Q6UDK9 (KITH_PSHV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:

UL23

Organism

Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) [Reference proteome]

Taxonomic identifier

670426 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Iltovirus › Psittacid herpesvirus 1

Virus host

Amazona oratrix (yellow-headed parrot) [TaxID: 152276]

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.
Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the herpesviruses thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW TMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Thymidine kinase		PRO_0000406816
Regions
	Nucleotide binding	11 – 18	8	ATP By similarity
Sites
	Active site	39	1	Proton acceptor By similarity
	Binding site	83	1	Substrate By similarity
	Binding site	132	1	Substrate By similarity
	Binding site	176	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6UDK9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 77788121FEACB803	FASTA	339	38,059
	10 20 30 40 50 60 MGRIVVLYVD GAFGIGKTTV LRQIQKSAAY RFRRIYLEEP MRAWRSWFVD DHDAIREIYT 70 80 90 100 110 120 TQELKDAGEI DLREASRRVC YAQVSLSAPF HIMNAVIYGI ISGESEATSA HLGEGDYFVG 130 140 150 160 170 180 VDRHPLASCL CFPVARFVTG YLEYTDLIAL VATLPDYPRG ASIAILDLSV EEQARRITER 190 200 210 220 230 240 SRSGEHVNKT FLRILRNVFI IMYNTVAYLR NVSIDKACAD REALEDFRGS QLESDMHKID 250 260 270 280 290 300 IQPRDDPNAS ETLFAVMASD ATWRKNRKQS ALFVYTMAKL DALLRSLNMH IVDINGLSQE 310 320 330 QCAEKVVAIS SKVPAVTARG NAPDLLFDAV EAYNADMGV

References

[1]	"Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses." Thureen D.R., Keeler C.L. Jr. J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY372243 Genomic DNA. Translation: AAQ73701.1.
RefSeq	NP_944395.1. NC_005264.1.
3D structure databases
ProteinModelPortal	Q6UDK9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2656999.
Family and domain databases
InterPro	IPR001889. Herpes_TK. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00693. Herpes_TK. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KITH_PSHV1

Accession

Primary (citable) accession number: Q6UDK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program