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Q6UDK9 (KITH_PSHV1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Thymidine kinase
PRO_0000406816

Regions

Nucleotide binding11 – 188ATP By similarity

Sites

Active site391Proton acceptor By similarity
Binding site831Substrate By similarity
Binding site1321Substrate By similarity
Binding site1761ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6UDK9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 77788121FEACB803

FASTA33938,059
        10         20         30         40         50         60 
MGRIVVLYVD GAFGIGKTTV LRQIQKSAAY RFRRIYLEEP MRAWRSWFVD DHDAIREIYT 

        70         80         90        100        110        120 
TQELKDAGEI DLREASRRVC YAQVSLSAPF HIMNAVIYGI ISGESEATSA HLGEGDYFVG 

       130        140        150        160        170        180 
VDRHPLASCL CFPVARFVTG YLEYTDLIAL VATLPDYPRG ASIAILDLSV EEQARRITER 

       190        200        210        220        230        240 
SRSGEHVNKT FLRILRNVFI IMYNTVAYLR NVSIDKACAD REALEDFRGS QLESDMHKID 

       250        260        270        280        290        300 
IQPRDDPNAS ETLFAVMASD ATWRKNRKQS ALFVYTMAKL DALLRSLNMH IVDINGLSQE 

       310        320        330 
QCAEKVVAIS SKVPAVTARG NAPDLLFDAV EAYNADMGV 

« Hide

References

[1]"Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
Thureen D.R., Keeler C.L. Jr.
J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY372243 Genomic DNA. Translation: AAQ73701.1.
RefSeqNP_944395.1. NC_005264.1.

3D structure databases

ProteinModelPortalQ6UDK9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2656999.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_PSHV1
AccessionPrimary (citable) accession number: Q6UDK9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families