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Q6UDJ5 (DEN_PSHV1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length3195 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins By similarity.

Subcellular location

Virion tegument Potential. Host nucleus By similarity.

Sequence similarities

Belongs to the herpesviridae deneddylase family.

Contains 2 ANK repeats.

Contains 1 peptidase C76 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 31953195Deneddylase
PRO_0000406796

Regions

Domain10 – 242233Peptidase C76
Repeat764 – 79431ANK 1
Repeat2151 – 218131ANK 2
Coiled coil1441 – 147131 Potential
Coiled coil1514 – 154633 Potential
Coiled coil1572 – 161140 Potential
Compositional bias838 – 980143Ala-rich
Compositional bias1656 – 16594Poly-Leu
Compositional bias1663 – 16664Poly-Ala
Compositional bias2286 – 22927Poly-Ala
Compositional bias2708 – 27114Poly-Pro

Sites

Active site301 By similarity
Active site1731 By similarity
Active site1751 By similarity
Site171Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6UDJ5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 04404B41D1563EFC

FASTA3,195344,441
        10         20         30         40         50         60 
MWPPGLGTVV AAASRSQFDA MYEEMCYAMC VETSAAFLRA CELAGPQAVQ SQNVLDTILD 

        70         80         90        100        110        120 
QGAEITRTSV ACETLPGGVK RYNMIDCQEL PRLWRGSGQE PDMLLLHTTT FGNIPYDSTF 

       130        140        150        160        170        180 
DYEEKVLMLN GQQLGEKAAA MAREGAAAVL VIGNRGLGVA FTGGRHDPVF VFDPHGWMGG 

       190        200        210        220        230        240 
AAYMSRLPNP TSLTGFIADY VERRSGIVVT LTFLLWLYPD GWNIEQESPE LRVEVISAAL 

       250        260        270        280        290        300 
RAISQPPDFV FLDQFSETVV SPALPVPMGA LRADRFAAKS IRAILARGTA PSPKKKPDSG 

       310        320        330        340        350        360 
EHGLPAGRPK PPKRHTPRSQ NPALLDSTEK LSNLSPVKVK KPNKGKKMSV IAEPPSAAAR 

       370        380        390        400        410        420 
TEQRGPGDSL GALAERPPWR LQGVRAAADV IAVPAASALA GLPEKPSDKL RGVLKYLPEA 

       430        440        450        460        470        480 
PTGGLSLGSG NALWAAILGT RVASLTDRLL VFLVENGITI RKAESEVGFL LDPVLAALAH 

       490        500        510        520        530        540 
RPDRGAVASL IGDTRLNLFA LVARKAALLR LTELRDDRVS AVLVHKVQQV SSAIVSDTKT 

       550        560        570        580        590        600 
ISAKLGALVD EISSEHPADA YGTLEKELLA FSLEKTAVVE RPDETTAPIL ELVERAAEIV 

       610        620        630        640        650        660 
DAIEKETRAK AEREDRARRA DEKLLAFAHS VWDEIDDIAG DVTRGVDVGS SQASAAASLA 

       670        680        690        700        710        720 
KRERIDIPEP SSMPPREDYS ELKILDDKAK ANAQKITDSA GKMLKVYANV IDYSISAFTS 

       730        740        750        760        770        780 
GTQSAIGRFA LASPALDHMK AWLDRIAYAD TLVDSLAGLT GRRESASPDW GRLSSLEPVR 

       790        800        810        820        830        840 
ILEGLIETGA DLSSDENLNH WTFQLFGAHA AGFMPSPSKW ISAIHGINTR AHEVGLSATA 

       850        860        870        880        890        900 
LAELETEIKA AEAMVADPGV RLECAKHALE SAKAAVAGKS DPEQKARLAA AQARAAKLVD 

       910        920        930        940        950        960 
SCQRDLDEAK RLVDEATKRD AEIKKAAAAL LRPVEKYQGL RGLGRSMAAA GLSDDAVAGI 

