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Protein

Heterogeneous nuclear ribonucleoprotein A3

Gene

Hnrnpa3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.1 Publication

GO - Molecular functioni

  • mRNA binding Source: RGD
  • RNA binding Source: RGD
  • RNA transmembrane transporter activity Source: RGD

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • mRNA transport Source: RGD
  • RNA splicing Source: UniProtKB-KW

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A3
Short name:
hnRNP A3
Gene namesi
Name:Hnrnpa3
Synonyms:Hnrpa3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi727807 Hnrnpa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818401 – 379Heterogeneous nuclear ribonucleoprotein A3Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei14PhosphoserineBy similarity1
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei43PhosphoserineBy similarity1
Modified residuei52Dimethylated arginine; alternateBy similarity1
Modified residuei52Omega-N-methylarginine; alternateBy similarity1
Modified residuei76Omega-N-methylarginineBy similarity1
Modified residuei112PhosphoserineBy similarity1
Modified residuei116PhosphoserineBy similarity1
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei124PhosphothreonineBy similarity1
Modified residuei134N6-acetyllysine; alternateBy similarity1
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei214Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei214Omega-N-methylarginine; alternateBy similarity1
Modified residuei216Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei216Omega-N-methylarginine; alternateBy similarity1
Modified residuei226Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei226Omega-N-methylarginine; alternateBy similarity1
Modified residuei239Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei239Omega-N-methylarginine; alternateBy similarity1
Modified residuei246Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei246Omega-N-methylarginine; alternateBy similarity1
Modified residuei257Omega-N-methylarginineBy similarity1
Modified residuei286Asymmetric dimethylarginine1 Publication1
Modified residuei351PhosphoserineBy similarity1
Modified residuei355Omega-N-methylarginineBy similarity1
Modified residuei359PhosphoserineCombined sources1
Modified residuei361PhosphotyrosineBy similarity1
Modified residuei365PhosphotyrosineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei371PhosphoserineBy similarity1
Modified residuei374PhosphotyrosineBy similarity1
Modified residuei376PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6URK4
PRIDEiQ6URK4

PTM databases

iPTMnetiQ6URK4
PhosphoSitePlusiQ6URK4

Expressioni

Gene expression databases

BgeeiENSRNOG00000052968
GenevisibleiQ6URK4 RN

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Protein-protein interaction databases

BioGridi2632241 interactor.
IntActiQ6URK4 1 interactor.
STRINGi10116.ENSRNOP00000041984

Structurei

3D structure databases

ProteinModelPortaliQ6URK4
SMRiQ6URK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 118RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini126 – 205RRM 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 379Gly-richAdd BLAST169

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140828
HOGENOMiHOG000234442
HOVERGENiHBG002295
InParanoidiQ6URK4
KOiK12741
OMAiYYDSTGY
OrthoDBiEOG091G1CPI

Family and domain databases

CDDicd12763 RRM1_hnRNPA3, 1 hit
cd12582 RRM2_hnRNPA3, 1 hit
Gene3Di3.30.70.3302 hits
InterProiView protein in InterPro
IPR034513 hnRNPA3_RRM1
IPR034516 hnRNPA3_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6URK4-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS
60 70 80 90 100
LREHFEKWGT LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV
110 120 130 140 150
DGRVVEPKRA VSREDSVKPG AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG
160 170 180 190 200
KIETIEVMED RQSGKKRGFA FVTFDDHDTV DKIVVQKYHT INGHNCEVKK
210 220 230 240 250
ALSKQEMQSA GSQRGRGGGS GNFMGRGGNF GGGGGNFGRG GNFGGRGGYG
260 270 280 290 300
GGGGGSRGSY GGGDGGYNGF GGDGGNYGGG PGYSSRGGYG GGGPGYGNQG
310 320 330 340 350
GGYGGGGGGY DGYNEGGNFG GGNYGGGGNY NDFGNYSGQQ QSNYGPMKGG
360 370
SFGGRSSGSP YGGGYGSGGG SGGYGSRRF
Length:379
Mass (Da):39,652
Last modified:July 5, 2004 - v1
Checksum:iD83C400A2B096E9B
GO
Isoform 2 (identifier: Q6URK4-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MEVKPPPGRPQPDSGRRRRRRGE → M

Show »
Length:357
Mass (Da):37,086
Checksum:i222DBB3DF00D2D7A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0114001 – 23MEVKP…RRRGE → M in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363226 mRNA Translation: AAQ63630.1
AY363227 mRNA Translation: AAQ63631.1
BC081878 mRNA Translation: AAH81878.1
RefSeqiNP_001104764.1, NM_001111294.1 [Q6URK4-1]
NP_001104765.1, NM_001111295.1 [Q6URK4-2]
NP_937765.1, NM_198132.3 [Q6URK4-1]
XP_008760133.1, XM_008761911.2 [Q6URK4-2]
XP_008760134.1, XM_008761912.2 [Q6URK4-2]
UniGeneiRn.107690
Rn.234205
Rn.99947

Genome annotation databases

EnsembliENSRNOT00000078872; ENSRNOP00000069876; ENSRNOG00000052968 [Q6URK4-1]
GeneIDi362152
KEGGirno:362152
UCSCiRGD:727807 rat [Q6URK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiROA3_RAT
AccessioniPrimary (citable) accession number: Q6URK4
Secondary accession number(s): Q6URK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome