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Q6UDJ2

- RIR1_PSHV1

UniProt

Q6UDJ2 - RIR1_PSHV1

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Protein

Ribonucleoside-diphosphate reductase large subunit

Gene

UL39

Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311SubstrateBy similarity
Sitei247 – 2471Important for hydrogen atom transferBy similarity
Binding sitei277 – 2771Substrate; via amide nitrogenBy similarity
Active sitei450 – 4501Proton acceptorBy similarity
Active sitei452 – 4521Cysteine radical intermediateBy similarity
Active sitei454 – 4541Proton acceptorBy similarity
Sitei467 – 4671Important for hydrogen atom transferBy similarity
Sitei781 – 7811Important for electron transferBy similarity
Sitei782 – 7821Important for electron transferBy similarity
Sitei807 – 8071Interacts with thioredoxin/glutaredoxinBy similarity
Sitei810 – 8101Interacts with thioredoxin/glutaredoxinBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication, Host-virus interaction

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
Short name:
R1
Alternative name(s):
Ribonucleotide reductase large subunit
Gene namesi
Name:UL39
OrganismiPsittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Taxonomic identifieri670426 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
Virus hostiAmazona oratrix (yellow-headed parrot) [TaxID: 152276]
ProteomesiUP000006840: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811Ribonucleoside-diphosphate reductase large subunitPRO_0000406807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi247 ↔ 467Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Heterodimer of a large subunit UL39 and a small subunit UL40.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6UDJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni246 – 2472Substrate bindingBy similarity
Regioni450 – 4545Substrate bindingBy similarity
Regioni636 – 6405Substrate bindingBy similarity

Sequence similaritiesi

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6UDJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSATSLVPP AAPDMREHEL GECAAFYAAE TPQRLFENLL HLENALKARG
60 70 80 90 100
YDTDSAGAPA LGPTTLTMEA IADRITLIIN RFKAAVRLDL ELYRLLAELV
110 120 130 140 150
HIRIRTKTVS MQAWIELRGL SRECAEFILE RKNFVCELME RFGEVYPTLS
160 170 180 190 200
RVGLQSARKF ESMYLGKLKN GRLESVGQFF LRIAAEAARG VANNDAFAAA
210 220 230 240 250
VFRDGTRAPD ANTVFCLFFM ALCRQEIVPP TPVMLFAGTE SRSYASCFLL
260 270 280 290 300
DVRGRHTRDV LTSIAEEIIP VMHSHGGIGL YMDCDSNWDD NSSGMMLALK
310 320 330 340 350
ALDSIIAASN AVSARPSGLC VYVEPWHRDI MKILRCRGVL AGNEETRCDN
360 370 380 390 400
TFFALWMPDL FMKRFEANGT WTLFDGRAAH LSDLYGEEFE KEYELLERKN
410 420 430 440 450
VGIATYPARD VMFALIKSAV STGTPFVMFK HAVNRNYFFD MAGRAMKCSN
460 470 480 490 500
LCTEIVHMTD DESVGVCNLT SLNLAAFVTR RNALPGTPPI GTFDYSSFRD
510 520 530 540 550
ACAVATVFIN ALMSLSNLPI KRATTGNERL RSIGIGVQGF HTACLLQGFG
560 570 580 590 600
LDSVEACRFN GKLFEALALT TFQTSCRICE LGMNPFRGFS ESKYAKGWLH
610 620 630 640 650
MDGWPARHLY FDGWDRLREN IKAYGLYNCQ LVALMPTASS SQLTEVSEGI
660 670 680 690 700
HPVFGNIFSK ITTTGEDIQL NVALMETIEC LYPNKAERRD ILERLHKNKW
710 720 730 740 750
STRGAFGAAL PSQHPLTKFD TAFEADQEHL LRLSADRAPF VDHSQSTTLY
760 770 780 790 800
VVEEDDGAVR ASRVAHLLTT AFKYGLKTGM YYCKVRKATD NGVFLGTDTC
810
RRDDPTCLAC Q
Length:811
Mass (Da):90,420
Last modified:July 5, 2004 - v1
Checksum:i92166F6616E4BE9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372243 Genomic DNA. Translation: AAQ73718.1.
RefSeqiNP_944412.1. NC_005264.1.

Genome annotation databases

GeneIDi2656977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372243 Genomic DNA. Translation: AAQ73718.1 .
RefSeqi NP_944412.1. NC_005264.1.

3D structure databases

ProteinModelPortali Q6UDJ2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2656977.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

InterProi IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
PROSITEi PS00089. RIBORED_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
    Thureen D.R., Keeler C.L. Jr.
    J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR1_PSHV1
AccessioniPrimary (citable) accession number: Q6UDJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3