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Protein

Potassium channel subfamily T member 2

Gene

KCNT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1025 – 1032ATPSequence analysis8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Potassium

Protein family/group databases

TCDBi1.A.1.3.6. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily T member 2
Alternative name(s):
Sequence like an intermediate conductance potassium channel subunit
Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1
Gene namesi
Name:KCNT2
Synonyms:SLICK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18866. KCNT2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
Transmembranei64 – 84Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini85 – 101ExtracellularSequence analysisAdd BLAST17
Transmembranei102 – 122Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini123 – 137CytoplasmicSequence analysisAdd BLAST15
Transmembranei138 – 158Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini159 – 164ExtracellularSequence analysis6
Transmembranei165 – 185Helical; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini186 – 198CytoplasmicSequence analysisAdd BLAST13
Transmembranei199 – 219Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini220 – 228ExtracellularSequence analysis9
Intramembranei229 – 249Pore-formingSequence analysisAdd BLAST21
Topological domaini250 – 256ExtracellularSequence analysis7
Transmembranei257 – 277Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini278 – 1135CytoplasmicSequence analysisAdd BLAST858

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162687.
PharmGKBiPA38726.

Chemistry databases

GuidetoPHARMACOLOGYi386.

Polymorphism and mutation databases

DMDMi74749370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003125031 – 1135Potassium channel subfamily T member 2Add BLAST1135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6UVM3.
PeptideAtlasiQ6UVM3.
PRIDEiQ6UVM3.

PTM databases

iPTMnetiQ6UVM3.
PhosphoSitePlusiQ6UVM3.

Expressioni

Gene expression databases

BgeeiENSG00000162687.
CleanExiHS_KCNT2.
ExpressionAtlasiQ6UVM3. baseline and differential.
GenevisibleiQ6UVM3. HS.

Organism-specific databases

HPAiHPA051218.

Interactioni

Protein-protein interaction databases

BioGridi131252. 8 interactors.
STRINGi9606.ENSP00000294725.

Structurei

3D structure databases

ProteinModelPortaliQ6UVM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini422 – 543RCK N-terminalAdd BLAST122

Sequence similaritiesi

Contains 1 RCK N-terminal domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3193. Eukaryota.
ENOG410XSMA. LUCA.
GeneTreeiENSGT00530000063026.
HOGENOMiHOG000231460.
HOVERGENiHBG055190.
InParanoidiQ6UVM3.
KOiK04947.
OMAiGPRYIMS.
OrthoDBiEOG091G011O.
PhylomeDBiQ6UVM3.
TreeFamiTF314283.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR003929. K_chnl_Ca-activ_BK_asu.
IPR013099. K_chnl_dom.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UVM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL
60 70 80 90 100
FFIKNQRSSL RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR
110 120 130 140 150
SLPLWGLQVS VALISLFETI LLGYLSYKGN IWEQILRIPF ILEIINAVPF
160 170 180 190 200
IISIFWPSLR NLFVPVFLNC WLAKHALENM INDLHRAIQR TQSAMFNQVL
210 220 230 240 250
ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF STVGFGDVTP
260 270 280 290 300
ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK
310 320 330 340 350
HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI
360 370 380 390 400
PMWSQRVIYL QGSALKDQDL LRAKMDDAEA CFILSSRCEV DRTSSDHQTI
410 420 430 440 450
LRAWAVKDFA PNCPLYVQIL KPENKFHIKF ADHVVCEEEF KYAMLALNCI
460 470 480 490 500
CPATSTLITL LVHTSRGQEG QQSPEQWQKM YGRCSGNEVY HIVLEESTFF
510 520 530 540 550
AEYEGKSFTY ASFHAHKKFG VCLIGVRRED NKNILLNPGP RYIMNSTDIC
560 570 580 590 600
FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI IASMGTVAID
610 620 630 640 650
LQDTSCRSAS GPTLSLPTEG SKEIRRPSIA PVLEVADTSS IQTCDLLSDQ
660 670 680 690 700
SEDETTPDEE MSSNLEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD
710 720 730 740 750
KSCQHNYYED AKAYGFKNKL IIVAAETAGN GLYNFIVPLR AYYRPKKELN
760 770 780 790 800
PIVLLLDNPP DMHFLDAICW FPMVYYMVGS IDNLDDLLRC GVTFAANMVV
810 820 830 840 850
VDKESTMSAE EDYMADAKTI VNVQTLFRLF SSLSIITELT HPANMRFMQF
860 870 880 890 900
RAKDCYSLAL SKLEKKERER GSNLAFMFRL PFAAGRVFSI SMLDTLLYQS
910 920 930 940 950
FVKDYMISIT RLLLGLDTTP GSGFLCSMKI TADDLWIRTY ARLYQKLCSS
960 970 980 990 1000
TGDVPIGIYR TESQKLTTSE SQISISVEEW EDTKDSKEQG HHRSNHRNST
1010 1020 1030 1040 1050
SSDQSDHPLL RRKSMQWARR LSRKGPKHSG KTAEKITQQR LNLYRRSERQ
1060 1070 1080 1090 1100
ELAELVKNRM KHLGLSTVGY DEMNDHQSTL SYILINPSPD TRIELNDVVY
1110 1120 1130
LIRPDPLAYL PNSEPSRRNS ICNVTGQDSR EETQL
Length:1,135
Mass (Da):130,501
Last modified:July 5, 2004 - v1
Checksum:i4957C6DAB1E030CF
GO
Isoform 2 (identifier: Q6UVM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     760-783: Missing.

