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Q6UUV9

- CRTC1_HUMAN

UniProt

Q6UUV9 - CRTC1_HUMAN

Protein

CREB-regulated transcription coactivator 1

Gene

CRTC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei42 – 432Breakpoint for translocation to form the MECT1-MAML2 and MAML2-MECT1 fusion proteins2 Publications
    Sitei575 – 5751Required for ubiquitination and degradationBy similarity

    GO - Molecular functioni

    1. cAMP response element binding protein binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. positive regulation of CREB transcription factor activity Source: InterPro
    2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. protein homotetramerization Source: InterPro
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Host-virus interaction, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CREB-regulated transcription coactivator 1
    Alternative name(s):
    Mucoepidermoid carcinoma translocated protein 1
    Transducer of regulated cAMP response element-binding protein 1
    Short name:
    TORC-1
    Short name:
    Transducer of CREB protein 1
    Gene namesi
    Name:CRTC1Imported
    Synonyms:KIAA0616Imported, MECT1Imported, TORC1Imported, WAMTP11 Publication
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16062. CRTC1.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins By similarity. Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.

    Organism-specific databases

    PharmGKBiPA30730.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 634634CREB-regulated transcription coactivator 1PRO_0000096354Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Phosphoserine; by SIK1 and SIK22 Publications
    Modified residuei161 – 1611Phosphothreonine2 Publications

    Post-translational modificationi

    Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6UUV9.
    PaxDbiQ6UUV9.
    PRIDEiQ6UUV9.

    PTM databases

    PhosphoSiteiQ6UUV9.

    Expressioni

    Tissue specificityi

    Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.2 Publications

    Gene expression databases

    ArrayExpressiQ6UUV9.
    BgeeiQ6UUV9.
    GenevestigatoriQ6UUV9.

    Organism-specific databases

    HPAiHPA022035.

    Interactioni

    Subunit structurei

    Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.1 Publication

    Protein-protein interaction databases

    BioGridi116952. 6 interactions.
    IntActiQ6UUV9. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UUV9.
    SMRiQ6UUV9. Positions 8-35.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi242 – 25817Nuclear export signalBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi299 – 36668Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TORC family.Curated

    Phylogenomic databases

    eggNOGiNOG85958.
    HOVERGENiHBG058314.
    KOiK15309.
    OMAiPQHSSTL.
    OrthoDBiEOG7MKW5P.
    PhylomeDBiQ6UUV9.
    TreeFamiTF321571.

    Family and domain databases

    InterProiIPR024786. TORC.
    IPR024785. TORC_C.
    IPR024784. TORC_M.
    IPR024783. TORC_N.
    [Graphical view]
    PANTHERiPTHR13589. PTHR13589. 1 hit.
    PfamiPF12886. TORC_C. 1 hit.
    PF12885. TORC_M. 1 hit.
    PF12884. TORC_N. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q6UUV9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY    50
    LQLGPSRGQY YGGSLPNVNQ IGSGTMDLPF QTPFQSSGLD TSRTTRHHGL 100
    VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTMYLSP PADTSWRRTN 150
    SDSALHQSTM TPTQPESFSS GSQDVHQKRV LLLTVPGMEE TTSEADKNLS 200
    KQAWDTKKTG SRPKSCEVPG INIFPSADQE NTTALIPATH NTGGSLPDLT 250
    NIHFPSPLPT PLDPEEPTFP ALSSSSSTGN LAANLTHLGI GGAGQGMSTP 300
    GSSPQHRPAG VSPLSLSTEA RRQQASPTLS PLSPITQAVA MDALSLEQQL 350
    PYAFFTQAGS QQPPPQPQPP PPPPPASQQP PPPPPPQAPV RLPPGGPLLP 400
    SASLTRGPQP PPLAVTVPSS LPQSPPENPG QPSMGIDIAS APALQQYRTS 450
    AGSPANQSPT SPVSNQGFSP GSSPQHTSTL GSVFGDAYYE QQMAARQANA 500
    LSHQLEQFNM MENAISSSSL YSPGSTLNYS QAAMMGLTGS HGSLPDSQQL 550
    GYASHSGIPN IILTVTGESP PSLSKELTSS LAGVGDVSFD SDSQFPLDEL 600
    KIDPLTLDGL HMLNDPDMVL ADPATEDTFR MDRL 634
    Length:634
    Mass (Da):67,300
    Last modified:July 5, 2005 - v2
    Checksum:iECDC427FF9D6920B
    GO
    Isoform 2Curated (identifier: Q6UUV9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-81: Q → QPSGFLGEALAAAPVSL

    Note: No experimental confirmation available.Curated

    Show »
    Length:650
    Mass (Da):68,782
    Checksum:i0458940C57945F4A
    GO
    Isoform 31 Publication (identifier: Q6UUV9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         475-503: Missing.
         580-634: SLAGVGDVSF...TEDTFRMDRL → HRGHLPDGPP...CSVPRQRPSL