       970        980        990       1000       1010       1020 
VAADTQVARV LRADAEAILA NYERDFAELR GAQLLGTSAP LLRAVNFIDP RSGLGLLEPG 

      1030       1040       1050       1060       1070       1080 
SRIFLSEAND DLMDAVEDAR TTRNTDSCSR AISALERIKW VIVEAEGAGQ WPKFAVAAAR 

      1090       1100       1110       1120       1130       1140 
ALEGLRAKAL IDDRAGLVRT TLAGMLKRAA IVSETVAKDT DDPEAAAERA LKFVEMARRE 

      1150       1160       1170       1180       1190       1200 
LRELELTDAE ELSSQDYVAL ERALVELAEA SRQKSIGLKK HAWRSRLRTL LERDRDDGEF 

      1210       1220       1230       1240       1250       1260 
SLDAWDQARD EGECYGGRDA VNDDLIKLAR AVIDGRIQLG LRLVRAFFAN NPYAAQASQA 

      1270       1280       1290       1300       1310       1320 
LPGDARGPVE LLESIRVAKW IFAFPGVADT YEYLFGISVV KLKALCEIGE EIVEAFDAAG 

      1330       1340       1350       1360       1370       1380 
SSDKNIDMHA FVQTVAGKLF QVSELTEFFD FYVRSYELFL DIRAALAETA GRVGALERTA 

      1390       1400       1410       1420       1430       1440 
LEQLGAEERA AESIRDPEAA KERLERGDRD PDALTAMREL HGGLKLESKK QFEKTAYLEP 

      1450       1460       1470       1480       1490       1500 
LEYGYAEARR ELERAIANVD AAKKLSQARV KDFLSSLLRE REANDQELSR NLKTLKSVLA 

      1510       1520       1530       1540       1550       1560 
ARSPKDVVAA LNGAETLDAV VKIYADRLAE AEAENEAAIV GAETMEWLKF AAKTIDGSKM 

      1570       1580       1590       1600       1610       1620 
ARETGGVGPT AAYAERLEKL CRARADADAK LKRLKDLYES FELALASAKE AGGKQKDESE 

      1630       1640       1650       1660       1670       1680 
DGWRRYEAAA NNLLTSAEAL GAQLRDEGNE QAGIKLLLLR EPAAAAYEKG LENAAAVIKD 

      1690       1700       1710       1720       1730       1740 
VRTTLDDTSA GMRRLLTLYE AAKTEFAKPG LERLQKEISY AIAKYPVPKW FLALHAAVGK 

      1750       1760       1770       1780       1790       1800 
LVELRLGLYH AYEGLKISTI PYAPVAPESE YVMPDAALTA ARVTAYMARS GKSVMTVTTH 

      1810       1820       1830       1840       1850       1860 
SLGIVGRAVV DEANQILEYK LCYATVSEKV AALWAAGSRL GAGQFGGLVL RDARDERGVE 

      1870       1880       1890       1900       1910       1920 
KFLGRGHAAV SLAATAAWLS GADTMITAEL GSYVTFCATG HWPAMRDRKQ LSMTVAACTT 

      1930       1940       1950       1960       1970       1980 
YCALAYATLT STYGSAADTA VDSHGQFVPP EKFEAANTSG AVAAGAARGA KRKFALSIQD 

      1990       2000       2010       2020       2030       2040 
VLILLAACEP AHLTYFCRLD LLRQVEYMHK TLEAVLSRAV RDRVGVSCLE PPKADDTRKY 

      2050       2060       2070       2080       2090       2100 
MPVVMPAARG RFDKSYGACF AIDRHDWDSV KAPHYVGKML EPWKTLPGTR ENAERLERIC 

      2110       2120       2130       2140       2150       2160 
GGTADAADGF TATLMMLAAT AIPANLLEAM WALLGPRDED LGENWQLGEG EVEGQWSGGA 

