Q6UDM0 (DUT_PSHV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

Name:

UL50

Organism

Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) [Reference proteome]

Taxonomic identifier

670426 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Iltovirus › Psittacid herpesvirus 1

Virus host

Amazona oratrix (yellow-headed parrot) [TaxID: 152276]

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000406814
Regions
	Region	327 – 329	3	Substrate binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6UDM0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 52E9D8630B7AE9EB	FASTA	414	44,834
	10 20 30 40 50 60 MEATTKKMAM IEIGKGWAAS CLEARTCVIS NEEDIYAEPR ADTPVLKLDS TVRTALPPGY 70 80 90 100 110 120 GIVISGTARN HKTAWEIVPG LVDSGYTGLL GLLLVPTDET PATGSAGGGI VSFSRGGVHA 130 140 150 160 170 180 RLTVIKLVPD DIMGACGAGA QRLPLKTAIT SFKGDEDLLG NGFDHCMESL ASIYPDILHV 190 200 210 220 230 240 QLDCPVYFGC TGCKAFYRRL GSCLETRPLN ELGSDHIYLR RGSAYESVNR FAAPDDVMFV 250 260 270 280 290 300 AMYGKWLLIG MAETPNEKLT VELRDDDSSP AALIPFHDTF GQKEAEDAGY DIRAPENCTL 310 320 330 340 350 360 PPGGSVRVIL RQKLHMGKGR AAFVMGRSSM NLKGVLVEPE RVVDDEWVSF NITNIRDAAA 370 380 390 400 410 FFRKNDRIAQ LVALEDKLEL MGGVDALPWR VVQSVQEEKK NSSRGDKGFG SSGV

References

[1]	"Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses." Thureen D.R., Keeler C.L. Jr. J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY372243 Genomic DNA. Translation: AAQ73690.1.
RefSeq	NP_944384.1. NC_005264.1.
3D structure databases
ProteinModelPortal	Q6UDM0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2656993.
Phylogenomic databases
ProtClustDB	PHA3124.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_PSHV1

Accession

Primary (citable) accession number: Q6UDM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program