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Q6UDJ5

- DEN_PSHV1

UniProt

Q6UDJ5 - DEN_PSHV1

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Protein

Deneddylase

Gene

UL36

Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei17 – 171Important for catalytic activityPROSITE-ProRule annotation
Active sitei30 – 301PROSITE-ProRule annotation
Active sitei173 – 1731PROSITE-ProRule annotation
Active sitei175 – 1751PROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro
  2. omega peptidase activity Source: InterPro

GO - Biological processi

  1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
Gene namesi
Name:UL36
OrganismiPsittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Taxonomic identifieri670426 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
Virus hostiAmazona oratrix (yellow-headed parrot) [TaxID: 152276]
ProteomesiUP000006840: Genome

Subcellular locationi

Virion tegument Curated. Host nucleus By similarity

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. viral tegument Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31953195DeneddylasePRO_0000406796Add
BLAST

Interactioni

Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6UDJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 242233Peptidase C76PROSITE-ProRule annotationAdd
BLAST
Repeati764 – 79431ANK 1Add
BLAST
Repeati2151 – 218131ANK 2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1441 – 147131Sequence AnalysisAdd
BLAST
Coiled coili1514 – 154633Sequence AnalysisAdd
BLAST
Coiled coili1572 – 161140Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi838 – 980143Ala-richAdd
BLAST
Compositional biasi1656 – 16594Poly-Leu
Compositional biasi1663 – 16664Poly-Ala
Compositional biasi2286 – 22927Poly-Ala
Compositional biasi2708 – 27114Poly-Pro

Sequence similaritiesi

Belongs to the herpesviridae deneddylase family.Curated
Contains 2 ANK repeats.Curated
Contains 1 peptidase C76 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Family and domain databases

