Q6ULP2 (AFTIN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aftiphilin

Gene names

Name:	AFTPH
Synonyms:	AFTH

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	937 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in membrane trafficking.
Subunit structure	Interacts with GGA1, GGA3, AP1G1 and AP1G2 via their GAE domain. Ref.1
Subcellular location	Cytoplasm. Note: Colocalizes with AP1G1 and clathrin. Ref.1
Domain	The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself By similarity.
Sequence caution	The sequence AAH22247.1 differs from that shown. Reason: Frameshift at position 919. The sequence BAB13930.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14949.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	AP-1 adaptor complex Inferred from direct assay PubMed 15758025. Source: UniProtKB cytosol Inferred from direct assay PubMed 15758025. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA
Molecular_function	clathrin binding Inferred from direct assay PubMed 15758025. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ULP2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ULP2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     819-846: Missing.

Isoform 3 (identifier: Q6ULP2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     819-820: AS → GT
     821-937: Missing.

Note: May be due to intron retention. No experimental confirmation available.

Isoform 4 (identifier: Q6ULP2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     888-888: Missing.

Isoform 5 (identifier: Q6ULP2-5)

The sequence of this isoform differs from the canonical sequence as follows:
     819-846: Missing.
     888-888: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 937	937	Aftiphilin		PRO_0000064488
Regions
	Region	825 – 829	5	Clathrin-binding Potential
	Motif	28 – 31	4	WXXF motif 1
	Motif	432 – 435	4	WXXF motif 2
	Motif	436 – 438	3	WXXF motif 3 (partial)
	Motif	478 – 481	4	WXXF motif 4
Amino acid modifications
	Modified residue	151	1	Phosphoserine Ref.8
	Modified residue	617	1	Phosphothreonine Ref.6 Ref.7
Natural variations
	Alternative sequence	819 – 846	28	Missing in isoform 2 and isoform 5.		VSP_013238
	Alternative sequence	819 – 820	2	AS → GT in isoform 3.		VSP_013239
	Alternative sequence	821 – 937	117	Missing in isoform 3.		VSP_013240
	Alternative sequence	888	1	Missing in isoform 4 and isoform 5.		VSP_013241
	Natural variant	233	1	D → G. Corresponds to variant rs35986567 [ dbSNP | Ensembl ].		VAR_056728
	Natural variant	301	1	E → K. Corresponds to variant rs3770740 [ dbSNP | Ensembl ].		VAR_056729
