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Q6UUV7

- CRTC3_HUMAN

UniProt

Q6UUV7 - CRTC3_HUMAN

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Protein

CREB-regulated transcription coactivator 3

Gene

CRTC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).7 Publications

GO - Molecular functioni

  1. cAMP response element binding protein binding Source: InterPro

GO - Biological processi

  1. energy homeostasis Source: Ensembl
  2. negative regulation of cAMP-mediated signaling Source: Ensembl
  3. negative regulation of lipid catabolic process Source: Ensembl
  4. positive regulation of CREB transcription factor activity Source: InterPro
  5. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. protein homotetramerization Source: InterPro
  7. transcription, DNA-templated Source: UniProtKB-KW
  8. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB-regulated transcription coactivator 3
Alternative name(s):
Transducer of regulated cAMP response element-binding protein 3
Short name:
TORC-3
Short name:
Transducer of CREB protein 3
Gene namesi
Name:CRTC3
Synonyms:TORC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:26148. CRTC3.

Subcellular locationi

Nucleus. Cytoplasm
Note: Appears to be mainly nuclear.

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi282 – 2821Y → F: Translocates to the cytoplasm. Represses basal TORC3 activity towards CREB. 1 Publication

Organism-specific databases

PharmGKBiPA142672074.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619CREB-regulated transcription coactivator 3PRO_0000318531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41Phosphoserine1 Publication
Modified residuei62 – 621Phosphoserine1 Publication
Modified residuei162 – 1621Phosphoserine; by SIK2By similarity
Modified residuei329 – 3291Phosphoserine1 Publication
Modified residuei370 – 3701Phosphoserine1 Publication
Modified residuei391 – 3911Phosphoserine2 Publications
Modified residuei443 – 4431Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6UUV7.
PaxDbiQ6UUV7.
PRIDEiQ6UUV7.

PTM databases

PhosphoSiteiQ6UUV7.

Expressioni

Tissue specificityi

Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.2 Publications

Gene expression databases

BgeeiQ6UUV7.
CleanExiHS_CRTC3.
ExpressionAtlasiQ6UUV7. baseline and differential.
GenevestigatoriQ6UUV7.

Organism-specific databases

HPAiHPA043735.

Interactioni

Subunit structurei

Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N-terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription.By similarity4 Publications

Protein-protein interaction databases

BioGridi122294. 6 interactions.
DIPiDIP-59211N.
IntActiQ6UUV7. 3 interactions.
STRINGi9606.ENSP00000268184.

Structurei

3D structure databases

ProteinModelPortaliQ6UUV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 103103Required for interaction with HTLV-1 TAXAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi180 – 1834Poly-Gly
Compositional biasi444 – 4518Poly-Pro

Sequence similaritiesi

Belongs to the TORC family.Curated

Phylogenomic databases

eggNOGiNOG74259.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000111980.
HOVERGENiHBG058314.
InParanoidiQ6UUV7.
KOiK16334.
OMAiYMGFCDG.
OrthoDBiEOG7MKW5P.
PhylomeDBiQ6UUV7.
TreeFamiTF321571.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UUV7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASPGSGSA NPRKFSEKIA LHTQRQAEET RAFEQLMTDL TLSRVQFQKL
60 70 80 90 100
QQLRLTQYHG GSLPNVSQLR SSASEFQPSF HQADNVRGTR HHGLVERPSR
110 120 130 140 150
NRFHPLHRRS GDKPGRQFDG SAFGANYSSQ PLDESWPRQQ PPWKDEKHPG
160 170 180 190 200
FRLTSALNRT NSDSALHTSA LSTKPQDPYG GGGQSAWPAP YMGFCDGENN
210 220 230 240 250
GHGEVASFPG PLKEENLLNV PKPLPKQLWE TKEIQSLSGR PRSCDVGGGN
260 270 280 290 300
AFPHNGQNLG LSPFLGTLNT GGSLPDLTNL HYSTPLPASL DTTDHHFGSM
310 320 330 340 350
SVGNSVNNIP AAMTHLGIRS SSGLQSSRSN PSIQATLNKT VLSSSLNNHP
360 370 380 390 400
QTSVPNASAL HPSLRLFSLS NPSLSTTNLS GPSRRRQPPV SPLTLSPGPE
410 420 430 440 450
AHQGFSRQLS STSPLAPYPT SQMVSSDRSQ LSFLPTEAQA QVSPPPPYPA
460 470 480 490 500
PQELTQPLLQ QPRAPEAPAQ QPQAASSLPQ SDFQLLPAQG SSLTNFFPDV
510 520 530 540 550
GFDQQSMRPG PAFPQQVPLV QQGSRELQDS FHLRPSPYSN CGSLPNTILP
560 570 580 590 600
EDSSTSLFKD LNSALAGLPE VSLNVDTPFP LEEELQIEPL SLDGLNMLSD
610
SSMGLLDPSV EETFRADRL
Length:619
Mass (Da):66,959
Last modified:February 5, 2008 - v2
Checksum:iA274B96DD1C2678E
GO
Isoform 3 (identifier: Q6UUV7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-551: Missing.

