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Protein

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Gene

Etfdh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accepts electrons from ETF and reduces ubiquinone.By similarity

Catalytic activityi

Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei304Ubiquinone; via carbonyl oxygenBy similarity1
Binding sitei305Ubiquinone; via amide nitrogenBy similarity1
Metal bindingi560Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi585Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi588Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi591Iron-sulfur (4Fe-4S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi70 – 84FADSequence analysisAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (EC:1.5.5.1)
Short name:
ETF-QO
Short name:
ETF-ubiquinone oxidoreductase
Alternative name(s):
Electron-transferring-flavoprotein dehydrogenase
Short name:
ETF dehydrogenase
Gene namesi
Name:Etfdh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735052. Etfdh.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Intramembranei108 – 129By similarityAdd BLAST22
Intramembranei427 – 446By similarityAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32Mitochondrion1 PublicationAdd BLAST32
ChainiPRO_000000866433 – 616Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95N6-acetyllysineBy similarity1
Modified residuei131N6-acetyllysineBy similarity1
Modified residuei222N6-acetyllysineBy similarity1
Modified residuei356N6-acetyllysineBy similarity1
Modified residuei415N6-acetyllysineBy similarity1
Modified residuei550PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6UPE1.
PRIDEiQ6UPE1.

PTM databases

iPTMnetiQ6UPE1.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013262.

Structurei

3D structure databases

ProteinModelPortaliQ6UPE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini576 – 6054Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Belongs to the ETF-QO/FixC family.Curated
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2415. Eukaryota.
COG0644. LUCA.
HOGENOMiHOG000259450.
HOVERGENiHBG005615.
InParanoidiQ6UPE1.
PhylomeDBiQ6UPE1.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UPE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVRLTKLSC PAYQWFHALK IKKCLPLCAP RCSSTSAVPQ ITTHYTIHPR
60 70 80 90 100
EKDKRWEGVN MERFAEEADV VIVGAGPAGL SAAIRLKQLA AEQEKDIRVC
110 120 130 140 150
LVEKAAQIGA HTLSGACLDP AAFKELFPDW KEKGAPLNTP VTEDRFAILT
160 170 180 190 200
EKHRIPVPIL PGLPMNNHGN YIVRLGHLVS WMGEQAEALG VEVYPGYAAA
210 220 230 240 250
EVLYHEDGSV KGIATNDVGI QKDGAPKTTF ERGLELHAKV TIFAEGCHGH
260 270 280 290 300
LAKQFYKKFD LRASCDAQTY GIGLKELWVI DEKKWKPGRV DHTVGWPLDR
310 320 330 340 350
HTYGGSFLYH LNEGEPLVAV GFVVGLDYQN PYLSPFREFQ RWKHHPSIRP
360 370 380 390 400
TLEGGKRIAY GARALNEGGL QSIPKLTFPG GLLIGCSPGF MNVPKIKGTH
410 420 430 440 450
TAMKSGSLAA EAIFKQLTSE NLQSKTAGLH VTEYEDNLKQ SWVWKELHAV
460 470 480 490 500
RNIRPSCHGI LGVYGGMIYT GIFYWILRGM EPWTLKHKGS DSEQLKPAKD
510 520 530 540 550
CTPIEYPKPD GQISFDLLSS VALSGTNHEH DQPAHLTLKD DSIPVNRNLS
560 570 580 590 600
IYDGPEQRFC PAGVYEFVPL EQGDGFRLQI NAQNCVHCKT CDIKDPSQNI
610
NWVVPEGGGG PAYNGM
Length:616
Mass (Da):68,198
Last modified:July 5, 2004 - v1
Checksum:i30575E165673B679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY365022 mRNA. Translation: AAQ67364.1.
UniGeneiRn.37277.

Genome annotation databases

UCSCiRGD:735052. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY365022 mRNA. Translation: AAQ67364.1.
UniGeneiRn.37277.

3D structure databases

ProteinModelPortaliQ6UPE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013262.

PTM databases

iPTMnetiQ6UPE1.

Proteomic databases

PaxDbiQ6UPE1.
PRIDEiQ6UPE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:735052. rat.

Organism-specific databases

RGDi735052. Etfdh.

Phylogenomic databases

eggNOGiKOG2415. Eukaryota.
COG0644. LUCA.
HOGENOMiHOG000259450.
HOVERGENiHBG005615.
InParanoidiQ6UPE1.
PhylomeDBiQ6UPE1.

Miscellaneous databases

PROiQ6UPE1.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETFD_RAT
AccessioniPrimary (citable) accession number: Q6UPE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.