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Q6UVK1

- CSPG4_HUMAN

UniProt

Q6UVK1 - CSPG4_HUMAN

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Protein

Chondroitin sulfate proteoglycan 4

Gene

CSPG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.3 Publications

GO - Molecular functioni

  1. protein kinase binding Source: UniProtKB
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. angiogenesis Source: UniProtKB-KW
  3. carbohydrate metabolic process Source: Reactome
  4. cell proliferation Source: Ensembl
  5. chondroitin sulfate biosynthetic process Source: Reactome
  6. chondroitin sulfate catabolic process Source: Reactome
  7. chondroitin sulfate metabolic process Source: Reactome
  8. dermatan sulfate biosynthetic process Source: Reactome
  9. glial cell migration Source: Ensembl
  10. glycosaminoglycan metabolic process Source: Reactome
  11. intracellular signal transduction Source: UniProtKB
  12. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  13. small molecule metabolic process Source: Reactome
  14. tissue remodeling Source: UniProtKB-KW
  15. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Transducer

Keywords - Biological processi

Angiogenesis, Differentiation, Tissue remodeling

Enzyme and pathway databases

ReactomeiREACT_120800. Dermatan sulfate biosynthesis.
REACT_120888. CS/DS degradation.
REACT_120989. Chondroitin sulfate biosynthesis.
REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_267642. Defective CHST14 causes EDS, musculocontractural type.
REACT_267659. Defective B3GAT3 causes JDSSDHD.
REACT_267682. Defective CHSY1 causes TPBS.
REACT_267708. Defective CHST3 causes SEDCJD.
REACT_267711. Defective B4GALT7 causes EDS, progeroid type.
SignaLinkiQ6UVK1.

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin sulfate proteoglycan 4
Alternative name(s):
Chondroitin sulfate proteoglycan NG2
Melanoma chondroitin sulfate proteoglycan
Melanoma-associated chondroitin sulfate proteoglycan
Gene namesi
Name:CSPG4
Synonyms:MCSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:2466. CSPG4.

Subcellular locationi

Apical cell membrane By similarity; Single-pass type I membrane protein By similarity; Extracellular side By similarity. Cell projectionlamellipodium membrane By similarity; Single-pass type I membrane protein By similarity; Extracellular side By similarity
Note: Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 22242195ExtracellularSequence AnalysisAdd
BLAST
Transmembranei2225 – 224521HelicalSequence AnalysisAdd
BLAST
Topological domaini2246 – 232277CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cell surface Source: UniProtKB
  3. extracellular region Source: Reactome
  4. extracellular vesicular exosome Source: UniProtKB
  5. focal adhesion Source: UniProtKB
  6. Golgi lumen Source: Reactome
  7. integral component of plasma membrane Source: ProtInc
  8. lysosomal lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 23222293Chondroitin sulfate proteoglycan 4PRO_0000041962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi169 ↔ 192PROSITE-ProRule annotation
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi354 ↔ 380PROSITE-ProRule annotation
Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi685 – 6851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi772 – 7721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi995 – 9951O-linked (Xyl...) (chondroitin sulfate)By similarity
Glycosylationi1131 – 11311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1202 – 12021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1364 – 13641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1449 – 14491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1645 – 16451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1909 – 19091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2016 – 20161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2034 – 20341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2040 – 20401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2075 – 20751N-linked (GlcNAc...)1 Publication
Modified residuei2252 – 22521Phosphothreonine; by PKC/PRKCABy similarity

Post-translational modificationi

O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.By similarity1 Publication
Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ6UVK1.
PaxDbiQ6UVK1.
PRIDEiQ6UVK1.

PTM databases

PhosphoSiteiQ6UVK1.

Expressioni

Tissue specificityi

Detected only in malignant melanoma cells.1 Publication

Gene expression databases

BgeeiQ6UVK1.
CleanExiHS_CSPG4.
GenevestigatoriQ6UVK1.

Organism-specific databases

HPAiCAB016189.
HPA002951.

Interactioni

Subunit structurei

Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16.By similarity4 Publications

Protein-protein interaction databases

BioGridi107846. 9 interactions.
IntActiQ6UVK1. 1 interaction.
MINTiMINT-1197576.
STRINGi9606.ENSP00000312506.

Structurei

3D structure databases

ProteinModelPortaliQ6UVK1.
SMRiQ6UVK1. Positions 50-369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 192163Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini202 – 380179Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Repeati430 – 52394CSPG 11 PublicationAdd
BLAST
Repeati556 – 64388CSPG 21 PublicationAdd
BLAST
Repeati665 – 764100CSPG 31 PublicationAdd
BLAST
Repeati792 – 87887CSPG 41 PublicationAdd
BLAST
Repeati900 – 98990CSPG 51 PublicationAdd
BLAST
Repeati1020 – 110889CSPG 61 PublicationAdd
BLAST
Repeati1128 – 121689CSPG 71 PublicationAdd
BLAST
Repeati1241 – 133797CSPG 81 PublicationAdd
BLAST
Repeati1360 – 144990CSPG 91 PublicationAdd
BLAST
Repeati1476 – 156186CSPG 101 PublicationAdd
BLAST
Repeati1583 – 167997CSPG 111 PublicationAdd
BLAST
Repeati1707 – 180397CSPG 121 PublicationAdd
BLAST
Repeati1835 – 192288CSPG 131 PublicationAdd
BLAST
Repeati1944 – 202986CSPG 141 PublicationAdd
BLAST
Repeati2048 – 2147100CSPG 151 PublicationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 639610Globular or compact configuration stabilized by disulfide bondsAdd
BLAST
Regioni30 – 639610Neurite growth inhibitionBy similarityAdd
BLAST
Regioni574 – 1040467Interaction with COL6A2By similarityAdd
BLAST
Regioni631 – 1446816Interaction with COL5A1By similarityAdd
BLAST
Regioni1586 – 2221636Neurite growth inhibitionBy similarityAdd
BLAST
Regioni1587 – 2221635Cysteine-containingAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2320 – 23223PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi639 – 1586948Gly/Ser-rich (glycosaminoglycan attachment domain)Add
BLAST

