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Q6UVK1

- CSPG4_HUMAN

UniProt

Q6UVK1 - CSPG4_HUMAN

Protein

Chondroitin sulfate proteoglycan 4

Gene

CSPG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.3 Publications

    GO - Molecular functioni

    1. protein kinase binding Source: UniProtKB
    2. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. angiogenesis Source: UniProtKB-KW
    3. carbohydrate metabolic process Source: Reactome
    4. cell proliferation Source: Ensembl
    5. chondroitin sulfate biosynthetic process Source: Reactome
    6. chondroitin sulfate catabolic process Source: Reactome
    7. chondroitin sulfate metabolic process Source: Reactome
    8. dermatan sulfate biosynthetic process Source: Reactome
    9. glial cell migration Source: Ensembl
    10. glycosaminoglycan metabolic process Source: Reactome
    11. intracellular signal transduction Source: UniProtKB
    12. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    13. small molecule metabolic process Source: Reactome
    14. tissue remodeling Source: UniProtKB-KW
    15. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Transducer

    Keywords - Biological processi

    Angiogenesis, Differentiation, Tissue remodeling

    Enzyme and pathway databases

    ReactomeiREACT_120800. Dermatan sulfate biosynthesis.
    REACT_120888. CS/DS degradation.
    REACT_120989. Chondroitin sulfate biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    SignaLinkiQ6UVK1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chondroitin sulfate proteoglycan 4
    Alternative name(s):
    Chondroitin sulfate proteoglycan NG2
    Melanoma chondroitin sulfate proteoglycan
    Melanoma-associated chondroitin sulfate proteoglycan
    Gene namesi
    Name:CSPG4
    Synonyms:MCSP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:2466. CSPG4.

    Subcellular locationi

    Apical cell membrane By similarity; Single-pass type I membrane protein By similarity; Extracellular side By similarity. Cell projectionlamellipodium membrane By similarity; Single-pass type I membrane protein By similarity; Extracellular side By similarity
    Note: Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes By similarity.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. cell surface Source: UniProtKB
    3. extracellular region Source: Reactome
    4. extracellular vesicular exosome Source: UniProt
    5. Golgi lumen Source: Reactome
    6. integral component of plasma membrane Source: ProtInc
    7. lamellipodium membrane Source: UniProtKB-SubCell
    8. lysosomal lumen Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26963.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 23222293Chondroitin sulfate proteoglycan 4PRO_0000041962Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi169 ↔ 192PROSITE-ProRule annotation
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi354 ↔ 380PROSITE-ProRule annotation
    Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi685 – 6851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi772 – 7721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi995 – 9951O-linked (Xyl...) (chondroitin sulfate)By similarity
    Glycosylationi1131 – 11311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1202 – 12021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1364 – 13641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1449 – 14491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1645 – 16451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1909 – 19091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2016 – 20161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2034 – 20341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2040 – 20401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2075 – 20751N-linked (GlcNAc...)1 Publication
    Modified residuei2252 – 22521Phosphothreonine; by PKC/PRKCABy similarity

    Post-translational modificationi

    O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation By similarity. Involved in interaction with MMP16 and ITGA4.By similarity1 Publication
    Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

    Proteomic databases

    MaxQBiQ6UVK1.
    PaxDbiQ6UVK1.
    PRIDEiQ6UVK1.

    PTM databases

    PhosphoSiteiQ6UVK1.

    Expressioni

    Tissue specificityi

    Detected only in malignant melanoma cells.1 Publication

    Gene expression databases

    BgeeiQ6UVK1.
    CleanExiHS_CSPG4.
    GenevestigatoriQ6UVK1.

    Organism-specific databases

    HPAiCAB016189.
    HPA002951.

    Interactioni

    Subunit structurei

    Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 By similarity. Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16.By similarity4 Publications

