Q6UVK1 (CSPG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chondroitin sulfate proteoglycan 4

Alternative name(s):
Chondroitin sulfate proteoglycan NG2
Melanoma chondroitin sulfate proteoglycan
Melanoma-associated chondroitin sulfate proteoglycan

Gene names

Name:	CSPG4
Synonyms:	MCSP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. Ref.2 Ref.6 Ref.7
Subunit structure	Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 By similarity. Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16. Ref.5 Ref.6 Ref.7 Ref.9
Subcellular location	Apical cell membrane; Single-pass type I membrane protein; Extracellular side By similarity. Cell projection › lamellipodium membrane; Single-pass type I membrane protein; Extracellular side By similarity. Note: Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes By similarity.
Tissue specificity	Detected only in malignant melanoma cells. Ref.1
Post-translational modification	O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation By similarity. Involved in interaction with MMP16 and ITGA4. Phosphorylation by PRKCA regulates its subcellular location and function in cell motility By similarity.
Miscellaneous	Valuable marker for several incompletely differentiated precursor cells.
Sequence similarities	Contains 15 CSPG (NG2) repeats. Contains 2 laminin G-like domains.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation Tissue remodeling
Cellular component	Cell membrane Cell projection Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein Proteoglycan
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPK activity Inferred from electronic annotation. Source: Compara angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW carbohydrate metabolic process Traceable author statement. Source: Reactome cell proliferation Inferred from electronic annotation. Source: Compara chondroitin sulfate biosynthetic process Traceable author statement. Source: Reactome chondroitin sulfate catabolic process Traceable author statement. Source: Reactome dermatan sulfate biosynthetic process Traceable author statement. Source: Reactome glial cell migration Inferred from electronic annotation. Source: Compara intracellular signal transduction Inferred from direct assay Ref.6. Source: UniProtKB positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay Ref.6. Source: UniProtKB tissue remodeling Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cell surface Traceable author statement Ref.6. Source: UniProtKB extracellular region Traceable author statement. Source: Reactome integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc lamellipodium membrane Inferred from electronic annotation. Source: UniProtKB-SubCell lysosomal lumen Traceable author statement. Source: Reactome
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 2322	2293	Chondroitin sulfate proteoglycan 4		PRO_0000041962
Regions
	Topological domain	30 – 2224	2195	Extracellular Potential
	Transmembrane	2225 – 2245	21	Helical; Potential
	Topological domain	2246 – 2322	77	Cytoplasmic Potential
	Domain	30 – 192	163	Laminin G-like 1
	Domain	202 – 380	179	Laminin G-like 2
	Repeat	430 – 523	94	CSPG 1
	Repeat	556 – 643	88	CSPG 2
	Repeat	665 – 764	100	CSPG 3
	Repeat	792 – 878	87	CSPG 4
	Repeat	900 – 989	90	CSPG 5
	Repeat	1020 – 1108	89	CSPG 6
	Repeat	1128 – 1216	89	CSPG 7
	Repeat	1241 – 1337	97	CSPG 8
