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Protein

Multidrug resistance-associated protein 1

Gene

ABCC1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi678 – 6858ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1327 – 13348ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
Gene namesi
Name:ABCC1
Synonyms:MRP1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularBy similarityAdd
BLAST
Transmembranei34 – 5421Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Topological domaini55 – 7420CytoplasmicBy similarityAdd
BLAST
Transmembranei75 – 9521Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Topological domaini96 – 1005ExtracellularBy similarity
Transmembranei101 – 12121Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Topological domaini122 – 13312CytoplasmicBy similarityAdd
BLAST
Transmembranei134 – 15421Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Topological domaini155 – 17218ExtracellularBy similarityAdd
BLAST
Transmembranei173 – 19321Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Topological domaini194 – 316123CytoplasmicBy similarityAdd
BLAST
Transmembranei317 – 33721Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Topological domaini338 – 36326ExtracellularBy similarityAdd
BLAST
Transmembranei364 – 38421Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Topological domaini385 – 44056CytoplasmicBy similarityAdd
BLAST
Transmembranei441 – 46121Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Topological domaini462 – 4643ExtracellularBy similarity
Transmembranei465 – 48521Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Topological domaini486 – 54762CytoplasmicBy similarityAdd
BLAST
Transmembranei548 – 56821Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Topological domaini569 – 59022ExtracellularBy similarityAdd
BLAST
Transmembranei591 – 61121Helical; Name=11PROSITE-ProRule annotationAdd
BLAST
Topological domaini612 – 967356CytoplasmicBy similarityAdd
BLAST
Transmembranei968 – 98821Helical; Name=12PROSITE-ProRule annotationAdd
BLAST
Topological domaini989 – 102537ExtracellularBy similarityAdd
BLAST
Transmembranei1026 – 104621Helical; Name=13PROSITE-ProRule annotationAdd
BLAST
Topological domaini1047 – 108943CytoplasmicBy similarityAdd
BLAST
Transmembranei1090 – 111021Helical; Name=14PROSITE-ProRule annotationAdd
BLAST
Topological domaini1111 – 11111ExtracellularBy similarity
Transmembranei1112 – 113221Helical; Name=15PROSITE-ProRule annotationAdd
BLAST
Topological domaini1133 – 120371CytoplasmicBy similarityAdd
BLAST
Transmembranei1204 – 122421Helical; Name=16PROSITE-ProRule annotationAdd
BLAST
Topological domaini1225 – 12262ExtracellularBy similarity
Transmembranei1227 – 124721Helical; Name=17PROSITE-ProRule annotationAdd
BLAST
Topological domaini1248 – 1531284CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15311531Multidrug resistance-associated protein 1PRO_0000093350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei277 – 2771PhosphotyrosineBy similarity
Modified residuei289 – 2891PhosphoserineBy similarity
Modified residuei503 – 5031N6-succinyllysineBy similarity
Modified residuei915 – 9151PhosphoserineBy similarity
Modified residuei930 – 9301PhosphoserineBy similarity
Glycosylationi1006 – 10061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6UR05.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000025361.

