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Q6UDM0 (DUT_PSHV1) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:UL50
OrganismPsittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) [Reference proteome]
Taxonomic identifier670426 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
Virus hostAmazona oratrix (yellow-headed parrot) [TaxID: 152276]

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000406814

Regions

Region327 – 3293Substrate binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6UDM0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 52E9D8630B7AE9EB

FASTA41444,834
        10         20         30         40         50         60 
MEATTKKMAM IEIGKGWAAS CLEARTCVIS NEEDIYAEPR ADTPVLKLDS TVRTALPPGY 

        70         80         90        100        110        120 
GIVISGTARN HKTAWEIVPG LVDSGYTGLL GLLLVPTDET PATGSAGGGI VSFSRGGVHA 

       130        140        150        160        170        180 
RLTVIKLVPD DIMGACGAGA QRLPLKTAIT SFKGDEDLLG NGFDHCMESL ASIYPDILHV 

       190        200        210        220        230        240 
QLDCPVYFGC TGCKAFYRRL GSCLETRPLN ELGSDHIYLR RGSAYESVNR FAAPDDVMFV 

       250        260        270        280        290        300 
AMYGKWLLIG MAETPNEKLT VELRDDDSSP AALIPFHDTF GQKEAEDAGY DIRAPENCTL 

       310        320        330        340        350        360 
PPGGSVRVIL RQKLHMGKGR AAFVMGRSSM NLKGVLVEPE RVVDDEWVSF NITNIRDAAA 

       370        380        390        400        410 
FFRKNDRIAQ LVALEDKLEL MGGVDALPWR VVQSVQEEKK NSSRGDKGFG SSGV 

« Hide

References

[1]"Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
Thureen D.R., Keeler C.L. Jr.
J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY372243 Genomic DNA. Translation: AAQ73690.1.
RefSeqNP_944384.1. NC_005264.1.

3D structure databases

ProteinModelPortalQ6UDM0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2656993.

Phylogenomic databases

ProtClustDBPHA3124.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_PSHV1
AccessionPrimary (citable) accession number: Q6UDM0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: October 16, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families