Q6UVM3 (KCNT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium channel subfamily T member 2

Alternative name(s):
Sequence like an intermediate conductance potassium channel subunit
Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1

Gene names

Name:	KCNT2
Synonyms:	SLICK

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1135 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane By similarity. Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. Ref.1 Ref.6
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Post-translational modification	Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity. Ref.6
Sequence similarities	Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily. [View classification] Contains 1 RCK N-terminal domain.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding Potassium
Molecular function	Ion channel Potassium channel
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	voltage-gated potassium channel complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-activated potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome voltage-gated potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UVM3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UVM3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     760-783: Missing.

Isoform 3 (identifier: Q6UVM3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     469-518: Missing.
     760-783: Missing.
     970-970: E → ESRKIASQ

Isoform 4 (identifier: Q6UVM3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     129-153: Missing.
     468-468: Q → QCVCLCCR
     760-783: Missing.
     970-970: E → ESRKIASQ
     1071-1135: DEMNDHQSTL...GQDSREETQL → GMLFKNYCIYGLVISCH

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1135	1135	Potassium channel subfamily T member 2		PRO_0000312503
Regions
	Topological domain	1 – 63	63	Cytoplasmic Potential
	Transmembrane	64 – 84	21	Helical; Name=Segment S1; Potential
	Topological domain	85 – 101	17	Extracellular Potential
	Transmembrane	102 – 122	21	Helical; Name=Segment S2; Potential
	Topological domain	123 – 137	15	Cytoplasmic Potential
	Transmembrane	138 – 158	21	Helical; Name=Segment S3; Potential
	Topological domain	159 – 164	6	Extracellular Potential
	Transmembrane	165 – 185	21	Helical; Name=Segment S4; Potential
	Topological domain	186 – 198	13	Cytoplasmic Potential
	Transmembrane	199 – 219	21	Helical; Name=Segment S5; Potential
	Topological domain	220 – 228	9	Extracellular Potential
	Intramembrane	229 – 249	21	Pore-forming; Potential
	Topological domain	250 – 256	7	Extracellular Potential
	Transmembrane	257 – 277	21	Helical; Name=Segment S6; Potential
	Topological domain	278 – 1135	858	Cytoplasmic Potential
	Domain	422 – 543	122	RCK N-terminal
	Nucleotide binding	1025 – 1032	8	ATP Potential
Amino acid modifications
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	129 – 153	25	Missing in isoform 4.		VSP_029852
	Alternative sequence	468	1	Q → QCVCLCCR in isoform 4.		VSP_029853
	Alternative sequence	469 – 518	50	Missing in isoform 3.		VSP_029854
	Alternative sequence	760 – 783	24	Missing in isoform 2, isoform 3 and isoform 4.		VSP_029855
	Alternative sequence	970	1	E → ESRKIASQ in isoform 3 and isoform 4.		VSP_029856
	Alternative sequence	1071 – 1135	65	DEMND…EETQL → GMLFKNYCIYGLVISCH in isoform 4.		VSP_029857
	Natural variant	33	1	V → I in a breast cancer sample; somatic mutation. Ref.7		VAR_037527
	Natural variant	413	1	C → W. Corresponds to variant rs12738104 [ dbSNP | Ensembl ].		VAR_037528
	Natural variant	429	1	K → N. Corresponds to variant rs12742082 [ dbSNP | Ensembl ].		VAR_037529