    Protein-protein interaction databases

    BioGridi107846. 5 interactions.
    IntActiQ6UVK1. 1 interaction.
    MINTiMINT-1197576.
    STRINGi9606.ENSP00000312506.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UVK1.
    SMRiQ6UVK1. Positions 50-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 22242195ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2246 – 232277CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2225 – 224521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 192163Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini202 – 380179Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati430 – 52394CSPG 11 PublicationAdd
    BLAST
    Repeati556 – 64388CSPG 21 PublicationAdd
    BLAST
    Repeati665 – 764100CSPG 31 PublicationAdd
    BLAST
    Repeati792 – 87887CSPG 41 PublicationAdd
    BLAST
    Repeati900 – 98990CSPG 51 PublicationAdd
    BLAST
    Repeati1020 – 110889CSPG 61 PublicationAdd
    BLAST
    Repeati1128 – 121689CSPG 71 PublicationAdd
    BLAST
    Repeati1241 – 133797CSPG 81 PublicationAdd
    BLAST
    Repeati1360 – 144990CSPG 91 PublicationAdd
    BLAST
    Repeati1476 – 156186CSPG 101 PublicationAdd
    BLAST
    Repeati1583 – 167997CSPG 111 PublicationAdd
    BLAST
    Repeati1707 – 180397CSPG 121 PublicationAdd
    BLAST
    Repeati1835 – 192288CSPG 131 PublicationAdd
    BLAST
    Repeati1944 – 202986CSPG 141 PublicationAdd
    BLAST
    Repeati2048 – 2147100CSPG 151 PublicationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 639610Globular or compact configuration stabilized by disulfide bondsAdd
    BLAST
    Regioni30 – 639610Neurite growth inhibitionBy similarityAdd
    BLAST
    Regioni574 – 1040467Interaction with COL6A2By similarityAdd
    BLAST
    Regioni631 – 1446816Interaction with COL5A1By similarityAdd
    BLAST
    Regioni1586 – 2221636Neurite growth inhibitionBy similarityAdd
    BLAST
    Regioni1587 – 2221635Cysteine-containingAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi2320 – 23223PDZ-binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi639 – 1586948Gly/Ser-rich (glycosaminoglycan attachment domain)Add
    BLAST

    Sequence similaritiesi

    Contains 15 CSPG (NG2) repeats.Curated
    Contains 2 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG261397.
    HOGENOMiHOG000170195.
    HOVERGENiHBG081360.
    InParanoidiQ6UVK1.
    KOiK08115.
    OMAiRPIYRFT.
    OrthoDBiEOG77DJ56.
    PhylomeDBiQ6UVK1.
    TreeFamiTF316876.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF02210. Laminin_G_2. 2 hits.
    [Graphical view]
    SMARTiSM00282. LamG. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6UVK1-1 [UniParc]FASTAAdd to Basket

