776984.
STRINGi9606.ENSP00000356940.

PTM databases

iPTMnetiQ6UVY6.
PhosphoSiteiQ6UVY6.

Polymorphism and mutation databases

BioMutaiMOXD1.
DMDMi74749373.

Proteomic databases

EPDiQ6UVY6.
MaxQBiQ6UVY6.
PaxDbiQ6UVY6.
PRIDEiQ6UVY6.

Protocols and materials databases

DNASUi26002.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336749; ENSP00000336998; ENSG00000079931. [Q6UVY6-2]
ENST00000367963; ENSP00000356940; ENSG00000079931. [Q6UVY6-1]
GeneIDi26002.
KEGGihsa:26002.
UCSCiuc003qde.4. human. [Q6UVY6-1]

Organism-specific databases

CTDi26002.
GeneCardsiMOXD1.
HGNCiHGNC:21063. MOXD1.
HPAiHPA035740.
MIMi609000. gene.
neXtProtiNX_Q6UVY6.
PharmGKBiPA134979178.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3568. Eukaryota.
ENOG410XR89. LUCA.
GeneTreeiENSGT00530000063085.
HOGENOMiHOG000037925.
HOVERGENiHBG100597.
InParanoidiQ6UVY6.
OMAiQDYFTNA.
OrthoDBiEOG7XDBFB.
PhylomeDBiQ6UVY6.
TreeFamiTF320698.

Enzyme and pathway databases

SignaLinkiQ6UVY6.

Miscellaneous databases

ChiTaRSiMOXD1. human.
GeneWikiiMonooxygenase_DBH-like_1.
GenomeRNAii26002.
NextBioi47730.
PROiQ6UVY6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6UVY6.
CleanExiHS_MOXD1.
ExpressionAtlasiQ6UVY6. baseline and differential.
GenevisibleiQ6UVY6. HS.

Family and domain databases

Gene3Di2.60.120.230. 1 hit.
2.60.120.310. 1 hit.
InterProiIPR014784. Cu2_ascorb_mOase-like_C.
IPR000323. Cu2_ascorb_mOase_N.
IPR024548. Cu2_monoox_C.
IPR000945. DBH-rel.
IPR005018. DOMON_domain.
IPR028463. MOXD1.
IPR008977. PHM/PNGase_F_dom.
[Graphical view]
PANTHERiPTHR10157. PTHR10157. 1 hit.
PTHR10157:SF28. PTHR10157:SF28. 1 hit.
PfamiPF03712. Cu2_monoox_C. 1 hit.
PF01082. Cu2_monooxygen. 1 hit.
PF03351. DOMON. 1 hit.
[Graphical view]
PRINTSiPR00767. DBMONOXGNASE.
SMARTiSM00664. DoH. 1 hit.
[Graphical view]
SUPFAMiSSF49742. SSF49742. 2 hits.
PROSITEiPS50836. DOMON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of a sequence homologue of dopamine beta-hydroxylase."
    Chambers K.J., Tonkin L.A., Chang E., Shelton D.N., Linskens M.H., Funk W.D.
    Gene 218:111-120(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION.
    Tissue: Fibroblast.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-539.
    Tissue: Skin.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-613 (ISOFORM 1).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 279-613.
    Tissue: Brain.
  8. "Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum."
    Xin X., Mains R.E., Eipper B.A.
    J. Biol. Chem. 279:48159-48167(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiMOXD1_HUMAN
AccessioniPrimary (citable) accession number: Q6UVY6
Secondary accession number(s): Q5THU6
, Q8NC97, Q8WV49, Q9H4M6, Q9Y4U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.