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Protein
Submitted name:

ATGR2

Gene

ATGR2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. angiotensin type II receptor activity Source: Ensembl
  2. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. aldosterone secretion Source: Ensembl
  2. brain renin-angiotensin system Source: Ensembl
  3. cell growth involved in cardiac muscle cell development Source: Ensembl
  4. cellular response to dexamethasone stimulus Source: Ensembl
  5. cellular sodium ion homeostasis Source: Ensembl
  6. cerebellar cortex development Source: Ensembl
  7. dopamine biosynthetic process Source: Ensembl
  8. exploration behavior Source: Ensembl
  9. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: Ensembl
  10. inflammatory response Source: Ensembl
  11. intracellular signal transduction Source: Ensembl
  12. negative regulation of fibroblast proliferation Source: Ensembl
  13. negative regulation of heart rate Source: Ensembl
  14. negative regulation of icosanoid secretion Source: Ensembl
  15. negative regulation of norepinephrine secretion Source: Ensembl
  16. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  17. positive regulation of cell proliferation Source: Ensembl
  18. positive regulation of cytokine secretion Source: Ensembl
  19. positive regulation of metanephric glomerulus development Source: Ensembl
  20. positive regulation of nitric-oxide synthase activity Source: Ensembl
  21. positive regulation of renal sodium excretion Source: Ensembl
  22. positive regulation of transcription, DNA-templated Source: Ensembl
  23. positive regulation of vasodilation Source: Ensembl
  24. regulation of apoptotic process Source: InterPro
  25. regulation of metanephros size Source: Ensembl
  26. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: Ensembl
  27. regulation of transcription factor import into nucleus Source: Ensembl
  28. renin-angiotensin regulation of aldosterone production Source: Ensembl
  29. response to organonitrogen compound Source: Ensembl
  30. vasodilation by angiotensin involved in regulation of systemic arterial blood pressure Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ATGR2Imported
Gene namesi
Name:ATGR2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. perinuclear region of cytoplasm Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ6UVH2.
ExpressionAtlasiQ6UVH2. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ6UVH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6UVH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YQSVIYPFLS QRRNPWQASY IVPLVWCMAC LSSLPTFYFR DVRTIEYLGV
60 70 80 90 100
NACIMAFPPE KYAQWSAGIA LMKNILGFII PLIFIATCYF GIRKHLLKTN
110 120 130 140
SYGKNRITRD QVLKMAAAVV LAFIICWLPF HVLTFLDALA WMGVINSC
Length:148
Mass (Da):16,983
Last modified:July 5, 2004 - v1
Checksum:i76DA6142BE8E014B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei148 – 1481Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH013177 Genomic DNA. Translation: AAQ62073.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH013177 Genomic DNA. Translation: AAQ62073.1.

3D structure databases

ProteinModelPortaliQ6UVH2.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ6UVH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

BgeeiQ6UVH2.
ExpressionAtlasiQ6UVH2. baseline and differential.

Family and domain databases

InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Partial sequence of the AGTR2 gene in Cantonese."
    Zhang M., Wang B., Zhao Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6UVH2_HUMAN
AccessioniPrimary (citable) accession number: Q6UVH2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.