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Protein

Choline dehydrogenase, mitochondrial

Gene

Chdh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.

Cofactori

FADBy similarity

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Choline dehydrogenase, mitochondrial (Chdh)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei516Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 79FADBy similarityAdd BLAST33

GO - Molecular functioni

  • choline dehydrogenase activity Source: RGD
  • flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.1.99.1 5301
ReactomeiR-RNO-6798163 Choline catabolism
UniPathwayiUPA00529; UER00385

Names & Taxonomyi

Protein namesi
Recommended name:
Choline dehydrogenase, mitochondrial (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Gene namesi
Name:Chdh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi735166 Chdh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000041843935 – 599Choline dehydrogenase, mitochondrialAdd BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei441N6-succinyllysineBy similarity1
Modified residuei489N6-acetyllysine; alternateBy similarity1
Modified residuei489N6-succinyllysine; alternateBy similarity1
Modified residuei501N6-acetyllysine; alternateBy similarity1
Modified residuei501N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6UPE0
PRIDEiQ6UPE0

PTM databases

iPTMnetiQ6UPE0
PhosphoSitePlusiQ6UPE0

Expressioni

Gene expression databases

BgeeiENSRNOG00000015859
GenevisibleiQ6UPE0 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021407

Structurei

3D structure databases

ProteinModelPortaliQ6UPE0
SMRiQ6UPE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1238 Eukaryota
COG2303 LUCA
GeneTreeiENSGT00530000063260
HOGENOMiHOG000139600
HOVERGENiHBG023639
InParanoidiQ6UPE0
KOiK00108
OMAiGWDYAHC
OrthoDBiEOG091G02M7
PhylomeDBiQ6UPE0
TreeFamiTF313911

Family and domain databases

Gene3Di3.50.50.604 hits
4.10.450.102 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UPE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQVLRSWSK RCLSPRGALA WAAQGQPRPP CSCAVASAAS GGKDEYTFIV
60 70 80 90 100
VGAGSAGCVL ANRLTEDPNH RVLLLEAGPK DLLMGSKRLQ WKIHMPAALV
110 120 130 140 150
ANLCDDKYNW YYHTEAQPGL DGRVLYWPRG RVWGGSSSLN AMVYIRGHAE
160 170 180 190 200
DYNRWHRQGA EGWDYAHCLP YFRKAQKHEL GANMYRGGDG PLHVSRGKTN
210 220 230 240 250
HPLHQAFLQA ARQAGYPFTE DMNGFQQEGF GWMDMTIHQG KRWSTASAYL
260 270 280 290 300
RPALSRPNLR AEVQTLVSRV LFEGTRAVGV EYIKDGQSHK AYVSREVILS
310 320 330 340 350
GGAINSPQLL MLSGVGNADD LKKLGIPVVC HLPGVGQNLQ DHLEIYIQHA
360 370 380 390 400
CTQPITLHSA QKPLRKVCIG LEWLWRFTGD GATAHLETGG FIRSRPGVPH
410 420 430 440 450
PDIQFHFLPS QVIDHGRKPT QQEAYQVHVG TMRATSVGWL KLRSTNPQDH
460 470 480 490 500
PMINPNYLST ETDVEDFRQC VKLTREIFAQ EAFAPFRGKE LQPGSHVQSD
510 520 530 540 550
KEIDAFVRAK ADSAYHPSCT CKMGQPSDPT AVVDQQTRVI GVENLRVIDA
560 570 580 590
SIMPSVVSGN LNAPTIMIAE KAADVIKGCP ALGDENVPVY KPQTLDTQR
Length:599
Mass (Da):66,389
Last modified:July 5, 2004 - v1
Checksum:i8ECDC1089B6236D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY365023 mRNA Translation: AAQ67365.1
CH474046 Genomic DNA Translation: EDL89007.1
BC085787 mRNA Translation: AAH85787.1
RefSeqiNP_942026.1, NM_198731.2
XP_006252640.1, XM_006252578.3
XP_006252641.1, XM_006252579.3
XP_006252642.1, XM_006252580.2
XP_008769206.1, XM_008770984.2
XP_008769207.1, XM_008770985.2
UniGeneiRn.22857

Genome annotation databases

EnsembliENSRNOT00000021407; ENSRNOP00000021407; ENSRNOG00000015859
GeneIDi290551
KEGGirno:290551
UCSCiRGD:735166 rat

Similar proteinsi

Entry informationi

Entry nameiCHDH_RAT
AccessioniPrimary (citable) accession number: Q6UPE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome