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Q6UDM0

- DUT_PSHV1

UniProt

Q6UDM0 - DUT_PSHV1

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

UL50

Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:UL50
    OrganismiPsittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
    Taxonomic identifieri670426 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
    Virus hostiAmazona oratrix (yellow-headed parrot) [TaxID: 152276]
    ProteomesiUP000006840: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000406814Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UDM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni327 – 3293Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q6UDM0-1 [UniParc]FASTAAdd to Basket

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    MEATTKKMAM IEIGKGWAAS CLEARTCVIS NEEDIYAEPR ADTPVLKLDS    50
    TVRTALPPGY GIVISGTARN HKTAWEIVPG LVDSGYTGLL GLLLVPTDET 100
    PATGSAGGGI VSFSRGGVHA RLTVIKLVPD DIMGACGAGA QRLPLKTAIT 150
    SFKGDEDLLG NGFDHCMESL ASIYPDILHV QLDCPVYFGC TGCKAFYRRL 200
    GSCLETRPLN ELGSDHIYLR RGSAYESVNR FAAPDDVMFV AMYGKWLLIG 250
    MAETPNEKLT VELRDDDSSP AALIPFHDTF GQKEAEDAGY DIRAPENCTL 300
    PPGGSVRVIL RQKLHMGKGR AAFVMGRSSM NLKGVLVEPE RVVDDEWVSF 350
    NITNIRDAAA FFRKNDRIAQ LVALEDKLEL MGGVDALPWR VVQSVQEEKK 400
    NSSRGDKGFG SSGV 414
    Length:414
    Mass (Da):44,834
    Last modified:July 5, 2004 - v1
    Checksum:i52E9D8630B7AE9EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY372243 Genomic DNA. Translation: AAQ73690.1.
    RefSeqiNP_944384.1. NC_005264.1.

    Genome annotation databases

    GeneIDi2656993.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY372243 Genomic DNA. Translation: AAQ73690.1 .
    RefSeqi NP_944384.1. NC_005264.1.

    3D structure databases

    ProteinModelPortali Q6UDM0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2656993.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
      Thureen D.R., Keeler C.L. Jr.
      J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_PSHV1
    AccessioniPrimary (citable) accession number: Q6UDM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3