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Q6UUV7

- CRTC3_HUMAN

UniProt

Q6UUV7 - CRTC3_HUMAN

Protein

CREB-regulated transcription coactivator 3

Gene

CRTC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).7 Publications

    GO - Molecular functioni

    1. cAMP response element binding protein binding Source: InterPro

    GO - Biological processi

    1. positive regulation of CREB transcription factor activity Source: InterPro
    2. protein homotetramerization Source: InterPro
    3. transcription, DNA-templated Source: UniProtKB-KW
    4. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Host-virus interaction, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CREB-regulated transcription coactivator 3
    Alternative name(s):
    Transducer of regulated cAMP response element-binding protein 3
    Short name:
    TORC-3
    Short name:
    Transducer of CREB protein 3
    Gene namesi
    Name:CRTC3
    Synonyms:TORC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:26148. CRTC3.

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: Appears to be mainly nuclear.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi282 – 2821Y → F: Translocates to the cytoplasm. Represses basal TORC3 activity towards CREB. 1 Publication

    Organism-specific databases

    PharmGKBiPA142672074.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619CREB-regulated transcription coactivator 3PRO_0000318531Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei4 – 41Phosphoserine1 Publication
    Modified residuei62 – 621Phosphoserine1 Publication
    Modified residuei162 – 1621Phosphoserine; by SIK2By similarity
    Modified residuei329 – 3291Phosphoserine1 Publication
    Modified residuei370 – 3701Phosphoserine1 Publication
    Modified residuei391 – 3911Phosphoserine2 Publications
    Modified residuei443 – 4431Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6UUV7.
    PaxDbiQ6UUV7.
    PRIDEiQ6UUV7.

    PTM databases

    PhosphoSiteiQ6UUV7.

    Expressioni

    Tissue specificityi

    Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.2 Publications

    Gene expression databases

    ArrayExpressiQ6UUV7.
    BgeeiQ6UUV7.
    CleanExiHS_CRTC3.
    GenevestigatoriQ6UUV7.

    Organism-specific databases

    HPAiHPA043735.

    Interactioni

    Subunit structurei

    Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction By similarity. Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N-terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription.By similarity4 Publications

    Protein-protein interaction databases

    BioGridi122294. 4 interactions.
    DIPiDIP-59211N.
    IntActiQ6UUV7. 3 interactions.
    STRINGi9606.ENSP00000268184.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UUV7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 103103Required for interaction with HTLV-1 TAXAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi180 – 1834Poly-Gly
    Compositional biasi444 – 4518Poly-Pro

    Sequence similaritiesi

    Belongs to the TORC family.Curated

    Phylogenomic databases

    eggNOGiNOG74259.
    HOGENOMiHOG000111980.
    HOVERGENiHBG058314.
    InParanoidiQ6UUV7.
    KOiK16334.
    OMAiYMGFCDG.
    OrthoDBiEOG7MKW5P.
    PhylomeDBiQ6UUV7.
    TreeFamiTF321571.

    Family and domain databases

    InterProiIPR024786. TORC.
    IPR024785. TORC_C.
    IPR024784. TORC_M.
    IPR024783. TORC_N.
    [Graphical view]
    PANTHERiPTHR13589. PTHR13589. 1 hit.
    PfamiPF12886. TORC_C. 1 hit.
    PF12885. TORC_M. 1 hit.
    PF12884. TORC_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6UUV7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAASPGSGSA NPRKFSEKIA LHTQRQAEET RAFEQLMTDL TLSRVQFQKL    50
    QQLRLTQYHG GSLPNVSQLR SSASEFQPSF HQADNVRGTR HHGLVERPSR 100
    NRFHPLHRRS GDKPGRQFDG SAFGANYSSQ PLDESWPRQQ PPWKDEKHPG 150
    FRLTSALNRT NSDSALHTSA LSTKPQDPYG GGGQSAWPAP YMGFCDGENN 200
    GHGEVASFPG PLKEENLLNV PKPLPKQLWE TKEIQSLSGR PRSCDVGGGN 250
    AFPHNGQNLG LSPFLGTLNT GGSLPDLTNL HYSTPLPASL DTTDHHFGSM 300
    SVGNSVNNIP AAMTHLGIRS SSGLQSSRSN PSIQATLNKT VLSSSLNNHP 350
    QTSVPNASAL HPSLRLFSLS NPSLSTTNLS GPSRRRQPPV SPLTLSPGPE 400
    AHQGFSRQLS STSPLAPYPT SQMVSSDRSQ LSFLPTEAQA QVSPPPPYPA 450
    PQELTQPLLQ QPRAPEAPAQ QPQAASSLPQ SDFQLLPAQG SSLTNFFPDV 500
    GFDQQSMRPG PAFPQQVPLV QQGSRELQDS FHLRPSPYSN CGSLPNTILP 550
    EDSSTSLFKD LNSALAGLPE VSLNVDTPFP LEEELQIEPL SLDGLNMLSD 600
    SSMGLLDPSV EETFRADRL 619
    Length:619
    Mass (Da):66,959
    Last modified:February 5, 2008 - v2
    Checksum:iA274B96DD1C2678E
    GO
    Isoform 3 (identifier: Q6UUV7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         551-551: Missing.

