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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

UL50

Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:UL50
OrganismiPsittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Taxonomic identifieri670426 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
Virus hostiAmazona oratrix (yellow-headed parrot) [TaxID: 152276]
ProteomesiUP000006840 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000406814Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6UDM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni327 – 3293Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6UDM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATTKKMAM IEIGKGWAAS CLEARTCVIS NEEDIYAEPR ADTPVLKLDS
60 70 80 90 100
TVRTALPPGY GIVISGTARN HKTAWEIVPG LVDSGYTGLL GLLLVPTDET
110 120 130 140 150
PATGSAGGGI VSFSRGGVHA RLTVIKLVPD DIMGACGAGA QRLPLKTAIT
160 170 180 190 200
SFKGDEDLLG NGFDHCMESL ASIYPDILHV QLDCPVYFGC TGCKAFYRRL
210 220 230 240 250
GSCLETRPLN ELGSDHIYLR RGSAYESVNR FAAPDDVMFV AMYGKWLLIG
260 270 280 290 300
MAETPNEKLT VELRDDDSSP AALIPFHDTF GQKEAEDAGY DIRAPENCTL
310 320 330 340 350
PPGGSVRVIL RQKLHMGKGR AAFVMGRSSM NLKGVLVEPE RVVDDEWVSF
360 370 380 390 400
NITNIRDAAA FFRKNDRIAQ LVALEDKLEL MGGVDALPWR VVQSVQEEKK
410
NSSRGDKGFG SSGV
Length:414
Mass (Da):44,834
Last modified:July 5, 2004 - v1
Checksum:i52E9D8630B7AE9EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372243 Genomic DNA. Translation: AAQ73690.1.
RefSeqiNP_944384.1. NC_005264.1.

Genome annotation databases

GeneIDi2656993.
KEGGivg:2656993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372243 Genomic DNA. Translation: AAQ73690.1.
RefSeqiNP_944384.1. NC_005264.1.

3D structure databases

ProteinModelPortaliQ6UDM0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2656993.
KEGGivg:2656993.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
    Thureen D.R., Keeler C.L. Jr.
    J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_PSHV1
AccessioniPrimary (citable) accession number: Q6UDM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.