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4957C6DAB1E030CF	FASTA	1,135	130,501
	10 20 30 40 50 60 MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL FFIKNQRSSL 70 80 90 100 110 120 RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR SLPLWGLQVS VALISLFETI 130 140 150 160 170 180 LLGYLSYKGN IWEQILRIPF ILEIINAVPF IISIFWPSLR NLFVPVFLNC WLAKHALENM 190 200 210 220 230 240 INDLHRAIQR TQSAMFNQVL ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF 250 260 270 280 290 300 STVGFGDVTP ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK 310 320 330 340 350 360 HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI PMWSQRVIYL 370 380 390 400 410 420 QGSALKDQDL LRAKMDDAEA CFILSSRCEV DRTSSDHQTI LRAWAVKDFA PNCPLYVQIL 430 440 450 460 470 480 KPENKFHIKF ADHVVCEEEF KYAMLALNCI CPATSTLITL LVHTSRGQEG QQSPEQWQKM 490 500 510 520 530 540 YGRCSGNEVY HIVLEESTFF AEYEGKSFTY ASFHAHKKFG VCLIGVRRED NKNILLNPGP 550 560 570 580 590 600 RYIMNSTDIC FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI IASMGTVAID 610 620 630 640 650 660 LQDTSCRSAS GPTLSLPTEG SKEIRRPSIA PVLEVADTSS IQTCDLLSDQ SEDETTPDEE 670 680 690 700 710 720 MSSNLEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD KSCQHNYYED AKAYGFKNKL 730 740 750 760 770 780 IIVAAETAGN GLYNFIVPLR AYYRPKKELN PIVLLLDNPP DMHFLDAICW FPMVYYMVGS 790 800 810 820 830 840 IDNLDDLLRC GVTFAANMVV VDKESTMSAE EDYMADAKTI VNVQTLFRLF SSLSIITELT 850 860 870 880 890 900 HPANMRFMQF RAKDCYSLAL SKLEKKERER GSNLAFMFRL PFAAGRVFSI SMLDTLLYQS 910 920 930 940 950 960 FVKDYMISIT RLLLGLDTTP GSGFLCSMKI TADDLWIRTY ARLYQKLCSS TGDVPIGIYR 970 980 990 1000 1010 1020 TESQKLTTSE SQISISVEEW EDTKDSKEQG HHRSNHRNST SSDQSDHPLL RRKSMQWARR 1030 1040 1050 1060 1070 1080 LSRKGPKHSG KTAEKITQQR LNLYRRSERQ ELAELVKNRM KHLGLSTVGY DEMNDHQSTL 1090 1100 1110 1120 1130 SYILINPSPD TRIELNDVVY LIRPDPLAYL PNSEPSRRNS ICNVTGQDSR EETQL
	Isoform 2 [UniParc]. Checksum: DE4D70DA9B495A9C	FASTA	1,111	127,654
	10 20 30 40 50 60 MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL FFIKNQRSSL 70 80 90 100 110 120 RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR SLPLWGLQVS VALISLFETI 130 140 150 160 170 180 LLGYLSYKGN IWEQILRIPF ILEIINAVPF IISIFWPSLR NLFVPVFLNC WLAKHALENM 190 200 210 220 230 240 INDLHRAIQR TQSAMFNQVL ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF 250 260 270 280 290 300 STVGFGDVTP ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK 310 320 330 340 350 360 HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI PMWSQRVIYL 370 380 390 400 410 420 QGSALKDQDL LRAKMDDAEA CFILSSRCEV DRTSSDHQTI LRAWAVKDFA PNCPLYVQIL 430 440 450 460 470 480 KPENKFHIKF ADHVVCEEEF KYAMLALNCI CPATSTLITL LVHTSRGQEG QQSPEQWQKM 490 500 510 520 530 540 YGRCSGNEVY HIVLEESTFF AEYEGKSFTY ASFHAHKKFG VCLIGVRRED NKNILLNPGP 550 560 570 580 590 600 RYIMNSTDIC FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI IASMGTVAID 610 620 630 640 650 660 LQDTSCRSAS GPTLSLPTEG SKEIRRPSIA PVLEVADTSS IQTCDLLSDQ SEDETTPDEE 670 680 690 700 710 720 MSSNLEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD KSCQHNYYED AKAYGFKNKL 730 740 750 760 770 780 IIVAAETAGN GLYNFIVPLR AYYRPKKELN PIVLLLDNPL DDLLRCGVTF AANMVVVDKE 790 800 810 820 830 840 STMSAEEDYM ADAKTIVNVQ TLFRLFSSLS IITELTHPAN MRFMQFRAKD CYSLALSKLE 850 860 870 880 890 900 KKERERGSNL AFMFRLPFAA GRVFSISMLD TLLYQSFVKD YMISITRLLL GLDTTPGSGF 910 920 930 940 950 960 LCSMKITADD LWIRTYARLY QKLCSSTGDV PIGIYRTESQ KLTTSESQIS ISVEEWEDTK 970 980 990 1000 1010 1020 DSKEQGHHRS NHRNSTSSDQ SDHPLLRRKS MQWARRLSRK GPKHSGKTAE KITQQRLNLY 1030 1040 1050 1060 1070 1080 RRSERQELAE LVKNRMKHLG LSTVGYDEMN DHQSTLSYIL INPSPDTRIE LNDVVYLIRP 1090 1100 1110 DPLAYLPNSE PSRRNSICNV TGQDSREETQ L