Show »
Length:1,111
Mass (Da):127,654
Checksum:iDE4D70DA9B495A9C
GO
Isoform 3 (identifier: Q6UVM3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     469-518: Missing.
     760-783: Missing.
     970-970: E → ESRKIASQ

Show »
Length:1,068
Mass (Da):122,551
Checksum:i1E86C928DE0F5F3A
GO
Isoform 4 (identifier: Q6UVM3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-153: Missing.
     468-468: Q → QCVCLCCR
     760-783: Missing.
     970-970: E → ESRKIASQ
     1071-1135: DEMNDHQSTL...GQDSREETQL → GMLFKNYCIYGLVISCH

Show »
Length:1,052
Mass (Da):120,830
Checksum:i50C3939611E2F3DB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03752733V → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_037528413C → W.Corresponds to variant rs12738104dbSNPEnsembl.1
Natural variantiVAR_037529429K → N.Corresponds to variant rs12742082dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029852129 – 153Missing in isoform 4. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_029853468Q → QCVCLCCR in isoform 4. 2 Publications1
Alternative sequenceiVSP_029854469 – 518Missing in isoform 3. CuratedAdd BLAST50
Alternative sequenceiVSP_029855760 – 783Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_029856970E → ESRKIASQ in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0298571071 – 1135DEMND…EETQL → GMLFKNYCIYGLVISCH in isoform 4. 2 PublicationsAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359444 mRNA. Translation: AAR06170.1.
AK131498 mRNA. Translation: BAD18642.1.
BX647852 mRNA. Translation: CAI46099.1.
AL358853
, AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71957.1.
AL358853
, AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71958.1.
AL591604
, AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72932.1.
AL591604
, AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72933.1.
AL138931
, AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15623.1.
AL138931
, AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15624.1.
AL139137
, AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16091.1.
AL139137
, AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16092.1.
BC103948 mRNA. Translation: AAI03949.1.
BC103949 mRNA. Translation: AAI03950.1.
BC103950 mRNA. Translation: AAI03951.1.
CCDSiCCDS1384.1. [Q6UVM3-1]
CCDS72994.1. [Q6UVM3-3]
CCDS72995.1. [Q6UVM3-2]
RefSeqiNP_001274748.1. NM_001287819.1. [Q6UVM3-2]
NP_001274749.1. NM_001287820.1. [Q6UVM3-3]
NP_940905.2. NM_198503.3. [Q6UVM3-1]
UniGeneiHs.657046.

Genome annotation databases

EnsembliENST00000294725; ENSP00000294725; ENSG00000162687. [Q6UVM3-1]
ENST00000367433; ENSP00000356403; ENSG00000162687. [Q6UVM3-2]
ENST00000609185; ENSP00000476657; ENSG00000162687. [Q6UVM3-3]
GeneIDi343450.
KEGGihsa:343450.
UCSCiuc001gtd.3. human. [Q6UVM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359444 mRNA. Translation: AAR06170.1.
AK131498 mRNA. Translation: BAD18642.1.
BX647852 mRNA. Translation: CAI46099.1.
AL358853
, AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71957.1.
AL358853
, AL138931, AL139137, AL591604 Genomic DNA. Translation: CAH71958.1.
AL591604
, AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72932.1.
AL591604
, AL138931, AL139137, AL358853 Genomic DNA. Translation: CAH72933.1.
AL138931
, AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15623.1.
AL138931
, AL139137, AL358853, AL591604 Genomic DNA. Translation: CAI15624.1.
AL139137
, AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16091.1.
AL139137
, AL138931, AL358853, AL591604 Genomic DNA. Translation: CAI16092.1.
BC103948 mRNA. Translation: AAI03949.1.
BC103949 mRNA. Translation: AAI03950.1.
BC103950 mRNA. Translation: AAI03951.1.
CCDSiCCDS1384.1. [Q6UVM3-1]
CCDS72994.1. [Q6UVM3-3]
CCDS72995.1. [Q6UVM3-2]
RefSeqiNP_001274748.1. NM_001287819.1. [Q6UVM3-2]
NP_001274749.1. NM_001287820.1. [Q6UVM3-3]
NP_940905.2. NM_198503.3. [Q6UVM3-1]
UniGeneiHs.657046.

3D structure databases

ProteinModelPortaliQ6UVM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131252. 8 interactors.
STRINGi9606.ENSP00000294725.

Chemistry databases

GuidetoPHARMACOLOGYi386.

Protein family/group databases

TCDBi1.A.1.3.6. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiQ6UVM3.
PhosphoSitePlusiQ6UVM3.

Polymorphism and mutation databases

DMDMi74749370.

Proteomic databases

PaxDbiQ6UVM3.
PeptideAtlasiQ6UVM3.
PRIDEiQ6UVM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294725; ENSP00000294725; ENSG00000162687. [Q6UVM3-1]
ENST00000367433; ENSP00000356403; ENSG00000162687. [Q6UVM3-2]
ENST00000609185; ENSP00000476657; ENSG00000162687. [Q6UVM3-3]
GeneIDi343450.
KEGGihsa:343450.
UCSCiuc001gtd.3. human. [Q6UVM3-1]

Organism-specific databases

CTDi343450.
GeneCardsiKCNT2.
HGNCiHGNC:18866. KCNT2.
HPAiHPA051218.
MIMi610044. gene.
neXtProtiNX_Q6UVM3.
OpenTargetsiENSG00000162687.
PharmGKBiPA38726.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3193. Eukaryota.
ENOG410XSMA. LUCA.
GeneTreeiENSGT00530000063026.
HOGENOMiHOG000231460.
HOVERGENiHBG055190.
InParanoidiQ6UVM3.
KOiK04947.
OMAiGPRYIMS.
OrthoDBiEOG091G011O.
PhylomeDBiQ6UVM3.
TreeFamiTF314283.

Miscellaneous databases

ChiTaRSiKCNT2. human.
GeneWikiiKCNT2.
GenomeRNAii343450.
PROiQ6UVM3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162687.
CleanExiHS_KCNT2.
ExpressionAtlasiQ6UVM3. baseline and differential.
GenevisibleiQ6UVM3. HS.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR003929. K_chnl_Ca-activ_BK_asu.
IPR013099. K_chnl_dom.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF03493. BK_channel_a. 1 hit.
PF07885. Ion_trans_2. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNT2_HUMAN
AccessioniPrimary (citable) accession number: Q6UVM3
Secondary accession number(s): Q3SY59, Q5VTN1, Q6ZMT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.