Q6UQ76 (MTLD_ALTAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Mannitol-1-phosphate 5-dehydrogenase Short name=M1PDH Short name=MPD Short name=MPDH EC=1.1.1.17
Organism	Alternaria alternata (Alternaria rot fungus)
Taxonomic identifier	5599 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Pleosporaceae › mitosporic Pleosporaceae › Alternaria › Alternaria alternata group

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway. Has a strong preference for NADH over NADPH. Ref.1
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371517
Regions
	Nucleotide binding	7 – 18	12	NAD By similarity
Sites
	Active site	216	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6UQ76 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A98836F5940BFEC6	FASTA	390	43,550
	10 20 30 40 50 60 MSYEKKAVHF GGGNIGRGFV AEFLHNSGYE VVFVDVMDSI IESLQKTKTY TVTEIGDDGE 70 80 90 100 110 120 RKFTIDHYRA INSKHEMDKV VQEIASADVV TCAVGPNILK FVAEPVAKAI EARTLDYPIA 130 140 150 160 170 180 VIACENAINA TTTWRGFIES KLSEETKKNI DSKARFANSA IDRIVPQQPP NGGLDVVIEK 190 200 210 220 230 240 FHEWCVEQKP FENGGKKPDV KGIHYVDDLE PYIERKLFTV NTSHATAAYY GHQNKVQYIH 250 260 270 280 290 300 EVLHDKKLHD TVRDAVKETA HLIVTKHGVE TAEQDAYVEE IIKRISNPVL KDNVERVGRA 310 320 330 340 350 360 PLRKLSRKER FIGPAAQLAE RGEKVDALLG AVEQAYRFQN VEGDEESVEL AKILKENSAE 370 380 390 EVVTKVNGIE KGQPLFDRLV AIVKKVQGGS

References

[1]	"Mannitol metabolism in the phytopathogenic fungus Alternaria alternata." Velez H., Glassbrook N.J., Daub M.E. Fungal Genet. Biol. 44:258-268(2007) [PubMed: 17092745] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY364263 Genomic DNA. Translation: AAQ63948.1.
3D structure databases
ProteinModelPortal	Q6UQ76.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_ALTAL

Accession

Primary (citable) accession number: Q6UQ76

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program