Sequence similaritiesi

Contains 15 CSPG (NG2) repeats.Curated
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG261397.
GeneTreeiENSGT00550000074429.
HOGENOMiHOG000170195.
HOVERGENiHBG081360.
InParanoidiQ6UVK1.
KOiK08115.
OMAiRPIYRFT.
OrthoDBiEOG77DJ56.
PhylomeDBiQ6UVK1.
TreeFamiTF316876.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF02210. Laminin_G_2. 2 hits.
[Graphical view]
SMARTiSM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UVK1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MQSGPRPPLP APGLALALTL TMLARLASAA SFFGENHLEV PVATALTDID
60 70 80 90 100
LQLQFSTSQP EALLLLAAGP ADHLLLQLYS GRLQVRLVLG QEELRLQTPA
110 120 130 140 150
ETLLSDSIPH TVVLTVVEGW ATLSVDGFLN ASSAVPGAPL EVPYGLFVGG
160 170 180 190 200
TGTLGLPYLR GTSRPLRGCL HAATLNGRSL LRPLTPDVHE GCAEEFSASD
210 220 230 240 250
DVALGFSGPH SLAAFPAWGT QDEGTLEFTL TTQSRQAPLA FQAGGRRGDF
260 270 280 290 300
IYVDIFEGHL RAVVEKGQGT VLLHNSVPVA DGQPHEVSVH INAHRLEISV
310 320 330 340 350
DQYPTHTSNR GVLSYLEPRG SLLLGGLDAE ASRHLQEHRL GLTPEATNAS
360 370 380 390 400
LLGCMEDLSV NGQRRGLREA LLTRNMAAGC RLEEEEYEDD AYGHYEAFST
410 420 430 440 450
LAPEAWPAME LPEPCVPEPG LPPVFANFTQ LLTISPLVVA EGGTAWLEWR
460 470 480 490 500
HVQPTLDLME AELRKSQVLF SVTRGARHGE LELDIPGAQA RKMFTLLDVV
510 520 530 540 550
NRKARFIHDG SEDTSDQLVL EVSVTARVPM PSCLRRGQTY LLPIQVNPVN
560 570 580 590 600
DPPHIIFPHG SLMVILEHTQ KPLGPEVFQA YDPDSACEGL TFQVLGTSSG
610 620 630 640 650
LPVERRDQPG EPATEFSCRE LEAGSLVYVH RGGPAQDLTF RVSDGLQASP
660 670 680 690 700
PATLKVVAIR PAIQIHRSTG LRLAQGSAMP ILPANLSVET NAVGQDVSVL
710 720 730 740 750
FRVTGALQFG ELQKQGAGGV EGAEWWATQA FHQRDVEQGR VRYLSTDPQH
760 770 780 790 800
HAYDTVENLA LEVQVGQEIL SNLSFPVTIQ RATVWMLRLE PLHTQNTQQE
810 820 830 840 850
TLTTAHLEAT LEEAGPSPPT FHYEVVQAPR KGNLQLQGTR LSDGQGFTQD
860 870 880 890 900
DIQAGRVTYG ATARASEAVE DTFRFRVTAP PYFSPLYTFP IHIGGDPDAP
910 920 930 940 950
VLTNVLLVVP EGGEGVLSAD HLFVKSLNSA SYLYEVMERP RHGRLAWRGT
960 970 980 990 1000
QDKTTMVTSF TNEDLLRGRL VYQHDDSETT EDDIPFVATR QGESSGDMAW
1010 1020 1030 1040 1050
EEVRGVFRVA IQPVNDHAPV QTISRIFHVA RGGRRLLTTD DVAFSDADSG
1060 1070 1080 1090 1100
FADAQLVLTR KDLLFGSIVA VDEPTRPIYR FTQEDLRKRR VLFVHSGADR
1110 1120 1130 1140 1150
GWIQLQVSDG QHQATALLEV QASEPYLRVA NGSSLVVPQG GQGTIDTAVL
1160 1170 1180 1190 1200
HLDTNLDIRS GDEVHYHVTA GPRWGQLVRA GQPATAFSQQ DLLDGAVLYS
1210 1220 1230 1240 1250
HNGSLSPRDT MAFSVEAGPV HTDATLQVTI ALEGPLAPLK LVRHKKIYVF
1260 1270 1280 1290 1300
QGEAAEIRRD QLEAAQEAVP PADIVFSVKS PPSAGYLVMV SRGALADEPP
1310 1320 1330 1340 1350
SLDPVQSFSQ EAVDTGRVLY LHSRPEAWSD AFSLDVASGL GAPLEGVLVE
