Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endoplasmic reticulum metallopeptidase 1

Gene

Ermp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures.1 Publication

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi199Zinc 1; catalyticBy similarity1
Metal bindingi211Zinc 1; catalyticBy similarity1
Metal bindingi211Zinc 2; catalyticBy similarity1
Active sitei245Proton acceptorBy similarity1
Metal bindingi246Zinc 2; catalyticBy similarity1
Metal bindingi272Zinc 1; catalyticBy similarity1
Sitei347Transition state stabilizerBy similarity1
Metal bindingi348Zinc 2; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • ovarian follicle development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum metallopeptidase 1Curated (EC:3.4.-.-Curated)
Alternative name(s):
Felix-ina1 Publication
Gene namesi
Name:Ermp1By similarity
Synonyms:Fxna1 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727831. Ermp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 66CytoplasmicCuratedAdd BLAST66
Transmembranei67 – 87Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini88 – 393LumenalCuratedAdd BLAST306
Transmembranei394 – 414Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini415 – 451CytoplasmicCuratedAdd BLAST37
Transmembranei452 – 472Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini473 – 480LumenalCurated8
Transmembranei481 – 501Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini502 – 515CytoplasmicCuratedAdd BLAST14
Transmembranei516 – 538Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini539 – 542LumenalCurated4
Transmembranei543 – 562Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini563 – 573CytoplasmicCuratedAdd BLAST11
Transmembranei574 – 594Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini595 – 615LumenalCuratedAdd BLAST21
Transmembranei616 – 636Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini637 – 645CytoplasmicCurated9
Transmembranei646 – 666Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini667 – 898LumenalCuratedAdd BLAST232

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002594941 – 898Endoplasmic reticulum metallopeptidase 1Add BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi176N-linked (GlcNAc...)PROSITE-ProRule annotation1
Disulfide bondi198 ↔ 216Sequence analysis
Glycosylationi724N-linked (GlcNAc...)PROSITE-ProRule annotation1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UPR8.
PRIDEiQ6UPR8.

PTM databases

SwissPalmiQ6UPR8.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in ovary, kidney, hypothalamus and hippocampus. Within the ovarian follicle, expressed in granulosa cells, but not in oocytes. Present in both preantral and antral follicles, but not in atretic antral follicle.1 Publication

Developmental stagei

Increasing expression in the ovary between fetal day 21 and postnatal day 2. Expression decreases thereafter to lower levels in adult ovaries.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi266948. 1 interactor.
STRINGi10116.ENSRNOP00000021958.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B62model-A104-383[»]
ProteinModelPortaliQ6UPR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M28 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2194. Eukaryota.
COG2234. LUCA.
HOGENOMiHOG000230679.
HOVERGENiHBG096075.
InParanoidiQ6UPR8.
PhylomeDBiQ6UPR8.

Family and domain databases

InterProiIPR007484. Peptidase_M28.
[Graphical view]
PfamiPF04389. Peptidase_M28. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UPR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWSSESAAV RRHRGTAERR EGQAAASHPQ REASAQEDAR GGGRMRGRTE
60 70 80 90 100
SGGESRGAKT ALSEARTALA LALYLLALRA LVQLSLQRLV LSRTSGLQGE
110 120 130 140 150
FDARQARVYL EHITAIGPRT TGSAENEILT VQYLLEQITL IEEQSNSLHR
160 170 180 190 200
ISVDVQRPTG SFSIDFLGGF TSYYDNITNV VVKLEPQDGA KYAVLANCHF
210 220 230 240 250
DSVANSPGAS DDAVSCAVML EVLRVMAASP EPLQHAVVFL FNGAEENVLQ
260 270 280 290 300
ASHGFITQHP WASLIRAFIN LEAAGVGGKE LVFQTGPENP WLVQAYVSAA
310 320 330 340 350
KHPFASVVAQ EVFQSGIIPS DTDFRIYRDF GNIPGIDLAF IENGYIYHTK
360 370 380 390 400
YDTADRILID SIQRAGDNIL AVLKYLATSD MLASSSEYRH GSMVFFDVLG
410 420 430 440 450
LLVIAYPSRV GSIINYMVVM AVVLYLGRKL LRPNHSNSNY VRDFLCGLGI
460 470 480 490 500
TFISWFTSLV TVLIIAVFVS LIGQSLSWYN YFYIAVCLYG TATVAKIILI
510 520 530 540 550
HTLAKRFYYV NASDLYLGEL FFDTSLFVHC GFLVALTAQG FCSAFMSAVW
560 570 580 590 600
VAFPLLTKLC VYKDFKKHGA KGRFIALYLL GMFIPYLYGL YLIWAVFEMF
610 620 630 640 650
TPILGRSGSE IPPDVVLASI LAVCVMILSS YFITFIYLVN STKKTILTLI
660 670 680 690 700
LVCAVTFLLV CSGAFFPYSS NPDSPKPKRV FLQHVSRTFH NLEGSVVKRD
710 720 730 740 750
SGIWINGFDY TGMSHVTPHI PEINDTIRAH CEENAPLCGF PWYLPVHFLI
760 770 780 790 800
RKNWYLPAPE ISPRNPAHFR LVSKEKMPWD SIKLTFEATG PSHMSFYVRT
810 820 830 840 850
HKGSTLSQWS LGNGIPVTSR GGDYFVFYSH GLQASAWQFW IEVQVSEEQP
860 870 880 890
EGMVTVAIAA HYLSGENKRS SQLDALKEKF PDWSFPSAWV STYSLFVF
Length:898
Mass (Da):99,897
Last modified:July 5, 2004 - v1
Checksum:iEF1E574C8BFAD1F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364634 mRNA. Translation: AAQ55282.2.
RefSeqiNP_908939.2. NM_184050.2.
UniGeneiRn.99609.

Genome annotation databases

GeneIDi373544.
KEGGirno:373544.
UCSCiRGD:727831. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364634 mRNA. Translation: AAQ55282.2.
RefSeqiNP_908939.2. NM_184050.2.
UniGeneiRn.99609.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B62model-A104-383[»]
ProteinModelPortaliQ6UPR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi266948. 1 interactor.
STRINGi10116.ENSRNOP00000021958.

PTM databases

SwissPalmiQ6UPR8.

Proteomic databases

PaxDbiQ6UPR8.
PRIDEiQ6UPR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373544.
KEGGirno:373544.
UCSCiRGD:727831. rat.

Organism-specific databases

CTDi79956.
RGDi727831. Ermp1.

Phylogenomic databases

eggNOGiKOG2194. Eukaryota.
COG2234. LUCA.
HOGENOMiHOG000230679.
HOVERGENiHBG096075.
InParanoidiQ6UPR8.
PhylomeDBiQ6UPR8.

Miscellaneous databases

PROiQ6UPR8.

Family and domain databases

InterProiIPR007484. Peptidase_M28.
[Graphical view]
PfamiPF04389. Peptidase_M28. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERMP1_RAT
AccessioniPrimary (citable) accession number: Q6UPR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.