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Q6UUV9

- CRTC1_HUMAN

UniProt

Q6UUV9 - CRTC1_HUMAN

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Protein
CREB-regulated transcription coactivator 1
Gene
CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons By similarity.6 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei42 – 432Breakpoint for translocation to form the MECT1-MAML2 and MAML2-MECT1 fusion proteins2 Publications
Sitei575 – 5751Required for ubiquitination and degradation By similarity

GO - Molecular functioni

  1. cAMP response element binding protein binding Source: UniProtKB
  2. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. positive regulation of CREB transcription factor activity Source: InterPro
  2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. protein homotetramerization Source: InterPro
  4. transcription, DNA-templated Source: UniProtKB-KW
  5. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB-regulated transcription coactivator 1
Alternative name(s):
Mucoepidermoid carcinoma translocated protein 1
Transducer of regulated cAMP response element-binding protein 1
Short name:
TORC-1
Short name:
Transducer of CREB protein 1
Gene namesi
Name:CRTC1
Synonyms:KIAA0616, MECT1, TORC1, WAMTP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16062. CRTC1.

Subcellular locationi

Cytoplasm. Nucleus
Note: Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins By similarity. Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels.3 Publications

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: UniProtKB
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.

Organism-specific databases

PharmGKBiPA30730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634CREB-regulated transcription coactivator 1
PRO_0000096354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine; by SIK1 and SIK21 Publication
Modified residuei161 – 1611Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 By similarity.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6UUV9.
PaxDbiQ6UUV9.
PRIDEiQ6UUV9.

PTM databases

PhosphoSiteiQ6UUV9.

Expressioni

Tissue specificityi

Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.2 Publications

Gene expression databases

ArrayExpressiQ6UUV9.
BgeeiQ6UUV9.
GenevestigatoriQ6UUV9.

Organism-specific databases

HPAiHPA022035.

Interactioni

Subunit structurei

Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.1 Publication

Protein-protein interaction databases

BioGridi116952. 6 interactions.
IntActiQ6UUV9. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6UUV9.
SMRiQ6UUV9. Positions 8-35.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi242 – 25817Nuclear export signal By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi299 – 36668Ser-rich
Add
BLAST

Sequence similaritiesi

Belongs to the TORC family.

Phylogenomic databases

eggNOGiNOG85958.
HOVERGENiHBG058314.
KOiK15309.
OMAiPQHSSTL.
OrthoDBiEOG7MKW5P.
PhylomeDBiQ6UUV9.
TreeFamiTF321571.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q6UUV9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY    50
LQLGPSRGQY YGGSLPNVNQ IGSGTMDLPF QTPFQSSGLD TSRTTRHHGL 100
VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTMYLSP PADTSWRRTN 150
SDSALHQSTM TPTQPESFSS GSQDVHQKRV LLLTVPGMEE TTSEADKNLS 200
KQAWDTKKTG SRPKSCEVPG INIFPSADQE NTTALIPATH NTGGSLPDLT 250
NIHFPSPLPT PLDPEEPTFP ALSSSSSTGN LAANLTHLGI GGAGQGMSTP 300
GSSPQHRPAG VSPLSLSTEA RRQQASPTLS PLSPITQAVA MDALSLEQQL 350
PYAFFTQAGS QQPPPQPQPP PPPPPASQQP PPPPPPQAPV RLPPGGPLLP 400
SASLTRGPQP PPLAVTVPSS LPQSPPENPG QPSMGIDIAS APALQQYRTS 450
AGSPANQSPT SPVSNQGFSP GSSPQHTSTL GSVFGDAYYE QQMAARQANA 500
LSHQLEQFNM MENAISSSSL YSPGSTLNYS QAAMMGLTGS HGSLPDSQQL 550
GYASHSGIPN IILTVTGESP PSLSKELTSS LAGVGDVSFD SDSQFPLDEL 600
KIDPLTLDGL HMLNDPDMVL ADPATEDTFR MDRL 634
Length:634
Mass (Da):67,300
Last modified:July 5, 2005 - v2
Checksum:iECDC427FF9D6920B
GO
Isoform 2 (identifier: Q6UUV9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-81: Q → QPSGFLGEALAAAPVSL

Note: No experimental confirmation available.

