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Protein

Cadherin-5

Gene

CDH5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561Calcium 1By similarity
Metal bindingi56 – 561Calcium 2By similarity
Metal bindingi57 – 571Calcium 1By similarity
Metal bindingi107 – 1071Calcium 1By similarity
Metal bindingi109 – 1091Calcium 1By similarity
Metal bindingi109 – 1091Calcium 2By similarity
Metal bindingi141 – 1411Calcium 2By similarity
Metal bindingi142 – 1421Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi143 – 1431Calcium 3By similarity
Metal bindingi144 – 1441Calcium 1By similarity
Metal bindingi144 – 1441Calcium 2By similarity
Metal bindingi145 – 1451Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi175 – 1751Calcium 3By similarity
Metal bindingi177 – 1771Calcium 2By similarity
Metal bindingi177 – 1771Calcium 3By similarity
Metal bindingi184 – 1841Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi229 – 2291Calcium 3By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-5
Alternative name(s):
Vascular endothelial cadherin
Short name:
VE-cadherin
CD_antigen: CD144
Gene namesi
Name:CDH5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini46 – 599554ExtracellularSequence analysisAdd
BLAST
Transmembranei600 – 62021HelicalSequence analysisAdd
BLAST
Topological domaini621 – 783163CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 4520Sequence analysisPRO_0000247562Add
BLAST
Chaini46 – 783738Cadherin-5PRO_0000247563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence analysis
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence analysis
Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).By similarity
O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6URK6.
PRIDEiQ6URK6.

Interactioni

Subunit structurei

Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1 (By similarity). Interacts with PARD3 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-48767N.
STRINGi9913.ENSBTAP00000009760.

Structurei

3D structure databases

ProteinModelPortaliQ6URK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 149106Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini150 – 256107Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini257 – 371115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini372 – 478107Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini478 – 585108Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ6URK6.
KOiK06533.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR030052. CDH5.
[Graphical view]
PANTHERiPTHR24027:SF89. PTHR24027:SF89. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6URK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQALVMLLAT GATYYLGLLA AAAAAVNPGR PNTPGSLPAH RRQKRDWIWN
60 70 80 90 100
QMHIDEERND SLPHYVGKIK SSVDPKKTEY QLRGESAGKV FRVDKNTGDV
110 120 130 140 150
YALERLDREK ISEYHLTALV VDKDSKKNLE SPSSFTIKVH DVNDNWPVFT
160 170 180 190 200
HRVFNASVPE MSGIGTSVIQ VTAMDADDPT VADHASVVYQ LTKGKENFDI
210 220 230 240 250
RGSGLIVTMN KHLDRETQDK YEVVVKAEDA QGRRGESGTA TVFITLQDVN
260 270 280 290 300
DNFPIFTQNR YTFSVPEDIR VGSPLGSLFV EDPDEPQNRK TKYSFVQGEY
310 320 330 340 350
RDTFTIDTDP SHNEGIIKPI KPLDYERIRQ YSFTIEATDP TIDLRYLGST
360 370 380 390 400
SPKNIARVII NVTDVDEPPI FQQPFYHFQL QENQKKPLIG SVLAKDPDAA
410 420 430 440 450
QRDIRYSIRR TSDKGQFFGI TKKGGIYNDK ELDREVYPWY NLTVEAKEVD
460 470 480 490 500
LSGTPTGKES IVQVHIEVMD ENDNAPEFAK PYEPKVCENA PQGKLVVQIS
510 520 530 540 550
ATDKDITPRD VKFKFSLSTE DSNFTLIDNH DNTANIIVKY GYFDRERAKV
560 570 580 590 600
HHLPVLISDN GRPSLTGTST LHVTVCKCNE HGEFTLCEEA AAQVGISIQA
610 620 630 640 650
LVAIFLCILT FTVITLLIIL RRRLRKQARA HGKSVPEIHE QLVTYDEEGG
660 670 680 690 700
GEMDTTSYDV SVLNSARHGG AKPPRPALDA RPSLYAQVQK PPRQAPGAHA
710 720 730 740 750
PGEMAAMIGV KKDEADHDGG GPPYDTLHIY GYEGAESIAE SLSSLGTDSS
760 770 780
DSDIDYDFLN DWGTRFKMLA ELYGSDPQEE LVY
Length:783
Mass (Da):87,467
Last modified:July 5, 2004 - v1
Checksum:i9193F3BAA3298D3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363224 mRNA. Translation: AAQ63484.1.
RefSeqiNP_001001601.1. NM_001001601.1.
UniGeneiBt.64659.

Genome annotation databases

GeneIDi414735.
KEGGibta:414735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363224 mRNA. Translation: AAQ63484.1.
RefSeqiNP_001001601.1. NM_001001601.1.
UniGeneiBt.64659.

3D structure databases

ProteinModelPortaliQ6URK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48767N.
STRINGi9913.ENSBTAP00000009760.

Proteomic databases

PaxDbiQ6URK6.
PRIDEiQ6URK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414735.
KEGGibta:414735.

Organism-specific databases

CTDi1003.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ6URK6.
KOiK06533.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR030052. CDH5.
[Graphical view]
PANTHERiPTHR24027:SF89. PTHR24027:SF89. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH5_BOVIN
AccessioniPrimary (citable) accession number: Q6URK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.