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Q6UVM3

- KCNT2_HUMAN

UniProt

Q6UVM3 - KCNT2_HUMAN

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Protein

Potassium channel subfamily T member 2

Gene

KCNT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1025 – 10328ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium-activated potassium channel activity Source: RefGenome
  3. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Potassium

Protein family/group databases

TCDBi1.A.1.3.6. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily T member 2
Alternative name(s):
Sequence like an intermediate conductance potassium channel subunit
Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1
Gene namesi
Name:KCNT2
Synonyms:SLICK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18866. KCNT2.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11351135Potassium channel subfamily T member 2PRO_0000312503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6UVM3.
PRIDEiQ6UVM3.

PTM databases

PhosphoSiteiQ6UVM3.

Expressioni

Gene expression databases

BgeeiQ6UVM3.
CleanExiHS_KCNT2.
ExpressionAtlasiQ6UVM3. baseline and differential.
GenevestigatoriQ6UVM3.

Organism-specific databases

HPAiHPA051218.

Structurei

3D structure databases

ProteinModelPortaliQ6UVM3.
SMRiQ6UVM3. Positions 227-285, 300-563, 713-914.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini85 – 10117ExtracellularSequence AnalysisAdd
BLAST
Topological domaini123 – 13715CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini159 – 1646ExtracellularSequence Analysis
Topological domaini186 – 19813CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini220 – 2289ExtracellularSequence Analysis
Topological domaini250 – 2567ExtracellularSequence Analysis
Topological domaini278 – 1135858CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei229 – 24921Pore-formingSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini422 – 543122RCK N-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 RCK N-terminal domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00530000063026.
HOGENOMiHOG000231460.
HOVERGENiHBG055190.
InParanoidiQ6UVM3.
KOiK04947.
OMAiNQDQQKK.
OrthoDBiEOG7VTDM4.
PhylomeDBiQ6UVM3.
TreeFamiTF314283.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013099. 2pore_dom_K_chnl_dom.
IPR003929. K_chnl_Ca-activ_BK_asu.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UVM3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL
60 70 80 90 100
FFIKNQRSSL RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR
110 120 130 140 150
SLPLWGLQVS VALISLFETI LLGYLSYKGN IWEQILRIPF ILEIINAVPF
160 170 180 190 200
IISIFWPSLR NLFVPVFLNC WLAKHALENM INDLHRAIQR TQSAMFNQVL
210 220 230 240 250
ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF STVGFGDVTP
260 270 280 290 300
ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK
310 320 330 340 350
HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI
360 370 380 390 400
PMWSQRVIYL QGSALKDQDL LRAKMDDAEA CFILSSRCEV DRTSSDHQTI
410 420 430 440 450
LRAWAVKDFA PNCPLYVQIL KPENKFHIKF ADHVVCEEEF KYAMLALNCI
460 470 480 490 500
CPATSTLITL LVHTSRGQEG QQSPEQWQKM YGRCSGNEVY HIVLEESTFF
510 520 530 540 550
AEYEGKSFTY ASFHAHKKFG VCLIGVRRED NKNILLNPGP RYIMNSTDIC
560 570 580 590 600
FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI IASMGTVAID
610 620 630 640 650
LQDTSCRSAS GPTLSLPTEG SKEIRRPSIA PVLEVADTSS IQTCDLLSDQ
660 670 680 690 700
SEDETTPDEE MSSNLEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD
710 720 730 740 750
KSCQHNYYED AKAYGFKNKL IIVAAETAGN GLYNFIVPLR AYYRPKKELN
760 770 780 790 800
PIVLLLDNPP DMHFLDAICW FPMVYYMVGS IDNLDDLLRC GVTFAANMVV
810 820 830 840 850
VDKESTMSAE EDYMADAKTI VNVQTLFRLF SSLSIITELT HPANMRFMQF
860 870 880 890 900
RAKDCYSLAL SKLEKKERER GSNLAFMFRL PFAAGRVFSI SMLDTLLYQS
910 920 930 940 950
FVKDYMISIT RLLLGLDTTP GSGFLCSMKI TADDLWIRTY ARLYQKLCSS
960 970 980 990 1000
TGDVPIGIYR TESQKLTTSE SQISISVEEW EDTKDSKEQG HHRSNHRNST
1010 1020 1030 1040 1050
SSDQSDHPLL RRKSMQWARR LSRKGPKHSG KTAEKITQQR LNLYRRSERQ
1060 1070 1080 1090 1100
ELAELVKNRM KHLGLSTVGY DEMNDHQSTL SYILINPSPD TRIELNDVVY
1110 1120 1130
LIRPDPLAYL PNSEPSRRNS ICNVTGQDSR EETQL
Length:1,135
Mass (Da):130,501
Last modified:July 5, 2004 - v1
Checksum:i4957C6DAB1E030CF
GO
Isoform 2 (identifier: Q6UVM3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     760-783: Missing.

