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Protein

CREB-regulated transcription coactivator 3

Gene

CRTC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).7 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.
R-HSA-400253. Circadian Clock.
SIGNORiQ6UUV7.

Names & Taxonomyi

Protein namesi
Recommended name:
CREB-regulated transcription coactivator 3
Alternative name(s):
Transducer of regulated cAMP response element-binding protein 3
Short name:
TORC-3
Short name:
Transducer of CREB protein 3
Gene namesi
Name:CRTC3
Synonyms:TORC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26148. CRTC3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi282Y → F: Translocates to the cytoplasm. Represses basal TORC3 activity towards CREB. 1 Publication1

Organism-specific databases

DisGeNETi64784.
OpenTargetsiENSG00000140577.
PharmGKBiPA142672074.

Polymorphism and mutation databases

BioMutaiCRTC3.
DMDMi167009130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185311 – 619CREB-regulated transcription coactivator 3Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineCombined sources1
Modified residuei62PhosphoserineCombined sources1
Modified residuei162Phosphoserine; by SIK2By similarity1
Modified residuei329PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6UUV7.
MaxQBiQ6UUV7.
PaxDbiQ6UUV7.
PeptideAtlasiQ6UUV7.
PRIDEiQ6UUV7.

PTM databases

iPTMnetiQ6UUV7.
PhosphoSitePlusiQ6UUV7.

Expressioni

Tissue specificityi

Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.2 Publications

Gene expression databases

BgeeiENSG00000140577.
CleanExiHS_CRTC3.
ExpressionAtlasiQ6UUV7. baseline and differential.
GenevisibleiQ6UUV7. HS.

Organism-specific databases

HPAiHPA043735.
HPA063691.

Interactioni

Subunit structurei

Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N-terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription.By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122294. 20 interactors.
DIPiDIP-59211N.
IntActiQ6UUV7. 19 interactors.
STRINGi9606.ENSP00000268184.

Structurei

3D structure databases

ProteinModelPortaliQ6UUV7.
SMRiQ6UUV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 103Required for interaction with HTLV-1 TAXAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi180 – 183Poly-Gly4
Compositional biasi444 – 451Poly-Pro8

Sequence similaritiesi

Belongs to the TORC family.Curated

Phylogenomic databases

eggNOGiENOG410IGNT. Eukaryota.
ENOG410XPDQ. LUCA.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000111980.
HOVERGENiHBG058314.
InParanoidiQ6UUV7.
KOiK16334.
OMAiGFCDGEN.
OrthoDBiEOG091G03YN.
PhylomeDBiQ6UUV7.
TreeFamiTF321571.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UUV7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASPGSGSA NPRKFSEKIA LHTQRQAEET RAFEQLMTDL TLSRVQFQKL
60 70 80 90 100
QQLRLTQYHG GSLPNVSQLR SSASEFQPSF HQADNVRGTR HHGLVERPSR
110 120 130 140 150
NRFHPLHRRS GDKPGRQFDG SAFGANYSSQ PLDESWPRQQ PPWKDEKHPG
160 170 180 190 200
FRLTSALNRT NSDSALHTSA LSTKPQDPYG GGGQSAWPAP YMGFCDGENN
210 220 230 240 250
GHGEVASFPG PLKEENLLNV PKPLPKQLWE TKEIQSLSGR PRSCDVGGGN
260 270 280 290 300
AFPHNGQNLG LSPFLGTLNT GGSLPDLTNL HYSTPLPASL DTTDHHFGSM
310 320 330 340 350
SVGNSVNNIP AAMTHLGIRS SSGLQSSRSN PSIQATLNKT VLSSSLNNHP
360 370 380 390 400
QTSVPNASAL HPSLRLFSLS NPSLSTTNLS GPSRRRQPPV SPLTLSPGPE
410 420 430 440 450
AHQGFSRQLS STSPLAPYPT SQMVSSDRSQ LSFLPTEAQA QVSPPPPYPA
460 470 480 490 500
PQELTQPLLQ QPRAPEAPAQ QPQAASSLPQ SDFQLLPAQG SSLTNFFPDV
510 520 530 540 550
GFDQQSMRPG PAFPQQVPLV QQGSRELQDS FHLRPSPYSN CGSLPNTILP
560 570 580 590 600
EDSSTSLFKD LNSALAGLPE VSLNVDTPFP LEEELQIEPL SLDGLNMLSD
610
SSMGLLDPSV EETFRADRL
Length:619
Mass (Da):66,959
Last modified:February 5, 2008 - v2
Checksum:iA274B96DD1C2678E
GO
Isoform 3 (identifier: Q6UUV7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-551: Missing.