InterProiIPR005210. Herpes_UL36.
IPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamiPF04843. Herpes_teg_N. 1 hit.
PF03586. Herpes_UL36. 1 hit.
[Graphical view]
PROSITEiPS51521. HTUSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UDJ5-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MWPPGLGTVV AAASRSQFDA MYEEMCYAMC VETSAAFLRA CELAGPQAVQ
60 70 80 90 100
SQNVLDTILD QGAEITRTSV ACETLPGGVK RYNMIDCQEL PRLWRGSGQE
110 120 130 140 150
PDMLLLHTTT FGNIPYDSTF DYEEKVLMLN GQQLGEKAAA MAREGAAAVL
160 170 180 190 200
VIGNRGLGVA FTGGRHDPVF VFDPHGWMGG AAYMSRLPNP TSLTGFIADY
210 220 230 240 250
VERRSGIVVT LTFLLWLYPD GWNIEQESPE LRVEVISAAL RAISQPPDFV
260 270 280 290 300
FLDQFSETVV SPALPVPMGA LRADRFAAKS IRAILARGTA PSPKKKPDSG
310 320 330 340 350
EHGLPAGRPK PPKRHTPRSQ NPALLDSTEK LSNLSPVKVK KPNKGKKMSV
360 370 380 390 400
IAEPPSAAAR TEQRGPGDSL GALAERPPWR LQGVRAAADV IAVPAASALA
410 420 430 440 450
GLPEKPSDKL RGVLKYLPEA PTGGLSLGSG NALWAAILGT RVASLTDRLL
460 470 480 490 500
VFLVENGITI RKAESEVGFL LDPVLAALAH RPDRGAVASL IGDTRLNLFA
510 520 530 540 550
LVARKAALLR LTELRDDRVS AVLVHKVQQV SSAIVSDTKT ISAKLGALVD
560 570 580 590 600
EISSEHPADA YGTLEKELLA FSLEKTAVVE RPDETTAPIL ELVERAAEIV
610 620 630 640 650
DAIEKETRAK AEREDRARRA DEKLLAFAHS VWDEIDDIAG DVTRGVDVGS
660 670 680 690 700
SQASAAASLA KRERIDIPEP SSMPPREDYS ELKILDDKAK ANAQKITDSA
710 720 730 740 750
GKMLKVYANV IDYSISAFTS GTQSAIGRFA LASPALDHMK AWLDRIAYAD
760 770 780 790 800
TLVDSLAGLT GRRESASPDW GRLSSLEPVR ILEGLIETGA DLSSDENLNH
810 820 830 840 850
WTFQLFGAHA AGFMPSPSKW ISAIHGINTR AHEVGLSATA LAELETEIKA
860 870 880 890 900
AEAMVADPGV RLECAKHALE SAKAAVAGKS DPEQKARLAA AQARAAKLVD
910 920 930 940 950
SCQRDLDEAK RLVDEATKRD AEIKKAAAAL LRPVEKYQGL RGLGRSMAAA
960 970 980 990 1000
GLSDDAVAGI VAADTQVARV LRADAEAILA NYERDFAELR GAQLLGTSAP
1010 1020 1030 1040 1050
LLRAVNFIDP RSGLGLLEPG SRIFLSEAND DLMDAVEDAR TTRNTDSCSR
1060 1070 1080 1090 1100
AISALERIKW VIVEAEGAGQ WPKFAVAAAR ALEGLRAKAL IDDRAGLVRT
1110 1120 1130 1140 1150
TLAGMLKRAA IVSETVAKDT DDPEAAAERA LKFVEMARRE LRELELTDAE
1160 1170 1180 1190 1200
ELSSQDYVAL ERALVELAEA SRQKSIGLKK HAWRSRLRTL LERDRDDGEF
1210 1220 1230 1240 1250
SLDAWDQARD EGECYGGRDA VNDDLIKLAR AVIDGRIQLG LRLVRAFFAN
1260 1270 1280 1290 1300
NPYAAQASQA LPGDARGPVE LLESIRVAKW IFAFPGVADT YEYLFGISVV
1310 1320 1330 1340 1350
KLKALCEIGE EIVEAFDAAG SSDKNIDMHA FVQTVAGKLF QVSELTEFFD
1360 1370 1380 1390 1400
FYVRSYELFL DIRAALAETA GRVGALERTA LEQLGAEERA AESIRDPEAA
1410 1420 1430 1440 1450
KERLERGDRD PDALTAMREL HGGLKLESKK QFEKTAYLEP LEYGYAEARR
1460 1470 1480 1490 1500
ELERAIANVD AAKKLSQARV KDFLSSLLRE REANDQELSR NLKTLKSVLA
1510 1520 1530 1540 1550
ARSPKDVVAA LNGAETLDAV VKIYADRLAE AEAENEAAIV GAETMEWLKF
1560 1570 1580 1590 1600
AAKTIDGSKM ARETGGVGPT AAYAERLEKL CRARADADAK LKRLKDLYES
1610 1620 1630 1640 1650
FELALASAKE AGGKQKDESE DGWRRYEAAA NNLLTSAEAL GAQLRDEGNE
1660 1670 1680 1690 1700
QAGIKLLLLR EPAAAAYEKG LENAAAVIKD VRTTLDDTSA GMRRLLTLYE
1710 1720 1730 1740 1750
AAKTEFAKPG LERLQKEISY AIAKYPVPKW FLALHAAVGK LVELRLGLYH
1760 1770 1780 1790 1800
AYEGLKISTI PYAPVAPESE YVMPDAALTA ARVTAYMARS GKSVMTVTTH
1810 1820 1830 1840 1850
SLGIVGRAVV DEANQILEYK LCYATVSEKV AALWAAGSRL GAGQFGGLVL