	Isoform 3 [UniParc]. Checksum: 1E86C928DE0F5F3A	FASTA	1,068	122,551
	10 20 30 40 50 60 MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL FFIKNQRSSL 70 80 90 100 110 120 RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR SLPLWGLQVS VALISLFETI 130 140 150 160 170 180 LLGYLSYKGN IWEQILRIPF ILEIINAVPF IISIFWPSLR NLFVPVFLNC WLAKHALENM 190 200 210 220 230 240 INDLHRAIQR TQSAMFNQVL ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF 250 260 270 280 290 300 STVGFGDVTP ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK 310 320 330 340 350 360 HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI PMWSQRVIYL 370 380 390 400 410 420 QGSALKDQDL LRAKMDDAEA CFILSSRCEV DRTSSDHQTI LRAWAVKDFA PNCPLYVQIL 430 440 450 460 470 480 KPENKFHIKF ADHVVCEEEF KYAMLALNCI CPATSTLITL LVHTSRGQFG VCLIGVRRED 490 500 510 520 530 540 NKNILLNPGP RYIMNSTDIC FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI 550 560 570 580 590 600 IASMGTVAID LQDTSCRSAS GPTLSLPTEG SKEIRRPSIA PVLEVADTSS IQTCDLLSDQ 610 620 630 640 650 660 SEDETTPDEE MSSNLEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD KSCQHNYYED 670 680 690 700 710 720 AKAYGFKNKL IIVAAETAGN GLYNFIVPLR AYYRPKKELN PIVLLLDNPL DDLLRCGVTF 730 740 750 760 770 780 AANMVVVDKE STMSAEEDYM ADAKTIVNVQ TLFRLFSSLS IITELTHPAN MRFMQFRAKD 790 800 810 820 830 840 CYSLALSKLE KKERERGSNL AFMFRLPFAA GRVFSISMLD TLLYQSFVKD YMISITRLLL 850 860 870 880 890 900 GLDTTPGSGF LCSMKITADD LWIRTYARLY QKLCSSTGDV PIGIYRTESQ KLTTSESRKI 910 920 930 940 950 960 ASQSQISISV EEWEDTKDSK EQGHHRSNHR NSTSSDQSDH PLLRRKSMQW ARRLSRKGPK 970 980 990 1000 1010 1020 HSGKTAEKIT QQRLNLYRRS ERQELAELVK NRMKHLGLST VGYDEMNDHQ STLSYILINP 1030 1040 1050 1060 SPDTRIELND VVYLIRPDPL AYLPNSEPSR RNSICNVTGQ DSREETQL
	Isoform 4 [UniParc]. Checksum: 50C3939611E2F3DB	FASTA	1,052	120,830
	10 20 30 40 50 60 MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL FFIKNQRSSL 70 80 90 100 110 120 RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR SLPLWGLQVS VALISLFETI 130 140 150 160 170 180 LLGYLSYKIF WPSLRNLFVP VFLNCWLAKH ALENMINDLH RAIQRTQSAM FNQVLILIST 190 200 210 220 230 240 LLCLIFTCIC GIQHLERIGK KLNLFDSLYF CIVTFSTVGF GDVTPETWSS KLFVVAMICV 250 260 270 280 290 300 ALVVLPIQFE QLAYLWMERQ KSGGNYSRHR AQTEKHVVLC VSSLKIDLLM DFLNEFYAHP 310 320 330 340 350 360 RLQDYYVVIL CPTEMDVQVR RVLQIPMWSQ RVIYLQGSAL KDQDLLRAKM DDAEACFILS 370 380 390 400 410 420 SRCEVDRTSS DHQTILRAWA VKDFAPNCPL YVQILKPENK FHIKFADHVV CEEEFKYAML 430 440 450 460 470 480 ALNCICPATS TLITLLVHTS RGQCVCLCCR EGQQSPEQWQ KMYGRCSGNE VYHIVLEEST 490 500 510 520 530 540 FFAEYEGKSF TYASFHAHKK FGVCLIGVRR EDNKNILLNP GPRYIMNSTD ICFYINITKE 550 560 570 580 590 600 ENSAFKNQDQ QRKSNVSRSF YHGPSRLPVH SIIASMGTVA IDLQDTSCRS ASGPTLSLPT 610 620 630 640 650 660 EGSKEIRRPS IAPVLEVADT SSIQTCDLLS DQSEDETTPD EEMSSNLEYA KGYPPYSPYI 670 680 690 700 710 720 GSSPTFCHLL HEKVPFCCLR LDKSCQHNYY EDAKAYGFKN KLIIVAAETA GNGLYNFIVP 730 740 750 760 770 780 LRAYYRPKKE LNPIVLLLDN PLDDLLRCGV TFAANMVVVD KESTMSAEED YMADAKTIVN 790 800 810 820 830 840 VQTLFRLFSS LSIITELTHP ANMRFMQFRA KDCYSLALSK LEKKERERGS NLAFMFRLPF 850 860 870 880 890 900 AAGRVFSISM LDTLLYQSFV KDYMISITRL LLGLDTTPGS GFLCSMKITA DDLWIRTYAR 910 920 930 940 950 960 LYQKLCSSTG DVPIGIYRTE SQKLTTSESR KIASQSQISI SVEEWEDTKD SKEQGHHRSN 970 980 990 1000 1010 1020 HRNSTSSDQS DHPLLRRKSM QWARRLSRKG PKHSGKTAEK ITQQRLNLYR RSERQELAEL 1030 1040 1050 VKNRMKHLGL STVGYGMLFK NYCIYGLVIS CH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP." Bhattacharjee A., Joiner W.J., Wu M., Yang Y., Sigworth F.J., Kaczmarek L.K. J. Neurosci. 