Show »
Length:1,111
Mass (Da):127,654
Checksum:iDE4D70DA9B495A9C
GO
Isoform 3 (identifier: Q6UVM3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     469-518: Missing.
     760-783: Missing.
     970-970: E → ESRKIASQ

Show »
Length:1,068
Mass (Da):122,551
Checksum:i1E86C928DE0F5F3A
GO
Isoform 4 (identifier: Q6UVM3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-153: Missing.
     468-468: Q → QCVCLCCR
     760-783: Missing.
     970-970: E → ESRKIASQ
     1071-1135: DEMNDHQSTL...GQDSREETQL → GMLFKNYCIYGLVISCH

Show »
Length:1,052
Mass (Da):120,830
Checksum:i50C3939611E2F3DB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331V → I in a breast cancer sample; somatic mutation. 1 Publication
VAR_037527
Natural varianti413 – 4131C → W.
Corresponds to variant rs12738104 [ dbSNP | Ensembl ].
VAR_037528
Natural varianti429 – 4291K → N.
Corresponds to variant rs12742082 [ dbSNP | Ensembl ].
VAR_037529

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei129 – 15325Missing in isoform 4. 2 PublicationsVSP_029852Add
BLAST
Alternative sequencei468 – 4681Q → QCVCLCCR in isoform 4. 2 PublicationsVSP_029853
Alternative sequencei469 – 51850Missing in isoform 3. CuratedVSP_029854Add
BLAST
Alternative sequencei760 – 78324Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_029855Add
BLAST
Alternative sequencei970 – 9701E → ESRKIASQ in isoform 3 and isoform 4. 2 PublicationsVSP_029856
Alternative sequencei1071 – 113565DEMND…EETQL → GMLFKNYCIYGLVISCH in isoform 4. 2 PublicationsVSP_029857Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY359444 mRNA. Translation: AAR06170.1.
AK131498 mRNA. Translation: BAD18642.1.
BX647852 mRNA. Translation: CAI46099.1.
AL358853
, AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71957.1.
AL358853
, AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71958.1.
AL591604
, AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72932.1.
AL591604
, AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72933.1.
AL138931
, AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15623.1.
AL138931
, AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15624.1.
AL139137
, AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16091.1.
AL139137
, AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16092.1.
BC103948 mRNA. Translation: AAI03949.1.
BC103949 mRNA. Translation: AAI03950.1.
BC103950 mRNA. Translation: AAI03951.1.
CCDSiCCDS1384.1. [Q6UVM3-1]
CCDS72994.1. [Q6UVM3-3]
CCDS72995.1. [Q6UVM3-2]
RefSeqiNP_001274748.1. NM_001287819.1. [Q6UVM3-2]
NP_001274749.1. NM_001287820.1. [Q6UVM3-3]
NP_940905.2. NM_198503.3. [Q6UVM3-1]
UniGeneiHs.657046.

Genome annotation databases

EnsembliENST00000294725; ENSP00000294725; ENSG00000162687. [Q6UVM3-1]
ENST00000367433; ENSP00000356403; ENSG00000162687. [Q6UVM3-2]
ENST00000609185; ENSP00000476657; ENSG00000162687. [Q6UVM3-3]
GeneIDi343450.
KEGGihsa:343450.
UCSCiuc001gtd.1. human. [Q6UVM3-1]
uc001gte.1. human. [Q6UVM3-3]
uc001gtf.1. human. [Q6UVM3-2]
uc001gth.1. human. [Q6UVM3-4]