Structurei

3D structure databases

ProteinModelPortaliQ6UR05.
SMRiQ6UR05. Positions 642-871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini325 – 608284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini644 – 868225ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini975 – 1256282ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1293 – 1527235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ6UR05.
KOiK05665.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UR05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRGFCSAD GSDPFWEWDV SWNTSNPDFT KCFQNTVLVW VPCCYLWLCF
60 70 80 90 100
PFYFLYLSRH DRGYIQMTYL NKTKTALGFV LWIVCWADLF YSFWERSWGK
110 120 130 140 150
ILAPVFLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLIALLCAL
160 170 180 190 200
AILRSKIMTA LKEDAEIDVF RDVTFYIYFS LVLIQLVLSC FSDRPPLFSE
210 220 230 240 250
TIHDLNPCPE SSASFLSRVT FWWITGLMVR GYRQPLESTD LWSLNKEDTS
260 270 280 290 300
EQVVPVLVKN WKKECAKSKR QQRKITYSSK DPAKPKGGSQ VDVNEEAEVL
310 320 330 340 350
IVKTPQKERE PSLFKVLYKT FGPYFLMSFL FKALHDLMMF AGPEILKLLI
360 370 380 390 400
NFVNDKKAPD WQGYLYTALL FICACLQTLV LHQYFHICFV SGMRIKTAVI
410 420 430 440 450
GAVYRKALVI TNSARKSSTV GEIVNLMSVD AQRFMDLATY INMIWSAPLQ
460 470 480 490 500
VILALYLLWL NLGPSVLAGV AVMILMVPLN AVMAMKTKTY QVAHMKSKDN
510 520 530 540 550
RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK KSAYLAAVGT
560 570 580 590 600
FTWVCTPFLV ALSTFAVYVT VDKNNILDAQ KAFVSLALFN ILRFPLNILP
610 620 630 640 650
MVISSIVQAS VSLKRLRIFL SHEELEPDSI ERRPVKDGGG ANSITVKNAT
660 670 680 690 700
FTWARSDPPT LSGITFSIPE GSLVAVVGQV GCGKSSLLSA LLAEMDKVEG
710 720 730 740 750
HVAIKGSVAY VPQQAWIQND SLRENILFGR QLQERYYKAV IEACALLPDL
760 770 780 790 800
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYCDSDIYL FDDPLSAVDA
810 820 830 840 850
HVGKHIFENV IGPKGMLKNK TRLLVTHSIS YLPQVDVIIV MTGGKISEMG
860 870 880 890 900
SYQELLARDG AFAEFLRTYA SGDQEQAEQD DGLTGVSSPG KEVKQMENGM
910 920 930 940 950
LVTDVAGKQL QRQLSNSSSY SGDVSRHHTS TAELQKAGPK NEDAWKLVEA
960 970 980 990 1000
DKAQTGQVKL SVYWDYMKAI GLFISFLSIF LFLCNHVASL VSNYWLSLWT
1010 1020 1030 1040 1050
DDPIVNGTQE HTKIRLSVYG ALGISQGITV FGYSMAVSIG GIFASRRLHV
1060 1070 1080 1090 1100
DLLQNVLRSP MSFFERTPSG NLVNRFSKEL DTVDSMIPQV IKMFMGSLFN
1110 1120 1130 1140 1150
VIGACIIILL ATPIASIIIP PLGLIYFFVQ RFYVASSRQL KRLESVSRSP
1160 1170 1180 1190 1200
VYSHFNETLL GVSVIRAFEE QERFIRQSDL KVDENQKAYY PSIVANRWLA
1210 1220 1230 1240 1250
VRLECVGNCI VLFAALFSVI SRHSLSAGLV GLSVSYSLQV TTYLNWLVRM
1260 1270 1280 1290 1300
SSEMETNIVA VERLKEYSET EKEAPWQIQE MAPPSTWPQV GRVEFRDYGL
1310 1320 1330 1340 1350
RYRENLDLVL KHINITINGG EKVGIVGRTG AGKSSLTLGL FRINESAEGE
1360 1370 1380 1390 1400
IIIDDINIAK IGLHDLRVKI TIIPQDPVLF SGSLRMNLDP FSQYSDEEVW
1410 1420 1430 1440 1450
TSLELAHLKD FVSGLPDKLN QECAEGGENL SVGQRQLVCL ARALLRKTKI
1460 1470 1480 1490 1500
LVLDEATAAV DLETDDLIQS TIRTQFDDCT VLTIAHRLNT IMDYTRVIVL
1510 1520 1530
DKGEIRECGQ PSDLLQQRGL FYSMAKDAGL V
Length:1,531
Mass (Da):171,792
Last modified:July 5, 2004 - v1
Checksum:i746361A71C6158BD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491A → S.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363728 mRNA. Translation: AAQ23148.1.
RefSeqiNP_001002971.1. NM_001002971.1.
UniGeneiCfa.3224.

Genome annotation databases

GeneIDi403453.
KEGGicfa:403453.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363728 mRNA. Translation: AAQ23148.1.
RefSeqiNP_001002971.1. NM_001002971.1.
UniGeneiCfa.3224.

3D structure databases

ProteinModelPortaliQ6UR05.
SMRiQ6UR05. Positions 642-871.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000025361.

Proteomic databases

PaxDbiQ6UR05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403453.
KEGGicfa:403453.

Organism-specific databases

CTDi4363.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ6UR05.
KOiK05665.

Miscellaneous databases

NextBioi20816971.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of the canine multidrug resistance-associated protein."
    Ma L., Pratt S.E., Cao J., Dantzig A.H., Moore R.E., Slapak C.A.
    Mol. Cancer Ther. 1:1335-1342(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, VARIANT SER-149.
    Strain: Beagle.
    Tissue: Heart and Kidney.

Entry informationi

Entry nameiMRP1_CANLF
AccessioniPrimary (citable) accession number: Q6UR05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: December 9, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.