23:11681-11691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Trachea.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Adipose tissue.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
[6]	"Opposite regulation of Slick and Slack K+ channels by neuromodulators." Santi C.M., Ferreira G., Yang B., Gazula V.R., Butler A., Wei A., Kaczmarek L.K., Salkoff L. J. Neurosci. 26:5059-5068(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-33.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY359444 mRNA. Translation: AAR06170.1. AK131498 mRNA. Translation: BAD18642.1. BX647852 mRNA. Translation: CAI46099.1. AL358853 , AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71957.1. AL358853 , AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71958.1. AL591604 , AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72932.1. AL591604 , AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72933.1. AL138931 , AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15623.1. AL138931 , AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15624.1. AL139137 , AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16091.1. AL139137 , AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16092.1. BC103948 mRNA. Translation: AAI03949.1. BC103949 mRNA. Translation: AAI03950.1. BC103950 mRNA. Translation: AAI03951.1.
IPI	IPI00398421. IPI00645277. IPI00843803. IPI00876957.
RefSeq	NP_940905.2. NM_198503.2.
UniGene	Hs.657046.
3D structure databases
ProteinModelPortal	Q6UVM3.
ModBase	Search...
PTM databases
PhosphoSite	Q6UVM3.
Polymorphism databases
DMDM	74749370.
Proteomic databases
PaxDb	Q6UVM3.
PRIDE	Q6UVM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294725; ENSP00000294725; ENSG00000162687. ENST00000367433; ENSP00000356403; ENSG00000162687.
GeneID	343450.
KEGG	hsa:343450.
UCSC	uc001gtd.1. human. uc001gte.1. human. uc001gtf.1. human. uc001gth.1. human.
Organism-specific databases
CTD	343450.
GeneCards	GC01M196194.
HGNC	HGNC:18866. KCNT2.
HPA	HPA051218.
MIM	610044. gene.
neXtProt	NX_Q6UVM3.
PharmGKB	PA38726.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231460.
HOVERGEN	HBG055190.
InParanoid	Q6UVM3.
KO	K04947.
OMA	KTYGRCS.
OrthoDB	EOG473PQG.
PhylomeDB	Q6UVM3.
Gene expression databases
ArrayExpress	Q6UVM3.
Bgee	Q6UVM3.
CleanEx	HS_KCNT2.
Genevestigator	Q6UVM3.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR013099. Ion_trans_2. IPR003929. K_chnl_Ca-activ_BK_asu. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF03493. BK_channel_a. 1 hit. PF07885. Ion_trans_2. 1 hit. [Graphical view]
PROSITE	PS51201. RCK_N. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	343450.
NextBio	98534.
SOURCE	Search...

Entry information

Entry name

KCNT2_HUMAN

Accession

Primary (citable) accession number: Q6UVM3
Secondary accession number(s): Q3SY59, Q5VTN1, Q6ZMT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.