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Protein

Heterogeneous nuclear ribonucleoprotein A3

Gene

Hnrnpa3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.1 Publication

GO - Molecular functioni

  • mRNA binding Source: RGD
  • nucleotide binding Source: InterPro
  • RNA transmembrane transporter activity Source: RGD

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • mRNA transport Source: RGD
  • RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A3
Short name:
hnRNP A3
Gene namesi
Name:Hnrnpa3
Synonyms:Hnrpa3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi727807. Hnrnpa3.

Subcellular locationi

  • Nucleus By similarity

  • Note: Component of ribonucleosomes.By similarity

GO - Cellular componenti

  • cytoplasm Source: RGD
  • messenger ribonucleoprotein complex Source: RGD
  • neuron projection Source: RGD
  • nucleus Source: RGD
  • ribonucleoprotein granule Source: RGD
  • spliceosomal complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818401 – 379Heterogeneous nuclear ribonucleoprotein A3Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei14PhosphoserineBy similarity1
Modified residuei43PhosphoserineBy similarity1
Modified residuei52Dimethylated arginine; alternateBy similarity1
Modified residuei52Omega-N-methylarginine; alternateBy similarity1
Modified residuei76Omega-N-methylarginineBy similarity1
Modified residuei112PhosphoserineBy similarity1
Modified residuei116PhosphoserineBy similarity1
Modified residuei124PhosphothreonineBy similarity1
Modified residuei134N6-acetyllysineBy similarity1
Modified residuei214Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei214Omega-N-methylarginine; alternateBy similarity1
Modified residuei216Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei216Omega-N-methylarginine; alternateBy similarity1
Modified residuei226Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei226Omega-N-methylarginine; alternateBy similarity1
Modified residuei239Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei239Omega-N-methylarginine; alternateBy similarity1
Modified residuei246Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei246Omega-N-methylarginine; alternateBy similarity1
Modified residuei257Omega-N-methylarginineBy similarity1
Modified residuei286Asymmetric dimethylarginine1 Publication1
Modified residuei351PhosphoserineBy similarity1
Modified residuei355Omega-N-methylarginineBy similarity1
Modified residuei359PhosphoserineCombined sources1
Modified residuei361PhosphotyrosineBy similarity1
Modified residuei365PhosphotyrosineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei371PhosphoserineBy similarity1
Modified residuei374PhosphotyrosineBy similarity1
Modified residuei376PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6URK4.
PRIDEiQ6URK4.

PTM databases

iPTMnetiQ6URK4.
PhosphoSitePlusiQ6URK4.

Expressioni

Gene expression databases

GenevisibleiQ6URK4. RN.

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Protein-protein interaction databases

BioGridi263224. 1 interactor.
STRINGi10116.ENSRNOP00000041984.

Structurei

3D structure databases

ProteinModelPortaliQ6URK4.
SMRiQ6URK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 118RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini126 – 205RRM 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 379Gly-richAdd BLAST169

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
HOVERGENiHBG002295.
InParanoidiQ6URK4.
KOiK12741.
OrthoDBiEOG091G1CPI.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6URK4-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS
60 70 80 90 100
LREHFEKWGT LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV
110 120 130 140 150
DGRVVEPKRA VSREDSVKPG AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG
160 170 180 190 200
KIETIEVMED RQSGKKRGFA FVTFDDHDTV DKIVVQKYHT INGHNCEVKK
210 220 230 240 250
ALSKQEMQSA GSQRGRGGGS GNFMGRGGNF GGGGGNFGRG GNFGGRGGYG
260 270 280 290 300
GGGGGSRGSY GGGDGGYNGF GGDGGNYGGG PGYSSRGGYG GGGPGYGNQG
310 320 330 340 350
GGYGGGGGGY DGYNEGGNFG GGNYGGGGNY NDFGNYSGQQ QSNYGPMKGG
360 370
SFGGRSSGSP YGGGYGSGGG SGGYGSRRF
Length:379
Mass (Da):39,652
Last modified:July 5, 2004 - v1
Checksum:iD83C400A2B096E9B
GO
Isoform 2 (identifier: Q6URK4-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MEVKPPPGRPQPDSGRRRRRRGE → M

Show »
Length:357
Mass (Da):37,086
Checksum:i222DBB3DF00D2D7A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0114001 – 23MEVKP…RRRGE → M in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363226 mRNA. Translation: AAQ63630.1.
AY363227 mRNA. Translation: AAQ63631.1.
BC081878 mRNA. Translation: AAH81878.1.
RefSeqiNP_001104764.1. NM_001111294.1. [Q6URK4-1]
NP_001104765.1. NM_001111295.1. [Q6URK4-2]
NP_937765.1. NM_198132.3. [Q6URK4-1]
XP_008760133.1. XM_008761911.2. [Q6URK4-2]
XP_008760134.1. XM_008761912.2. [Q6URK4-2]
UniGeneiRn.107690.
Rn.234205.
Rn.99947.

Genome annotation databases

EnsembliENSRNOT00000078872; ENSRNOP00000069876; ENSRNOG00000052968. [Q6URK4-1]
GeneIDi362152.
KEGGirno:362152.
UCSCiRGD:727807. rat. [Q6URK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363226 mRNA. Translation: AAQ63630.1.
AY363227 mRNA. Translation: AAQ63631.1.
BC081878 mRNA. Translation: AAH81878.1.
RefSeqiNP_001104764.1. NM_001111294.1. [Q6URK4-1]
NP_001104765.1. NM_001111295.1. [Q6URK4-2]
NP_937765.1. NM_198132.3. [Q6URK4-1]
XP_008760133.1. XM_008761911.2. [Q6URK4-2]
XP_008760134.1. XM_008761912.2. [Q6URK4-2]
UniGeneiRn.107690.
Rn.234205.
Rn.99947.

3D structure databases

ProteinModelPortaliQ6URK4.
SMRiQ6URK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi263224. 1 interactor.
STRINGi10116.ENSRNOP00000041984.

PTM databases

iPTMnetiQ6URK4.
PhosphoSitePlusiQ6URK4.

Proteomic databases

PaxDbiQ6URK4.
PRIDEiQ6URK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000078872; ENSRNOP00000069876; ENSRNOG00000052968. [Q6URK4-1]
GeneIDi362152.
KEGGirno:362152.
UCSCiRGD:727807. rat. [Q6URK4-1]

Organism-specific databases

CTDi220988.
RGDi727807. Hnrnpa3.

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
HOVERGENiHBG002295.
InParanoidiQ6URK4.
KOiK12741.
OrthoDBiEOG091G1CPI.

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ6URK4.

Gene expression databases

GenevisibleiQ6URK4. RN.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROA3_RAT
AccessioniPrimary (citable) accession number: Q6URK4
Secondary accession number(s): Q6URK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.