    Show »
    Length:593
    Mass (Da):62,530
    Checksum:iB7D8709B0C731D29
    GO

    Sequence cautioni

    The sequence AAH17075.3 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH23614.2 differs from that shown. Reason: Erroneous initiation.
    The sequence AAP12463.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti84 – 841F → S in BAB14822. (PubMed:14702039)Curated
    Sequence conflicti384 – 3841P → S in BAB14822. (PubMed:14702039)Curated
    Sequence conflicti556 – 5561S → G in BAB14822. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti286 – 2861T → A.
    Corresponds to variant rs3746266 [ dbSNP | Ensembl ].
    VAR_053934
    Natural varianti311 – 3111V → I.1 Publication
    Corresponds to variant rs36070283 [ dbSNP | Ensembl ].
    VAR_053935
    Natural varianti328 – 3281T → A.1 Publication
    Corresponds to variant rs3746266 [ dbSNP | Ensembl ].
    VAR_053936

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 811Q → QPSGFLGEALAAAPVSL in isoform 2. 2 PublicationsVSP_051749
    Alternative sequencei475 – 50329Missing in isoform 3. 3 PublicationsVSP_051750Add
    BLAST
    Alternative sequencei580 – 63455SLAGV…RMDRL → HRGHLPDGPPVSGHAGTLPL SRPDGASPARGRPCSVPRQR PSL in isoform 3. 3 PublicationsVSP_051751Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY360171 mRNA. Translation: AAQ98856.1.
    AY040323 mRNA. Translation: AAK93832.1.
    AY040324 mRNA. Translation: AAK93833.1. Different termination.
    AK024089 mRNA. Translation: BAB14822.1.
    AC003107 Genomic DNA. No translation available.
    AC004476 Genomic DNA. No translation available.
    AC006123 Genomic DNA. Translation: AAC97072.1.
    CH471106 Genomic DNA. Translation: EAW84730.1.
    BC017075 mRNA. Translation: AAH17075.3. Different initiation.
    BC023614 mRNA. Translation: AAH23614.2. Different initiation.
    BC028050 mRNA. Translation: AAH28050.1.
    AB014516 mRNA. Translation: BAA31591.1.
    AY186997 mRNA. Translation: AAP12462.1. Different termination.
    AY186998 mRNA. Translation: AAP12463.1. Different initiation.
    CCDSiCCDS32963.1. [Q6UUV9-1]
    CCDS42525.1. [Q6UUV9-2]
    PIRiT00388.
    RefSeqiNP_001091952.1. NM_001098482.1. [Q6UUV9-2]
    NP_056136.2. NM_015321.2. [Q6UUV9-1]
    UniGeneiHs.371096.

    Genome annotation databases

    EnsembliENST00000321949; ENSP00000323332; ENSG00000105662. [Q6UUV9-1]
    ENST00000338797; ENSP00000345001; ENSG00000105662. [Q6UUV9-2]
    GeneIDi23373.
    KEGGihsa:23373.
    UCSCiuc002nkb.4. human. [Q6UUV9-1]
    uc010ebv.3. human. [Q6UUV9-2]

    Polymorphism databases

    DMDMi68565585.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY360171 mRNA. Translation: AAQ98856.1 .
    AY040323 mRNA. Translation: AAK93832.1 .
    AY040324 mRNA. Translation: AAK93833.1 . Different termination.
    AK024089 mRNA. Translation: BAB14822.1 .
    AC003107 Genomic DNA. No translation available.
    AC004476 Genomic DNA. No translation available.
    AC006123 Genomic DNA. Translation: AAC97072.1 .
    CH471106 Genomic DNA. Translation: EAW84730.1 .
    BC017075 mRNA. Translation: AAH17075.3 . Different initiation.
    BC023614 mRNA. Translation: AAH23614.2 . Different initiation.
    BC028050 mRNA. Translation: AAH28050.1 .
    AB014516 mRNA. Translation: BAA31591.1 .
    AY186997 mRNA. Translation: AAP12462.1 . Different termination.
    AY186998 mRNA. Translation: AAP12463.1 . Different initiation.
    CCDSi CCDS32963.1. [Q6UUV9-1 ]
    CCDS42525.1. [Q6UUV9-2 ]
    PIRi T00388.
    RefSeqi NP_001091952.1. NM_001098482.1. [Q6UUV9-2 ]
    NP_056136.2. NM_015321.2. [Q6UUV9-1 ]
    UniGenei Hs.371096.

    3D structure databases

    ProteinModelPortali Q6UUV9.
    SMRi Q6UUV9. Positions 8-35.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116952. 6 interactions.
    IntActi Q6UUV9. 4 interactions.

    PTM databases

    PhosphoSitei Q6UUV9.