	Natural variant	550	1	N → S. Corresponds to variant rs3770739 [ dbSNP | Ensembl ].		VAR_056730
Experimental info
	Sequence conflict	734	1	D → G in BAB13930. Ref.2
	Sequence conflict	850	1	P → L in AAR14726. Ref.1
	Sequence conflict	895	1	E → G in AAH22247. Ref.5
	Sequence conflict	905	1	I → V in AAH47529. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: CC9CF52CE10F2C36	FASTA	937	102,200
	10 20 30 40 50 60 MEPDIIRMYS SSPPPLDNGA EDDDDDEFGE FGGFSEVSPS GVGFVDFDTP DYTRPKEEFV 70 80 90 100 110 120 PSNHFMPIHE FSENVDSLTS FKSIKNGNDK DITAELSAPV KGQSDVLLST TSKEIISSEM 130 140 150 160 170 180 LATSIDGMER PGNLNKVVEQ RQNVGTLESF SPGDFRTNMN VVHQNKQLES CNGEKPPCLE 190 200 210 220 230 240 ILTNGFAVLE TVNPQGTDDL DNVADSKGRK PLSTHSTEYN LDSVPSPAEE FADFATFSKK 250 260 270 280 290 300 ERIQLEEIEC AVLNDREALT IRENNKINRV NELNSVKEVA LGRSLDNKGD TDGEDQVCVS 310 320 330 340 350 360 EISIVTNRGF SVEKQGLPTL QQDEFLQSGV QSKAWSLVDS ADNSEAIRRE QCKTEEKLDL 370 380 390 400 410 420 LTSKCAHLCM DSVKTSDDEV GSPKEESRKF TNFQSPNIDP TEENDLDDSL SVKNGDSSND 430 440 450 460 470 480 FVTCNDINED DFGDFGDFGS ASGSTPPFVT GTQDSMSDAT FEESSEHFPH FSEPGDDFGE 490 500 510 520 530 540 FGDINAVSCQ EETILTKSDL KQTSDNLSEE CQLARKSSGT GTEPVAKLKN GQEGEIGHFD 550 560 570 580 590 600 SVPNIQDDCN GFQDSDDFAD FSSAGPSQVV DWNAFEDEQK DSCSWAAFGD QQATESHHRK 610 620 630 640 650 660 EAWQSHRTDE NIDTPGTPKT HSVPSATSKG AVASGHLQES ATSVQTALLN RLERIFEACF 670 680 690 700 710 720 PSILVPDAEE EVTSLKHLLE TSTLPIKTRE ALPESGELLD VWTELQDIHD AHGLRYQWGG 730 740 750 760 770 780 SHSNKKLLSS LGIDTRNILF TGNKKQPVIV PMYAAGLGML EPTKEPLKPL SAAEKIASIG 790 800 810 820 830 840 QTATMSPDMN TCTSDQFQES LPPVQFDWSS SGLTNPLDAS GGSTLLNLDF FGPVDDSSSS 850 860 870 880 890 900 SSTTIPGVDP ELYELTTSKL EISTSSLKVT DAFARLMSTV EKTSTSTSRK PKREEHLSEE 910 920 930 AIKVIAGLPD LTFMHAKVLM FPATLTPSTS SQEKADG
	Isoform 2 [UniParc]. Checksum: B931F39110FDBB8E	FASTA	909	99,458
	10 20 30 40 50 60 MEPDIIRMYS SSPPPLDNGA EDDDDDEFGE FGGFSEVSPS GVGFVDFDTP DYTRPKEEFV 70 80 90 100 110 120 PSNHFMPIHE FSENVDSLTS FKSIKNGNDK DITAELSAPV KGQSDVLLST TSKEIISSEM 130 140 150 160 170 180 LATSIDGMER PGNLNKVVEQ RQNVGTLESF SPGDFRTNMN VVHQNKQLES CNGEKPPCLE 190 200 210 220 230 240 ILTNGFAVLE TVNPQGTDDL DNVADSKGRK PLSTHSTEYN LDSVPSPAEE FADFATFSKK 250 260 270 280 290 300 ERIQLEEIEC AVLNDREALT IRENNKINRV NELNSVKEVA LGRSLDNKGD TDGEDQVCVS 310 320 330 340 350 360 EISIVTNRGF SVEKQGLPTL QQDEFLQSGV QSKAWSLVDS ADNSEAIRRE QCKTEEKLDL 370 380 390 400 410 420 LTSKCAHLCM DSVKTSDDEV GSPKEESRKF TNFQSPNIDP TEENDLDDSL SVKNGDSSND 430 440 450 460 470 480 FVTCNDINED DFGDFGDFGS