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Q6UKI2

- AMNLS_CANFA

UniProt

Q6UKI2 - AMNLS_CANFA

Protein

Protein amnionless

Gene

AMN

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm By similarity.By similarity

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein amnionless
    Gene namesi
    Name:AMN
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in AMN could be a cause of a canine form of megaloblastic anemia 1 (MGA1).

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 458439Protein amnionlessPRO_0000020701Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ6UKI2.

    Interactioni

    Subunit structurei

    Interacts with CUBN/cubilin.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 366347ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini388 – 45871CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei367 – 38721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini203 – 25452VWFCAdd
    BLAST

    Sequence similaritiesi

    Contains 1 VWFC domain.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG037321.
    KOiK18259.

    Family and domain databases

    InterProiIPR026112. AMN.
    [Graphical view]
    PANTHERiPTHR14995. PTHR14995. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6UKI2-1 [UniParc]FASTAAdd to Basket

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    MGALGRALLW LQLCALARAA YKLWVPTTDF EAAANWSQNR TPCAGAVVQF    50
    PADKAVSVVV RASHGFSDML LPRDGEFVLA SGAGFGAADA GRDPDCGAGA 100
    PALFLDPDRF SWHDPRLWRS GDAARGLFSV DAERVPCRHD DVVFPPDASF 150
    RVGLGPGARP ARVRSVQVLG QTFTRDEDLA AFLASRAGRL RFHGPGALRV 200
    GPGACADPSG CVCGDAEVQP WICAALLQPL GGRCPPAACP DALRPEGQCC 250
    DLCGAIVSLT HGPTFDIERY RARLLRAFLP QYPGLQAAVS KVRRRPGPHT 300
    EVQVVLAETG PQPGGAGRLA RALLADVAEH GEALGVLSAT ARESGAPVGD 350
    GSAAGPLGSG SRAGLAGGVA AGLLLLLLAL AAGLLLLRRA PRLRWTKRER 400
    LVATPVEAPL GFSNPVFDVA GSVGPVPRTP QPPPAQQAGS SSTSRSYFVN 450
    PLFAEAEA 458
    Length:458
    Mass (Da):47,618
    Last modified:July 5, 2004 - v1
    Checksum:i4927E33B466B8D5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY368152 mRNA. Translation: AAR13399.1.
    RefSeqiNP_001002960.1. NM_001002960.1.
    UniGeneiCfa.33575.

    Genome annotation databases

    GeneIDi403434.
    KEGGicfa:403434.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY368152 mRNA. Translation: AAR13399.1 .
    RefSeqi NP_001002960.1. NM_001002960.1.
    UniGenei Cfa.33575.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6UKI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403434.
    KEGGi cfa:403434.

    Organism-specific databases

    CTDi 81693.

    Phylogenomic databases

    HOVERGENi HBG037321.
    KOi K18259.

    Miscellaneous databases

    NextBioi 20816952.

    Family and domain databases

    InterProi IPR026112. AMN.
    [Graphical view ]
    PANTHERi PTHR14995. PTHR14995. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless."
      Fyfe J.C., Madsen M., Hoejrup P., Christensen E.I., Tanner S.M., de la Chapelle A., He Q., Moestrup S.K.
      Blood 103:1573-1579(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Canine Imerslund-Grasbeck syndrome maps to a region orthologous to HSA14q."
      He Q., Fyfe J.C., Schaeffer A.A., Kilkenney A., Werner P., Kirkness E.F., Henthorn P.S.
      Mamm. Genome 14:758-764(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN CANINE MGA1.

    Entry informationi

    Entry nameiAMNLS_CANFA
    AccessioniPrimary (citable) accession number: Q6UKI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3