	Repeat	1360 – 1449	90	CSPG 9
	Repeat	1476 – 1561	86	CSPG 10
	Repeat	1583 – 1679	97	CSPG 11
	Repeat	1707 – 1803	97	CSPG 12
	Repeat	1835 – 1922	88	CSPG 13
	Repeat	1944 – 2029	86	CSPG 14
	Repeat	2048 – 2147	100	CSPG 15
	Region	30 – 639	610	Globular or compact configuration stabilized by disulfide bonds
	Region	30 – 639	610	Neurite growth inhibition By similarity
	Region	574 – 1040	467	Interaction with COL6A2 By similarity
	Region	631 – 1446	816	Interaction with COL5A1 By similarity
	Region	1586 – 2221	636	Neurite growth inhibition By similarity
	Region	1587 – 2221	635	Cysteine-containing
	Motif	2320 – 2322	3	PDZ-binding
	Compositional bias	639 – 1586	948	Gly/Ser-rich (glycosaminoglycan attachment domain)
Amino acid modifications
	Modified residue	2252	1	Phosphothreonine; by PKC/PRKCA By similarity
	Glycosylation	130	1	N-linked (GlcNAc...) Potential
	Glycosylation	348	1	N-linked (GlcNAc...) Potential
	Glycosylation	427	1	N-linked (GlcNAc...) Potential
	Glycosylation	685	1	N-linked (GlcNAc...) Potential
	Glycosylation	772	1	N-linked (GlcNAc...) Potential
	Glycosylation	995	1	O-linked (Xyl...) (chondroitin sulfate) By similarity
	Glycosylation	1131	1	N-linked (GlcNAc...) Potential
	Glycosylation	1202	1	N-linked (GlcNAc...) Potential
	Glycosylation	1364	1	N-linked (GlcNAc...) Potential
	Glycosylation	1449	1	N-linked (GlcNAc...) Potential
	Glycosylation	1645	1	N-linked (GlcNAc...) Potential
	Glycosylation	1909	1	N-linked (GlcNAc...) Potential
	Glycosylation	2016	1	N-linked (GlcNAc...) Potential
	Glycosylation	2034	1	N-linked (GlcNAc...) Potential
	Glycosylation	2040	1	N-linked (GlcNAc...) Potential
	Glycosylation	2075	1	N-linked (GlcNAc...) Ref.10
	Disulfide bond	169 ↔ 192		By similarity
	Disulfide bond	354 ↔ 380		By similarity
Natural variations
	Natural variant	1703	1	R → H. Corresponds to variant rs8023621 [ dbSNP | Ensembl ].		VAR_061733
Experimental info
	Sequence conflict	5 – 6	2	PR → RG in CAA65529. Ref.1
	Sequence conflict	5 – 6	2	PR → RG in AAQ62842. Ref.2
	Sequence conflict	477 – 478	2	RH → HY in CAA65529. Ref.1
	Sequence conflict	486	1	P → L in CAA65529. Ref.1
	Sequence conflict	631	1	R → C in CAA65529. Ref.1
	Sequence conflict	715 – 717	3	QGA → HST in CAA65529. Ref.1
	Sequence conflict	942	1	H → L in CAA65529. Ref.1
	Sequence conflict	1208	1	R → E in CAA65529. Ref.1
	Sequence conflict	1405	1	A → P in CAA65529. Ref.1
	Sequence conflict	1557	1	R → P in CAA65529. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6UVK1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 0B4F39AFC5ADD3CA	FASTA	2,322	250,537
	10 20 30 40 50 60 MQSGPRPPLP APGLALALTL TMLARLASAA SFFGENHLEV PVATALTDID LQLQFSTSQP 70 80 90 100 110 120 EALLLLAAGP ADHLLLQLYS GRLQVRLVLG QEELRLQTPA ETLLSDSIPH TVVLTVVEGW 130 140 150 160 170 180 ATLSVDGFLN ASSAVPGAPL EVPYGLFVGG TGTLGLPYLR GTSRPLRGCL HAATLNGRSL 190 200 210 220 230 240 LRPLTPDVHE GCAEEFSASD DVALGFSGPH SLAAFPAWGT QDEGTLEFTL TTQSRQAPLA 250 260 270 280 290 300 FQAGGRRGDF IYVDIFEGHL RAVVEKGQGT VLLHNSVPVA DGQPHEVSVH INAHRLEISV 310 320 330 340 350 360 DQYPTHTSNR GVLSYLEPRG SLLLGGLDAE ASRHLQEHRL GLTPEATNAS LLGCMEDLSV 370 380 390 400 410 420 NGQRRGLREA LLTRNMAAGC RLEEEEYEDD AYGHYEAFST LAPEAWPAME LPEPCVPEPG 430 440 450 460 470 480 LPPVFANFTQ LLTISPLVVA EGGTAWLEWR HVQPTLDLME AELRKSQVLF SVTRGARHGE 490 500 510 520 530 540 LELDIPGAQA RKMFTLLDVV NRKARFIHDG SEDTSDQLVL EVSVTARVPM