Show »
Length:618
Mass (Da):66,830
Checksum:i9825C1290FBD27C4
GO

Sequence cautioni

The sequence BAC03424.1 differs from that shown. Reason: Frameshift at position 82. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti545 – 5451P → S in BAB15160. (PubMed:14702039)Curated
Sequence conflicti616 – 6161A → T in BAC03424. (PubMed:12693554)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721S → N.2 Publications
Corresponds to variant rs8033595 [ dbSNP | Ensembl ].
VAR_038758
Natural varianti346 – 3461L → S.1 Publication
VAR_038759

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei551 – 5511Missing in isoform 3. 1 PublicationVSP_031220

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360173 mRNA. Translation: AAQ98858.1.
AK090443 mRNA. Translation: BAC03424.1. Frameshift.
AC021422 Genomic DNA. No translation available.
AC103739 Genomic DNA. No translation available.
AK025521 mRNA. Translation: BAB15160.1.
BC074730 mRNA. Translation: AAH74730.2.
BC074731 mRNA. Translation: AAH74731.3.
CCDSiCCDS32331.1. [Q6UUV7-1]
CCDS45348.1. [Q6UUV7-3]
RefSeqiNP_001036039.1. NM_001042574.2. [Q6UUV7-3]
NP_073606.3. NM_022769.4. [Q6UUV7-1]
UniGeneiHs.567572.

Genome annotation databases

EnsembliENST00000268184; ENSP00000268184; ENSG00000140577. [Q6UUV7-1]
ENST00000420329; ENSP00000416573; ENSG00000140577. [Q6UUV7-3]
GeneIDi64784.
KEGGihsa:64784.
UCSCiuc002bpo.4. human. [Q6UUV7-3]
uc002bpp.4. human. [Q6UUV7-1]

Polymorphism databases

DMDMi167009130.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360173 mRNA. Translation: AAQ98858.1 .
AK090443 mRNA. Translation: BAC03424.1 . Frameshift.
AC021422 Genomic DNA. No translation available.
AC103739 Genomic DNA. No translation available.
AK025521 mRNA. Translation: BAB15160.1 .
BC074730 mRNA. Translation: AAH74730.2 .
BC074731 mRNA. Translation: AAH74731.3 .
CCDSi CCDS32331.1. [Q6UUV7-1 ]
CCDS45348.1. [Q6UUV7-3 ]
RefSeqi NP_001036039.1. NM_001042574.2. [Q6UUV7-3 ]
NP_073606.3. NM_022769.4. [Q6UUV7-1 ]
UniGenei Hs.567572.

3D structure databases

ProteinModelPortali Q6UUV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122294. 6 interactions.
DIPi DIP-59211N.
IntActi Q6UUV7. 3 interactions.
STRINGi 9606.ENSP00000268184.

PTM databases

PhosphoSitei Q6UUV7.

Polymorphism databases

DMDMi 167009130.

Proteomic databases

MaxQBi Q6UUV7.
PaxDbi Q6UUV7.
PRIDEi Q6UUV7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268184 ; ENSP00000268184 ; ENSG00000140577 . [Q6UUV7-1 ]
ENST00000420329 ; ENSP00000416573 ; ENSG00000140577 . [Q6UUV7-3 ]
GeneIDi 64784.
KEGGi hsa:64784.
UCSCi uc002bpo.4. human. [Q6UUV7-3 ]
uc002bpp.4. human. [Q6UUV7-1 ]

Organism-specific databases

CTDi 64784.
GeneCardsi GC15P091073.
HGNCi HGNC:26148. CRTC3.
HPAi HPA043735.
MIMi 608986. gene.
neXtProti NX_Q6UUV7.
PharmGKBi PA142672074.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74259.
GeneTreei ENSGT00390000010652.
HOGENOMi HOG000111980.
HOVERGENi HBG058314.
InParanoidi Q6UUV7.
KOi K16334.
OMAi YMGFCDG.
OrthoDBi EOG7MKW5P.
PhylomeDBi Q6UUV7.
TreeFami TF321571.

Miscellaneous databases

ChiTaRSi CRTC3. human.
GeneWikii CRTC3.
GenomeRNAii 64784.
NextBioi 66826.
PROi Q6UUV7.
SOURCEi Search...

Gene expression databases

Bgeei Q6UUV7.
CleanExi HS_CRTC3.
ExpressionAtlasi Q6UUV7. baseline and differential.
Genevestigatori Q6UUV7.

Family and domain databases

InterProi IPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view ]
PANTHERi PTHR13589. PTHR13589. 1 hit.
Pfami PF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells."
    Iourgenko V., Zhang W., Mickanin C., Daly I., Jiang C., Hexham J.M., Orth A.P., Miraglia L., Meltzer J., Garza D., Chirn G.-W., McWhinnie E., Cohen D., Skelton J., Terry R., Yu Y., Bodian D., Buxton F.P.
    , Zhu J., Song C., Labow M.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:12147-12152(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CREB1, VARIANT ASN-72.
  2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ASN-72.
    Tissue: Spleen.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 217-619 (ISOFORM 1).
    Tissue: Hepatoma.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-619 (ISOFORM 1), VARIANT SER-346.
    Tissue: Brain.
  6. Cited for: TISSUE SPECIFICITY.
  7. "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector."
    Screaton R.A., Conkright M.D., Katoh Y., Best J.L., Canettieri G., Jeffries S., Guzman E., Niessen S., Yates J.R. III, Takemori H., Okamoto M., Montminy M.
    Cell 119:61-74(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION, MUTAGENESIS OF TYR-282.
  8. "Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3."
    Koga H., Ohshima T., Shimotohno K.
    J. Biol. Chem. 279:52978-52983(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTLV-1 TAX, FUNCTION.
  9. "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins."
    Bittinger M.A., McWhinnie E., Meltzer J., Iourgenko V., Latario B., Liu X., Chen C.H., Song C., Garza D., Labow M.
    Curr. Biol. 14:2156-2161(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade."
    Katoh Y., Takemori H., Lin X.-Z., Tamura M., Muraoka M., Satoh T., Tsuchiya Y., Min L., Doi J., Miyauchi A., Witters L.A., Nakamura H., Okamoto M.
    FEBS J. 273:2730-2748(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  12. "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats."
    Siu Y.-T., Chin K.-T., Siu K.-L., Yee Wai Choy E., Jeang K.-T., Jin D.-Y.
    J. Virol. 80:7052-7059(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTLV-1 TAX.
  13. "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells."
    Wu Z., Huang X., Feng Y., Handschin C., Feng Y., Gullicksen P.S., Bare O., Labow M., Spiegelman B., Stevenson S.C.
    Proc. Natl. Acad. Sci. U.S.A. 103:14379-14384(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  14. "BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3."
    Hishiki T., Ohshima T., Ego T., Shimotohno K.
    J. Biol. Chem. 282:28335-28343(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCL3 IN BCL3/TORC3/CREB1 COMPLEX, FUNCTION.
  15. Cited for: FUNCTION.
  16. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391 AND SER-443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329; SER-370 AND SER-443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62 AND SER-391, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCRTC3_HUMAN
AccessioniPrimary (citable) accession number: Q6UUV7
Secondary accession number(s): Q6DK61
, Q6DK62, Q8NF38, Q9H6U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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