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Protein

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Gene

Etfdh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accepts electrons from ETF and reduces ubiquinone.By similarity

Catalytic activityi

Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei304 – 3041Ubiquinone; via carbonyl oxygenBy similarity
Binding sitei305 – 3051Ubiquinone; via amide nitrogenBy similarity
Metal bindingi560 – 5601Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi585 – 5851Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi588 – 5881Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi591 – 5911Iron-sulfur (4Fe-4S)Sequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 8415FADSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (EC:1.5.5.1)
Short name:
ETF-QO
Short name:
ETF-ubiquinone oxidoreductase
Alternative name(s):
Electron-transferring-flavoprotein dehydrogenase
Short name:
ETF dehydrogenase
Gene namesi
Name:Etfdh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735052. Etfdh.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei108 – 12922By similarityAdd
BLAST
Intramembranei427 – 44620By similarityAdd
BLAST

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrial membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232Mitochondrion1 PublicationAdd
BLAST
Chaini33 – 616584Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialPRO_0000008664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951N6-acetyllysineBy similarity
Modified residuei131 – 1311N6-acetyllysineBy similarity
Modified residuei222 – 2221N6-acetyllysineBy similarity
Modified residuei356 – 3561N6-acetyllysineBy similarity
Modified residuei415 – 4151N6-acetyllysineBy similarity
Modified residuei550 – 5501PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6UPE1.
PRIDEiQ6UPE1.

PTM databases

iPTMnetiQ6UPE1.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013262.

Structurei

3D structure databases

ProteinModelPortaliQ6UPE1.
SMRiQ6UPE1. Positions 38-616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini576 – 605304Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETF-QO/FixC family.Curated
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2415. Eukaryota.
COG0644. LUCA.
HOGENOMiHOG000259450.
HOVERGENiHBG005615.
InParanoidiQ6UPE1.
PhylomeDBiQ6UPE1.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UPE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVRLTKLSC PAYQWFHALK IKKCLPLCAP RCSSTSAVPQ ITTHYTIHPR
60 70 80 90 100
EKDKRWEGVN MERFAEEADV VIVGAGPAGL SAAIRLKQLA AEQEKDIRVC
110 120 130 140 150
LVEKAAQIGA HTLSGACLDP AAFKELFPDW KEKGAPLNTP VTEDRFAILT
160 170 180 190 200
EKHRIPVPIL PGLPMNNHGN YIVRLGHLVS WMGEQAEALG VEVYPGYAAA
210 220 230 240 250
EVLYHEDGSV KGIATNDVGI QKDGAPKTTF ERGLELHAKV TIFAEGCHGH
260 270 280 290 300
LAKQFYKKFD LRASCDAQTY GIGLKELWVI DEKKWKPGRV DHTVGWPLDR
310 320 330 340 350
HTYGGSFLYH LNEGEPLVAV GFVVGLDYQN PYLSPFREFQ RWKHHPSIRP
360 370 380 390 400
TLEGGKRIAY GARALNEGGL QSIPKLTFPG GLLIGCSPGF MNVPKIKGTH
410 420 430 440 450
TAMKSGSLAA EAIFKQLTSE NLQSKTAGLH VTEYEDNLKQ SWVWKELHAV
460 470 480 490 500
RNIRPSCHGI LGVYGGMIYT GIFYWILRGM EPWTLKHKGS DSEQLKPAKD
510 520 530 540 550
CTPIEYPKPD GQISFDLLSS VALSGTNHEH DQPAHLTLKD DSIPVNRNLS
560 570 580 590 600
IYDGPEQRFC PAGVYEFVPL EQGDGFRLQI NAQNCVHCKT CDIKDPSQNI
610
NWVVPEGGGG PAYNGM
Length:616
Mass (Da):68,198
Last modified:July 5, 2004 - v1
Checksum:i30575E165673B679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY365022 mRNA. Translation: AAQ67364.1.
UniGeneiRn.37277.

Genome annotation databases

UCSCiRGD:735052. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY365022 mRNA. Translation: AAQ67364.1.
UniGeneiRn.37277.

3D structure databases

ProteinModelPortaliQ6UPE1.
SMRiQ6UPE1. Positions 38-616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013262.

PTM databases

iPTMnetiQ6UPE1.

Proteomic databases

PaxDbiQ6UPE1.
PRIDEiQ6UPE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:735052. rat.

Organism-specific databases

RGDi735052. Etfdh.

Phylogenomic databases

eggNOGiKOG2415. Eukaryota.
COG0644. LUCA.
HOGENOMiHOG000259450.
HOVERGENiHBG005615.
InParanoidiQ6UPE1.
PhylomeDBiQ6UPE1.

Miscellaneous databases

PROiQ6UPE1.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETFD_RAT
AccessioniPrimary (citable) accession number: Q6UPE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.