Show »
Length:650
Mass (Da):68,782
Checksum:i0458940C57945F4A
GO
Isoform 31 Publication (identifier: Q6UUV9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-503: Missing.
     580-634: SLAGVGDVSF...TEDTFRMDRL → HRGHLPDGPP...CSVPRQRPSL

Show »
Length:593
Mass (Da):62,530
Checksum:iB7D8709B0C731D29
GO

Sequence cautioni

The sequence AAH17075.3 differs from that shown. Reason: Erroneous initiation.
The sequence AAH23614.2 differs from that shown. Reason: Erroneous initiation.
The sequence AAP12463.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti286 – 2861T → A.
Corresponds to variant rs3746266 [ dbSNP | Ensembl ].
VAR_053934
Natural varianti311 – 3111V → I.1 Publication
Corresponds to variant rs36070283 [ dbSNP | Ensembl ].
VAR_053935
Natural varianti328 – 3281T → A.1 Publication
Corresponds to variant rs3746266 [ dbSNP | Ensembl ].
VAR_053936

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei81 – 811Q → QPSGFLGEALAAAPVSL in isoform 2.
VSP_051749
Alternative sequencei475 – 50329Missing in isoform 3.
VSP_051750Add
BLAST
Alternative sequencei580 – 63455SLAGV…RMDRL → HRGHLPDGPPVSGHAGTLPL SRPDGASPARGRPCSVPRQR PSL in isoform 3.
VSP_051751Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841F → S in BAB14822. 1 Publication
Sequence conflicti384 – 3841P → S in BAB14822. 1 Publication
Sequence conflicti556 – 5561S → G in BAB14822. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY360171 mRNA. Translation: AAQ98856.1.
AY040323 mRNA. Translation: AAK93832.1.
AY040324 mRNA. Translation: AAK93833.1. Different termination.
AK024089 mRNA. Translation: BAB14822.1.
AC003107 Genomic DNA. No translation available.
AC004476 Genomic DNA. No translation available.
AC006123 Genomic DNA. Translation: AAC97072.1.
CH471106 Genomic DNA. Translation: EAW84730.1.
BC017075 mRNA. Translation: AAH17075.3. Different initiation.
BC023614 mRNA. Translation: AAH23614.2. Different initiation.
BC028050 mRNA. Translation: AAH28050.1.
AB014516 mRNA. Translation: BAA31591.1.
AY186997 mRNA. Translation: AAP12462.1. Different termination.
AY186998 mRNA. Translation: AAP12463.1. Different initiation.
CCDSiCCDS32963.1. [Q6UUV9-1]
CCDS42525.1. [Q6UUV9-2]
PIRiT00388.
RefSeqiNP_001091952.1. NM_001098482.1. [Q6UUV9-2]
NP_056136.2. NM_015321.2. [Q6UUV9-1]
UniGeneiHs.371096.

Genome annotation databases

EnsembliENST00000321949; ENSP00000323332; ENSG00000105662. [Q6UUV9-1]
ENST00000338797; ENSP00000345001; ENSG00000105662. [Q6UUV9-2]
GeneIDi23373.
KEGGihsa:23373.
UCSCiuc002nkb.4. human. [Q6UUV9-1]
uc010ebv.3. human. [Q6UUV9-2]

Polymorphism databases

DMDMi68565585.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY360171 mRNA. Translation: AAQ98856.1 .
AY040323 mRNA. Translation: AAK93832.1 .
AY040324 mRNA. Translation: AAK93833.1 . Different termination.
AK024089 mRNA. Translation: BAB14822.1 .
AC003107 Genomic DNA. No translation available.
AC004476 Genomic DNA. No translation available.
AC006123 Genomic DNA. Translation: AAC97072.1 .
CH471106 Genomic DNA. Translation: EAW84730.1 .
BC017075 mRNA. Translation: AAH17075.3 . Different initiation.
BC023614 mRNA. Translation: AAH23614.2 . Different initiation.
BC028050 mRNA. Translation: AAH28050.1 .
AB014516 mRNA. Translation: BAA31591.1 .
AY186997 mRNA. Translation: AAP12462.1 . Different termination.
AY186998 mRNA. Translation: AAP12463.1 . Different initiation.
CCDSi CCDS32963.1. [Q6UUV9-1 ]
CCDS42525.1. [Q6UUV9-2 ]
PIRi T00388.
RefSeqi NP_001091952.1. NM_001098482.1. [Q6UUV9-2 ]
NP_056136.2. NM_015321.2. [Q6UUV9-1 ]
UniGenei Hs.371096.

3D structure databases

ProteinModelPortali Q6UUV9.
SMRi Q6UUV9. Positions 8-35.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116952. 6 interactions.
IntActi Q6UUV9. 4 interactions.