Polymorphism databases

DMDMi74749370.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY359444 mRNA. Translation: AAR06170.1 .
AK131498 mRNA. Translation: BAD18642.1 .
BX647852 mRNA. Translation: CAI46099.1 .
AL358853
, AL138931 , AL139137 , AL591604 Genomic DNA. Translation: CAH71957.1 .
AL358853
, AL138931 , AL139137 , AL591604 Genomic DNA. Translation: CAH71958.1 .
AL591604
, AL138931 , AL139137 , AL358853 Genomic DNA. Translation: CAH72932.1 .
AL591604
, AL138931 , AL139137 , AL358853 Genomic DNA. Translation: CAH72933.1 .
AL138931
, AL139137 , AL358853 , AL591604 Genomic DNA. Translation: CAI15623.1 .
AL138931
, AL139137 , AL358853 , AL591604 Genomic DNA. Translation: CAI15624.1 .
AL139137
, AL138931 , AL358853 , AL591604 Genomic DNA. Translation: CAI16091.1 .
AL139137
, AL138931 , AL358853 , AL591604 Genomic DNA. Translation: CAI16092.1 .
BC103948 mRNA. Translation: AAI03949.1 .
BC103949 mRNA. Translation: AAI03950.1 .
BC103950 mRNA. Translation: AAI03951.1 .
CCDSi CCDS1384.1. [Q6UVM3-1 ]
CCDS72994.1. [Q6UVM3-3 ]
CCDS72995.1. [Q6UVM3-2 ]
RefSeqi NP_001274748.1. NM_001287819.1. [Q6UVM3-2 ]
NP_001274749.1. NM_001287820.1. [Q6UVM3-3 ]
NP_940905.2. NM_198503.3. [Q6UVM3-1 ]
UniGenei Hs.657046.

3D structure databases

ProteinModelPortali Q6UVM3.
SMRi Q6UVM3. Positions 227-285, 300-563, 713-914.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 386.

Protein family/group databases

TCDBi 1.A.1.3.6. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q6UVM3.

Polymorphism databases

DMDMi 74749370.

Proteomic databases

PaxDbi Q6UVM3.
PRIDEi Q6UVM3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294725 ; ENSP00000294725 ; ENSG00000162687 . [Q6UVM3-1 ]
ENST00000367433 ; ENSP00000356403 ; ENSG00000162687 . [Q6UVM3-2 ]
ENST00000609185 ; ENSP00000476657 ; ENSG00000162687 . [Q6UVM3-3 ]
GeneIDi 343450.
KEGGi hsa:343450.
UCSCi uc001gtd.1. human. [Q6UVM3-1 ]
uc001gte.1. human. [Q6UVM3-3 ]
uc001gtf.1. human. [Q6UVM3-2 ]
uc001gth.1. human. [Q6UVM3-4 ]

Organism-specific databases

CTDi 343450.
GeneCardsi GC01M196194.
HGNCi HGNC:18866. KCNT2.
HPAi HPA051218.
MIMi 610044. gene.
neXtProti NX_Q6UVM3.
PharmGKBi PA38726.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00530000063026.
HOGENOMi HOG000231460.
HOVERGENi HBG055190.
InParanoidi Q6UVM3.
KOi K04947.
OMAi NQDQQKK.
OrthoDBi EOG7VTDM4.
PhylomeDBi Q6UVM3.
TreeFami TF314283.

Miscellaneous databases

GeneWikii KCNT2.
GenomeRNAii 343450.
NextBioi 98534.
PROi Q6UVM3.
SOURCEi Search...

Gene expression databases

Bgeei Q6UVM3.
CleanExi HS_KCNT2.
ExpressionAtlasi Q6UVM3. baseline and differential.
Genevestigatori Q6UVM3.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR013099. 2pore_dom_K_chnl_dom.
IPR003929. K_chnl_Ca-activ_BK_asu.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP."
    Bhattacharjee A., Joiner W.J., Wu M., Yang Y., Sigworth F.J., Kaczmarek L.K.
    J. Neurosci. 23:11681-11691(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Adipose tissue.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
  6. "Opposite regulation of Slick and Slack K+ channels by neuromodulators."
    Santi C.M., Ferreira G., Yang B., Gazula V.R., Butler A., Wei A., Kaczmarek L.K., Salkoff L.
    J. Neurosci. 26:5059-5068(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-33.

Entry informationi

Entry nameiKCNT2_HUMAN
AccessioniPrimary (citable) accession number: Q6UVM3
Secondary accession number(s): Q3SY59, Q5VTN1, Q6ZMT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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