Reviewed, UniProtKB/Swiss-Prot Q6UGN0 (GPD_TRIAT)

Names and origin

Protein names

Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD+]
    EC=1.1.1.8

Gene names

Name:

gld1

Organism

Trichoderma atroviride (Hypocrea atroviridis)

Taxonomic identifier

63577 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Hypocreaceae › mitosporic Hypocreaceae › Trichoderma

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
Sequence similarities	Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	Glycerol-3-phosphate dehydrogenase [NAD+]		PRO_0000138097
Regions
	Nucleotide binding	17 – 22	6	NAD By similarity
	Region	344 – 345	2	Substrate binding By similarity
Sites
	Active site	278	1	Proton acceptor By similarity
	Binding site	120	1	NAD By similarity
	Binding site	143	1	NAD; via amide nitrogen By similarity
	Binding site	143	1	Substrate By similarity
	Binding site	176	1	NAD; via amide nitrogen By similarity
	Binding site	344	1	NAD By similarity
	Binding site	373	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6UGN0-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: AF84DC639B08C90F	FASTA	427	46,351
	10 20 30 40 50 60 MAFLGGYEKK HKVTIVGSGN WGSTIAKIVA ENTRANKDVF EEDVQMWVFE EDVTIAKDSK 70 80 90 100 110 120 HYDESIGDAP QKLTHVINKY HENVKYLPGI TLPSNIIANP SLVDAVQDSS ILIFNLPHQF 130 140 150 160 170 180 IRNVCNQIRG KILPFARGIS CIKGVNVSDD GVSLFSEWIG DGLSIYVGAL SGANIASEIA 190 200 210 220 230 240 AEKWSETTIA YDPPPMDNSR APTPRSQSPG LTMTVTEPPA DMQHRDARGR KSKTKLTPVP 250 260 270 280 290 300 AEYPPLDHAC FHSLFHRPYF HVEMVSDVAG VSLGGALKNI VALAAGFVDG RGWGDNAKAA 310 320 330 340 350 360 VMRIGLMEMV KFGKEFFGET VHTATFTESS AGVADLITSC SGGRNFRCAR KAVEKGITVD 370 380 390 400 410 420 EVEKQDLNGQ KLQGTSTAFE VNSFLTARGL EKDYPLLTAV NAILLGKASV DDIPSLVSDT ERKQPLP

References

[1]

"The fungal STRE-element-binding protein Seb1 is involved but not essential for glycerol dehydrogenase (gld1) gene expression and glycerol accumulation in Trichoderma atroviride during osmotic stress." Seidl V., Seiboth B., Karaffa L., Kubicek C.P. Fungal Genet. Biol. 41:1132-1140(2004) [PubMed: 15531216] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: P1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY370658 Genomic DNA. Translation: AAR14209.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR013328. DHase_multihelical. IPR016040. NAD(P)-bd. IPR017751. NAD-dep_Gly3P_DH_euk. IPR006168. NAD-dep_Gly3P_DHase. IPR011128. NAD-dep_Gly3P_DHase_N. IPR006109. NAD_Gly3P_DHase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR11728. NAD_Gly3P_DH. 1 hit.
Pfam	PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view]
PRINTS	PR00077. GPDHDRGNASE.
ProDom	PD001278. NAD_Gly3P_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00957. NAD_G3PDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPD_TRIAT

Accession

Primary (citable) accession number: Q6UGN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)