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Q6UGN0

- GPD_HYPAT

UniProt

Q6UGN0 - GPD_HYPAT

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Protein
Glycerol-3-phosphate dehydrogenase [NAD(+)]
Gene
gld1
Organism
Hypocrea atroviridis (Trichoderma atroviride)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201NAD By similarity
Binding sitei143 – 1431NAD; via amide nitrogen By similarity
Binding sitei143 – 1431Substrate By similarity
Binding sitei176 – 1761NAD; via amide nitrogen By similarity
Active sitei278 – 2781Proton acceptor By similarity
Binding sitei344 – 3441NAD By similarity
Binding sitei373 – 3731NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 226NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
Name:gld1
OrganismiHypocrea atroviridis (Trichoderma atroviride)
Taxonomic identifieri63577 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Glycerol-3-phosphate dehydrogenase [NAD(+)]
PRO_0000138097Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6UGN0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 3452Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UGN0-1 [UniParc]FASTAAdd to Basket

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MAFLGGYEKK HKVTIVGSGN WGSTIAKIVA ENTRANKDVF EEDVQMWVFE    50
EDVTIAKDSK HYDESIGDAP QKLTHVINKY HENVKYLPGI TLPSNIIANP 100
SLVDAVQDSS ILIFNLPHQF IRNVCNQIRG KILPFARGIS CIKGVNVSDD 150
GVSLFSEWIG DGLSIYVGAL SGANIASEIA AEKWSETTIA YDPPPMDNSR 200
APTPRSQSPG LTMTVTEPPA DMQHRDARGR KSKTKLTPVP AEYPPLDHAC 250
FHSLFHRPYF HVEMVSDVAG VSLGGALKNI VALAAGFVDG RGWGDNAKAA 300
VMRIGLMEMV KFGKEFFGET VHTATFTESS AGVADLITSC SGGRNFRCAR 350
KAVEKGITVD EVEKQDLNGQ KLQGTSTAFE VNSFLTARGL EKDYPLLTAV 400
NAILLGKASV DDIPSLVSDT ERKQPLP 427
Length:427
Mass (Da):46,351
Last modified:July 5, 2004 - v1
Checksum:iAF84DC639B08C90F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY370658 Genomic DNA. Translation: AAR14209.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY370658 Genomic DNA. Translation: AAR14209.1 .

3D structure databases

ProteinModelPortali Q6UGN0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The fungal STRE-element-binding protein Seb1 is involved but not essential for glycerol dehydrogenase (gld1) gene expression and glycerol accumulation in Trichoderma atroviride during osmotic stress."
    Seidl V., Seiboth B., Karaffa L., Kubicek C.P.
    Fungal Genet. Biol. 41:1132-1140(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: P1.

Entry informationi

Entry nameiGPD_HYPAT
AccessioniPrimary (citable) accession number: Q6UGN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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