1360 1370 1380 1390 1400
LEVLPAAIPL EAQNFSVPEG GSLTLAPPLL RVSGPYFPTL LGLSLQVLEP
1410 1420 1430 1440 1450
PQHGALQKED GPQARTLSAF SWRMVEEQLI RYVHDGSETL TDSFVLMANA
1460 1470 1480 1490 1500
SEMDRQSHPV AFTVTVLPVN DQPPILTTNT GLQMWEGATA PIPAEALRST
1510 1520 1530 1540 1550
DGDSGSEDLV YTIEQPSNGR VVLRGAPGTE VRSFTQAQLD GGLVLFSHRG
1560 1570 1580 1590 1600
TLDGGFRFRL SDGEHTSPGH FFRVTAQKQV LLSLKGSQTL TVCPGSVQPL
1610 1620 1630 1640 1650
SSQTLRASSS AGTDPQLLLY RVVRGPQLGR LFHAQQDSTG EALVNFTQAE
1660 1670 1680 1690 1700
VYAGNILYEH EMPPEPFWEA HDTLELQLSS PPARDVAATL AVAVSFEAAC
1710 1720 1730 1740 1750
PQRPSHLWKN KGLWVPEGQR ARITVAALDA SNLLASVPSP QRSEHDVLFQ
1760 1770 1780 1790 1800
VTQFPSRGQL LVSEEPLHAG QPHFLQSQLA AGQLVYAHGG GGTQQDGFHF
1810 1820 1830 1840 1850
RAHLQGPAGA SVAGPQTSEA FAITVRDVNE RPPQPQASVP LRLTRGSRAP
1860 1870 1880 1890 1900
ISRAQLSVVD PDSAPGEIEY EVQRAPHNGF LSLVGGGLGP VTRFTQADVD
1910 1920 1930 1940 1950
SGRLAFVANG SSVAGIFQLS MSDGASPPLP MSLAVDILPS AIEVQLRAPL
1960 1970 1980 1990 2000
EVPQALGRSS LSQQQLRVVS DREEPEAAYR LIQGPQYGHL LVGGRPTSAF
2010 2020 2030 2040 2050
SQFQIDQGEV VFAFTNFSSS HDHFRVLALA RGVNASAVVN VTVRALLHVW
2060 2070 2080 2090 2100
AGGPWPQGAT LRLDPTVLDA GELANRTGSV PRFRLLEGPR HGRVVRVPRA
2110 2120 2130 2140 2150
RTEPGGSQLV EQFTQQDLED GRLGLEVGRP EGRAPGPAGD SLTLELWAQG
2160 2170 2180 2190 2200
VPPAVASLDF ATEPYNAARP YSVALLSVPE AARTEAGKPE SSTPTGEPGP
2210 2220 2230 2240 2250
MASSPEPAVA KGGFLSFLEA NMFSVIIPMC LVLLLLALIL PLLFYLRKRN
2260 2270 2280 2290 2300
KTGKHDVQVL TAKPRNGLAG DTETFRKVEP GQAIPLTAVP GQGPPPGGQP
2310 2320
DPELLQFCRT PNPALKNGQY WV
Length:2,322
Mass (Da):250,537
Last modified:May 18, 2010 - v2
Checksum:i0B4F39AFC5ADD3CA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 62PR → RG in CAA65529. (PubMed:8790396)Curated
Sequence conflicti5 – 62PR → RG in AAQ62842. (PubMed:15210734)Curated
Sequence conflicti477 – 4782RH → HY in CAA65529. (PubMed:8790396)Curated
Sequence conflicti486 – 4861P → L in CAA65529. (PubMed:8790396)Curated
Sequence conflicti631 – 6311R → C in CAA65529. (PubMed:8790396)Curated
Sequence conflicti715 – 7173QGA → HST in CAA65529. (PubMed:8790396)Curated
Sequence conflicti942 – 9421H → L in CAA65529. (PubMed:8790396)Curated
Sequence conflicti1208 – 12081R → E in CAA65529. (PubMed:8790396)Curated
Sequence conflicti1405 – 14051A → P in CAA65529. (PubMed:8790396)Curated
Sequence conflicti1557 – 15571R → P in CAA65529. (PubMed:8790396)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1703 – 17031R → H.
Corresponds to variant rs8023621 [ dbSNP | Ensembl ].
VAR_061733

