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Q6UGN0

- GPD_HYPAT

UniProt

Q6UGN0 - GPD_HYPAT

Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

gld1

Organism
Hypocrea atroviridis (Trichoderma atroviride)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201NADBy similarity
    Binding sitei143 – 1431NAD; via amide nitrogenBy similarity
    Binding sitei143 – 1431SubstrateBy similarity
    Binding sitei176 – 1761NAD; via amide nitrogenBy similarity
    Active sitei278 – 2781Proton acceptorBy similarity
    Binding sitei344 – 3441NADBy similarity
    Binding sitei373 – 3731NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 226NADBy similarity

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
    Gene namesi
    Name:gld1
    OrganismiHypocrea atroviridis (Trichoderma atroviride)
    Taxonomic identifieri63577 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

    Subcellular locationi

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427Glycerol-3-phosphate dehydrogenase [NAD(+)]PRO_0000138097Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UGN0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni344 – 3452Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00957. NAD_G3PDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6UGN0-1 [UniParc]FASTAAdd to Basket

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    MAFLGGYEKK HKVTIVGSGN WGSTIAKIVA ENTRANKDVF EEDVQMWVFE    50
    EDVTIAKDSK HYDESIGDAP QKLTHVINKY HENVKYLPGI TLPSNIIANP 100
    SLVDAVQDSS ILIFNLPHQF IRNVCNQIRG KILPFARGIS CIKGVNVSDD 150
    GVSLFSEWIG DGLSIYVGAL SGANIASEIA AEKWSETTIA YDPPPMDNSR 200
    APTPRSQSPG LTMTVTEPPA DMQHRDARGR KSKTKLTPVP AEYPPLDHAC 250
    FHSLFHRPYF HVEMVSDVAG VSLGGALKNI VALAAGFVDG RGWGDNAKAA 300
    VMRIGLMEMV KFGKEFFGET VHTATFTESS AGVADLITSC SGGRNFRCAR 350
    KAVEKGITVD EVEKQDLNGQ KLQGTSTAFE VNSFLTARGL EKDYPLLTAV 400
    NAILLGKASV DDIPSLVSDT ERKQPLP 427
    Length:427
    Mass (Da):46,351
    Last modified:July 5, 2004 - v1
    Checksum:iAF84DC639B08C90F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY370658 Genomic DNA. Translation: AAR14209.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY370658 Genomic DNA. Translation: AAR14209.1 .

    3D structure databases

    ProteinModelPortali Q6UGN0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00957. NAD_G3PDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The fungal STRE-element-binding protein Seb1 is involved but not essential for glycerol dehydrogenase (gld1) gene expression and glycerol accumulation in Trichoderma atroviride during osmotic stress."
      Seidl V., Seiboth B., Karaffa L., Kubicek C.P.
      Fungal Genet. Biol. 41:1132-1140(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: P1.

    Entry informationi

    Entry nameiGPD_HYPAT
    AccessioniPrimary (citable) accession number: Q6UGN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3