PTM databases

PhosphoSitei Q6UUV9.

Polymorphism databases

DMDMi 68565585.

Proteomic databases

MaxQBi Q6UUV9.
PaxDbi Q6UUV9.
PRIDEi Q6UUV9.

Protocols and materials databases

DNASUi 23373.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321949 ; ENSP00000323332 ; ENSG00000105662 . [Q6UUV9-1 ]
ENST00000338797 ; ENSP00000345001 ; ENSG00000105662 . [Q6UUV9-2 ]
GeneIDi 23373.
KEGGi hsa:23373.
UCSCi uc002nkb.4. human. [Q6UUV9-1 ]
uc010ebv.3. human. [Q6UUV9-2 ]

Organism-specific databases

CTDi 23373.
GeneCardsi GC19P018794.
HGNCi HGNC:16062. CRTC1.
HPAi HPA022035.
MIMi 607536. gene.
neXtProti NX_Q6UUV9.
PharmGKBi PA30730.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85958.
HOVERGENi HBG058314.
KOi K15309.
OMAi PQHSSTL.
OrthoDBi EOG7MKW5P.
PhylomeDBi Q6UUV9.
TreeFami TF321571.

Miscellaneous databases

ChiTaRSi CRTC1. human.
GeneWikii CRTC1.
GenomeRNAii 23373.
NextBioi 45456.
PROi Q6UUV9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6UUV9.
Bgeei Q6UUV9.
Genevestigatori Q6UUV9.

Family and domain databases

InterProi IPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view ]
PANTHERi PTHR13589. PTHR13589. 1 hit.
Pfami PF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells."
    Iourgenko V., Zhang W., Mickanin C., Daly I., Jiang C., Hexham J.M., Orth A.P., Miraglia L., Meltzer J., Garza D., Chirn G.-W., McWhinnie E., Cohen D., Skelton J., Terry R., Yu Y., Bodian D., Buxton F.P.
    , Zhu J., Song C., Labow M.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:12147-12152(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CREB1.
  2. "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway."
    Tonon G., Modi S., Wu L., Kubo A., Coxon A.B., Komiya T., O'Neil K., Stover K., El-Naggar A., Griffin J.D., Kirsch I.R., Kaye F.J.
    Nat. Genet. 33:208-213(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), CHROMOSOMAL TRANSLOCATION WITH MAML2.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Embryo.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-311 AND ALA-328.
    Tissue: Brain, Colon and Eye.
  7. "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors."
    Enlund F., Behboudi A., Andren Y., Oberg C., Lendahl U., Mark J., Stenman G.
    Exp. Cell Res. 292:21-28(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-104 (ISOFORMS 1/3), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH MAML2.
    Tissue: Carcinoma.
  8. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-634 (ISOFORM 2).
    Tissue: Brain.
  9. Cited for: FUNCTION, SUBUNIT, INTERACTION WITH CREB1 AND TAF4.
  10. "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins."
    Bittinger M.A., McWhinnie E., Meltzer J., Iourgenko V., Latario B., Liu X., Chen C.H., Song C., Garza D., Labow M.
    Curr. Biol. 14:2156-2161(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.
  11. "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion."
    Behboudi A., Winnes M., Gorunova L., van den Oord J.J., Mertens F., Enlund F., Stenman G.
    Genes Chromosomes Cancer 43:202-205(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION.
  12. "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade."
    Katoh Y., Takemori H., Lin X.-Z., Tamura M., Muraoka M., Satoh T., Tsuchiya Y., Min L., Doi J., Miyauchi A., Witters L.A., Nakamura H., Okamoto M.
    FEBS J. 273:2730-2748(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT SER-151, SUBCELLULAR LOCATION.
  13. "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats."
    Siu Y.-T., Chin K.-T., Siu K.-L., Yee Wai Choy E., Jeang K.-T., Jin D.-Y.
    J. Virol. 80:7052-7059(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTLV-1 TAX, FUNCTION.
  14. "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells."
    Wu Z., Huang X., Feng Y., Handschin C., Feng Y., Gullicksen P.S., Bare O., Labow M., Spiegelman B., Stevenson S.C.
    Proc. Natl. Acad. Sci. U.S.A. 103:14379-14384(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  15. Cited for: FUNCTION.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCRTC1_HUMAN
AccessioniPrimary (citable) accession number: Q6UUV9
Secondary accession number(s): A6NMG5
, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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