    Show »
    Length:618
    Mass (Da):66,830
    Checksum:i9825C1290FBD27C4
    GO

    Sequence cautioni

    The sequence BAC03424.1 differs from that shown. Reason: Frameshift at position 82.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti545 – 5451P → S in BAB15160. (PubMed:14702039)Curated
    Sequence conflicti616 – 6161A → T in BAC03424. (PubMed:12693554)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti72 – 721S → N.2 Publications
    Corresponds to variant rs8033595 [ dbSNP | Ensembl ].
    VAR_038758
    Natural varianti346 – 3461L → S.1 Publication
    VAR_038759

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei551 – 5511Missing in isoform 3. 1 PublicationVSP_031220

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY360173 mRNA. Translation: AAQ98858.1.
    AK090443 mRNA. Translation: BAC03424.1. Frameshift.
    AC021422 Genomic DNA. No translation available.
    AC103739 Genomic DNA. No translation available.
    AK025521 mRNA. Translation: BAB15160.1.
    BC074730 mRNA. Translation: AAH74730.2.
    BC074731 mRNA. Translation: AAH74731.3.
    CCDSiCCDS32331.1. [Q6UUV7-1]
    CCDS45348.1. [Q6UUV7-3]
    RefSeqiNP_001036039.1. NM_001042574.2. [Q6UUV7-3]
    NP_073606.3. NM_022769.4. [Q6UUV7-1]
    UniGeneiHs.567572.

    Genome annotation databases

    EnsembliENST00000268184; ENSP00000268184; ENSG00000140577. [Q6UUV7-1]
    ENST00000420329; ENSP00000416573; ENSG00000140577. [Q6UUV7-3]
    GeneIDi64784.
    KEGGihsa:64784.
    UCSCiuc002bpo.4. human. [Q6UUV7-3]
    uc002bpp.4. human. [Q6UUV7-1]

    Polymorphism databases

    DMDMi167009130.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY360173 mRNA. Translation: AAQ98858.1 .
    AK090443 mRNA. Translation: BAC03424.1 . Frameshift.
    AC021422 Genomic DNA. No translation available.
    AC103739 Genomic DNA. No translation available.
    AK025521 mRNA. Translation: BAB15160.1 .
    BC074730 mRNA. Translation: AAH74730.2 .
    BC074731 mRNA. Translation: AAH74731.3 .
    CCDSi CCDS32331.1. [Q6UUV7-1 ]
    CCDS45348.1. [Q6UUV7-3 ]
    RefSeqi NP_001036039.1. NM_001042574.2. [Q6UUV7-3 ]
    NP_073606.3. NM_022769.4. [Q6UUV7-1 ]
    UniGenei Hs.567572.

    3D structure databases

    ProteinModelPortali Q6UUV7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122294. 4 interactions.
    DIPi DIP-59211N.
    IntActi Q6UUV7. 3 interactions.
    STRINGi 9606.ENSP00000268184.

    PTM databases

    PhosphoSitei Q6UUV7.

    Polymorphism databases

    DMDMi 167009130.

    Proteomic databases

    MaxQBi Q6UUV7.
    PaxDbi Q6UUV7.
    PRIDEi Q6UUV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268184 ; ENSP00000268184 ; ENSG00000140577 . [Q6UUV7-1 ]
    ENST00000420329 ; ENSP00000416573 ; ENSG00000140577 . [Q6UUV7-3 ]
    GeneIDi 64784.
    KEGGi hsa:64784.
    UCSCi uc002bpo.4. human. [Q6UUV7-3 ]
    uc002bpp.4. human. [Q6UUV7-1 ]

    Organism-specific databases

    CTDi 64784.
    GeneCardsi GC15P091073.
    HGNCi HGNC:26148. CRTC3.
    HPAi HPA043735.
    MIMi 608986. gene.
    neXtProti NX_Q6UUV7.
    PharmGKBi PA142672074.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74259.
    HOGENOMi HOG000111980.
    HOVERGENi HBG058314.
    InParanoidi Q6UUV7.
    KOi K16334.
    OMAi YMGFCDG.
    OrthoDBi EOG7MKW5P.
    PhylomeDBi Q6UUV7.
    TreeFami TF321571.

    Miscellaneous databases

    ChiTaRSi CRTC3. human.
    GeneWikii CRTC3.
    GenomeRNAii 64784.
    NextBioi 66826.
    PROi Q6UUV7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6UUV7.
    Bgeei Q6UUV7.
    CleanExi HS_CRTC3.
    Genevestigatori Q6UUV7.

    Family and domain databases

    InterProi IPR024786. TORC.
    IPR024785. TORC_C.
    IPR024784. TORC_M.
    IPR024783. TORC_N.
    [Graphical view ]
    PANTHERi PTHR13589. PTHR13589. 1 hit.
    Pfami PF12886. TORC_C. 1 hit.
    PF12885. TORC_M. 1 hit.
    PF12884. TORC_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells."
      Iourgenko V., Zhang W., Mickanin C., Daly I., Jiang C., Hexham J.M., Orth A.P., Miraglia L., Meltzer J., Garza D., Chirn G.-W., McWhinnie E., Cohen D., Skelton J., Terry R., Yu Y., Bodian D., Buxton F.P.
      , Zhu J., Song C., Labow M.A.
      Proc. Natl. Acad. Sci. U.S.A. 100:12147-12152(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CREB1, VARIANT ASN-72.
    2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
      Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
      DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ASN-72.
      Tissue: Spleen.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 217-619 (ISOFORM 1).
      Tissue: Hepatoma.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-619 (ISOFORM 1), VARIANT SER-346.
      Tissue: Brain.
    6. Cited for: TISSUE SPECIFICITY.
    7. "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector."
      Screaton R.A., Conkright M.D., Katoh Y., Best J.L., Canettieri G., Jeffries S., Guzman E., Niessen S., Yates J.R. III, Takemori H., Okamoto M., Montminy M.
      Cell 119:61-74(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION, MUTAGENESIS OF TYR-282.
    8. "Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3."
      Koga H., Ohshima T., Shimotohno K.
      J. Biol. Chem. 279:52978-52983(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HTLV-1 TAX, FUNCTION.
    9. "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins."
      Bittinger M.A., McWhinnie E., Meltzer J., Iourgenko V., Latario B., Liu X., Chen C.H., Song C., Garza D., Labow M.
      Curr. Biol. 14:2156-2161(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade."
      Katoh Y., Takemori H., Lin X.-Z., Tamura M., Muraoka M., Satoh T., Tsuchiya Y., Min L., Doi J., Miyauchi A., Witters L.A., Nakamura H., Okamoto M.
      FEBS J. 273:2730-2748(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
    12. "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats."
      Siu Y.-T., Chin K.-T., Siu K.-L., Yee Wai Choy E., Jeang K.-T., Jin D.-Y.
      J. Virol. 80:7052-7059(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HTLV-1 TAX.
    13. "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells."
      Wu Z., Huang X., Feng Y., Handschin C., Feng Y., Gullicksen P.S., Bare O., Labow M., Spiegelman B., Stevenson S.C.
      Proc. Natl. Acad. Sci. U.S.A. 103:14379-14384(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    14. "BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3."
      Hishiki T., Ohshima T., Ego T., Shimotohno K.
      J. Biol. Chem. 282:28335-28343(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BCL3 IN BCL3/TORC3/CREB1 COMPLEX, FUNCTION.
    15. Cited for: FUNCTION.
    16. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391 AND SER-443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329; SER-370 AND SER-443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62 AND SER-391, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiCRTC3_HUMAN
    AccessioniPrimary (citable) accession number: Q6UUV7
    Secondary accession number(s): Q6DK61
    , Q6DK62, Q8NF38, Q9H6U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3