PSCLRRGQTY 550 560 570 580 590 600 LLPIQVNPVN DPPHIIFPHG SLMVILEHTQ KPLGPEVFQA YDPDSACEGL TFQVLGTSSG 610 620 630 640 650 660 LPVERRDQPG EPATEFSCRE LEAGSLVYVH RGGPAQDLTF RVSDGLQASP PATLKVVAIR 670 680 690 700 710 720 PAIQIHRSTG LRLAQGSAMP ILPANLSVET NAVGQDVSVL FRVTGALQFG ELQKQGAGGV 730 740 750 760 770 780 EGAEWWATQA FHQRDVEQGR VRYLSTDPQH HAYDTVENLA LEVQVGQEIL SNLSFPVTIQ 790 800 810 820 830 840 RATVWMLRLE PLHTQNTQQE TLTTAHLEAT LEEAGPSPPT FHYEVVQAPR KGNLQLQGTR 850 860 870 880 890 900 LSDGQGFTQD DIQAGRVTYG ATARASEAVE DTFRFRVTAP PYFSPLYTFP IHIGGDPDAP 910 920 930 940 950 960 VLTNVLLVVP EGGEGVLSAD HLFVKSLNSA SYLYEVMERP RHGRLAWRGT QDKTTMVTSF 970 980 990 1000 1010 1020 TNEDLLRGRL VYQHDDSETT EDDIPFVATR QGESSGDMAW EEVRGVFRVA IQPVNDHAPV 1030 1040 1050 1060 1070 1080 QTISRIFHVA RGGRRLLTTD DVAFSDADSG FADAQLVLTR KDLLFGSIVA VDEPTRPIYR 1090 1100 1110 1120 1130 1140 FTQEDLRKRR VLFVHSGADR GWIQLQVSDG QHQATALLEV QASEPYLRVA NGSSLVVPQG 1150 1160 1170 1180 1190 1200 GQGTIDTAVL HLDTNLDIRS GDEVHYHVTA GPRWGQLVRA GQPATAFSQQ DLLDGAVLYS 1210 1220 1230 1240 1250 1260 HNGSLSPRDT MAFSVEAGPV HTDATLQVTI ALEGPLAPLK LVRHKKIYVF QGEAAEIRRD 1270 1280 1290 1300 1310 1320 QLEAAQEAVP PADIVFSVKS PPSAGYLVMV SRGALADEPP SLDPVQSFSQ EAVDTGRVLY 1330 1340 1350 1360 1370 1380 LHSRPEAWSD AFSLDVASGL GAPLEGVLVE LEVLPAAIPL EAQNFSVPEG GSLTLAPPLL 1390 1400 1410 1420 1430 1440 RVSGPYFPTL LGLSLQVLEP PQHGALQKED GPQARTLSAF SWRMVEEQLI RYVHDGSETL 1450 1460 1470 1480 1490 1500 TDSFVLMANA SEMDRQSHPV AFTVTVLPVN DQPPILTTNT GLQMWEGATA PIPAEALRST 1510 1520 1530 1540 1550 1560 DGDSGSEDLV YTIEQPSNGR VVLRGAPGTE VRSFTQAQLD GGLVLFSHRG TLDGGFRFRL 1570 1580 1590 1600 1610 1620 SDGEHTSPGH FFRVTAQKQV LLSLKGSQTL TVCPGSVQPL SSQTLRASSS AGTDPQLLLY 1630 1640 1650 1660 1670 1680 RVVRGPQLGR LFHAQQDSTG EALVNFTQAE VYAGNILYEH EMPPEPFWEA HDTLELQLSS 1690 1700 1710 1720 1730 1740 PPARDVAATL AVAVSFEAAC PQRPSHLWKN KGLWVPEGQR ARITVAALDA SNLLASVPSP 1750 1760 1770 1780 1790 1800 QRSEHDVLFQ VTQFPSRGQL LVSEEPLHAG QPHFLQSQLA AGQLVYAHGG GGTQQDGFHF 1810 1820 1830 1840 1850 1860 RAHLQGPAGA SVAGPQTSEA FAITVRDVNE RPPQPQASVP LRLTRGSRAP ISRAQLSVVD 1870 1880 1890 1900 1910 1920 PDSAPGEIEY EVQRAPHNGF LSLVGGGLGP VTRFTQADVD SGRLAFVANG SSVAGIFQLS 1930 1940 1950 1960 1970 1980 MSDGASPPLP MSLAVDILPS AIEVQLRAPL EVPQALGRSS LSQQQLRVVS DREEPEAAYR 1990 2000 2010 2020 2030 2040 LIQGPQYGHL LVGGRPTSAF SQFQIDQGEV VFAFTNFSSS HDHFRVLALA RGVNASAVVN 2050 2060 2070 2080 2090 2100 VTVRALLHVW AGGPWPQGAT LRLDPTVLDA GELANRTGSV PRFRLLEGPR HGRVVRVPRA 2110 2120 2130 2140 2150 2160 RTEPGGSQLV EQFTQQDLED GRLGLEVGRP EGRAPGPAGD SLTLELWAQG VPPAVASLDF 2170 2180 2190 2200 2210 2220 ATEPYNAARP YSVALLSVPE AARTEAGKPE SSTPTGEPGP MASSPEPAVA KGGFLSFLEA 2230 2240 2250 2260 2270 2280 NMFSVIIPMC LVLLLLALIL PLLFYLRKRN KTGKHDVQVL TAKPRNGLAG DTETFRKVEP 2290 2300 2310 2320 GQAIPLTAVP GQGPPPGGQP DPELLQFCRT PNPALKNGQY WV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan." Pluschke G., Vanek M., Evans A., Dittmar T., Schmid P., Itin P., Filardo E.J., Reisfeld R.A. Proc. Natl. Acad. Sci. U.S.A. 93:9710-9715(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Melanoma.
[2]	"Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms." Yang J., Price M.A., Neudauer C.L., Wilson C., Ferrone S., Xia H., Iida J., Simpson M.A., McCarthy J.B. J. Cell Biol. 165:881-891(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Tissue: Melanoma.