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    MQSGPRPPLP APGLALALTL TMLARLASAA SFFGENHLEV PVATALTDID     50
    LQLQFSTSQP EALLLLAAGP ADHLLLQLYS GRLQVRLVLG QEELRLQTPA 100
    ETLLSDSIPH TVVLTVVEGW ATLSVDGFLN ASSAVPGAPL EVPYGLFVGG 150
    TGTLGLPYLR GTSRPLRGCL HAATLNGRSL LRPLTPDVHE GCAEEFSASD 200
    DVALGFSGPH SLAAFPAWGT QDEGTLEFTL TTQSRQAPLA FQAGGRRGDF 250
    IYVDIFEGHL RAVVEKGQGT VLLHNSVPVA DGQPHEVSVH INAHRLEISV 300
    DQYPTHTSNR GVLSYLEPRG SLLLGGLDAE ASRHLQEHRL GLTPEATNAS 350
    LLGCMEDLSV NGQRRGLREA LLTRNMAAGC RLEEEEYEDD AYGHYEAFST 400
    LAPEAWPAME LPEPCVPEPG LPPVFANFTQ LLTISPLVVA EGGTAWLEWR 450
    HVQPTLDLME AELRKSQVLF SVTRGARHGE LELDIPGAQA RKMFTLLDVV 500
    NRKARFIHDG SEDTSDQLVL EVSVTARVPM PSCLRRGQTY LLPIQVNPVN 550
    DPPHIIFPHG SLMVILEHTQ KPLGPEVFQA YDPDSACEGL TFQVLGTSSG 600
    LPVERRDQPG EPATEFSCRE LEAGSLVYVH RGGPAQDLTF RVSDGLQASP 650
    PATLKVVAIR PAIQIHRSTG LRLAQGSAMP ILPANLSVET NAVGQDVSVL 700
    FRVTGALQFG ELQKQGAGGV EGAEWWATQA FHQRDVEQGR VRYLSTDPQH 750
    HAYDTVENLA LEVQVGQEIL SNLSFPVTIQ RATVWMLRLE PLHTQNTQQE 800
    TLTTAHLEAT LEEAGPSPPT FHYEVVQAPR KGNLQLQGTR LSDGQGFTQD 850
    DIQAGRVTYG ATARASEAVE DTFRFRVTAP PYFSPLYTFP IHIGGDPDAP 900
    VLTNVLLVVP EGGEGVLSAD HLFVKSLNSA SYLYEVMERP RHGRLAWRGT 950
    QDKTTMVTSF TNEDLLRGRL VYQHDDSETT EDDIPFVATR QGESSGDMAW 1000
    EEVRGVFRVA IQPVNDHAPV QTISRIFHVA RGGRRLLTTD DVAFSDADSG 1050
    FADAQLVLTR KDLLFGSIVA VDEPTRPIYR FTQEDLRKRR VLFVHSGADR 1100
    GWIQLQVSDG QHQATALLEV QASEPYLRVA NGSSLVVPQG GQGTIDTAVL 1150
    HLDTNLDIRS GDEVHYHVTA GPRWGQLVRA GQPATAFSQQ DLLDGAVLYS 1200
    HNGSLSPRDT MAFSVEAGPV HTDATLQVTI ALEGPLAPLK LVRHKKIYVF 1250
    QGEAAEIRRD QLEAAQEAVP PADIVFSVKS PPSAGYLVMV SRGALADEPP 1300
    SLDPVQSFSQ EAVDTGRVLY LHSRPEAWSD AFSLDVASGL GAPLEGVLVE 1350
    LEVLPAAIPL EAQNFSVPEG GSLTLAPPLL RVSGPYFPTL LGLSLQVLEP 1400
    PQHGALQKED GPQARTLSAF SWRMVEEQLI RYVHDGSETL TDSFVLMANA 1450
    SEMDRQSHPV AFTVTVLPVN DQPPILTTNT GLQMWEGATA PIPAEALRST 1500
    DGDSGSEDLV YTIEQPSNGR VVLRGAPGTE VRSFTQAQLD GGLVLFSHRG 1550
    TLDGGFRFRL SDGEHTSPGH FFRVTAQKQV LLSLKGSQTL TVCPGSVQPL 1600
    SSQTLRASSS AGTDPQLLLY RVVRGPQLGR LFHAQQDSTG EALVNFTQAE 1650
    VYAGNILYEH EMPPEPFWEA HDTLELQLSS PPARDVAATL AVAVSFEAAC 1700
    PQRPSHLWKN KGLWVPEGQR ARITVAALDA SNLLASVPSP QRSEHDVLFQ 1750
    VTQFPSRGQL LVSEEPLHAG QPHFLQSQLA AGQLVYAHGG GGTQQDGFHF 1800
    RAHLQGPAGA SVAGPQTSEA FAITVRDVNE RPPQPQASVP LRLTRGSRAP 1850
    ISRAQLSVVD PDSAPGEIEY EVQRAPHNGF LSLVGGGLGP VTRFTQADVD 1900
    SGRLAFVANG SSVAGIFQLS MSDGASPPLP MSLAVDILPS AIEVQLRAPL 1950
    EVPQALGRSS LSQQQLRVVS DREEPEAAYR LIQGPQYGHL LVGGRPTSAF 2000
    SQFQIDQGEV VFAFTNFSSS HDHFRVLALA RGVNASAVVN VTVRALLHVW 2050
    AGGPWPQGAT LRLDPTVLDA GELANRTGSV PRFRLLEGPR HGRVVRVPRA 2100
    RTEPGGSQLV EQFTQQDLED GRLGLEVGRP EGRAPGPAGD SLTLELWAQG 2150
    VPPAVASLDF ATEPYNAARP YSVALLSVPE AARTEAGKPE SSTPTGEPGP 2200
    MASSPEPAVA KGGFLSFLEA NMFSVIIPMC LVLLLLALIL PLLFYLRKRN 2250
    KTGKHDVQVL TAKPRNGLAG DTETFRKVEP GQAIPLTAVP GQGPPPGGQP 2300
    DPELLQFCRT PNPALKNGQY WV 2322
    Length:2,322
    Mass (Da):250,537
    Last modified:May 18, 2010 - v2
    Checksum:i0B4F39AFC5ADD3CA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 62PR → RG in CAA65529. (PubMed:8790396)Curated
    Sequence conflicti5 – 62PR → RG in AAQ62842. (PubMed:15210734)Curated
    Sequence conflicti477 – 4782RH → HY in CAA65529. (PubMed:8790396)Curated
    Sequence conflicti486 – 4861P → L in CAA65529. (PubMed:8790396)Curated
    Sequence conflicti631 – 6311R → C in CAA65529. (PubMed:8790396)Curated
    Sequence conflicti715 – 7173QGA → HST in CAA65529. (PubMed:8790396)Curated
    Sequence conflicti942 – 9421H → L in CAA65529. (PubMed:8790396)Curated
    Sequence conflicti1208 – 12081R → E in CAA65529. (PubMed:8790396)Curated
    Sequence conflicti1405 – 14051A → P in CAA65529. (PubMed:8790396)Curated
    Sequence conflicti1557 – 15571R → P in CAA65529. (PubMed:8790396)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1703 – 17031R → H.
    Corresponds to variant rs8023621 [ dbSNP | Ensembl ].
    VAR_061733

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96753 mRNA. Translation: CAA65529.1.
    AY359468 mRNA. Translation: AAQ62842.1.
    AC105020 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99239.1.
    CH471136 Genomic DNA. Translation: EAW99240.1.
    CCDSiCCDS10284.1.
    RefSeqiNP_001888.2. NM_001897.4.
    UniGeneiHs.513044.

