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Q6UDJ5

- DEN_PSHV1

UniProt

Q6UDJ5 - DEN_PSHV1

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Protein
Deneddylase
Gene
UL36
Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei17 – 171Important for catalytic activity By similarity
Active sitei30 – 301 By similarity
Active sitei173 – 1731 By similarity
Active sitei175 – 1751 By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro
  2. omega peptidase activity Source: InterPro

GO - Biological processi

  1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
Gene namesi
Name:UL36
OrganismiPsittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Taxonomic identifieri670426 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
Virus hostiAmazona oratrix (yellow-headed parrot) [TaxID: 152276]
ProteomesiUP000006840: Genome

Subcellular locationi

Virion tegument Reviewed prediction. Host nucleus By similarity

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
  2. viral tegument Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31953195Deneddylase
PRO_0000406796Add
BLAST

Interactioni

Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6UDJ5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 242233Peptidase C76
Add
BLAST
Repeati764 – 79431ANK 1
Add
BLAST
Repeati2151 – 218131ANK 2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1441 – 147131 Reviewed prediction
Add
BLAST
Coiled coili1514 – 154633 Reviewed prediction
Add
BLAST
Coiled coili1572 – 161140 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi838 – 980143Ala-rich
Add
BLAST
Compositional biasi1656 – 16594Poly-Leu
Compositional biasi1663 – 16664Poly-Ala
Compositional biasi2286 – 22927Poly-Ala
Compositional biasi2708 – 27114Poly-Pro

Sequence similaritiesi

Contains 2 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Family and domain databases

InterProiIPR005210. Herpes_UL36.
IPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamiPF04843. Herpes_teg_N. 1 hit.
PF03586. Herpes_UL36. 1 hit.
[Graphical view]
PROSITEiPS51521. HTUSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UDJ5-1 [UniParc]FASTAAdd to Basket