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96753 mRNA. Translation: CAA65529.1.
AY359468 mRNA. Translation: AAQ62842.1.
AC105020 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99239.1.
CH471136 Genomic DNA. Translation: EAW99240.1.
CCDSiCCDS10284.1.
RefSeqiNP_001888.2. NM_001897.4.
UniGeneiHs.513044.

Genome annotation databases

EnsembliENST00000308508; ENSP00000312506; ENSG00000173546.
GeneIDi1464.
KEGGihsa:1464.
UCSCiuc002baw.3. human.

Polymorphism databases

DMDMi296434468.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96753 mRNA. Translation: CAA65529.1 .
AY359468 mRNA. Translation: AAQ62842.1 .
AC105020 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99239.1 .
CH471136 Genomic DNA. Translation: EAW99240.1 .
CCDSi CCDS10284.1.
RefSeqi NP_001888.2. NM_001897.4.
UniGenei Hs.513044.

3D structure databases

ProteinModelPortali Q6UVK1.
SMRi Q6UVK1. Positions 50-369.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107846. 9 interactions.
IntActi Q6UVK1. 1 interaction.
MINTi MINT-1197576.
STRINGi 9606.ENSP00000312506.

PTM databases

PhosphoSitei Q6UVK1.

Polymorphism databases

DMDMi 296434468.

Proteomic databases

MaxQBi Q6UVK1.
PaxDbi Q6UVK1.
PRIDEi Q6UVK1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308508 ; ENSP00000312506 ; ENSG00000173546 .
GeneIDi 1464.
KEGGi hsa:1464.
UCSCi uc002baw.3. human.

Organism-specific databases

CTDi 1464.
GeneCardsi GC15M075966.
H-InvDB HIX0026925.
HIX0038117.
HIX0172852.
HIX0177623.
HIX0177624.
HGNCi HGNC:2466. CSPG4.
HPAi CAB016189.
HPA002951.
MIMi 601172. gene.
neXtProti NX_Q6UVK1.
PharmGKBi PA26963.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG261397.
GeneTreei ENSGT00550000074429.
HOGENOMi HOG000170195.
HOVERGENi HBG081360.
InParanoidi Q6UVK1.
KOi K08115.
OMAi RPIYRFT.
OrthoDBi EOG77DJ56.
PhylomeDBi Q6UVK1.
TreeFami TF316876.

Enzyme and pathway databases

Reactomei REACT_120800. Dermatan sulfate biosynthesis.
REACT_120888. CS/DS degradation.
REACT_120989. Chondroitin sulfate biosynthesis.
REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_267642. Defective CHST14 causes EDS, musculocontractural type.
REACT_267659. Defective B3GAT3 causes JDSSDHD.
REACT_267682. Defective CHSY1 causes TPBS.
REACT_267708. Defective CHST3 causes SEDCJD.
REACT_267711. Defective B4GALT7 causes EDS, progeroid type.
SignaLinki Q6UVK1.

Miscellaneous databases

ChiTaRSi CSPG4. human.
GeneWikii CSPG4.
GenomeRNAii 1464.
NextBioi 6013.
PROi Q6UVK1.
SOURCEi Search...

Gene expression databases

Bgeei Q6UVK1.
CleanExi HS_CSPG4.
Genevestigatori Q6UVK1.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
SMARTi SM00282. LamG. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
PROSITEi PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan."
    Pluschke G., Vanek M., Evans A., Dittmar T., Schmid P., Itin P., Filardo E.J., Reisfeld R.A.
    Proc. Natl. Acad. Sci. U.S.A. 93:9710-9715(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Melanoma.
  2. "Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms."
    Yang J., Price M.A., Neudauer C.L., Wilson C., Ferrone S., Xia H., Iida J., Simpson M.A., McCarthy J.B.
    J. Cell Biol. 165:881-891(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Melanoma.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion."
    Iida J., Meijne A.M.L., Oegema T.R. Jr., Yednock T.A., Kovach N.L., Furcht L.T., McCarthy J.B.
    J. Biol. Chem. 273:5955-5962(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITGA4.
  6. "Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas."
    Eisenmann K.M., McCarthy J.B., Simpson M.A., Keely P.J., Guan J.-L., Tachibana K., Lim L., Manser E., Furcht L.T., Iida J.
    Nat. Cell Biol. 1:507-513(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCAR1; CDC42 AND ACK1, FUNCTION.
  7. "Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen."
    Iida J., Pei D., Kang T., Simpson M.A., Herlyn M., Furcht L.T., McCarthy J.B.
    J. Biol. Chem. 276:18786-18794(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MMP16, FUNCTION.
  8. "A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family."
    Staub E., Hinzmann B., Rosenthal A.
    FEBS Lett. 527:114-118(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF CSPG REPEATS.
  9. "NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."
    Fukushi J., Makagiansar I.T., Stallcup W.B.
    Mol. Biol. Cell 15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITGA3; ITGB1 AND LGALS3.
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2075.
    Tissue: Plasma.

Entry informationi

Entry nameiCSPG4_HUMAN
AccessioniPrimary (citable) accession number: Q6UVK1
Secondary accession number(s): D3DW77, Q92675
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Valuable marker for several incompletely differentiated precursor cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3