      2170       2180       2190       2200       2210       2220 
ASAAAAAMLR FMLRRAAAVD NYTVATSGGT AGLALDSLSA KLLGPAGGSI MFLLKEDAVN 

      2230       2240       2250       2260       2270       2280 
LRRLLAFDVA LLSILFGAKV VIAYETSALS RESGLLLCSS VFDARRGNRF ADILCADHRA 

      2290       2300       2310       2320       2330       2340 
CASDSAAAAA DALKKIALAD PNRIENACLL QQVEELASAL HSKPLSYAQP FLFLANTSNQ 

      2350       2360       2370       2380       2390       2400 
ITQVLIPAKA RPSEFFVTLR RDAAYEEVPL RRADRQAFPD EIDAKDIEGG DLFFSATVGG 

      2410       2420       2430       2440       2450       2460 
EVPVLDNPAH IAPAPPEYDR GEGNLFPFAG SRRSAPSEEE ALSKAAGSKR NQIDAHGQNI 

      2470       2480       2490       2500       2510       2520 
SQPARAGNTK IERASGKNRK TENNVTEHQT AARGRAAAPP TETKTTEKRQ KCPPRESPLS 

      2530       2540       2550       2560       2570       2580 
RDERAPHDGL SAGAAEPRPP RGDSDDDRHK HETPHGVSDK AAEPPAVPSA EPRGPSTELI 

      2590       2600       2610       2620       2630       2640 
GGNWKSLPKT KPRRTSSGLR RKHQASASVH KHRTHGSSDD DSEDGEATYG FGSCRGRQRR 

      2650       2660       2670       2680       2690       2700 
STLGGKKRSG TDRTAEFLKK ATCVDKLEKF SRSGESPKAQ NGTADVACDR LGERGNELSP 

      2710       2720       2730       2740       2750       2760 
PRAPASSPPP PGKQADHGID QREIVPPNAQ YGITTVVDPR QVRLPSSDDG DPAEEEDARD 

      2770       2780       2790       2800       2810       2820 
VEEGEEDVAG QWDSNYDVCL PTYDTDHAAQ EEKDFDLASN NGTGGALPAA DHAISAINDW 

      2830       2840       2850       2860       2870       2880 
VIADTDASAG VGTDWSEEDE DAPAADDGRS TNVEVATHGY TSDDSAADDE SKRARATRDS 

      2890       2900       2910       2920       2930       2940 
SPPQHYPASP LAPSTPSSLP TPADTDNDTA ILELDRNSGG DTDSNDDHAP PTDTGDAPPL 

      2950       2960       2970       2980       2990       3000 
CSEGELTPST DEECAVVQDD ARKKQENSSH ERKDDGVRWE IDLDSDQGDY SDASDDCKIP 

      3010       3020       3030       3040       3050       3060 
DGPRVAPEKD IKNKQLEKSE SDSCGGQGDP STEPQQPLWE VYSPYDNSDS DDKAGNRKDP 

      3070       3080       3090       3100       3110       3120 
KLDGAALDMR SSRLRADAKS ITSYVNDINE AVRDGGSAAA EFFARSEQSC IDSEDDARHL 

      3130       3140       3150       3160       3170       3180 
DKSRATLASD LDDHQSDQPR ESLAPLDPET RSKMYTSLAV TCRLILRGMR HAQDAASAGV 

      3190 
AELLTETNRI KMMLN 

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References

[1]"Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
Thureen D.R., Keeler C.L. Jr.
J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY372243 Genomic DNA. Translation: AAQ73715.1.
RefSeqNP_944409.1. NC_005264.1.

3D structure databases

ProteinModelPortalQ6UDJ5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2657005.

Family and domain databases

InterProIPR005210. Herpes_UL36.
IPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamPF04843. Herpes_teg_N. 1 hit.
PF03586. Herpes_UL36. 1 hit.
[Graphical view]
PROSITEPS51521. HTUSP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDEN_PSHV1
AccessionPrimary (citable) accession number: Q6UDJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries