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Q6UVM3

- KCNT2_HUMAN

UniProt

Q6UVM3 - KCNT2_HUMAN

Protein

Potassium channel subfamily T member 2

Gene

KCNT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane By similarity. Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.By similarity2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1025 – 10328ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium-activated potassium channel activity Source: RefGenome
    3. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Potassium channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, Potassium

    Protein family/group databases

    TCDBi1.A.1.3.6. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily T member 2
    Alternative name(s):
    Sequence like an intermediate conductance potassium channel subunit
    Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1
    Gene namesi
    Name:KCNT2
    Synonyms:SLICK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18866. KCNT2.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38726.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11351135Potassium channel subfamily T member 2PRO_0000312503Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ6UVM3.
    PRIDEiQ6UVM3.

    PTM databases

    PhosphoSiteiQ6UVM3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6UVM3.
    BgeeiQ6UVM3.
    CleanExiHS_KCNT2.
    GenevestigatoriQ6UVM3.

    Organism-specific databases

    HPAiHPA051218.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UVM3.
    SMRiQ6UVM3. Positions 227-285, 300-563, 713-914.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6363CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini85 – 10117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 13715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 1646ExtracellularSequence Analysis
    Topological domaini186 – 19813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini220 – 2289ExtracellularSequence Analysis
    Topological domaini250 – 2567ExtracellularSequence Analysis
    Topological domaini278 – 1135858CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei229 – 24921Pore-formingSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8421Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini422 – 543122RCK N-terminalAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RCK N-terminal domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231460.
    HOVERGENiHBG055190.
    InParanoidiQ6UVM3.
    KOiK04947.
    OMAiNQDQQKK.
    OrthoDBiEOG7VTDM4.
    PhylomeDBiQ6UVM3.
    TreeFamiTF314283.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR013099. 2pore_dom_K_chnl_dom.
    IPR003929. K_chnl_Ca-activ_BK_asu.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF03493. BK_channel_a. 1 hit.
    PF07885. Ion_trans_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6UVM3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL     50
    FFIKNQRSSL RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR 100
    SLPLWGLQVS VALISLFETI LLGYLSYKGN IWEQILRIPF ILEIINAVPF 150
    IISIFWPSLR NLFVPVFLNC WLAKHALENM INDLHRAIQR TQSAMFNQVL 200
    ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF STVGFGDVTP 250
    ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK 300
    HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI 350
    PMWSQRVIYL QGSALKDQDL LRAKMDDAEA CFILSSRCEV DRTSSDHQTI 400
    LRAWAVKDFA PNCPLYVQIL KPENKFHIKF ADHVVCEEEF KYAMLALNCI 450
    CPATSTLITL LVHTSRGQEG QQSPEQWQKM YGRCSGNEVY HIVLEESTFF 500
    AEYEGKSFTY ASFHAHKKFG VCLIGVRRED NKNILLNPGP RYIMNSTDIC 550
    FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI IASMGTVAID 600
    LQDTSCRSAS GPTLSLPTEG SKEIRRPSIA PVLEVADTSS IQTCDLLSDQ 650
    SEDETTPDEE MSSNLEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD 700
    KSCQHNYYED AKAYGFKNKL IIVAAETAGN GLYNFIVPLR AYYRPKKELN 750
    PIVLLLDNPP DMHFLDAICW FPMVYYMVGS IDNLDDLLRC GVTFAANMVV 800
    VDKESTMSAE EDYMADAKTI VNVQTLFRLF SSLSIITELT HPANMRFMQF 850
    RAKDCYSLAL SKLEKKERER GSNLAFMFRL PFAAGRVFSI SMLDTLLYQS 900
    FVKDYMISIT RLLLGLDTTP GSGFLCSMKI TADDLWIRTY ARLYQKLCSS 950
    TGDVPIGIYR TESQKLTTSE SQISISVEEW EDTKDSKEQG HHRSNHRNST 1000
    SSDQSDHPLL RRKSMQWARR LSRKGPKHSG KTAEKITQQR LNLYRRSERQ 1050
    ELAELVKNRM KHLGLSTVGY DEMNDHQSTL SYILINPSPD TRIELNDVVY 1100
    LIRPDPLAYL PNSEPSRRNS ICNVTGQDSR EETQL 1135
    Length:1,135
    Mass (Da):130,501
    Last modified:July 5, 2004 - v1
    Checksum:i4957C6DAB1E030CF
    GO
    Isoform 2 (identifier: Q6UVM3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         760-783: Missing.

    Show »
    Length:1,111
    Mass (Da):127,654
    Checksum:iDE4D70DA9B495A9C
    GO
    Isoform 3 (identifier: Q6UVM3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         469-518: Missing.
         760-783: Missing.
         970-970: E → ESRKIASQ

    Show »
    Length:1,068
    Mass (Da):122,551
    Checksum:i1E86C928DE0F5F3A
    GO
    Isoform 4 (identifier: Q6UVM3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         129-153: Missing.
         468-468: Q → QCVCLCCR
         760-783: Missing.
         970-970: E → ESRKIASQ
         1071-1135: DEMNDHQSTL...GQDSREETQL → GMLFKNYCIYGLVISCH

    Show »
    Length:1,052
    Mass (Da):120,830
    Checksum:i50C3939611E2F3DB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331V → I in a breast cancer sample; somatic mutation. 1 Publication
    VAR_037527
    Natural varianti413 – 4131C → W.
    Corresponds to variant rs12738104 [ dbSNP | Ensembl ].
    VAR_037528
    Natural varianti429 – 4291K → N.
    Corresponds to variant rs12742082 [ dbSNP | Ensembl ].
    VAR_037529

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei129 – 15325Missing in isoform 4. 2 PublicationsVSP_029852Add
    BLAST
    Alternative sequencei468 – 4681Q → QCVCLCCR in isoform 4. 2 PublicationsVSP_029853
    Alternative sequencei469 – 51850Missing in isoform 3. CuratedVSP_029854Add
    BLAST
    Alternative sequencei760 – 78324Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_029855Add
    BLAST
    Alternative sequencei970 – 9701E → ESRKIASQ in isoform 3 and isoform 4. 2 PublicationsVSP_029856
    Alternative sequencei1071 – 113565DEMND…EETQL → GMLFKNYCIYGLVISCH in isoform 4. 2 PublicationsVSP_029857Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359444 mRNA. Translation: AAR06170.1.
    AK131498 mRNA. Translation: BAD18642.1.
    BX647852 mRNA. Translation: CAI46099.1.
    AL358853
    , AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71957.1.
    AL358853
    , AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71958.1.
    AL591604
    , AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72932.1.
    AL591604
    , AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72933.1.
    AL138931
    , AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15623.1.
    AL138931
    , AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15624.1.
    AL139137
    , AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16091.1.
    AL139137
    , AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16092.1.
    BC103948 mRNA. Translation: AAI03949.1.
    BC103949 mRNA. Translation: AAI03950.1.
    BC103950 mRNA. Translation: AAI03951.1.
    CCDSiCCDS1384.1. [Q6UVM3-1]
    RefSeqiNP_001274748.1. NM_001287819.1. [Q6UVM3-2]
    NP_001274749.1. NM_001287820.1. [Q6UVM3-3]
    NP_940905.2. NM_198503.3. [Q6UVM3-1]
    UniGeneiHs.657046.

    Genome annotation databases

    EnsembliENST00000294725; ENSP00000294725; ENSG00000162687. [Q6UVM3-1]
    ENST00000367433; ENSP00000356403; ENSG00000162687. [Q6UVM3-2]
    ENST00000609185; ENSP00000476657; ENSG00000162687. [Q6UVM3-3]
    GeneIDi343450.
    KEGGihsa:343450.
    UCSCiuc001gtd.1. human. [Q6UVM3-1]
    uc001gte.1. human. [Q6UVM3-3]
    uc001gtf.1. human. [Q6UVM3-2]
    uc001gth.1. human. [Q6UVM3-4]

