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Protein

Ribonucleoside-diphosphate reductase large subunit

Gene

RIR1

Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311SubstrateUniRule annotation
Sitei247 – 2471Important for hydrogen atom transferUniRule annotation
Binding sitei277 – 2771Substrate; via amide nitrogenUniRule annotation
Active sitei450 – 4501Proton acceptorUniRule annotation
Active sitei452 – 4521Cysteine radical intermediateUniRule annotation
Active sitei454 – 4541Proton acceptorUniRule annotation
Sitei467 – 4671Important for hydrogen atom transferUniRule annotation
Sitei781 – 7811Important for electron transferUniRule annotation
Sitei782 – 7821Important for electron transferUniRule annotation
Sitei807 – 8071Interacts with thioredoxin/glutaredoxinUniRule annotation
Sitei810 – 8101Interacts with thioredoxin/glutaredoxinUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication, Host-virus interaction

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunitUniRule annotation (EC:1.17.4.1UniRule annotation)
Short name:
R1UniRule annotation
Alternative name(s):
Ribonucleotide reductase large subunitUniRule annotation
Gene namesi
Name:RIR1UniRule annotation
Ordered Locus Names:UL39
OrganismiPsittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Taxonomic identifieri670426 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
Virus hostiAmazona oratrix (yellow-headed parrot) [TaxID: 152276]
Proteomesi
  • UP000006840 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811Ribonucleoside-diphosphate reductase large subunitPRO_0000406807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi247 ↔ 467Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6UDJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni246 – 2472Substrate bindingUniRule annotation
Regioni450 – 4545Substrate bindingUniRule annotation
Regioni636 – 6405Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Phylogenomic databases

KOiK10807.

Family and domain databases

HAMAPiMF_04026. HSV_RIR1. 1 hit.
InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UDJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSATSLVPP AAPDMREHEL GECAAFYAAE TPQRLFENLL HLENALKARG
60 70 80 90 100
YDTDSAGAPA LGPTTLTMEA IADRITLIIN RFKAAVRLDL ELYRLLAELV
110 120 130 140 150
HIRIRTKTVS MQAWIELRGL SRECAEFILE RKNFVCELME RFGEVYPTLS
160 170 180 190 200
RVGLQSARKF ESMYLGKLKN GRLESVGQFF LRIAAEAARG VANNDAFAAA
210 220 230 240 250
VFRDGTRAPD ANTVFCLFFM ALCRQEIVPP TPVMLFAGTE SRSYASCFLL
260 270 280 290 300
DVRGRHTRDV LTSIAEEIIP VMHSHGGIGL YMDCDSNWDD NSSGMMLALK
310 320 330 340 350
ALDSIIAASN AVSARPSGLC VYVEPWHRDI MKILRCRGVL AGNEETRCDN
360 370 380 390 400
TFFALWMPDL FMKRFEANGT WTLFDGRAAH LSDLYGEEFE KEYELLERKN
410 420 430 440 450
VGIATYPARD VMFALIKSAV STGTPFVMFK HAVNRNYFFD MAGRAMKCSN
460 470 480 490 500
LCTEIVHMTD DESVGVCNLT SLNLAAFVTR RNALPGTPPI GTFDYSSFRD
510 520 530 540 550
ACAVATVFIN ALMSLSNLPI KRATTGNERL RSIGIGVQGF HTACLLQGFG
560 570 580 590 600
LDSVEACRFN GKLFEALALT TFQTSCRICE LGMNPFRGFS ESKYAKGWLH
610 620 630 640 650
MDGWPARHLY FDGWDRLREN IKAYGLYNCQ LVALMPTASS SQLTEVSEGI
660 670 680 690 700
HPVFGNIFSK ITTTGEDIQL NVALMETIEC LYPNKAERRD ILERLHKNKW
710 720 730 740 750
STRGAFGAAL PSQHPLTKFD TAFEADQEHL LRLSADRAPF VDHSQSTTLY
760 770 780 790 800
VVEEDDGAVR ASRVAHLLTT AFKYGLKTGM YYCKVRKATD NGVFLGTDTC
810
RRDDPTCLAC Q
Length:811
Mass (Da):90,420
Last modified:July 5, 2004 - v1
Checksum:i92166F6616E4BE9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372243 Genomic DNA. Translation: AAQ73718.1.
RefSeqiNP_944412.1. NC_005264.1.

Genome annotation databases

GeneIDi2656977.
KEGGivg:2656977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372243 Genomic DNA. Translation: AAQ73718.1.
RefSeqiNP_944412.1. NC_005264.1.

3D structure databases

ProteinModelPortaliQ6UDJ2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2656977.
KEGGivg:2656977.

Phylogenomic databases

KOiK10807.

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

HAMAPiMF_04026. HSV_RIR1. 1 hit.
InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIR1_PSHV1
AccessioniPrimary (citable) accession number: Q6UDJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.