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Q6UGN0

- GPD_HYPAT

UniProt

Q6UGN0 - GPD_HYPAT

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

gld1

Organism
Hypocrea atroviridis (Trichoderma atroviride)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201NADBy similarity
Binding sitei143 – 1431NAD; via amide nitrogenBy similarity
Binding sitei143 – 1431SubstrateBy similarity
Binding sitei176 – 1761NAD; via amide nitrogenBy similarity
Active sitei278 – 2781Proton acceptorBy similarity
Binding sitei344 – 3441NADBy similarity
Binding sitei373 – 3731NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 226NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
Name:gld1
OrganismiHypocrea atroviridis (Trichoderma atroviride)
Taxonomic identifieri63577 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Glycerol-3-phosphate dehydrogenase [NAD(+)]PRO_0000138097Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6UGN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 3452Substrate bindingBy similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UGN0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFLGGYEKK HKVTIVGSGN WGSTIAKIVA ENTRANKDVF EEDVQMWVFE
60 70 80 90 100
EDVTIAKDSK HYDESIGDAP QKLTHVINKY HENVKYLPGI TLPSNIIANP
110 120 130 140 150
SLVDAVQDSS ILIFNLPHQF IRNVCNQIRG KILPFARGIS CIKGVNVSDD
160 170 180 190 200
GVSLFSEWIG DGLSIYVGAL SGANIASEIA AEKWSETTIA YDPPPMDNSR
210 220 230 240 250
APTPRSQSPG LTMTVTEPPA DMQHRDARGR KSKTKLTPVP AEYPPLDHAC
260 270 280 290 300
FHSLFHRPYF HVEMVSDVAG VSLGGALKNI VALAAGFVDG RGWGDNAKAA
310 320 330 340 350
VMRIGLMEMV KFGKEFFGET VHTATFTESS AGVADLITSC SGGRNFRCAR
360 370 380 390 400
KAVEKGITVD EVEKQDLNGQ KLQGTSTAFE VNSFLTARGL EKDYPLLTAV
410 420
NAILLGKASV DDIPSLVSDT ERKQPLP
Length:427
Mass (Da):46,351
Last modified:July 5, 2004 - v1
Checksum:iAF84DC639B08C90F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY370658 Genomic DNA. Translation: AAR14209.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY370658 Genomic DNA. Translation: AAR14209.1 .

3D structure databases

ProteinModelPortali Q6UGN0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The fungal STRE-element-binding protein Seb1 is involved but not essential for glycerol dehydrogenase (gld1) gene expression and glycerol accumulation in Trichoderma atroviride during osmotic stress."
    Seidl V., Seiboth B., Karaffa L., Kubicek C.P.
    Fungal Genet. Biol. 41:1132-1140(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: P1.

Entry informationi

Entry nameiGPD_HYPAT
AccessioniPrimary (citable) accession number: Q6UGN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3