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Q6UDJ2

- RIR1_PSHV1

UniProt

Q6UDJ2 - RIR1_PSHV1

Protein

Ribonucleoside-diphosphate reductase large subunit

Gene

UL39

Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei231 – 2311SubstrateBy similarity
    Sitei247 – 2471Important for hydrogen atom transferBy similarity
    Binding sitei277 – 2771Substrate; via amide nitrogenBy similarity
    Active sitei450 – 4501Proton acceptorBy similarity
    Active sitei452 – 4521Cysteine radical intermediateBy similarity
    Active sitei454 – 4541Proton acceptorBy similarity
    Sitei467 – 4671Important for hydrogen atom transferBy similarity
    Sitei781 – 7811Important for electron transferBy similarity
    Sitei782 – 7821Important for electron transferBy similarity
    Sitei807 – 8071Interacts with thioredoxin/glutaredoxinBy similarity
    Sitei810 – 8101Interacts with thioredoxin/glutaredoxinBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-UniPathway
    2. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication, Host-virus interaction

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
    Short name:
    R1
    Alternative name(s):
    Ribonucleotide reductase large subunit
    Gene namesi
    Name:UL39
    OrganismiPsittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
    Taxonomic identifieri670426 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
    Virus hostiAmazona oratrix (yellow-headed parrot) [TaxID: 152276]
    ProteomesiUP000006840: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 811811Ribonucleoside-diphosphate reductase large subunitPRO_0000406807Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi247 ↔ 467Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Interactioni

    Subunit structurei

    Heterodimer of a large subunit UL39 and a small subunit UL40.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UDJ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni246 – 2472Substrate bindingBy similarity
    Regioni450 – 4545Substrate bindingBy similarity
    Regioni636 – 6405Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR013346. NrdE_NrdA.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    [Graphical view]
    PRINTSiPR01183. RIBORDTASEM1.
    TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
    PROSITEiPS00089. RIBORED_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6UDJ2-1 [UniParc]FASTAAdd to Basket

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    MSSATSLVPP AAPDMREHEL GECAAFYAAE TPQRLFENLL HLENALKARG    50
    YDTDSAGAPA LGPTTLTMEA IADRITLIIN RFKAAVRLDL ELYRLLAELV 100
    HIRIRTKTVS MQAWIELRGL SRECAEFILE RKNFVCELME RFGEVYPTLS 150
    RVGLQSARKF ESMYLGKLKN GRLESVGQFF LRIAAEAARG VANNDAFAAA 200
    VFRDGTRAPD ANTVFCLFFM ALCRQEIVPP TPVMLFAGTE SRSYASCFLL 250
    DVRGRHTRDV LTSIAEEIIP VMHSHGGIGL YMDCDSNWDD NSSGMMLALK 300
    ALDSIIAASN AVSARPSGLC VYVEPWHRDI MKILRCRGVL AGNEETRCDN 350
    TFFALWMPDL FMKRFEANGT WTLFDGRAAH LSDLYGEEFE KEYELLERKN 400
    VGIATYPARD VMFALIKSAV STGTPFVMFK HAVNRNYFFD MAGRAMKCSN 450
    LCTEIVHMTD DESVGVCNLT SLNLAAFVTR RNALPGTPPI GTFDYSSFRD 500
    ACAVATVFIN ALMSLSNLPI KRATTGNERL RSIGIGVQGF HTACLLQGFG 550
    LDSVEACRFN GKLFEALALT TFQTSCRICE LGMNPFRGFS ESKYAKGWLH 600
    MDGWPARHLY FDGWDRLREN IKAYGLYNCQ LVALMPTASS SQLTEVSEGI 650
    HPVFGNIFSK ITTTGEDIQL NVALMETIEC LYPNKAERRD ILERLHKNKW 700
    STRGAFGAAL PSQHPLTKFD TAFEADQEHL LRLSADRAPF VDHSQSTTLY 750
    VVEEDDGAVR ASRVAHLLTT AFKYGLKTGM YYCKVRKATD NGVFLGTDTC 800
    RRDDPTCLAC Q 811
    Length:811
    Mass (Da):90,420
    Last modified:July 5, 2004 - v1
    Checksum:i92166F6616E4BE9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY372243 Genomic DNA. Translation: AAQ73718.1.
    RefSeqiNP_944412.1. NC_005264.1.

    Genome annotation databases

    GeneIDi2656977.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY372243 Genomic DNA. Translation: AAQ73718.1 .
    RefSeqi NP_944412.1. NC_005264.1.

    3D structure databases

    ProteinModelPortali Q6UDJ2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2656977.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    InterProi IPR013346. NrdE_NrdA.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    [Graphical view ]
    PRINTSi PR01183. RIBORDTASEM1.
    TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
    PROSITEi PS00089. RIBORED_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Psittacid herpesvirus 1 and infectious laryngotracheitis virus: Comparative genome sequence analysis of two avian alphaherpesviruses."
      Thureen D.R., Keeler C.L. Jr.
      J. Virol. 80:7863-7872(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRIR1_PSHV1
    AccessioniPrimary (citable) accession number: Q6UDJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3