    Polymorphism databases

    DMDMi 68565585.

    Proteomic databases

    MaxQBi Q6UUV9.
    PaxDbi Q6UUV9.
    PRIDEi Q6UUV9.

    Protocols and materials databases

    DNASUi 23373.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321949 ; ENSP00000323332 ; ENSG00000105662 . [Q6UUV9-1 ]
    ENST00000338797 ; ENSP00000345001 ; ENSG00000105662 . [Q6UUV9-2 ]
    GeneIDi 23373.
    KEGGi hsa:23373.
    UCSCi uc002nkb.4. human. [Q6UUV9-1 ]
    uc010ebv.3. human. [Q6UUV9-2 ]

    Organism-specific databases

    CTDi 23373.
    GeneCardsi GC19P018794.
    HGNCi HGNC:16062. CRTC1.
    HPAi HPA022035.
    MIMi 607536. gene.
    neXtProti NX_Q6UUV9.
    PharmGKBi PA30730.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85958.
    HOVERGENi HBG058314.
    KOi K15309.
    OMAi PQHSSTL.
    OrthoDBi EOG7MKW5P.
    PhylomeDBi Q6UUV9.
    TreeFami TF321571.

    Miscellaneous databases

    ChiTaRSi CRTC1. human.
    GeneWikii CRTC1.
    GenomeRNAii 23373.
    NextBioi 45456.
    PROi Q6UUV9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6UUV9.
    Bgeei Q6UUV9.
    Genevestigatori Q6UUV9.

    Family and domain databases

    InterProi IPR024786. TORC.
    IPR024785. TORC_C.
    IPR024784. TORC_M.
    IPR024783. TORC_N.
    [Graphical view ]
    PANTHERi PTHR13589. PTHR13589. 1 hit.
    Pfami PF12886. TORC_C. 1 hit.
    PF12885. TORC_M. 1 hit.
    PF12884. TORC_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells."
      Iourgenko V., Zhang W., Mickanin C., Daly I., Jiang C., Hexham J.M., Orth A.P., Miraglia L., Meltzer J., Garza D., Chirn G.-W., McWhinnie E., Cohen D., Skelton J., Terry R., Yu Y., Bodian D., Buxton F.P.
      , Zhu J., Song C., Labow M.A.
      Proc. Natl. Acad. Sci. U.S.A. 100:12147-12152(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CREB1.
    2. "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway."
      Tonon G., Modi S., Wu L., Kubo A., Coxon A.B., Komiya T., O'Neil K., Stover K., El-Naggar A., Griffin J.D., Kirsch I.R., Kaye F.J.
      Nat. Genet. 33:208-213(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), CHROMOSOMAL TRANSLOCATION WITH MAML2.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: EmbryoImported.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-311 AND ALA-328.
      Tissue: BrainImported, Colon and EyeImported.
    7. "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors."
      Enlund F., Behboudi A., Andren Y., Oberg C., Lendahl U., Mark J., Stenman G.
      Exp. Cell Res. 292:21-28(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-104 (ISOFORMS 1/3), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH MAML2.
      Tissue: Carcinoma1 Publication.
    8. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-634 (ISOFORM 2).
      Tissue: BrainImported.
    9. Cited for: FUNCTION, SUBUNIT, INTERACTION WITH CREB1 AND TAF4.
    10. "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins."
      Bittinger M.A., McWhinnie E., Meltzer J., Iourgenko V., Latario B., Liu X., Chen C.H., Song C., Garza D., Labow M.
      Curr. Biol. 14:2156-2161(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.
    11. "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion."
      Behboudi A., Winnes M., Gorunova L., van den Oord J.J., Mertens F., Enlund F., Stenman G.
      Genes Chromosomes Cancer 43:202-205(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION.
    12. "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade."
      Katoh Y., Takemori H., Lin X.-Z., Tamura M., Muraoka M., Satoh T., Tsuchiya Y., Min L., Doi J., Miyauchi A., Witters L.A., Nakamura H., Okamoto M.
      FEBS J. 273:2730-2748(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-151, SUBCELLULAR LOCATION.
    13. "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats."
      Siu Y.-T., Chin K.-T., Siu K.-L., Yee Wai Choy E., Jeang K.-T., Jin D.-Y.
      J. Virol. 80:7052-7059(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HTLV-1 TAX, FUNCTION.
    14. "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells."
      Wu Z., Huang X., Feng Y., Handschin C., Feng Y., Gullicksen P.S., Bare O., Labow M., Spiegelman B., Stevenson S.C.
      Proc. Natl. Acad. Sci. U.S.A. 103:14379-14384(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    15. Cited for: FUNCTION.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiCRTC1_HUMAN
    AccessioniPrimary (citable) accession number: Q6UUV9
    Secondary accession number(s): A6NMG5
    , O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3