ASGSTPPFVT GTQDSMSDAT FEESSEHFPH FSEPGDDFGE 490 500 510 520 530 540 FGDINAVSCQ EETILTKSDL KQTSDNLSEE CQLARKSSGT GTEPVAKLKN GQEGEIGHFD 550 560 570 580 590 600 SVPNIQDDCN GFQDSDDFAD FSSAGPSQVV DWNAFEDEQK DSCSWAAFGD QQATESHHRK 610 620 630 640 650 660 EAWQSHRTDE NIDTPGTPKT HSVPSATSKG AVASGHLQES ATSVQTALLN RLERIFEACF 670 680 690 700 710 720 PSILVPDAEE EVTSLKHLLE TSTLPIKTRE ALPESGELLD VWTELQDIHD AHGLRYQWGG 730 740 750 760 770 780 SHSNKKLLSS LGIDTRNILF TGNKKQPVIV PMYAAGLGML EPTKEPLKPL SAAEKIASIG 790 800 810 820 830 840 QTATMSPDMN TCTSDQFQES LPPVQFDWSS SGLTNPLDGV DPELYELTTS KLEISTSSLK 850 860 870 880 890 900 VTDAFARLMS TVEKTSTSTS RKPKREEHLS EEAIKVIAGL PDLTFMHAKV LMFPATLTPS TSSQEKADG
	Isoform 3 [UniParc]. Checksum: 35A9CF525DDF54AF	FASTA	820	89,720
	10 20 30 40 50 60 MEPDIIRMYS SSPPPLDNGA EDDDDDEFGE FGGFSEVSPS GVGFVDFDTP DYTRPKEEFV 70 80 90 100 110 120 PSNHFMPIHE FSENVDSLTS FKSIKNGNDK DITAELSAPV KGQSDVLLST TSKEIISSEM 130 140 150 160 170 180 LATSIDGMER PGNLNKVVEQ RQNVGTLESF SPGDFRTNMN VVHQNKQLES CNGEKPPCLE 190 200 210 220 230 240 ILTNGFAVLE TVNPQGTDDL DNVADSKGRK PLSTHSTEYN LDSVPSPAEE FADFATFSKK 250 260 270 280 290 300 ERIQLEEIEC AVLNDREALT IRENNKINRV NELNSVKEVA LGRSLDNKGD TDGEDQVCVS 310 320 330 340 350 360 EISIVTNRGF SVEKQGLPTL QQDEFLQSGV QSKAWSLVDS ADNSEAIRRE QCKTEEKLDL 370 380 390 400 410 420 LTSKCAHLCM DSVKTSDDEV GSPKEESRKF TNFQSPNIDP TEENDLDDSL SVKNGDSSND 430 440 450 460 470 480 FVTCNDINED DFGDFGDFGS ASGSTPPFVT GTQDSMSDAT FEESSEHFPH FSEPGDDFGE 490 500 510 520 530 540 FGDINAVSCQ EETILTKSDL KQTSDNLSEE CQLARKSSGT GTEPVAKLKN GQEGEIGHFD 550 560 570 580 590 600 SVPNIQDDCN GFQDSDDFAD FSSAGPSQVV DWNAFEDEQK DSCSWAAFGD QQATESHHRK 610 620 630 640 650 660 EAWQSHRTDE NIDTPGTPKT HSVPSATSKG AVASGHLQES ATSVQTALLN RLERIFEACF 670 680 690 700 710 720 PSILVPDAEE EVTSLKHLLE TSTLPIKTRE ALPESGELLD VWTELQDIHD AHGLRYQWGG 730 740 750 760 770 780 SHSNKKLLSS LGIDTRNILF TGNKKQPVIV PMYAAGLGML EPTKEPLKPL SAAEKIASIG 790 800 810 820 QTATMSPDMN TCTSDQFQES LPPVQFDWSS SGLTNPLDGT
	Isoform 4 [UniParc]. Checksum: 7F84B4D6890BCDF7	FASTA	936	102,113
	10 20 30 40 50 60 MEPDIIRMYS SSPPPLDNGA EDDDDDEFGE FGGFSEVSPS GVGFVDFDTP DYTRPKEEFV 70 80 90 100 110 120 PSNHFMPIHE FSENVDSLTS FKSIKNGNDK DITAELSAPV KGQSDVLLST TSKEIISSEM 130 140 150 160 170 180 LATSIDGMER PGNLNKVVEQ RQNVGTLESF SPGDFRTNMN VVHQNKQLES CNGEKPPCLE 190 200 210 220 230 240 ILTNGFAVLE TVNPQGTDDL DNVADSKGRK PLSTHSTEYN LDSVPSPAEE FADFATFSKK 250 260 270 280 290 300 ERIQLEEIEC AVLNDREALT IRENNKINRV NELNSVKEVA LGRSLDNKGD TDGEDQVCVS 310 320 330 340 350 360 EISIVTNRGF SVEKQGLPTL QQDEFLQSGV QSKAWSLVDS ADNSEAIRRE