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Protein

Protein amnionless

Gene

AMN

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Necessary for efficient absorption of vitamin B12 (By similarity). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein amnionless
Gene namesi
Name:AMN
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

  • Apical cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity
  • Endosome By similarity
  • Membranecoated pit By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 366ExtracellularSequence analysisAdd BLAST347
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 458CytoplasmicSequence analysisAdd BLAST71

GO - Cellular componenti

  • apical plasma membrane Source: CACAO
  • clathrin-coated pit Source: UniProtKB-SubCell
  • endosome Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Coated pit, Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in AMN could be a cause of a canine form of megaloblastic anemia 1 (MGA1).

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002070120 – 458Protein amnionlessAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6UKI2.

Interactioni

Subunit structurei

Interacts with CUBN/cubilin.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 254VWFCAdd BLAST52

Sequence similaritiesi

Contains 1 VWFC domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG037321.
InParanoidiQ6UKI2.
KOiK18259.

Family and domain databases

InterProiIPR026112. AMN.
[Graphical view]
PANTHERiPTHR14995. PTHR14995. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UKI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALGRALLW LQLCALARAA YKLWVPTTDF EAAANWSQNR TPCAGAVVQF
60 70 80 90 100
PADKAVSVVV RASHGFSDML LPRDGEFVLA SGAGFGAADA GRDPDCGAGA
110 120 130 140 150
PALFLDPDRF SWHDPRLWRS GDAARGLFSV DAERVPCRHD DVVFPPDASF
160 170 180 190 200
RVGLGPGARP ARVRSVQVLG QTFTRDEDLA AFLASRAGRL RFHGPGALRV
210 220 230 240 250
GPGACADPSG CVCGDAEVQP WICAALLQPL GGRCPPAACP DALRPEGQCC
260 270 280 290 300
DLCGAIVSLT HGPTFDIERY RARLLRAFLP QYPGLQAAVS KVRRRPGPHT
310 320 330 340 350
EVQVVLAETG PQPGGAGRLA RALLADVAEH GEALGVLSAT ARESGAPVGD
360 370 380 390 400
GSAAGPLGSG SRAGLAGGVA AGLLLLLLAL AAGLLLLRRA PRLRWTKRER
410 420 430 440 450
LVATPVEAPL GFSNPVFDVA GSVGPVPRTP QPPPAQQAGS SSTSRSYFVN

PLFAEAEA
Length:458
Mass (Da):47,618
Last modified:July 5, 2004 - v1
Checksum:i4927E33B466B8D5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY368152 mRNA. Translation: AAR13399.1.
RefSeqiNP_001002960.1. NM_001002960.1.
UniGeneiCfa.33575.

Genome annotation databases

GeneIDi403434.
KEGGicfa:403434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY368152 mRNA. Translation: AAR13399.1.
RefSeqiNP_001002960.1. NM_001002960.1.
UniGeneiCfa.33575.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6UKI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403434.
KEGGicfa:403434.

Organism-specific databases

CTDi81693.

Phylogenomic databases

HOVERGENiHBG037321.
InParanoidiQ6UKI2.
KOiK18259.

Family and domain databases

InterProiIPR026112. AMN.
[Graphical view]
PANTHERiPTHR14995. PTHR14995. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAMNLS_CANLF
AccessioniPrimary (citable) accession number: Q6UKI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.