Reviewed, UniProtKB/Swiss-Prot Q6URB0 (CCPR_CRYNV)

Names and origin

Protein names

Recommended name:
    Cytochrome c peroxidase, mitochondrial
      Short name=CCP
    EC=1.11.1.5

Gene names

Name:

CCP1

Organism

Cryptococcus neoformans var. grubii (Filobasidiella neoformans var. grubii)

Taxonomic identifier

178876 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.
Subunit structure	Forms a one-to-one complex with cytochrome c By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cytochrome-c peroxidase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 32	32	Mitochondrion Potential
	Chain	33 – 377	345	Cytochrome c peroxidase, mitochondrial		PRO_0000045290
Sites
	Active site	138	1	Proton acceptor By similarity
	Active site	277	1	Tryptophan radical intermediate By similarity
	Metal binding	261	1	Iron (heme axial ligand)
	Site	134	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6URB0-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0B41F38D621D78B4	FASTA	377	42,088
	10 20 30 40 50 60 MSFRAPNLIR STVGRRAGQT LNLRSQVIRR RFATEGGPEI TKPSAPRSSN TGYIFAGLGV 70 80 90 100 110 120 AAVGAAYYFY GTGRTEHDST NKADTVVREA VATVEAKTGL RRGKDEYQKV YNRIAETLDK 130 140 150 160 170 180 EGYDDGSLAP VLLRLAWHAS GTYSKADGTG GSNFATMRFK PEAEHSANNG LHVAREHMEK 190 200 210 220 230 240 IKQEFPWISY GDLWTLGGVC AIQESGGPTI PWRPGRIDGY AAQVTPDGRL PDATQAQDHL 250 260 270 280 290 300 RFIFNRMGFN DQEIVALSGA HAMGRCHPNR SGFDGPWTFS PVTFSNQYFA LLRDEPWQWK 310 320 330 340 350 360 KWTGPAQFED KKTKTLMMLP TDMALVKDKS FKKYVDIYAD NEEKFFSDFA KAFSKLIELG 370 VPERQWAGEP WTMATSD

References

[1]	"Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans." Giles S.S., Perfect J.R., Cox G.M. Fungal Genet. Biol. 42:20-29(2005) [PubMed: 15588993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: H99.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY363612 Genomic DNA. Translation: AAR20479.1.
3D structure databases
HSSP	HSSP built from PDB template 1APX based on UniProtKB P48534.
ModBase	Search...
Protein family/group databases
PeroxiBase	3838. CnCcP01_grubiiH99.
Family and domain databases
InterPro	IPR002207. Asc_perxdse. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00459. ASPEROXIDASE. PR00458. PEROXIDASE.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCPR_CRYNV

Accession

Primary (citable) accession number: Q6URB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 5, 2004
Last modified:	May 5, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)