[3]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion." Iida J., Meijne A.M.L., Oegema T.R. Jr., Yednock T.A., Kovach N.L., Furcht L.T., McCarthy J.B. J. Biol. Chem. 273:5955-5962(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ITGA4.
[6]	"Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas." Eisenmann K.M., McCarthy J.B., Simpson M.A., Keely P.J., Guan J.-L., Tachibana K., Lim L., Manser E., Furcht L.T., Iida J. Nat. Cell Biol. 1:507-513(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BCAR1; CDC42 AND ACK1, FUNCTION.
[7]	"Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen." Iida J., Pei D., Kang T., Simpson M.A., Herlyn M., Furcht L.T., McCarthy J.B. J. Biol. Chem. 276:18786-18794(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MMP16, FUNCTION.
[8]	"A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family." Staub E., Hinzmann B., Rosenthal A. FEBS Lett. 527:114-118(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF CSPG REPEATS.
[9]	"NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin." Fukushi J., Makagiansar I.T., Stallcup W.B. Mol. Biol. Cell 15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ITGA3; ITGB1 AND LGALS3.
[10]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2075, MASS SPECTROMETRY. Tissue: Plasma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X96753 mRNA. Translation: CAA65529.1. AY359468 mRNA. Translation: AAQ62842.1. AC105020 Genomic DNA. No translation available. CH471136 Genomic DNA. Translation: EAW99239.1. CH471136 Genomic DNA. Translation: EAW99240.1.
IPI	IPI00019157.
RefSeq	NP_001888.2. NM_001897.4.
UniGene	Hs.513044.
3D structure databases
ProteinModelPortal	Q6UVK1.
SMR	Q6UVK1. Positions 8-369, 541-569, 1819-1874.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1197576.
STRING	9606.ENSP00000312506.
PTM databases
PhosphoSite	Q6UVK1.
Polymorphism databases
DMDM	296434468.
Proteomic databases
PaxDb	Q6UVK1.
PRIDE	Q6UVK1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308508; ENSP00000312506; ENSG00000173546.
GeneID	1464.
KEGG	hsa:1464.
UCSC	uc002baw.3. human.
Organism-specific databases
CTD	1464.
GeneCards	GC15M075966.
H-InvDB	HIX0026925. HIX0038117. HIX0172852. HIX0177623. HIX0177624.
HGNC	HGNC:2466. CSPG4.
HPA	CAB016189. HPA002951.
MIM	601172. gene.
neXtProt	NX_Q6UVK1.
PharmGKB	PA26963.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG261397.
HOGENOM	HOG000170195.
HOVERGEN	HBG081360.
InParanoid	Q6UVK1.
KO	K08115.
OMA	RPIYRFT.
OrthoDB	EOG42BX7N.
PhylomeDB	Q6UVK1.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_116125. Disease.
Gene expression databases
Bgee	Q6UVK1.
CleanEx	HS_CSPG4.
Genevestigator	Q6UVK1.
GermOnline	ENSG00000173546. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 2 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR027210. Cspg4. IPR001791. Laminin_G. [Graphical view]
PANTHER	PTHR32539:SF0. PTHR32539:SF0. 1 hit.
Pfam	PF02210. Laminin_G_2. 2 hits. [Graphical view]
SMART	SM00282. LamG. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 2 hits.
PROSITE	PS50025. LAM_G_DOMAIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CSPG4. human.
GenomeRNAi	1464.
NextBio	6013.
SOURCE	Search...

Entry information

Entry name

CSPG4_HUMAN

Accession

Primary (citable) accession number: Q6UVK1
Secondary accession number(s): D3DW77, Q92675

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.