Show »
Length:618
Mass (Da):66,830
Checksum:i9825C1290FBD27C4
GO

Sequence cautioni

The sequence BAC03424 differs from that shown. Reason: Frameshift at position 82.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti545P → S in BAB15160 (PubMed:14702039).Curated1
Sequence conflicti616A → T in BAC03424 (PubMed:12693554).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03875872S → N.2 PublicationsCorresponds to variant rs8033595dbSNPEnsembl.1
Natural variantiVAR_038759346L → S.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031220551Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360173 mRNA. Translation: AAQ98858.1.
AK090443 mRNA. Translation: BAC03424.1. Frameshift.
AC021422 Genomic DNA. No translation available.
AC103739 Genomic DNA. No translation available.
AK025521 mRNA. Translation: BAB15160.1.
BC074730 mRNA. Translation: AAH74730.2.
BC074731 mRNA. Translation: AAH74731.3.
CCDSiCCDS32331.1. [Q6UUV7-1]
CCDS45348.1. [Q6UUV7-3]
RefSeqiNP_001036039.1. NM_001042574.2. [Q6UUV7-3]
NP_073606.3. NM_022769.4. [Q6UUV7-1]
UniGeneiHs.567572.

Genome annotation databases

EnsembliENST00000268184; ENSP00000268184; ENSG00000140577. [Q6UUV7-1]
ENST00000420329; ENSP00000416573; ENSG00000140577. [Q6UUV7-3]
GeneIDi64784.
KEGGihsa:64784.
UCSCiuc002bpo.5. human. [Q6UUV7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360173 mRNA. Translation: AAQ98858.1.
AK090443 mRNA. Translation: BAC03424.1. Frameshift.
AC021422 Genomic DNA. No translation available.
AC103739 Genomic DNA. No translation available.
AK025521 mRNA. Translation: BAB15160.1.
BC074730 mRNA. Translation: AAH74730.2.
BC074731 mRNA. Translation: AAH74731.3.
CCDSiCCDS32331.1. [Q6UUV7-1]
CCDS45348.1. [Q6UUV7-3]
RefSeqiNP_001036039.1. NM_001042574.2. [Q6UUV7-3]
NP_073606.3. NM_022769.4. [Q6UUV7-1]
UniGeneiHs.567572.

3D structure databases

ProteinModelPortaliQ6UUV7.
SMRiQ6UUV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122294. 20 interactors.
DIPiDIP-59211N.
IntActiQ6UUV7. 19 interactors.
STRINGi9606.ENSP00000268184.

PTM databases

iPTMnetiQ6UUV7.
PhosphoSitePlusiQ6UUV7.

Polymorphism and mutation databases

BioMutaiCRTC3.
DMDMi167009130.

Proteomic databases

EPDiQ6UUV7.
MaxQBiQ6UUV7.
PaxDbiQ6UUV7.
PeptideAtlasiQ6UUV7.
PRIDEiQ6UUV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268184; ENSP00000268184; ENSG00000140577. [Q6UUV7-1]
ENST00000420329; ENSP00000416573; ENSG00000140577. [Q6UUV7-3]
GeneIDi64784.
KEGGihsa:64784.
UCSCiuc002bpo.5. human. [Q6UUV7-1]

Organism-specific databases

CTDi64784.
DisGeNETi64784.
GeneCardsiCRTC3.
HGNCiHGNC:26148. CRTC3.
HPAiHPA043735.
HPA063691.
MIMi608986. gene.
neXtProtiNX_Q6UUV7.
OpenTargetsiENSG00000140577.
PharmGKBiPA142672074.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGNT. Eukaryota.
ENOG410XPDQ. LUCA.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000111980.
HOVERGENiHBG058314.
InParanoidiQ6UUV7.
KOiK16334.
OMAiGFCDGEN.
OrthoDBiEOG091G03YN.
PhylomeDBiQ6UUV7.
TreeFamiTF321571.

Enzyme and pathway databases

ReactomeiR-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.
R-HSA-400253. Circadian Clock.
SIGNORiQ6UUV7.

Miscellaneous databases

ChiTaRSiCRTC3. human.
GeneWikiiCRTC3.
GenomeRNAii64784.
PROiQ6UUV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140577.
CleanExiHS_CRTC3.
ExpressionAtlasiQ6UUV7. baseline and differential.
GenevisibleiQ6UUV7. HS.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRTC3_HUMAN
AccessioniPrimary (citable) accession number: Q6UUV7
Secondary accession number(s): Q6DK61
, Q6DK62, Q8NF38, Q9H6U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.