QCKTEEKLDL 370 380 390 400 410 420 LTSKCAHLCM DSVKTSDDEV GSPKEESRKF TNFQSPNIDP TEENDLDDSL SVKNGDSSND 430 440 450 460 470 480 FVTCNDINED DFGDFGDFGS ASGSTPPFVT GTQDSMSDAT FEESSEHFPH FSEPGDDFGE 490 500 510 520 530 540 FGDINAVSCQ EETILTKSDL KQTSDNLSEE CQLARKSSGT GTEPVAKLKN GQEGEIGHFD 550 560 570 580 590 600 SVPNIQDDCN GFQDSDDFAD FSSAGPSQVV DWNAFEDEQK DSCSWAAFGD QQATESHHRK 610 620 630 640 650 660 EAWQSHRTDE NIDTPGTPKT HSVPSATSKG AVASGHLQES ATSVQTALLN RLERIFEACF 670 680 690 700 710 720 PSILVPDAEE EVTSLKHLLE TSTLPIKTRE ALPESGELLD VWTELQDIHD AHGLRYQWGG 730 740 750 760 770 780 SHSNKKLLSS LGIDTRNILF TGNKKQPVIV PMYAAGLGML EPTKEPLKPL SAAEKIASIG 790 800 810 820 830 840 QTATMSPDMN TCTSDQFQES LPPVQFDWSS SGLTNPLDAS GGSTLLNLDF FGPVDDSSSS 850 860 870 880 890 900 SSTTIPGVDP ELYELTTSKL EISTSSLKVT DAFARLMSTV EKTSTSTRKP KREEHLSEEA 910 920 930 IKVIAGLPDL TFMHAKVLMF PATLTPSTSS QEKADG
	Isoform 5 [UniParc]. Checksum: 028209277B9C75A4	FASTA	908	99,371
	10 20 30 40 50 60 MEPDIIRMYS SSPPPLDNGA EDDDDDEFGE FGGFSEVSPS GVGFVDFDTP DYTRPKEEFV 70 80 90 100 110 120 PSNHFMPIHE FSENVDSLTS FKSIKNGNDK DITAELSAPV KGQSDVLLST TSKEIISSEM 130 140 150 160 170 180 LATSIDGMER PGNLNKVVEQ RQNVGTLESF SPGDFRTNMN VVHQNKQLES CNGEKPPCLE 190 200 210 220 230 240 ILTNGFAVLE TVNPQGTDDL DNVADSKGRK PLSTHSTEYN LDSVPSPAEE FADFATFSKK 250 260 270 280 290 300 ERIQLEEIEC AVLNDREALT IRENNKINRV NELNSVKEVA LGRSLDNKGD TDGEDQVCVS 310 320 330 340 350 360 EISIVTNRGF SVEKQGLPTL QQDEFLQSGV QSKAWSLVDS ADNSEAIRRE QCKTEEKLDL 370 380 390 400 410 420 LTSKCAHLCM DSVKTSDDEV GSPKEESRKF TNFQSPNIDP TEENDLDDSL SVKNGDSSND 430 440 450 460 470 480 FVTCNDINED DFGDFGDFGS ASGSTPPFVT GTQDSMSDAT FEESSEHFPH FSEPGDDFGE 490 500 510 520 530 540 FGDINAVSCQ EETILTKSDL KQTSDNLSEE CQLARKSSGT GTEPVAKLKN GQEGEIGHFD 550 560 570 580 590 600 SVPNIQDDCN GFQDSDDFAD FSSAGPSQVV DWNAFEDEQK DSCSWAAFGD QQATESHHRK 610 620 630 640 650 660 EAWQSHRTDE NIDTPGTPKT HSVPSATSKG AVASGHLQES ATSVQTALLN RLERIFEACF 670 680 690 700 710 720 PSILVPDAEE EVTSLKHLLE TSTLPIKTRE ALPESGELLD VWTELQDIHD AHGLRYQWGG 730 740 750 760 770 780 SHSNKKLLSS LGIDTRNILF TGNKKQPVIV PMYAAGLGML EPTKEPLKPL SAAEKIASIG 790 800 810 820 830 840 QTATMSPDMN TCTSDQFQES LPPVQFDWSS SGLTNPLDGV DPELYELTTS KLEISTSSLK 850 860 870 880 890 900 VTDAFARLMS TVEKTSTSTR KPKREEHLSE EAIKVIAGLP DLTFMHAKVL MFPATLTPST SSQEKADG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Definition of the consensus motif recognized by gamma-adaptin ear domains." Mattera R., Ritter B., Sidhu S.S., McPherson P.S., Bonifacino J.S. J. Biol. Chem. 279:8018-8028(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), SUBCELLULAR LOCATION, INTERACTION WITH GGA1; GGA3; AP1G1 AND AP1G2. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 347-937 (ISOFORM 1). Tissue: Colon and Embryo.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Amygdala.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 724-937 (ISOFORM 5). Tissue: Brain and Lung.