    Genome annotation databases

    EnsembliENST00000308508; ENSP00000312506; ENSG00000173546.
    GeneIDi1464.
    KEGGihsa:1464.
    UCSCiuc002baw.3. human.

    Polymorphism databases

    DMDMi296434468.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96753 mRNA. Translation: CAA65529.1 .
    AY359468 mRNA. Translation: AAQ62842.1 .
    AC105020 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99239.1 .
    CH471136 Genomic DNA. Translation: EAW99240.1 .
    CCDSi CCDS10284.1.
    RefSeqi NP_001888.2. NM_001897.4.
    UniGenei Hs.513044.

    3D structure databases

    ProteinModelPortali Q6UVK1.
    SMRi Q6UVK1. Positions 50-369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107846. 5 interactions.
    IntActi Q6UVK1. 1 interaction.
    MINTi MINT-1197576.
    STRINGi 9606.ENSP00000312506.

    PTM databases

    PhosphoSitei Q6UVK1.

    Polymorphism databases

    DMDMi 296434468.

    Proteomic databases

    MaxQBi Q6UVK1.
    PaxDbi Q6UVK1.
    PRIDEi Q6UVK1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308508 ; ENSP00000312506 ; ENSG00000173546 .
    GeneIDi 1464.
    KEGGi hsa:1464.
    UCSCi uc002baw.3. human.

    Organism-specific databases

    CTDi 1464.
    GeneCardsi GC15M075966.
    H-InvDB HIX0026925.
    HIX0038117.
    HIX0172852.
    HIX0177623.
    HIX0177624.
    HGNCi HGNC:2466. CSPG4.
    HPAi CAB016189.
    HPA002951.
    MIMi 601172. gene.
    neXtProti NX_Q6UVK1.
    PharmGKBi PA26963.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261397.
    HOGENOMi HOG000170195.
    HOVERGENi HBG081360.
    InParanoidi Q6UVK1.
    KOi K08115.
    OMAi RPIYRFT.
    OrthoDBi EOG77DJ56.
    PhylomeDBi Q6UVK1.
    TreeFami TF316876.

    Enzyme and pathway databases

    Reactomei REACT_120800. Dermatan sulfate biosynthesis.
    REACT_120888. CS/DS degradation.
    REACT_120989. Chondroitin sulfate biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    SignaLinki Q6UVK1.

    Miscellaneous databases

    ChiTaRSi CSPG4. human.
    GeneWikii CSPG4.
    GenomeRNAii 1464.
    NextBioi 6013.
    PROi Q6UVK1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6UVK1.
    CleanExi HS_CSPG4.
    Genevestigatori Q6UVK1.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF02210. Laminin_G_2. 2 hits.
    [Graphical view ]
    SMARTi SM00282. LamG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan."
      Pluschke G., Vanek M., Evans A., Dittmar T., Schmid P., Itin P., Filardo E.J., Reisfeld R.A.
      Proc. Natl. Acad. Sci. U.S.A. 93:9710-9715(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Melanoma.
    2. "Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms."
      Yang J., Price M.A., Neudauer C.L., Wilson C., Ferrone S., Xia H., Iida J., Simpson M.A., McCarthy J.B.
      J. Cell Biol. 165:881-891(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Melanoma.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion."
      Iida J., Meijne A.M.L., Oegema T.R. Jr., Yednock T.A., Kovach N.L., Furcht L.T., McCarthy J.B.
      J. Biol. Chem. 273:5955-5962(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ITGA4.
    6. "Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas."
      Eisenmann K.M., McCarthy J.B., Simpson M.A., Keely P.J., Guan J.-L., Tachibana K., Lim L., Manser E., Furcht L.T., Iida J.
      Nat. Cell Biol. 1:507-513(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BCAR1; CDC42 AND ACK1, FUNCTION.
    7. "Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen."
      Iida J., Pei D., Kang T., Simpson M.A., Herlyn M., Furcht L.T., McCarthy J.B.
      J. Biol. Chem. 276:18786-18794(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MMP16, FUNCTION.
    8. "A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family."
      Staub E., Hinzmann B., Rosenthal A.
      FEBS Lett. 527:114-118(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF CSPG REPEATS.
    9. "NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."
      Fukushi J., Makagiansar I.T., Stallcup W.B.
      Mol. Biol. Cell 15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ITGA3; ITGB1 AND LGALS3.
    10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2075.
      Tissue: Plasma.

    Entry informationi

    Entry nameiCSPG4_HUMAN
    AccessioniPrimary (citable) accession number: Q6UVK1
    Secondary accession number(s): D3DW77, Q92675
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Valuable marker for several incompletely differentiated precursor cells.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3