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Q6UDJ5

- DEN_PSHV1

UniProt

Q6UDJ5 - DEN_PSHV1

Protein

Deneddylase

Gene

UL36

Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei17 – 171Important for catalytic activityPROSITE-ProRule annotation
    Active sitei30 – 301PROSITE-ProRule annotation
    Active sitei173 – 1731PROSITE-ProRule annotation
    Active sitei175 – 1751PROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: InterPro
    2. omega peptidase activity Source: InterPro

    GO - Biological processi

    1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
    Gene namesi
    Name:UL36
    OrganismiPsittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
    Taxonomic identifieri670426 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
    Virus hostiAmazona oratrix (yellow-headed parrot) [TaxID: 152276]
    ProteomesiUP000006840: Genome

    Subcellular locationi

    Virion tegument Curated. Host nucleus By similarity

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. viral tegument Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus, Virion, Virion tegument

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 31953195DeneddylasePRO_0000406796Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UDJ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 242233Peptidase C76PROSITE-ProRule annotationAdd
    BLAST
    Repeati764 – 79431ANK 1Add
    BLAST
    Repeati2151 – 218131ANK 2Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1441 – 147131Sequence AnalysisAdd
    BLAST
    Coiled coili1514 – 154633Sequence AnalysisAdd
    BLAST
    Coiled coili1572 – 161140Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi838 – 980143Ala-richAdd
    BLAST
    Compositional biasi1656 – 16594Poly-Leu
    Compositional biasi1663 – 16664Poly-Ala
    Compositional biasi2286 – 22927Poly-Ala
    Compositional biasi2708 – 27114Poly-Pro

    Sequence similaritiesi

    Belongs to the herpesviridae deneddylase family.Curated
    Contains 2 ANK repeats.Curated
    Contains 1 peptidase C76 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Family and domain databases

    InterProiIPR005210. Herpes_UL36.
    IPR006928. Pept_C76_UL36-USP.
    [Graphical view]
    PfamiPF04843. Herpes_teg_N. 1 hit.
    PF03586. Herpes_UL36. 1 hit.
    [Graphical view]
    PROSITEiPS51521. HTUSP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6UDJ5-1 [UniParc]FASTAAdd to Basket

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    MWPPGLGTVV AAASRSQFDA MYEEMCYAMC VETSAAFLRA CELAGPQAVQ     50
    SQNVLDTILD QGAEITRTSV ACETLPGGVK RYNMIDCQEL PRLWRGSGQE 100
    PDMLLLHTTT FGNIPYDSTF DYEEKVLMLN GQQLGEKAAA MAREGAAAVL 150
    VIGNRGLGVA FTGGRHDPVF VFDPHGWMGG AAYMSRLPNP TSLTGFIADY 200
    VERRSGIVVT LTFLLWLYPD GWNIEQESPE LRVEVISAAL RAISQPPDFV 250
    FLDQFSETVV SPALPVPMGA LRADRFAAKS IRAILARGTA PSPKKKPDSG 300
    EHGLPAGRPK PPKRHTPRSQ NPALLDSTEK LSNLSPVKVK KPNKGKKMSV 350
    IAEPPSAAAR TEQRGPGDSL GALAERPPWR LQGVRAAADV IAVPAASALA 400
    GLPEKPSDKL RGVLKYLPEA PTGGLSLGSG NALWAAILGT RVASLTDRLL 450
    VFLVENGITI RKAESEVGFL LDPVLAALAH RPDRGAVASL IGDTRLNLFA 500
    LVARKAALLR LTELRDDRVS AVLVHKVQQV SSAIVSDTKT ISAKLGALVD 550
    EISSEHPADA YGTLEKELLA FSLEKTAVVE RPDETTAPIL ELVERAAEIV 600
    DAIEKETRAK AEREDRARRA DEKLLAFAHS VWDEIDDIAG DVTRGVDVGS 650
    SQASAAASLA KRERIDIPEP SSMPPREDYS ELKILDDKAK ANAQKITDSA 700
    GKMLKVYANV IDYSISAFTS GTQSAIGRFA LASPALDHMK AWLDRIAYAD 750
    TLVDSLAGLT GRRESASPDW GRLSSLEPVR ILEGLIETGA DLSSDENLNH 800
    WTFQLFGAHA AGFMPSPSKW ISAIHGINTR AHEVGLSATA LAELETEIKA 850
    AEAMVADPGV RLECAKHALE SAKAAVAGKS DPEQKARLAA AQARAAKLVD 900
    SCQRDLDEAK RLVDEATKRD AEIKKAAAAL LRPVEKYQGL RGLGRSMAAA 950
    GLSDDAVAGI VAADTQVARV LRADAEAILA NYERDFAELR GAQLLGTSAP 1000
    LLRAVNFIDP RSGLGLLEPG SRIFLSEAND DLMDAVEDAR TTRNTDSCSR 1050
    AISALERIKW VIVEAEGAGQ WPKFAVAAAR ALEGLRAKAL IDDRAGLVRT 1100
    TLAGMLKRAA IVSETVAKDT DDPEAAAERA LKFVEMARRE LRELELTDAE 1150
    ELSSQDYVAL ERALVELAEA SRQKSIGLKK HAWRSRLRTL LERDRDDGEF 1200
    SLDAWDQARD EGECYGGRDA VNDDLIKLAR AVIDGRIQLG LRLVRAFFAN 1250
    NPYAAQASQA LPGDARGPVE LLESIRVAKW IFAFPGVADT YEYLFGISVV 1300
    KLKALCEIGE EIVEAFDAAG SSDKNIDMHA FVQTVAGKLF QVSELTEFFD 1350
    FYVRSYELFL DIRAALAETA GRVGALERTA LEQLGAEERA AESIRDPEAA 1400
    KERLERGDRD PDALTAMREL HGGLKLESKK QFEKTAYLEP LEYGYAEARR 1450
    ELERAIANVD AAKKLSQARV KDFLSSLLRE REANDQELSR NLKTLKSVLA 1500
    ARSPKDVVAA LNGAETLDAV VKIYADRLAE AEAENEAAIV GAETMEWLKF 1550
    AAKTIDGSKM ARETGGVGPT AAYAERLEKL CRARADADAK LKRLKDLYES 1600
    FELALASAKE AGGKQKDESE DGWRRYEAAA NNLLTSAEAL GAQLRDEGNE 1650
    QAGIKLLLLR EPAAAAYEKG LENAAAVIKD VRTTLDDTSA GMRRLLTLYE 1700
    AAKTEFAKPG LERLQKEISY AIAKYPVPKW FLALHAAVGK LVELRLGLYH 1750
    AYEGLKISTI PYAPVAPESE YVMPDAALTA ARVTAYMARS GKSVMTVTTH 1800
    SLGIVGRAVV DEANQILEYK LCYATVSEKV AALWAAGSRL GAGQFGGLVL 1850
    RDARDERGVE KFLGRGHAAV SLAATAAWLS GADTMITAEL GSYVTFCATG 1900
    HWPAMRDRKQ LSMTVAACTT YCALAYATLT STYGSAADTA VDSHGQFVPP 1950
    EKFEAANTSG AVAAGAARGA KRKFALSIQD VLILLAACEP AHLTYFCRLD 2000
    LLRQVEYMHK TLEAVLSRAV RDRVGVSCLE PPKADDTRKY MPVVMPAARG 2050
    RFDKSYGACF AIDRHDWDSV KAPHYVGKML EPWKTLPGTR ENAERLERIC 2100
    GGTADAADGF TATLMMLAAT AIPANLLEAM WALLGPRDED LGENWQLGEG 2150
    EVEGQWSGGA ASAAAAAMLR FMLRRAAAVD NYTVATSGGT AGLALDSLSA 2200
    KLLGPAGGSI MFLLKEDAVN LRRLLAFDVA LLSILFGAKV VIAYETSALS 2250
    RESGLLLCSS VFDARRGNRF ADILCADHRA CASDSAAAAA DALKKIALAD 2300
    PNRIENACLL QQVEELASAL HSKPLSYAQP FLFLANTSNQ ITQVLIPAKA 2350
    RPSEFFVTLR RDAAYEEVPL RRADRQAFPD EIDAKDIEGG DLFFSATVGG 2400
    EVPVLDNPAH IAPAPPEYDR GEGNLFPFAG SRRSAPSEEE ALSKAAGSKR 2450
    NQIDAHGQNI SQPARAGNTK IERASGKNRK TENNVTEHQT AARGRAAAPP 2500
    TETKTTEKRQ KCPPRESPLS RDERAPHDGL SAGAAEPRPP RGDSDDDRHK 2550
    HETPHGVSDK AAEPPAVPSA EPRGPSTELI GGNWKSLPKT KPRRTSSGLR 2600
    RKHQASASVH KHRTHGSSDD DSEDGEATYG FGSCRGRQRR STLGGKKRSG 2650
    TDRTAEFLKK ATCVDKLEKF SRSGESPKAQ NGTADVACDR LGERGNELSP 2700
    PRAPASSPPP PGKQADHGID QREIVPPNAQ YGITTVVDPR QVRLPSSDDG 2750
    DPAEEEDARD VEEGEEDVAG QWDSNYDVCL PTYDTDHAAQ EEKDFDLASN 2800
    NGTGGALPAA DHAISAINDW VIADTDASAG VGTDWSEEDE DAPAADDGRS 2850
    TNVEVATHGY TSDDSAADDE SKRARATRDS SPPQHYPASP LAPSTPSSLP 2900
    TPADTDNDTA ILELDRNSGG DTDSNDDHAP PTDTGDAPPL CSEGELTPST 2950
    DEECAVVQDD ARKKQENSSH ERKDDGVRWE IDLDSDQGDY SDASDDCKIP 3000
    DGPRVAPEKD IKNKQLEKSE SDSCGGQGDP STEPQQPLWE VYSPYDNSDS 3050
    DDKAGNRKDP KLDGAALDMR SSRLRADAKS ITSYVNDINE AVRDGGSAAA 3100
    EFFARSEQSC IDSEDDARHL DKSRATLASD LDDHQSDQPR ESLAPLDPET 3150
    RSKMYTSLAV TCRLILRGMR HAQDAASAGV AELLTETNRI KMMLN 3195
    Length:3,195
    Mass (Da):344,441
    Last modified:July 5, 2004 - v1
    Checksum:i04404B41D1563EFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY372243 Genomic DNA. Translation: AAQ73715.1.
    RefSeqiNP_944409.1. NC_005264.1.

    Genome annotation databases

    GeneIDi2657005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY372243 Genomic DNA. Translation: AAQ73715.1 .
    RefSeqi NP_944409.1. NC_005264.1.

    3D structure databases

    ProteinModelPortali Q6UDJ5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2657005.

    Family and domain databases

    InterProi IPR005210. Herpes_UL36.
    IPR006928. Pept_C76_UL36-USP.
    [Graphical view ]
    Pfami PF04843. Herpes_teg_N. 1 hit.
    PF03586. Herpes_UL36. 1 hit.
    [Graphical view ]
    PROSITEi PS51521. HTUSP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
      Thureen D.R., Keeler C.L. Jr.
      J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDEN_PSHV1
    AccessioniPrimary (citable) accession number: Q6UDJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3