Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6UVM3 (KCNT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel subfamily T member 2
Alternative name(s):
Sequence like an intermediate conductance potassium channel subunit
Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1
Gene names
Name:KCNT2
Synonyms:SLICK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1135 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane By similarity. Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. Ref.1 Ref.6

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Post-translational modification

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity. Ref.6

Sequence similarities

Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily. [View classification]

Contains 1 RCK N-terminal domain.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6UVM3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6UVM3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     760-783: Missing.
Isoform 3 (identifier: Q6UVM3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     469-518: Missing.
     760-783: Missing.
     970-970: E → ESRKIASQ
Isoform 4 (identifier: Q6UVM3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     129-153: Missing.
     468-468: Q → QCVCLCCR
     760-783: Missing.
     970-970: E → ESRKIASQ
     1071-1135: DEMNDHQSTL...GQDSREETQL → GMLFKNYCIYGLVISCH

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11351135Potassium channel subfamily T member 2
PRO_0000312503

Regions

Topological domain1 – 6363Cytoplasmic Potential
Transmembrane64 – 8421Helical; Name=Segment S1; Potential
Topological domain85 – 10117Extracellular Potential
Transmembrane102 – 12221Helical; Name=Segment S2; Potential
Topological domain123 – 13715Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=Segment S3; Potential
Topological domain159 – 1646Extracellular Potential
Transmembrane165 – 18521Helical; Name=Segment S4; Potential
Topological domain186 – 19813Cytoplasmic Potential
Transmembrane199 – 21921Helical; Name=Segment S5; Potential
Topological domain220 – 2289Extracellular Potential
Intramembrane229 – 24921Pore-forming; Potential
Topological domain250 – 2567Extracellular Potential
Transmembrane257 – 27721Helical; Name=Segment S6; Potential
Topological domain278 – 1135858Cytoplasmic Potential
Domain422 – 543122RCK N-terminal
Nucleotide binding1025 – 10328ATP Potential

Amino acid modifications

Glycosylation991N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence129 – 15325Missing in isoform 4.
VSP_029852
Alternative sequence4681Q → QCVCLCCR in isoform 4.
VSP_029853
Alternative sequence469 – 51850Missing in isoform 3.
VSP_029854
Alternative sequence760 – 78324Missing in isoform 2, isoform 3 and isoform 4.
VSP_029855
Alternative sequence9701E → ESRKIASQ in isoform 3 and isoform 4.
VSP_029856
Alternative sequence1071 – 113565DEMND…EETQL → GMLFKNYCIYGLVISCH in isoform 4.
VSP_029857
Natural variant331V → I in a breast cancer sample; somatic mutation. Ref.7
VAR_037527
Natural variant4131C → W.
Corresponds to variant rs12738104 [ dbSNP | Ensembl ].
VAR_037528
Natural variant4291K → N.
Corresponds to variant rs12742082 [ dbSNP | Ensembl ].
VAR_037529

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4957C6DAB1E030CF

FASTA1,135130,501
        10         20         30         40         50         60 
MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL FFIKNQRSSL 

        70         80         90        100        110        120 
RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR SLPLWGLQVS VALISLFETI 

       130        140        150        160        170        180 
LLGYLSYKGN IWEQILRIPF ILEIINAVPF IISIFWPSLR NLFVPVFLNC WLAKHALENM 

       190        200        210        220        230        240 
INDLHRAIQR TQSAMFNQVL ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF 

       250        260        270        280        290        300 
STVGFGDVTP ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK 

       310        320        330        340        350        360 
HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI PMWSQRVIYL 

       370        380        390        400        410        420 
QGSALKDQDL LRAKMDDAEA CFILSSRCEV DRTSSDHQTI LRAWAVKDFA PNCPLYVQIL 

       430        440        450        460        470        480 
KPENKFHIKF ADHVVCEEEF KYAMLALNCI CPATSTLITL LVHTSRGQEG QQSPEQWQKM 

       490        500        510        520        530        540 
YGRCSGNEVY HIVLEESTFF AEYEGKSFTY ASFHAHKKFG VCLIGVRRED NKNILLNPGP 

       550        560        570        580        590        600 
RYIMNSTDIC FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI IASMGTVAID 

       610        620        630        640        650        660 
LQDTSCRSAS GPTLSLPTEG SKEIRRPSIA PVLEVADTSS IQTCDLLSDQ SEDETTPDEE 

       670        680        690        700        710        720 
MSSNLEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD KSCQHNYYED AKAYGFKNKL 

       730        740        750        760        770        780 
IIVAAETAGN GLYNFIVPLR AYYRPKKELN PIVLLLDNPP DMHFLDAICW FPMVYYMVGS 

       790        800        810        820        830        840 
IDNLDDLLRC GVTFAANMVV VDKESTMSAE EDYMADAKTI VNVQTLFRLF SSLSIITELT 

       850        860        870        880        890        900 
HPANMRFMQF RAKDCYSLAL SKLEKKERER GSNLAFMFRL PFAAGRVFSI SMLDTLLYQS 

       910        920        930        940        950        960 
FVKDYMISIT RLLLGLDTTP GSGFLCSMKI TADDLWIRTY ARLYQKLCSS TGDVPIGIYR 

       970        980        990       1000       1010       1020 
TESQKLTTSE SQISISVEEW EDTKDSKEQG HHRSNHRNST SSDQSDHPLL RRKSMQWARR 

      1030       1040       1050       1060       1070       1080 
LSRKGPKHSG KTAEKITQQR LNLYRRSERQ ELAELVKNRM KHLGLSTVGY DEMNDHQSTL 

      1090       1100       1110       1120       1130 
SYILINPSPD TRIELNDVVY LIRPDPLAYL PNSEPSRRNS ICNVTGQDSR EETQL 

« Hide

Isoform 2 [UniParc].

Checksum: DE4D70DA9B495A9C
Show »

FASTA1,111127,654
Isoform 3 [UniParc].

Checksum: 1E86C928DE0F5F3A
Show »

FASTA1,068122,551
Isoform 4 [UniParc].

Checksum: 50C3939611E2F3DB
Show »

FASTA1,052120,830

References

« Hide 'large scale' references
[1]"Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP."
Bhattacharjee A., Joiner W.J., Wu M., Yang Y., Sigworth F.J., Kaczmarek L.K.
J. Neurosci. 23:11681-11691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Trachea.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Adipose tissue.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
[6]"Opposite regulation of Slick and Slack K+ channels by neuromodulators."
Santi C.M., Ferreira G., Yang B., Gazula V.R., Butler A., Wei A., Kaczmarek L.K., Salkoff L.
J. Neurosci. 26:5059-5068(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION.
[7]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-33.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY359444 mRNA. Translation: AAR06170.1.
AK131498 mRNA. Translation: BAD18642.1.
BX647852 mRNA. Translation: CAI46099.1.
AL358853 expand/collapse EMBL AC list , AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71957.1.
AL358853 expand/collapse EMBL AC list , AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71958.1.
AL591604 expand/collapse EMBL AC list , AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72932.1.
AL591604 expand/collapse EMBL AC list , AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72933.1.
AL138931 expand/collapse EMBL AC list , AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15623.1.
AL138931 expand/collapse EMBL AC list , AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15624.1.
AL139137 expand/collapse EMBL AC list , AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16091.1.
AL139137 expand/collapse EMBL AC list , AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16092.1.
BC103948 mRNA. Translation: AAI03949.1.
BC103949 mRNA. Translation: AAI03950.1.
BC103950 mRNA. Translation: AAI03951.1.
RefSeqNP_001274748.1. NM_001287819.1.
NP_001274749.1. NM_001287820.1.
NP_940905.2. NM_198503.3.
UniGeneHs.657046.

3D structure databases

ProteinModelPortalQ6UVM3.
SMRQ6UVM3. Positions 227-285, 300-563, 713-914.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY386.

Protein family/group databases

TCDB1.A.1.3.6. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteQ6UVM3.

Polymorphism databases

DMDM74749370.

Proteomic databases

PaxDbQ6UVM3.
PRIDEQ6UVM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294725; ENSP00000294725; ENSG00000162687. [Q6UVM3-1]
ENST00000367433; ENSP00000356403; ENSG00000162687. [Q6UVM3-2]
ENST00000609185; ENSP00000476657; ENSG00000162687. [Q6UVM3-3]
GeneID343450.
KEGGhsa:343450.
UCSCuc001gtd.1. human. [Q6UVM3-1]
uc001gte.1. human. [Q6UVM3-3]
uc001gtf.1. human. [Q6UVM3-2]
uc001gth.1. human. [Q6UVM3-4]

Organism-specific databases

CTD343450.
GeneCardsGC01M196194.
HGNCHGNC:18866. KCNT2.
HPAHPA051218.
MIM610044. gene.
neXtProtNX_Q6UVM3.
PharmGKBPA38726.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231460.
HOVERGENHBG055190.
InParanoidQ6UVM3.
KOK04947.
OMANQDQQKK.
OrthoDBEOG7VTDM4.
PhylomeDBQ6UVM3.
TreeFamTF314283.

Gene expression databases

ArrayExpressQ6UVM3.
BgeeQ6UVM3.
CleanExHS_KCNT2.
GenevestigatorQ6UVM3.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR013099. 2pore_dom_K_chnl_dom.
IPR003929. K_chnl_Ca-activ_BK_asu.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKCNT2.
GenomeRNAi343450.
NextBio98534.
PROQ6UVM3.
SOURCESearch...

Entry information

Entry nameKCNT2_HUMAN
AccessionPrimary (citable) accession number: Q6UVM3
Secondary accession number(s): Q3SY59, Q5VTN1, Q6ZMT3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM