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Q6UDK9

- KITH_PSHV1

UniProt

Q6UDK9 - KITH_PSHV1

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Protein
Thymidine kinase
Gene
UL23
Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Proton acceptor By similarity
Binding sitei83 – 831Substrate By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei176 – 1761ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:UL23
OrganismiPsittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Taxonomic identifieri670426 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
Virus hostiAmazona oratrix (yellow-headed parrot) [TaxID: 152276]
ProteomesiUP000006840: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Thymidine kinase
PRO_0000406816Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6UDK9.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6UDK9-1 [UniParc]FASTAAdd to Basket

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MGRIVVLYVD GAFGIGKTTV LRQIQKSAAY RFRRIYLEEP MRAWRSWFVD    50
DHDAIREIYT TQELKDAGEI DLREASRRVC YAQVSLSAPF HIMNAVIYGI 100
ISGESEATSA HLGEGDYFVG VDRHPLASCL CFPVARFVTG YLEYTDLIAL 150
VATLPDYPRG ASIAILDLSV EEQARRITER SRSGEHVNKT FLRILRNVFI 200
IMYNTVAYLR NVSIDKACAD REALEDFRGS QLESDMHKID IQPRDDPNAS 250
ETLFAVMASD ATWRKNRKQS ALFVYTMAKL DALLRSLNMH IVDINGLSQE 300
QCAEKVVAIS SKVPAVTARG NAPDLLFDAV EAYNADMGV 339
Length:339
Mass (Da):38,059
Last modified:July 5, 2004 - v1
Checksum:i77788121FEACB803
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY372243 Genomic DNA. Translation: AAQ73701.1.
RefSeqiNP_944395.1. NC_005264.1.

Genome annotation databases

GeneIDi2656999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY372243 Genomic DNA. Translation: AAQ73701.1 .
RefSeqi NP_944395.1. NC_005264.1.

3D structure databases

ProteinModelPortali Q6UDK9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2656999.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
    Thureen D.R., Keeler C.L. Jr.
    J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_PSHV1
AccessioniPrimary (citable) accession number: Q6UDK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3