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MWPPGLGTVV AAASRSQFDA MYEEMCYAMC VETSAAFLRA CELAGPQAVQ     50
SQNVLDTILD QGAEITRTSV ACETLPGGVK RYNMIDCQEL PRLWRGSGQE 100
PDMLLLHTTT FGNIPYDSTF DYEEKVLMLN GQQLGEKAAA MAREGAAAVL 150
VIGNRGLGVA FTGGRHDPVF VFDPHGWMGG AAYMSRLPNP TSLTGFIADY 200
VERRSGIVVT LTFLLWLYPD GWNIEQESPE LRVEVISAAL RAISQPPDFV 250
FLDQFSETVV SPALPVPMGA LRADRFAAKS IRAILARGTA PSPKKKPDSG 300
EHGLPAGRPK PPKRHTPRSQ NPALLDSTEK LSNLSPVKVK KPNKGKKMSV 350
IAEPPSAAAR TEQRGPGDSL GALAERPPWR LQGVRAAADV IAVPAASALA 400
GLPEKPSDKL RGVLKYLPEA PTGGLSLGSG NALWAAILGT RVASLTDRLL 450
VFLVENGITI RKAESEVGFL LDPVLAALAH RPDRGAVASL IGDTRLNLFA 500
LVARKAALLR LTELRDDRVS AVLVHKVQQV SSAIVSDTKT ISAKLGALVD 550
EISSEHPADA YGTLEKELLA FSLEKTAVVE RPDETTAPIL ELVERAAEIV 600
DAIEKETRAK AEREDRARRA DEKLLAFAHS VWDEIDDIAG DVTRGVDVGS 650
SQASAAASLA KRERIDIPEP SSMPPREDYS ELKILDDKAK ANAQKITDSA 700
GKMLKVYANV IDYSISAFTS GTQSAIGRFA LASPALDHMK AWLDRIAYAD 750
TLVDSLAGLT GRRESASPDW GRLSSLEPVR ILEGLIETGA DLSSDENLNH 800
WTFQLFGAHA AGFMPSPSKW ISAIHGINTR AHEVGLSATA LAELETEIKA 850
AEAMVADPGV RLECAKHALE SAKAAVAGKS DPEQKARLAA AQARAAKLVD 900
SCQRDLDEAK RLVDEATKRD AEIKKAAAAL LRPVEKYQGL RGLGRSMAAA 950
GLSDDAVAGI VAADTQVARV LRADAEAILA NYERDFAELR GAQLLGTSAP 1000
LLRAVNFIDP RSGLGLLEPG SRIFLSEAND DLMDAVEDAR TTRNTDSCSR 1050
AISALERIKW VIVEAEGAGQ WPKFAVAAAR ALEGLRAKAL IDDRAGLVRT 1100
TLAGMLKRAA IVSETVAKDT DDPEAAAERA LKFVEMARRE LRELELTDAE 1150
ELSSQDYVAL ERALVELAEA SRQKSIGLKK HAWRSRLRTL LERDRDDGEF 1200
SLDAWDQARD EGECYGGRDA VNDDLIKLAR AVIDGRIQLG LRLVRAFFAN 1250
NPYAAQASQA LPGDARGPVE LLESIRVAKW IFAFPGVADT YEYLFGISVV 1300
KLKALCEIGE EIVEAFDAAG SSDKNIDMHA FVQTVAGKLF QVSELTEFFD 1350
FYVRSYELFL DIRAALAETA GRVGALERTA LEQLGAEERA AESIRDPEAA 1400
KERLERGDRD PDALTAMREL HGGLKLESKK QFEKTAYLEP LEYGYAEARR 1450
ELERAIANVD AAKKLSQARV KDFLSSLLRE REANDQELSR NLKTLKSVLA 1500
ARSPKDVVAA LNGAETLDAV VKIYADRLAE AEAENEAAIV GAETMEWLKF 1550
AAKTIDGSKM ARETGGVGPT AAYAERLEKL CRARADADAK LKRLKDLYES 1600
FELALASAKE AGGKQKDESE DGWRRYEAAA NNLLTSAEAL GAQLRDEGNE 1650
QAGIKLLLLR EPAAAAYEKG LENAAAVIKD VRTTLDDTSA GMRRLLTLYE 1700
AAKTEFAKPG LERLQKEISY AIAKYPVPKW FLALHAAVGK LVELRLGLYH 1750
AYEGLKISTI PYAPVAPESE YVMPDAALTA ARVTAYMARS GKSVMTVTTH 1800
SLGIVGRAVV DEANQILEYK LCYATVSEKV AALWAAGSRL GAGQFGGLVL 1850
RDARDERGVE KFLGRGHAAV SLAATAAWLS GADTMITAEL GSYVTFCATG 1900
HWPAMRDRKQ LSMTVAACTT YCALAYATLT STYGSAADTA VDSHGQFVPP 1950
EKFEAANTSG AVAAGAARGA KRKFALSIQD VLILLAACEP AHLTYFCRLD 2000
LLRQVEYMHK TLEAVLSRAV RDRVGVSCLE PPKADDTRKY MPVVMPAARG 2050
RFDKSYGACF AIDRHDWDSV KAPHYVGKML EPWKTLPGTR ENAERLERIC 2100
GGTADAADGF TATLMMLAAT AIPANLLEAM WALLGPRDED LGENWQLGEG 2150
EVEGQWSGGA ASAAAAAMLR FMLRRAAAVD NYTVATSGGT AGLALDSLSA 2200
KLLGPAGGSI MFLLKEDAVN LRRLLAFDVA LLSILFGAKV VIAYETSALS 2250
RESGLLLCSS VFDARRGNRF ADILCADHRA CASDSAAAAA DALKKIALAD 2300
PNRIENACLL QQVEELASAL HSKPLSYAQP FLFLANTSNQ ITQVLIPAKA 2350
RPSEFFVTLR RDAAYEEVPL RRADRQAFPD EIDAKDIEGG DLFFSATVGG 2400
EVPVLDNPAH IAPAPPEYDR GEGNLFPFAG SRRSAPSEEE ALSKAAGSKR 2450
NQIDAHGQNI SQPARAGNTK IERASGKNRK TENNVTEHQT AARGRAAAPP 2500
TETKTTEKRQ KCPPRESPLS RDERAPHDGL SAGAAEPRPP RGDSDDDRHK 2550
HETPHGVSDK AAEPPAVPSA EPRGPSTELI GGNWKSLPKT KPRRTSSGLR 2600
RKHQASASVH KHRTHGSSDD DSEDGEATYG FGSCRGRQRR STLGGKKRSG 2650
TDRTAEFLKK ATCVDKLEKF SRSGESPKAQ NGTADVACDR LGERGNELSP 2700
PRAPASSPPP PGKQADHGID QREIVPPNAQ YGITTVVDPR QVRLPSSDDG 2750
DPAEEEDARD VEEGEEDVAG QWDSNYDVCL PTYDTDHAAQ EEKDFDLASN 2800
NGTGGALPAA DHAISAINDW VIADTDASAG VGTDWSEEDE DAPAADDGRS 2850
TNVEVATHGY TSDDSAADDE SKRARATRDS SPPQHYPASP LAPSTPSSLP 2900
TPADTDNDTA ILELDRNSGG DTDSNDDHAP PTDTGDAPPL CSEGELTPST 2950
DEECAVVQDD ARKKQENSSH ERKDDGVRWE IDLDSDQGDY SDASDDCKIP 3000
DGPRVAPEKD IKNKQLEKSE SDSCGGQGDP STEPQQPLWE VYSPYDNSDS 3050
DDKAGNRKDP KLDGAALDMR SSRLRADAKS ITSYVNDINE AVRDGGSAAA 3100
EFFARSEQSC IDSEDDARHL DKSRATLASD LDDHQSDQPR ESLAPLDPET 3150
RSKMYTSLAV TCRLILRGMR HAQDAASAGV AELLTETNRI KMMLN 3195
Length:3,195
Mass (Da):344,441
Last modified:July 5, 2004 - v1
Checksum:i04404B41D1563EFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY372243 Genomic DNA. Translation: AAQ73715.1.
RefSeqiNP_944409.1. NC_005264.1.

Genome annotation databases

GeneIDi2657005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY372243 Genomic DNA. Translation: AAQ73715.1 .
RefSeqi NP_944409.1. NC_005264.1.

3D structure databases

ProteinModelPortali Q6UDJ5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2657005.

Family and domain databases

InterProi IPR005210. Herpes_UL36.
IPR006928. Pept_C76_UL36-USP.
[Graphical view ]
Pfami PF04843. Herpes_teg_N. 1 hit.
PF03586. Herpes_UL36. 1 hit.
[Graphical view ]
PROSITEi PS51521. HTUSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
    Thureen D.R., Keeler C.L. Jr.
    J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDEN_PSHV1
AccessioniPrimary (citable) accession number: Q6UDJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3