[6]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-617, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-617, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY367088 mRNA. Translation: AAR14726.1. AK000087 mRNA. Translation: BAA90936.1. AK021899 mRNA. Translation: BAB13930.1. Different initiation. AK024658 mRNA. Translation: BAB14949.1. Different initiation. AL833962 mRNA. Translation: CAE46209.1. CH471053 Genomic DNA. Translation: EAW99938.1. CH471053 Genomic DNA. Translation: EAW99941.1. BC022247 mRNA. Translation: AAH22247.1. Sequence problems. BC047529 mRNA. Translation: AAH47529.1.
IPI	IPI00329005. IPI00429547. IPI00434952. IPI00554475. IPI00554740.
RefSeq	NP_001002243.1. NM_001002243.2. NP_060127.3. NM_017657.4. NP_982261.2. NM_203437.3.
UniGene	Hs.655167.
3D structure databases
ProteinModelPortal	Q6ULP2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ULP2. 4 interactions.
STRING	9606.ENSP00000238855.
PTM databases
PhosphoSite	Q6ULP2.
Polymorphism databases
DMDM	62286617.
Proteomic databases
PaxDb	Q6ULP2.
PRIDE	Q6ULP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000238855; ENSP00000238855; ENSG00000119844. ENST00000238856; ENSP00000238856; ENSG00000119844. ENST00000409933; ENSP00000387071; ENSG00000119844. ENST00000422803; ENSP00000397726; ENSG00000119844.
GeneID	54812.
KEGG	hsa:54812.
UCSC	uc002scz.3. human. uc002sda.3. human. uc002sdb.3. human. uc002sdc.3. human.
Organism-specific databases
CTD	54812.
GeneCards	GC02P064751.
HGNC	HGNC:25951. AFTPH.
HPA	HPA034991.
neXtProt	NX_Q6ULP2.
PharmGKB	PA145149871.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40359.
HOVERGEN	HBG050464.
InParanoid	Q6ULP2.
OMA	NDFVTCN.
Gene expression databases
ArrayExpress	Q6ULP2.
Bgee	Q6ULP2.
CleanEx	HS_AFTPH.
Genevestigator	Q6ULP2.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	AFTPH. human.
GenomeRNAi	54812.
NextBio	57537.

Entry information

Entry name

AFTIN_HUMAN

Accession

Primary (citable) accession number: Q6ULP2
Secondary accession number(s): D6W5E9 , Q6ZM66, Q86VW3, Q8TCF3, Q9H7E3, Q9HAB9, Q9NXS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	March 29, 2005
Last modified:	April 3, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.