1860 1870 1880 1890 1900
RDARDERGVE KFLGRGHAAV SLAATAAWLS GADTMITAEL GSYVTFCATG
1910 1920 1930 1940 1950
HWPAMRDRKQ LSMTVAACTT YCALAYATLT STYGSAADTA VDSHGQFVPP
1960 1970 1980 1990 2000
EKFEAANTSG AVAAGAARGA KRKFALSIQD VLILLAACEP AHLTYFCRLD
2010 2020 2030 2040 2050
LLRQVEYMHK TLEAVLSRAV RDRVGVSCLE PPKADDTRKY MPVVMPAARG
2060 2070 2080 2090 2100
RFDKSYGACF AIDRHDWDSV KAPHYVGKML EPWKTLPGTR ENAERLERIC
2110 2120 2130 2140 2150
GGTADAADGF TATLMMLAAT AIPANLLEAM WALLGPRDED LGENWQLGEG
2160 2170 2180 2190 2200
EVEGQWSGGA ASAAAAAMLR FMLRRAAAVD NYTVATSGGT AGLALDSLSA
2210 2220 2230 2240 2250
KLLGPAGGSI MFLLKEDAVN LRRLLAFDVA LLSILFGAKV VIAYETSALS
2260 2270 2280 2290 2300
RESGLLLCSS VFDARRGNRF ADILCADHRA CASDSAAAAA DALKKIALAD
2310 2320 2330 2340 2350
PNRIENACLL QQVEELASAL HSKPLSYAQP FLFLANTSNQ ITQVLIPAKA
2360 2370 2380 2390 2400
RPSEFFVTLR RDAAYEEVPL RRADRQAFPD EIDAKDIEGG DLFFSATVGG
2410 2420 2430 2440 2450
EVPVLDNPAH IAPAPPEYDR GEGNLFPFAG SRRSAPSEEE ALSKAAGSKR
2460 2470 2480 2490 2500
NQIDAHGQNI SQPARAGNTK IERASGKNRK TENNVTEHQT AARGRAAAPP
2510 2520 2530 2540 2550
TETKTTEKRQ KCPPRESPLS RDERAPHDGL SAGAAEPRPP RGDSDDDRHK
2560 2570 2580 2590 2600
HETPHGVSDK AAEPPAVPSA EPRGPSTELI GGNWKSLPKT KPRRTSSGLR
2610 2620 2630 2640 2650
RKHQASASVH KHRTHGSSDD DSEDGEATYG FGSCRGRQRR STLGGKKRSG
2660 2670 2680 2690 2700
TDRTAEFLKK ATCVDKLEKF SRSGESPKAQ NGTADVACDR LGERGNELSP
2710 2720 2730 2740 2750
PRAPASSPPP PGKQADHGID QREIVPPNAQ YGITTVVDPR QVRLPSSDDG
2760 2770 2780 2790 2800
DPAEEEDARD VEEGEEDVAG QWDSNYDVCL PTYDTDHAAQ EEKDFDLASN
2810 2820 2830 2840 2850
NGTGGALPAA DHAISAINDW VIADTDASAG VGTDWSEEDE DAPAADDGRS
2860 2870 2880 2890 2900
TNVEVATHGY TSDDSAADDE SKRARATRDS SPPQHYPASP LAPSTPSSLP
2910 2920 2930 2940 2950
TPADTDNDTA ILELDRNSGG DTDSNDDHAP PTDTGDAPPL CSEGELTPST
2960 2970 2980 2990 3000
DEECAVVQDD ARKKQENSSH ERKDDGVRWE IDLDSDQGDY SDASDDCKIP
3010 3020 3030 3040 3050
DGPRVAPEKD IKNKQLEKSE SDSCGGQGDP STEPQQPLWE VYSPYDNSDS
3060 3070 3080 3090 3100
DDKAGNRKDP KLDGAALDMR SSRLRADAKS ITSYVNDINE AVRDGGSAAA
3110 3120 3130 3140 3150
EFFARSEQSC IDSEDDARHL DKSRATLASD LDDHQSDQPR ESLAPLDPET
3160 3170 3180 3190
RSKMYTSLAV TCRLILRGMR HAQDAASAGV AELLTETNRI KMMLN
Length:3,195
Mass (Da):344,441
Last modified:July 5, 2004 - v1
Checksum:i04404B41D1563EFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372243 Genomic DNA. Translation: AAQ73715.1.
RefSeqiNP_944409.1. NC_005264.1.

Genome annotation databases

GeneIDi2657005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372243 Genomic DNA. Translation: AAQ73715.1 .
RefSeqi NP_944409.1. NC_005264.1.

3D structure databases

ProteinModelPortali Q6UDJ5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2657005.

Family and domain databases

InterProi IPR005210. Herpes_UL36.
IPR006928. Pept_C76_UL36-USP.
[Graphical view ]
Pfami PF04843. Herpes_teg_N. 1 hit.
PF03586. Herpes_UL36. 1 hit.
[Graphical view ]
PROSITEi PS51521. HTUSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
    Thureen D.R., Keeler C.L. Jr.
    J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDEN_PSHV1
AccessioniPrimary (citable) accession number: Q6UDJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3