    Polymorphism databases

    DMDMi74749370.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359444 mRNA. Translation: AAR06170.1 .
    AK131498 mRNA. Translation: BAD18642.1 .
    BX647852 mRNA. Translation: CAI46099.1 .
    AL358853
    , AL138931 , AL139137 , AL591604 Genomic DNA. Translation: CAH71957.1 .
    AL358853
    , AL138931 , AL139137 , AL591604 Genomic DNA. Translation: CAH71958.1 .
    AL591604
    , AL138931 , AL139137 , AL358853 Genomic DNA. Translation: CAH72932.1 .
    AL591604
    , AL138931 , AL139137 , AL358853 Genomic DNA. Translation: CAH72933.1 .
    AL138931
    , AL139137 , AL358853 , AL591604 Genomic DNA. Translation: CAI15623.1 .
    AL138931
    , AL139137 , AL358853 , AL591604 Genomic DNA. Translation: CAI15624.1 .
    AL139137
    , AL138931 , AL358853 , AL591604 Genomic DNA. Translation: CAI16091.1 .
    AL139137
    , AL138931 , AL358853 , AL591604 Genomic DNA. Translation: CAI16092.1 .
    BC103948 mRNA. Translation: AAI03949.1 .
    BC103949 mRNA. Translation: AAI03950.1 .
    BC103950 mRNA. Translation: AAI03951.1 .
    CCDSi CCDS1384.1. [Q6UVM3-1 ]
    RefSeqi NP_001274748.1. NM_001287819.1. [Q6UVM3-2 ]
    NP_001274749.1. NM_001287820.1. [Q6UVM3-3 ]
    NP_940905.2. NM_198503.3. [Q6UVM3-1 ]
    UniGenei Hs.657046.

    3D structure databases

    ProteinModelPortali Q6UVM3.
    SMRi Q6UVM3. Positions 227-285, 300-563, 713-914.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 386.

    Protein family/group databases

    TCDBi 1.A.1.3.6. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q6UVM3.

    Polymorphism databases

    DMDMi 74749370.

    Proteomic databases

    PaxDbi Q6UVM3.
    PRIDEi Q6UVM3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294725 ; ENSP00000294725 ; ENSG00000162687 . [Q6UVM3-1 ]
    ENST00000367433 ; ENSP00000356403 ; ENSG00000162687 . [Q6UVM3-2 ]
    ENST00000609185 ; ENSP00000476657 ; ENSG00000162687 . [Q6UVM3-3 ]
    GeneIDi 343450.
    KEGGi hsa:343450.
    UCSCi uc001gtd.1. human. [Q6UVM3-1 ]
    uc001gte.1. human. [Q6UVM3-3 ]
    uc001gtf.1. human. [Q6UVM3-2 ]
    uc001gth.1. human. [Q6UVM3-4 ]

    Organism-specific databases

    CTDi 343450.
    GeneCardsi GC01M196194.
    HGNCi HGNC:18866. KCNT2.
    HPAi HPA051218.
    MIMi 610044. gene.
    neXtProti NX_Q6UVM3.
    PharmGKBi PA38726.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231460.
    HOVERGENi HBG055190.
    InParanoidi Q6UVM3.
    KOi K04947.
    OMAi NQDQQKK.
    OrthoDBi EOG7VTDM4.
    PhylomeDBi Q6UVM3.
    TreeFami TF314283.

    Miscellaneous databases

    GeneWikii KCNT2.
    GenomeRNAii 343450.
    NextBioi 98534.
    PROi Q6UVM3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6UVM3.
    Bgeei Q6UVM3.
    CleanExi HS_KCNT2.
    Genevestigatori Q6UVM3.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR013099. 2pore_dom_K_chnl_dom.
    IPR003929. K_chnl_Ca-activ_BK_asu.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF03493. BK_channel_a. 1 hit.
    PF07885. Ion_trans_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP."
      Bhattacharjee A., Joiner W.J., Wu M., Yang Y., Sigworth F.J., Kaczmarek L.K.
      J. Neurosci. 23:11681-11691(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Adipose tissue.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    6. "Opposite regulation of Slick and Slack K+ channels by neuromodulators."
      Santi C.M., Ferreira G., Yang B., Gazula V.R., Butler A., Wei A., Kaczmarek L.K., Salkoff L.
      J. Neurosci. 26:5059-5068(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION.
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-33.

    Entry informationi

    Entry nameiKCNT2_HUMAN
    AccessioniPrimary (citable) accession number: Q6UVM3
    Secondary accession number(s): Q3SY59, Q5VTN1, Q6ZMT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3